This Week in Virology
TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.
Sun, April 06, 2025
Taking a shot at dementia
TWiV notes the passing of Klaus Conzelmann, then reviews reverse-zoonoses of 2009 H1N1 pandemic influenza A viruses and evolution in United States swine, and reduction in dementia incidence in recipients of Zostavax. Hosts: Vincent Racaniello , Alan Dove , and Rich Condit Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 Reverse zoonoses of 2009 H1N1 in US swine (PLoS Path) Zostavax reduces dementia (Nature) Letters read on TWiV 1207 Timestamps by Jolene Ramsey. Thanks! Weekly Picks Rich – Certain Roller Coasters May Help Small Kidney Stones Pass Alan – Analog and Asimov’s science fiction magazines Vincent – Science Under Threat in the United States: How scientists and institutions should respond Listener Pick Charles – Why Techdirt Is Now A Democracy Blog (Whether We Like It Or Not)
Sat, April 05, 2025
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin and Vincent Racaniello lament about the continuing measles outbreak, whether or not the measles outbreak was predicted, the FACTS about vaccination, high pathogenic influenza, H5N1 contaminated raw pet food, children’s deaths, before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections and vaccination schedules and the efficacy of Moderna’s seasonal mRNA vaccine, societal burden of COVID-19 and influenza, the FDA missed deadline for approving Novovax COVID vaccine, the WasterwaterScan dashboard, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, long COVID interventions, and Canada’s long COVID dashboard. Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode CDC buried a measles forecast that stressed the need for vaccinations….TRANSPARENCY? (Politico) Measles cases and outbreaks (CDC Rubeola) Measles 159 in Texas …. (Texas Health and Human Services) 2025 Measles outbreak guidance (New Mexico Health) Measles and rubella weekly monitoring report (Government of Canada) Enhanced epidemiological summary Measles in Ontario (Public Health Ontario) Measles and rubella weekly monitoring report (Government of Canada) Enhanced epidemiological summary Measles in Ontario (Public Health Ontario) Measles exposures in Ontario (Public Health Ontario) Measles vaccine recommendations from NYP ( jpg ) Get the <a href= "https://www.health
Sun, March 30, 2025
Pluviosity didn't kill the bat
TWiV reviews liver damage caused by over use of vitamin A in Texas, vitamin A does not change clinical course of measles in high income country, NIH cuts COVID-19 research, US ends vaccine funds for poor countries, anti-vaxxer hired to study vaccines and autism, new DURC policy, Jamaican fruit bat competence for filoviruses, and human outbreaks of Oropouche virus reassortant in Brazil. Hosts: Vincent Racaniello , Alan Dove , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 Vitamin A liver disease in Texas (NY Times) Vitamin A doesn’t help measles in high-income countries (Pediat Inf Dis) NIH cancels COVID grants (Science) US ends vaccine funds for poor countries (NY Times) Anti-vaxxer to study vaccines and autism (Sci Based Med) DURC rules revised ( USG and NIH guidance) Filoviruses and Jamaican fruit bats (Nat Comm) Oropouche outbreaks in Brazil (Nat Med) <a title="" href= "https://www.npr.org/sections/shots-health-news/202
Sat, March 29, 2025
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin with Vincent Racaniello rue about the continuing measles outbreak, the FACTS about vaccination, irresponsibility of promoting vitamin A therapy “lifelong liver damage or vaccinaton!”, high pathogenic influenza and egg importation before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections and vaccination schedules and if vaccination affects long COVID, the WasterwaterScan dashboard, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, long COVID interventions, how to track long symptoms using a wearable device and how these data will never be used with the closing of governmental long COVID programs and offices. Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Measles cases and outbreaks (CDC Rubeola) Measles 159 in Texas …. (Texas Health and Human Services) 2025 Measles outbreak guidance (New Mexico Health) 10 in Ohio and 23 in Kansas….. oh my ! (US News) Measles data (Kansas: Department of Health and Enivornment) Health director urges parents to ensure children are vaccinated against measles (Ohio: Department of Health) Get the FACTS about measles (NY State Department of Health) New York Governor Kathy Hochul sounds alarm for measles vaccine amid 4 confirmed cases (abc News) Get the FACTS about measles (NY State Department of Health) Long-term dynamics of measles virus–specific neutralizing antibodies in children vaccinated before 12 months of age (CID) M
Sun, March 23, 2025
What's old is flu again
TWiV explains why RFK Jr.’s proposal to let H5N1 infections in birds ‘rip’ is a bad idea, phase 1/2 trial of combined influenza/COVID mRNA vaccines, and how your first influenza virus exposure shapes the B cell response to influenza vaccination 50 years later. Hosts: Vincent Racaniello , Rich Condit , and Brianne Barker Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 RFK Jr. says let H5N1 rip through flocks (NY Times) Combined flu/COVID mRNA vaccine (Nat Comm) Rare syndrome after COVID vaccination ( NY Times , medRxiv ) Imprinting lasts 50 years (Immunity) Imprinting protects against H5N1 and H7N9 (Science) Letters read on TWiV 1203 Timestamps by Jolene Ramsey. Thanks! Weekly Picks Brianne – Node-Focal Plane Image Competition Rich – Periodic cooking of eggs Vincent – The use of placebo controls in clinical trials Listener Picks
Sat, March 22, 2025
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin and Vincent Racaniello rue about the unknowns of Sudan disease and new cases of paralytic polio, discuss the growing measles outbreak, exposure of newborns to measles, the FACTS about vaccination, high pathogenic influenza in dairy cows and cats, RFK’s statement “just let the virus rip through the hens” before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, what happens when antiviral therapy is delayed, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, long COVID interventions and the relationship between EBV and long COVID. Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode New cases of poliomyelitis (GPEI) Polio in Africa (CIDRAP) Program for Monitoring Emerging Diseases (PROMED) ProMED Subscriptions (PROMED) Measles infected baby and exposes 12 (NY Post) Measles 159 in Texas …. (Texas Health and Human Services) 2025 Measles outbreak guidance (New Mexico Health) Get the FACTS about measles (NY State Department of Health) Revising US MMR vaccine recommendations amid changing domestic risks (JAMA Network) Long-term dynamics of measles virus–specific neutralizing antibodies in children vaccinated before 12 months of age (CID) Newborns exposed to measles in Texas hospital (NBC News) Newborns exposed in West Texas <a href= "https://www.cidrap.umn.edu/measles/newborns-exposed-west-texas-me
Sun, March 16, 2025
Booster shots with Adam Ratner
Infectious diseases physician and author of ‘Booster Shots’ Adam Ratner joins TWiV to discuss measles, measles vaccination, how to approach anti-vaccine sentiment, and the uncertain future of children’s’ health. Hosts: Vincent Racaniello , Brianne Barker , and Jolene Ramsey Guest: Adam Ratner Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Booster Shots by Adam Ratner The Cutter Incident by Paul Offit Timestamps by Jolene Ramsey. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.
Sat, March 15, 2025
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin and Vincent Racaniello bemoan the continued outbreak of Sudan virus and growing number of paralytic polio cases before discussing growing measles outbreak in the US and Europe, the vaccine, an interview with a parent whose child died of measles infection, adverse effects of vaccination and how parents do not think they have accurate information about “bird flu” before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, what happens when antiviral therapy is delayed, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, long COVID interventions and the benefits of antiviral therapies on post acute SARS-Cov-2 infection sequelae. Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Sudan virus disease(WHO) New cases of poliomyelitis (GPEI) Measles 159 in Texas …. (Texas Health and Human Services) 2025 Measles outbreak guidance (New Mexico Health) First cases of measles in Oklahoma (Oklahoma) Measles case on Long Island (CBS News) Public health confirms measles case in Los Angeles County (County of Los Angeles Public Health) Measles exposure (Department of public health: City of Philadelphia) Where US measles outbreaks are spreading (New York Times) Statement from the chief public health officer of Canada on the increase in measles cases and the risk to people in Canada(Health Canada) <a
Sun, March 09, 2025
Loosely contained
TWiV covers a second death over 150 cases of measles in Texas, utter failure of removal of type 2 poliovirus from OPV, more OPV doses administered in Gaza, second Ebola outbreak in Sudan, vaccine being tested, Trump administration cancels $400 million in grants to Columbia University, bat-infecting merbecovirus that binds human ACE2 and infects human cells, and innate immune sensing of rotavirus by intestinal epithelial cells leads to diarrhea. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 Second child dies of measles (NY Times) Over 150 measles cases in Texas (Texas DSHS) Utter failure of removal of OPV2 from OPV (Science) Over 600,000 doses of OPV administered in Gaza (polioeradication) Second outbreak of Sudan Ebola in Uganda (IAVI) Columbia grants canceled by administration (NBC News) Bat merbecovirus also infects human cells via Ace2 (Cell) Recent virus research, was proper containment used ? (NY Times) Innate immune sensing of rotatvirus leads to diarrhea (Cell Host Microbe) Timestamps by <a href= "
Sat, March 08, 2025
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin with Vincent Racaniello deliberate the effect of the absence of US foreign aid on the Ebola outbreak in Uganda and death of two children, continued use of nOPV2 in Gaza and the utter failure of type 2 poliovirus removal from the oral poliovirus vaccine, growing measles outbreak in the US including the death of a second child, measles infection parties, the use of fat soluble vitamin A and fish liver oil as anti-viral therapies as well as the history and proven safety of the measles vaccine before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, what happens when antiviral therapy is delayed, provides information for Columbia University Irving Medical Center’s long COVID treatment center, and where to go for answers to your long COVID questions, long COVID interventions. Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode African region: outbreaks and other emergencies(WHO Bitstream) US withdrawal……death of 4 year old children from Ebola (CIDRAP) Science and health writer Apoorva Mandavilli (NY Times) US foreign aid pullback ……death of 4 year old in Uganda (NY Times) Another Ebola death reported in Kampala (Monitor) African region: outbreaks and other emergencies(WHO Bitstream) More than 600,000 doses of nOPV2 in Gaza last week (GPEI) Utter failure of the global withdrawal of the Sabin oral poliovirus type 2 vaccine 2016 (Science) Measles 159 in Texas …. (Texas Health and Human Services) Second child dies in the growing measles out
Sun, March 02, 2025
The long and short of influenza
TWiV reviews passing of Ann Palmenberg, deadly illness in western Congo, US disruption of mpox and ebolavirus programs, first measles death in Texas outbreak, flu vaccine selection meeting postponed, US withdraws from polio, malaria, HIV programs and more, clade 2.3.4.4b H5N1 viruses have a long HA stalk, and systems vaccinology to identify predictors of durable antibody response to multiple vaccines in humans. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 Ann Palmenberg dies (Cress) Ann at Chumakov Symposium (YouTube) Unknown illness in Congo (NY Times) Bad news about mpox outbreak (NPR) US interrupts Ebola prevention program (NPR) First measles death in Texas (Texas Trib) Flu vaccine selection meeting canceled (NY Times) US ends funding for polio, HIV, malaria and more (NY Times) Clade 2.3.4.4b H5N1 neuraminidase has a long stalk (mBio) Predictors of durable antibody responses to vaccines (Nat Immunol) Review of <a title="" href= "https://ww
Sat, March 01, 2025
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin and Vincent Racaniello lament about the downfall of public health from “postponement” of the advisory committee on immunization practices and the FDA VRBPAC influenza strain selection meetings to how the communication pause prevents public notice of NIH study section meetings, and withdrawal of CDC promotions for the ‘flu vaccine’ before discussing the end of Ebola outbreak in Uganda, funding from Saudi Arabia for polio eradication, the continuing and growing measles outbreak in the US including misinformation from the Secretary of HHS, highly pathogenic avian flu and its economic effect, ie the cost of eggs before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, an update of Paxlovid administration, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, long COVID interventions and FDA approval of adjuvanted Novovax COVID vaccine. Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Phantom ACIP (CDC) Postponement of ACIP…..hummmm (STATNews) Influenza Strain selection VRBPAC cancelled (Reuters) How NIH funded research is impacted by government communication pause (NY Times) Can be reviewed but still no money (STATNews) Final push to end Ebola in Uganda (WHO Uganda) Saudi Arabia sponsors polio eradication effort (GPEI)) $500 million from Saudi Arabia to immunize 370 million children against polio (CIDRAP) Measles 124 in <a href= "https://www.dshs.texas.gov/news-alerts/
Sun, February 23, 2025
Dickson Despommier, parasitologist without borders
The entire TWiV team comes together to pay tribute to Dickson Despommier, then reviews antibodies to H5N1 virus in veterinarians working with dairy cattle, Elisabeth Bik donates prize money for data integrity analyses, measles outbreak in Texas, and use of an alternative genetic code by human microbiome phages. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , Kathy Spindler , Brianne Barker , Daniel Griffin , Angela Mingarelli, and Jolene Ramsey Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 Livestream tribute to Dickson (Office Hours) Dickson’s Wikipedia page Dickson’s obituary (NY Times) Dickson websites: trichinella.org , thelivingriver.org , fordhamopolis.com , despommierphotoart.com Alan’s tribute to Dickson (alandove.com) H5N1 seroprevalence (MMWR) Elisabeth Bik donates prize money (Science) Measles outbreak in Texas (Texas DSHS) Human microbiome phages use alternative genetic code (Nat Comm) <a title="" href= "https://www.microbe.tv/twiv/twi
Sat, February 22, 2025
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin and Vincent Racaniello reminiscence about Dickson before discussing discharging Ebola patients, another announcement of emergency measures to control polio spread and the third nOPV2 vaccination campaign in Gaza in less than 6 months, the measles outbreak in the US, vaccination campaign for chickens against high pathogenic avian flu before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, an update of Paxlovid administration provides information for Columbia University Irving Medical Center’s long COVID treatment center, and where to go for answers to your long COVID questions. Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode In memory of Dickson (NY Times) All Ebola patients discharged in Uganda (DG Alerts) Uganda discharges Ebola patients (WHO Uganda) Emergency measures to stop polio…..isn’t this the same plan as last year? (GPEI)) A third nOPV2 campaign…..but I thought OPV stops transmission (Reuters) Worst outbreak of measles in 30 years for Texas…. go big or go home ! (AP News) Measles 58 in Texas …. (Texas Health and Human Services) High pathogenic avain influenza virus infection of indoor domestic cats (CDC MMWR) Avian influenza in dairy cattle in Arizona (AZEIN) <a href= "https://www.cidrap.umn.edu/avian-influenza-bird-flu/third-avian-flu-spillover-reported-ari
Sun, February 16, 2025
HPV or not to B
TWiV reviews a facility accident that killed monkeys, new bird blu genotype found in Nevada dairy cattle, Argentina plans to leave WHO, yellow fever on the rise, dynamics of HPV infections in women, and Epstein-Barr virus protein targets B cell receptor for degradation. Hosts: Vincent Racaniello , Alan Dove , and Angela Mingarelli Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 Accident kills monkeys at SC research supply facility (Science) D1.1 Genotype in Dairy Cattle in Nevada (APHIS) Argentina to leave WHO (CIDRAP) Yellow fever on the rise (CIDRAP) HPV dynamics in women (PLoS Biol) EBV protein degrades B cell receptor (PNAS) Letters read on TWiV 1193 Timestamps by Jolene Ramsey. Thanks! Weekly Picks Angela – Mitochondrial swap from cancer to immune cells thwarts anti-tumour defences ( one , two ) Alan – A little adventure game Vincent – The Staggering Success of Vaccines Listener Picks John
Sat, February 15, 2025
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss confirmation of Robert F Kennedy as HHS sectary, mpox, Ebola, how the American people support vaccine development and administration, the measles outbreak in the US-Texas, Georgia and influenza: the number of human infections, high avian flu in mammals, house cats and dairy cows before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, an update of Paxlovid administration provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, how long COVID varies between children and adults and if viral infection reduces telomere length in sperm. Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Confirmation of RFK, Jr as HHS sect (NY Times) Did you know mpox in NY ?….(Reuters) Mpox in sex workers in the Congo and in NY (CIDRAP) 9 confirmed, 265 suspected Ebola cases in Uganda (AP news) WHAT!? Support vaccines : availability and development. WHAT? (Businesswire) Measles rising in the unvaccinated . You mean the vaccines does something positive? (ABC News) Measles in Texas ….go big or go home (Texas Health and Human Services) Vaccination Conscientious exemptions in Texas (Texas Health and Human Services) 2, 6, 14 measles hospitalizations in Texas (CNN) <a href= "https://www.cdc.gov/schoolvaxview/da
Sun, February 09, 2025
The pandemic duo
TWiV reviews freezes and unfreezes of US government grants, how prior COVID-19 vaccination prevents over-reaction of the innate immune response during infections, and how bat genomes illuminate adaptations to viral tolerance and disease resistance. Hosts: Vincent Racaniello and Alan Dove Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 NIH freezes (ScienceAdviser) Is your research on Trump’s hit list ? (ScienceInsider) Prior COVID-19 vaccination tames innate responses (Sci Transl Med) Bat genomes illuminate viral tolerance and disease resistance (Nature) Letters read on TWiV 1191 Timestamps by Jolene Ramsey. Thanks! Weekly Picks Alan – NOAA Space Weather Prediction Center dashboards Vincent – He created a hummingbird paradise in his backyard Listener Picks Christiane – Contact your members of Congress about the Pause in Federal Grant Funding Charles – What’s trending in the world of pseudoscience Intro music is by Ronald Jenkees Send yo
Sat, February 08, 2025
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss changes in access to public health information and aid mechanisms such as the return of MMWR, the largest tuberculosis outbreak in the US ever, lack of USAID in fighting Marburg and Ebola outbreaks in Africa, discussing if avian influenza virus is airborne, how eggs are effected and the emergence of second spillover into dairy cattle, how the difference between nOPV2 and Sabin OPV2 is a minor reduction in the association of vaccine associated paralytic poliomyelitis before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, an update of Paxlovid administration provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, how children may be affected by long COVID and if SARS-CoV-2 and other inflammatory syndromes increase the risk of Alzheimer’s disease. Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode The return of MMWR (CDC) Largest tuberculosis outbreak ever in the US (Kansas Department of Health and Environment) Marburg virus outbreak in Tanzania (Doctors without borders) No USAID, Ebola outbreak in Uganda spreads (CBS News) WHO accelerates efforts to Ebola response in Uganda (WHO: Uganda) Global partners enable access to vaccine and treatment for Ebola outbreak in Uganda (WHO) Ventilation and respiratory viruses (CDC National Institute for Occupational saf
Sun, February 02, 2025
Viruses making waves
TWiV notes the HHS communication pause, and describes research showing that rotavirus viroporin activity is necessary for intracellular calcium signals that contribute to viral pathogenesis, and control of human orthrflavivirus vaccine challenge by T cells in the absence of neutralizing antibodies. Hosts: Vincent Racaniello , Alan Dove , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 Rotavirus viroporin activity, calcium waves , and pathogenesis (Sci Adv) T cells control human orthoflavivirus challenge (Nat Micro) Letters read on TWiV 1189 Timestamps by Jolene Ramsey. Thanks! Weekly Picks Brianne – The Perfect Cacio e Pepe Recipe, According to Science (primary article here ) Kathy – Dragonflies Loop-the-Loop Alan – My Beloved Monster , by Caleb Carr Vincent – Why Did the FDA Ban Red Dye #3 Listener Picks Anne –
Sat, February 01, 2025
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss changes in access to public health information, the Marburg and Ebola outbreaks in Africa, the largest tuberculosis outbreak in the US ever, the politicization of polio vaccine campaigns in Pakistan, effect of high pathogenic influenza in animals and on the economy before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, trials and devices to relieve some neurological complications of long COVID and the ramifications of long COVID in children, healthcare workers and adults. Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode No morbidity and mortality in the US this week? (NPR) More support for Marburg outbreak in Tanzania (Reliefweb) Tanzania confirming second Marburg case (CIDRAP) Norovirus mRNA vaccine …..hmmmm? (moderna) What is noronvirus? (modernatx) Largest tuberculosis outbreak ever in the US (Reuters) Ebola outbreak in DRC during US:WHO strain (STAT News) Uganda Ebola outbreak…..1 dead (Reuters) Polio outside endemic zone due to militants? (Washington Post) Mpox <a href= "https://www
Sun, January 26, 2025
The tau of herpesvirus
TWiV explains a new blood test for head and neck cancer, Japanese regulators approve tecovirimat for mpox, an entry receptor for enterovirus D68, and anti-herpetic tau preserves neurons via a DNA sensing pathway in Alzheimer’s disease. Hosts: Vincent Racaniello , Kathy Spindler , Brianne Barker , and Angela Mingarelli Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 Entry receptor for EV-D68 (Cell Host Microbe) Anti-herpetic tau preserves neurons in Alzheimers (Cell Rep) Letters read on TWiV 1187 Timestamps by Jolene Ramsey. Thanks! Weekly Picks Angela – Good genes are nice, but joy is better Brianne – Beaker Hair Clip Kathy – Pareidolia explained by street artist David Zinn TEDx talk Also visit zinnart.com Alan – Screwworm is coming back in the Americas Vincent – Dr. Jay Bhattacharya Was Nice to Someone During a Debate. That Doesn’t Erase the Consequences of His Misinformation Listener Picks Sarah – <a ti
Sat, January 25, 2025
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin and co-host Vincent Racaniello lament about the public changes from withdrawing from the WHO to health and scientific communication pauses by the Trump Administration after a brief discussion of Marburg in Tanzania and mpox in England before reviewing cats and bird flu, the recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, and where to go for answers to your long COVID questions. Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Tanzania confirms Marburg virus outbreak (Reuters) Clade Ib mpox in England (Reuters) Withdrawing from the World Health Organization (WhiteHouse) Fees costs behind withdrawing from WHO ….is that what we are suppose to believe? (Sky News) Sorry to see you go , US? (WHO) Where are the updates ? (CDC Health Alert Network) Pause in health communications of all kind (Washington Post) NIH chaos…..streaming to a halt? (STAT News) Devastation at the NIH, hiring traveling, meetings, communications(Science) Protect your cat from bird flu (NPR) No communication and <a href= "https://www.cidrap.umn.edu/antimicrobial-stewardship/study-highlights-risk-treating-asymptomatic-bacteriuria-antibiot
Sun, January 19, 2025
The birds and the Bs
TWiV explains Guillain-Barré Syndrome associated with RSV vaccines, outbreaks of metapneumovirus in China and India, editors resign to protest Elsevier’s use of AI in publishing, global distribution and diversity of wild bird associated pathogens, and broadly inhibitory anti-neuraminidase antibody from human memory B cells. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 GBS with RSV vaccine (FDA) Increase in respiratory infections in China (ECDC) Elsevier journal editors resign (Retract Watch) Wild bird associated pathogens (Med) Broad anti-neuraminidase antibody (Cell Host Micr) Letters read on TWiV 1185 Timestamps by Jolene . Thanks! Weekly Picks Brianne – Dear Reviewer 2 Rich – National Data Buoy Center Alan –
Sat, January 18, 2025
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses current and past outbreaks of “vaccine” preventable diseases including whooping cough, polio and measles with your co-host Vincent Racaniello and the recent increase in norovirus outbreaks, if alcohol-based hand sanitizers aid in the spread of norovirus before reviewing the recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, if “long COVID” like symptoms occurs after influenza and how long COVID may associate with neurological complicates that control verbal memory. Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Notable infectious diseases in US (CDC NNDSS) Get your Tdap : whooping cough case increase (California Department of Public Health) Resurgence of measles among preschool aged children 1989-1991 (CDC: MMWR) Adults vulnerable to ‘childhood’ diseases (NY Times) Pivotal decision that led to a resurgence of polio (NY Times) Can polio return due to lagging vaccination ? (NY Times) NoroSTAT Data Table (CDC Norovirus) The discovery of the 27-nm Norwalk virus : an historic perspective (JID) Why the “ Ferrari of viruses ” is surging through the northern hemisphere (Science) Waste water scan for 11 pathogens (WastewaterSCan) Norovirus at Chipotle, $25million food fine (NY Times) Chipotle food issues: <a href= "https://newsroom.chipot
Sun, January 12, 2025
More than 2024 viruses
TWiV reviews some of their favorite virology stories from 2024. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 SARS-CoV-2 origins ( TWiV Special ) TWiV 1163: Hepadnaviridae in the heartland TWiV 1117 Pol dances with the RNA that brought it HPV vaccine success (TWiV 1083 , 1151 , 1159 , 1173 ) Monkeypox (TWiV 1095 , 1119 , 1143 , 1145 , 1147 ) Influenza H5N1 virus (V TWiV 1113 , TWiV 1131 , TWiV 1173 ) Influenza B/Yamagata removed from vaccine ( TWiV 1161 ) Fiasco of poliomylelitis eradication ( TWiV 1091 , TWiV 1125 , TWiV 1105 , TWiV 1151 , TWiV 1145 , TWiV 1147 , TWiV 1161 , <a href= "https://w
Sat, January 11, 2025
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses how vaccination and vaccine hesitancy affects public health and disease spread in terms of mpox, the first human death from H5N1 in US, why one should not feed their pets raw pet food and the metapneumonia outbreak in China before reviewing the recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, how nirmatrelvir-ritonavir/Paxlovid reduces adverse outcomes of COVID in patients with kidney disease, provides information for Columbia University Irving Medical Center’s long COVID treatment center, SARS-CoV-2 infection affects skin conditions including shingles and if long antiviral treatment affects long COVID. Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Mpox vaccination hesitancy , previous immunisation coverage, and vaccination readiness in the African region (eClincial Medicine) Global prevalence and correlates of mpox vaccine acceptance and uptake (Communications Medicine) First case of new mpox variant in France (Reuters) First “Bird flu” death in US (NY Times) Emerging threat of H5N1 to human health (NEJM) Don’t feed your pets raw food (County of Los Angeles Public Health) Oregon, nationwide raw pet food recall (CIRAP) Raw cat food avian flu, is this like raw milk? (CIDRAP) Human metapneumovirus surging in China (The Guardian) Viral video of <a href= "https://economictimes.indiatimes.com/news/international/global-trends/hmpv-china-viral-video-showing-hmpv-chaos-at-china-hos
Sun, January 05, 2025
Seek and ye shall find, coronaviruses and phage
TWiV discusses an outbreak of influenza H5N1 that killed over half of the great cats at a Washington sanctuary, origin and cross-species transmission of bat coronaviruses in China, and the diverse and abundant phages that enter cells via receptors encoded on conjugative plasmids. Hosts: Vincent Racaniello , Rich Condit , and Jolene Ramsey Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 H5N1 virus kills great cats at Washington sanctuary (CNN) Macroevolution of bat coronaviruses in China (Nat Comm) EcoHealth Alliance funding suspended (Science) Conjugative plasmids support diverse and abundant phages (Nat Comm) Letters read on TWiV 1181 Timestamps by Jolene . Thanks! Weekly Picks Rich – Pareidolia ( wiki ) Jolene – Pathways to Science database Vincent – Wendy Carlos and Switched-On Bach Listener Picks Arjan – Gutsick Gibbon’s YouTube channel Alan – 2024 Nobel Prize Lectures in Chemistry Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not b
Sat, January 04, 2025
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the recent increase in norovirus outbreaks, human cases of H5N1 avian influenza, before reviewing the recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, how effective Molnupiravir is and provides information for Columbia University Irving Medical Center’s long COVID treatment center. Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Norovirus: Waste water scan for 11 pathogens (WastewaterSCan) Adolescent with Influenza A H5N1 infection (NEJM) Highly pathogenic avian Influenza A ( H5N1) virus infections in humans (NEJM) Emerging threat of H5N1 to human health (NEJM) US respiratory virus activity (CDC Respiratory Illnesses) In-hospital outcomes of healthcare-associated Coronavirus Disease 2019 (Omicron) versus healthcare-associated Influenza (CID) Waste water scan for 11 pathogens (WastewaterSCan) US respiratory virus activity (CDC Respiratory Illnesses) Weekly surveillance report: cliff notes (CDC FluView) RSV: Waste water scan for 11 pathogens (WastewaterSCan) RSV- Net work (CDC Respiratory Syncytial virus Infection) US respiratory virus activity (CDC Respiratory Illnesses) Waste water scan for <a href= "https://data.wastewaterscan.org/?charts=CjIQACABSABaBk4gR2VuZXIKMjAyNC0wOC0wN3IKMjAyNC0wOS0
Sun, December 29, 2024
Dark matter and warning signs
TWiV reviews RFK Jr’s demand to revoke polio vaccine, Wuhan lab samples do not include close relatives to SARS-CoV-2, using artificial intelligence to discover the RNA virosphere, and biomarkers that discriminate early and late phases of respiratory virus infections from a SARS-CoV-2 human challenge study. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , Kathy Spindler , and Angela Mingarelli Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 RFK Jr lawyer wants revocation of polio vaccine (CNN) Wuhan lab has no samples close to SARS-CoV-2 (Nature) Using AI to discover RNA virosphere (Cell) SARS-CoV-2 human challenge reveals biomarkers (Nat Comm) Does this challenge study pass the smell test? ( TWiV 863 ) Letters read on TWiV 1179 Timestamps by Jolene . Thanks! Weekly Picks Angela – Science’s 2024 breakthrough of the year, Lenacapavir “the long shot”. NEJM papers with Lenacapavir trials: one and two . Kathy – Bach Toccatta and Fugue on floor piano Rich – Never Cry Wolf Vincent – <a href= "http://naturemappingfoundation.org/natmap/facts/crow_vs_raven.ht
Sat, December 28, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin deep dives into the whooping cough epidemic and bird flu in big cats, and in conjunction with your host Vincent Racaniello discusses the recent case of paralytic poliomyelitis in Israel, measles outbreaks and HHS campaign for vaccine safety campaign before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, if the COVID mRNA vaccine is effective against symptomatic SARS-CoV-2 infection and hospitalization in children, where to find PEMGARDA, information for Columbia University Irving Medical Center’s long COVID treatment center, how long COVID effects one’s activities, personality and neuropsychiatric symptoms. Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Highest level of whooping cough cases in a decade (NBC News) Provisional pertussis surveillance report (CDC) Polio moves into Israel (Jerusalem Post) Polio today (GPEI) Measles- the let’s get real vaccination campaign (CDC) Measles fact sheet (CDC) Measles- near you (CDC) Let’s get real about childhood vaccines (HHS) The FACTS about childhood vaccines (HHS) Tigers and cougars dying from bird flu, oh my! (NY Times) US respiratory virus activity (CDC Respiratory Illnesses) Waste water scan for 11 pathogens (WastewaterSCan) US<a href= "https://w
Sun, December 22, 2024
Going to school for flu
At the School for Influenza in Brisbane, TWiV speaks with Kirsty, Erik and Rebecca about their careers and their research. Host: Vincent Racaniello Guests: Kirsty Short , Erik Karlsson , and Rebecca Cox Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Diabetes, obesity, and COVID-19 severity (Diab Care) Rice farming and zoonosis in Cambodia (One Health) Influenza correlates of protection (mBio) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.
Sat, December 21, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin continues his discussion of whether the mysterious respiratory illness in the Congo is malaria, and in conjunction with your host Vincent Racaniello discusses how routine childhood immunizations especially that against poliovirus are threatened by Robert F Kennedy Jr and Aaron Siri, the origin of the SAR-CoV-2 virus and retraction of Didier Raoult’s research, then returns to discussing the first case of severe disease following H5N1 infection in humans and the state of California’s “bird flu emergency”, the benefit of the measles vaccine, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how vaccination reduced hospitalization of children between 5-17 years, the ACIP recommendation for the immunocompromised, where to find PEMGARDA, information for Columbia Unversity Irving Medical Center’s long COVID treatment center, long COVID in cancer patients and the physical malaises of long COVID. Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Mystery disease in DRC kills mostly children (ALJAZEERA) Malaria— mysterious disease in DRC? (ALJAZEERA) Mysterious disease in DRC is severe malaria (ALJAZEERA) Confirmed first severe human H5N1 case (CIDRAP) California declares bird flu emergency (Reuters) RFK’s lawyer asks FDA to revoke approval of the polio vaccine (NY Times) NO WAY! Vaccination promotes survival and health? (LANCET) 10.6 million cases of measles this year alone! (WHO) <a href= "https://docs.google.com/document/d/1jSW5pYsNSTN2IbRPAJqthapEJHTORld0Yvn5AEpGW
Sun, December 15, 2024
A hitchiker's guide to virology
TWiV reviews the appearance of poliovirus in Europe, mystery disease in DRC, global burden of Chikungunya, viruses of parasitic nematodes that induce antibody responses in vertebrate hosts, and picobirnaviruses, do they infect eukaryotes or prokaryotes? Hosts: Vincent Racaniello , Alan Dove , and Jolene Ramsey Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV 2025 Write your senators about RFK Jr Support science education at MicrobeTV Poliovirus in Europe (WHO) DRC mystery disease (Reuters) Global burden of chikungunya (BMJ Global Health) RNA viruses of parasitic nematodes (Nat Micro) Picobirnaviruses encode bacterial lysins (PNAS) Prokaryotic ribosome binding site in picobirnavirus genome (Virology) Letters read on TWiV 1175 Timestamps by Jolene . Thanks! Weekly Picks Alan – Sondehub and radiosonde hunting Jolene – Book “ 10 to 25: The Science of Motivating Young People ” By David Yeager Vincent – <a href= "https://sciencebasedmedicine.org/notsat
Sat, December 14, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin deep dives into whether the mysterious respiratory illness in the Congo is malaria, and in conjunction with your host Vincent Racaniello discusses the failure of the poliovirus eradication campaign with virus circulation detected throughout Europe and how we should focus on disease control not virus circulation, then returns to discussing avian influenza in raw milk and the early stoppage of the mpox antiviral Tecovirimat before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, if there is a difference in protection against the development of severe disease between an mRNA or a protein based vaccine, where to find PEMGARDA, and information for Columbia Unversity Irving Medical Center’s long COVID treatment center. Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode IIs the mysterious disease in the Congo, malaria? (AP News) State of global health , year-end remarks by WHO director-general (WHO) Really, progress towards poliomyelitis eradication ? (CDC MMWR) Increases in confirm cases ¹ control of poliomyelitis (WHO) Polio European Union and United Kingdom, is that 1 global entry ? (Science) Is the WHO the global CDC? polio vaccination guidelines (WHO) Do you feed your cats raw milk ? (Public Health LA county) Is there avian influenza in the zoo near you? (Maricopa) Don’t <a href= "https://www.cidrap.umn.edu/avian-influenza-bird-flu/avian
Sun, December 08, 2024
Holy Cow! Convergent evolution!
TWiV reviews nominees to head NIH, FDA, and CDC, cervical cancer decline following HPV vaccination, local dengue in Texas, human isolate of H5N1 virus is transmissible and virulent in animal models, and shared mechanisms of immune evasion among animal and bacterial viruses. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , Kathy Spindler , Brianne Barker , and Jolene Ramsey Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Bhattacharya nominated to head NIH (Science) Makary nominated to head FDA (Science) Weldon nominated to head CDC (Chief Healthcare Exec) Cervical cancer declining following vaccination (JAMA Net) Local dengue case in Texas (Texas HHS) H5N1 human isolate transmissible and virulent (Nature) H5 current situation (CDC) Global H5N1 cases (Our World in Data) Conserved immune evasion in animal and bacterial viruses (Cell) Timestamps by Jolene . Thanks! Weekly Picks Brianne – Pale Blue Pod Kathy – PhysicsGirl recent Instagram post , <a href= "htt
Sat, December 07, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin summarizes influenza and RSV circulation in the US, the benefit of administering oseltamivir early and if influenza vaccination reduces secondary household infections, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how 1st or 2nd trimester SARS-CoV-2 infections may shorten newborn telomeres, what are B1 cells, if IgG4 responses are critical for protection elicited by mRNA vaccines, if there is a difference in protection against the development of severe disease between an mRNA or a protein based vaccine, where to find PEMGARDA, if remdesivir reduces readmission of vulnerable patients once hospitalized for COVID-19, information for Columbia University Irving Medical Center’s long COVID treatment center, if transcutaneous electrical nerve stimulation ameliorates musculoskeletal pain and fatigue during long COVID, do antihistamines reduce post-acute sequelae of SARS-CoV-2 infection and how long can SARS-CoV-2 antigens be detected in blood. Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Influenza weekly surveillance report: cliff notes (CDC FluView) US respiratory virus activity (CDC Respiratory Illnesses) Influenza vaccines protect against secondary infections in households (JAMA Network) Benefit of early oseltamivir therapy for influenza A (CID) RSV- Net work (CDC Respiratory Syncytial virus Infection) COVID-19 deaths (CDC) COVID-19 national and regional trends (CDC) Waste water scan for 11 pathogens (WastewaterSCan) COVID-19 variant tracker (CDC) SARS-CoV-2 <a href= "https://nextstrain.org/
Sun, December 01, 2024
The born immunity
TWiV reviews susceptibility to vaccine-preventable infections in asylum seekers, the economic power of vaccines, French university tries to bury its investigation of a faculty member’s ethical lapses, transmission dynamics of SARS-CoV-2 in New Zealand before and after COVID-19, and a germ line encoded antibody that recognizes a broad array of enveloped viruses. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Why RFK Jr is not suitable for HHS (YouTube) Write your Senators to oppose RFK Jr Support MicrobeTV ASV 2025 Susceptibility to infections in asylum seekers (NEJM) RSV hospitalization in adults (JAMA Net Open) Ethics failings at French university (Science) RSV transmission in New Zealand (Nat Commun) Glycan reactive IgM binds multiple viruses (SciImmunol) Timestamps by Jolene . Thanks! Weekly Picks Brianne – Publication of Updated Human Cell Atlas Rich – Astroscale Alan – E3 ubiquitin ligase game , and an article abou
Sat, November 30, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin dives into H5N1/influenza and RSV circulation in the US, whether or not H5N1 is “adapting” for human-human transmission, why drinking raw milk may NOT be the best idea despite RFK Jr endorsement, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how if I encounter no one I can infect no one, the efficacy of COVID-19 boosters, how vaccines are the ‘seat belt’ of public health, the results of two PLACEBO control studies assessing antiviral therapy for COVID-19, where to find PEMGARDA, susceptibility of neurological complications in young to middle-aged adults and how discussing the origins of the pandemic and rise of scientific harassment will allow you to avoid a political conversation around your Thanksgiving day table, the interplay between transmission and immunity for virus spread and who to call if you do get sick this holiday. Happy Thanksgiving! Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Influenza weekly surveillance report: cliff notes (CDC FluView) US respiratory virus activity (CDC Respiratory Illnesses) RSV- Net work (CDC Respiratory Syncytial virus Infection) In case you missed, US respiratory virus activity (CDC Respiratory Illnesses) Adaptation of H5N1 to humans…..sequence analysis (Nature) Favoring human transmission for H5N1 ?(Youtube: medcram) From 2022: unprecedented bird flu outbreaks sweeping the world…..and we are still talking about it? (Nature) What children get flu: First child in US infected with H5N1 (CDC Newsroom) Bird flu detected in raw milk ……but RFK at HHS says it is safe? (NBC News) COVID-19 <a h
Sun, November 24, 2024
Can anyone hook me up with a duck?
TWiV travels to Brisbane, Australia for the Options XII for the control of influenza conference, and meets up with Stephanie Gras and Jenna Guthmiller to talk about their careers and their research. Hosts: Vincent Racaniello , Kathy Spindler , and Steph Langel Guests: Stephanie Gras and Jenna Guthmiller Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Goldilocks zone of influenza immunity (J Inf Dis) Broadly neutralizing HA antibodies (Nature) T cell epitopes needed for influenza vaccines (Clin Transl Immunol) T cell epitopes conserved in emerging H5N1 viruses (Clin Transl Immunol) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.
Sat, November 23, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin briefly discusses the E.coli outbreak associated with onions from McDonald’s before deep diving into the announcement of Robert F Kennedy Jr. nomination for Secretary of Human and Health Services with highlights from MicrobeTV’s own Vincent Racaniello and Paul Offit ( Beyond the Noise ), the global measles outbreak, underutilization of influenza antivirals for children and teens, the $350 million 2025 order for mpox vaccination, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, the effectiveness of N95 mask, the interplay between transmission and immunity for virus spread, where to find PEMGARDA, and translational science being conducted to understand long COVID including ongoing clinical trials, development of animal models and how sex may affect outcomes. Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Micky D’s onions linked to E. coli outbreak….another reason to not eat fast food (CDC) RFK Jr. series…..does he get anything right? (FactCheck.org) Salk polio vaccine : a calculated risk? (BMJ) How to conduct a controlled vaccine trial (American Journal Public Health Nations Health) Safety and efficacy of BNT162b2 mRNA COVID-19 vaccine (NEJM) Another Safety and efficacy study: mRNA-1273 SARS-CoV-2 vaccine (NEJM) ….. SERIOUSLY! can’t RFK Jr get it correct? (FactCheck.org) ‘I’ve Come Home Today’: RFK Jr . (the Defenders Children’s Health Defense News & Views) Thank God for sensible people: Racaniello and Offit (microbeTV) RFK Jr. : MAN CAN’T YOU GET ANYTHING RIGHT? (Annenberg Public Policy Center: Univer
Sun, November 17, 2024
Virus cloak and entry
TWiV reveals a novel H5N1 reassortant virus in Cambodia, circulating vaccine derived poliovirus type 2 in more countries, circulation in the blood of humans of infectious parvovirus B19 coated with active proteases, and B cell receptor dependent enhancement of dengue virus infection. Hosts: Vincent Racaniello , Dickson Despommier , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV Fundraiser Novel H5N1 in Cambodia (medRxiv) More cVDVP2 circulation (polioeradication.org) Infectious parvovirus B19 with proteases (Nat Comm) B cell receptor enhancement of dengue disease (PLoS Path) Timestamps by Jolene . Thanks! Weekly Picks Brianne – See How Many Lives Vaccines Have Saved Around the World based on Lancet study Dickson – 2024 Wildlife Photographer of the Year Kathy – 450 Million year old arthropods preserved in fool’s gold. Primary article Pyrite video Vincent – ‘<a href= "
Sat, November 16, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin apprises us about the first case of highly pathogenic influenza in Canda, children dying of influenza infection and novel genetic reassortments of the virus, the Marburg virus outbreak in Rwanda, number of mpox infections, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how scientific mistrust has affected COVID-19 vaccine administration, resolution of the FDA hold on Novovax’s combination influenza and COVID vaccine, where to find PEMGARDA, how Paxlovid SAVES you money, when to use steroids to treat COVID-19 and how trace amounts of cytokines elicted during SARS-CoV-2 infection negatively impact cardiac function. Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Bird flu flew into British Columbia Canada (Global News Canada) H5N1 in British Columbia (CIDRAP) Highly Pathogenic Avian Influenza flies commercial and domestic (USDA) Countdown till the end of Marburg outbreak (WHO Rwanda) First kid’s death due to flu (CIDRAP) Influenza weekly surveillance report: clift notes (CDC FluView) H5N1 novel reassortments in migratory birds in China (Emerging Infectious Diseases) Serologic evidence of recent infection with highly pathogenic avian influenza A (MMWR) Seriously? 50,000 mpox cases in African outbreak (CIDRAP) Respiratory virus activity (CDC Respiratory Illnesses) COVID-19 <a href= "https://covid.cdc.gov/covid-data-tracker/#ma
Sun, November 10, 2024
What doesn't kill us primes our macrophages
TWiV notes the passing of virologist Diane Griffin, first H5N1 influenza virus in US pigs, Innate immune control of influenza virus interspecies adaptation via IFITM3, and antiviral trained innate immunity in alveolar macrophages after SARS-CoV-2 infection reduces secondary influenza A virus disease. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV Fundraiser Diane Griffin passes (Johns Hopkins) Diane Griffin on TWiV 453 First H5N1 influenza virus in US pigs (CIDRAP) IFITM3 controls interspecies influenza virus infection (Nat Comm) Trained innate immunity by alveolar macrophages (Immunity) Timestamps by Jolene . Thanks! Weekly Picks Angela – See a giant ‘ghost particle’ detector and more — October’s best science images Brianne – October 27 APoD: Bat nebula Dickson – Nikon Small World Contest 2024 winners Kathy – AAAS 150th anniversary video, celebrating scientists and Pew’s 2024 annual
Sat, November 09, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin informs us about the World Health Organization research and development plan to combat endemic pathogens including hepatitis C virus, RSV and dengue virus, another case of mpox in Britian, the Marburg virus outbreak in Rwanda, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, if there is a benefit to additional COVID vaccinations after the initial series, ISDA guideline for using anti-SARS-CoV-2 monoclonal antibody therapy for prophylaxis, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, if and how do severe secondary bacterial infections develop following SARS-CoV-2 infection, and if COVID-19 associates with a risk of autoimmune and autoinflammatory connective tissue disorders. Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Is the WHO the world’s NIH: endemic pathogens initiative (eBioMedicine) Another two cases of mpox in Britian (Reuters) How to stop Marburg virus (Rwanda Biomedical Centre) Marburg Virus fact sheet (Rwanda Biomedical Centre) Influenza weekly surveillance report: cliff notes (CDC FluView) RSV NETwork (CDC RSV) Respiratory virus activity (CDC Respiratory Illnesses) COVID-19 deaths (CDC) COVID-19 national and regional trends (CDC) Waste water scan for 11 pathogens (WastewaterSCan) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) Symptom reduction after<a href= "
Sun, November 03, 2024
Hepadnaviridae in the heartland
From the 2024 International Hepatitis B virus meeting in Chicago, TWiV speaks with Mala Maini and John Tavis about their careers, the replication and transmission of HBV, and the HBV Foundation. Hosts: Vincent Racaniello and Rich Condit Guests: Mala Maini and John Tavis Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Immunobiology and pathogenesis of hepatitis B virus infection (Nat Rev Immunol) HBV Foundation https://www.hepb.org/ Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.
Sat, November 02, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin informs us about “walking pneumonia”, the phase of the polio supplemental immunization campaign in Gaza, mpox circulation, the Marburg virus outbreak in Rwanda, the beginning of influenza season, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, contrasting public health concerns between the US and the UK, if mRNA boosters affect mucosal immunity against SARS-CoV-2 infection, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, if antiviral therapy prevents long COVID and viral sequalae in healthy young marines. Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Mycoplasma pneumoniae infections increasing (CDC) Polio vaccination campaign restarts (Reuters) North Gaza polio campaign postponed (Reuters) 1St clade 1b mpox in UK (GOV.UK) UK imports mpox (CIDRAP) Clinical trial of MVA-BN for children (Bavarian-Nordic) How to stop Marburg virus (Rwanda Biomedical Centre) Marburg Virus fact sheet (Rwanda Biomedical Centre) Laboratory confirmed influenza associated hospitalizations 2010-2023 (CDC) Influenza weekly surveillance report: cliff notes (CDC FluView) Mucosal nirsevimab levels in breakthrough bronchiolitis (LANCET Infectious Diseases) RSV NETwork (CDC RSV) Respiratory virus activity (CDC Respiratory Illnesses) COVID-19 <a href= "https://covi
Sun, October 27, 2024
Baby you can drive my gene
TWiV reviews continuing expansion of poliovirus type 2, removal of influenza B/Yamagata from the vaccine, Nobel Prize for miRNAs, protective immune response with a adenovirus-associated virus vector expressing a computationally designed hemagglutinin, and viral gene drive during herpes simplex 1 infection in mice. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Continued expansion of type 2 poliovirus (reliefweb) No more polio case map at polioeradication.org B/Yamagata removed from flu vaccine (NPR) Nobel Prizes for miRNA (ScienceInsider) AAV-vectored influenza vaccine (J Virol) Herpesvirus type 1 gene drive in mice (Nat Commun) Timestamps by Jolene . Thanks! Weekly Picks Brianne – Virus and Vaccines Information Page from NIH All of Us Research Program Kathy – For a Pivotal Vaccine: Trial, Error and Two Young Lives Rich – October 17 2024 APOD: The Clipper and the Comet Alan – Opening a deep-sea vent <a hre
Sat, October 26, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin informs us about mpox circulation, the Marburg virus outbreak in Rwanda, new recommendations for the RSV and pneumococcal vaccines by the CDC, the beginning of influenza season, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, contrasting public health concerns between the US and the UK, what the risk of SARS-CoV-2 transmission is when indoors, the difference between NVX-CoV2327 and BNT162b2 for adolescents, why 65 years and older should get a second boost of the COVID-19 vaccine, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, the clinical trial for evaluating how novel treatments of COVID-19 affect long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome after SARS-CoV-2 infection. Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Grim marker: mpox over a 1000 deaths in Africa (CIDRAP) Global trend of mpox outbreak 2022-2024 (WHO) Second time mpox is a global public health emergency (Reuters) Mpox variant in Germany (Reuters) Epidemiological analysis of confirmed mpox cases in Burundi (EuroSurveillance) The 63rd case of Marburg virus infections in Rwanda (CIDRAP) How to stop Marburg virus (Rwanda Biomedical Centre) Marburg virus fact sheet (Rwanda Biomedical Centre) FDA approves RSV vaccine ABRYSVO for 18-59 individuals of increased risk (Pfizer) Respiratory syncytial virus infection- NET (CDC) New <a href= "https://www.cd
Sun, October 20, 2024
Eliminating cervical cancer, and endometrial immunity
Vincent travels to the Karolinska Institute in Stockholm to meet up with Niklas Björkström and Joakim Dillner to review their research on the endometrial immune system, and the plan to eliminate cervical cancer in Sweden. Host: Vincent Racaniello Guests: Niklas Björkström and Joakim Dillner Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Endometrial immune system variation (Sci Immunol) Immune defense in the womb (News from Karolinska) HPV vaccination and screening for elimination (Nat Comm) Cervical cancer elimination strategies (Int J Cancer) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.
Sat, October 19, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin informs us about mpox circulation and new vaccine approval, the Marburg virus outbreak in Rwanda, and the largest outbreak of whooping cough in a decade before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, immunity among those over 65th following the 3rd dose of the COVID-19 mRNA vaccine, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, how well the SARS-CoV-2 rapid antigen test performed, what do when healthcare workers succumb to SARS-CoV-2 infection, the effect of remdesivir on survival and readmission of hospitalized patients, if cognitive impairment following virus infection impairs one’s driving and how long COVID affects Chinese society. Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Undiagnosed MPXV infections are high in men who have sex with men (BMC Infectious Diseases) WHO, now a vaccine approval agency, Jynneos for teens (CIDRAP) Mpox outbreak global trends (WHO) How to stop Marburg virus (Rwanda Biomedical Centre) Marburg virus fact sheet (Rwanda Biomedical Centre) Largest whooping cough outbreak in US in a decade (NPR) COVID-19 deaths (CDC) COVID-19 national and regional trends (CDC) Waste water scan for 11 pathogens (WastewaterSCan) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) Insurance relates to <a href= "https://academic.oup.com/jid/advance-article/doi/10.1093/i
Sun, October 13, 2024
Superworm liquefaction and a pandemic prophylactic
TWiV reviews Marburg virus outbreak in Rwanda, cryo-EM based discovery of a parvovirus causing black wasting disease in farmed beetles, and a mosaic nanoparticle experimental vaccine that elicits cross-reactive sarbecovirus responses in pre-vaccinated animals. Hosts: Vincent Racaniello , Alan Dove , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Marburg virus disease , Rwanda (WHO) Suspected German Marburg case tests negative (Politico) Cryo-EM discovery of insect parvovirus (Cell) Mosaic sarbecovirus nanoparticle experimental vaccine (Cell) Letters r ead on TWiV 1157 Timestamps by Jolene . Thanks! Weekly Picks Brianne – ASM Lesson Plans Alan – A City on Mars , and this blog by a ham radio operator hit by Hurricane Helene Vincent – How to Win A Nobel Prize Listener Pick Laura – <a title="" href= "https://www.insidehighered.com/news/faculty-issues/teaching/2024/09/06/how-scientists-use-public-engagement-combat-misinformation?mc_cid=8f8a7caa4b&mc_ei
Sat, October 12, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin updates us about polio SIA campaign in Gaza, the durability of protection following administration of GSK’s recombinant antigen RSV vaccine, mpox in an Ugandan jail, the Marburg virus outbreak in Rwanda, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, immunogenicity, reactogenicity and safety of different COVID-19 vaccine platforms, disease severity in those not previously vaccinated with those vaccinated but not infected, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if COVID-19 doubles the risk for heart attacks, stroke and death and if COVID-19 affects the regions of the brainstem. Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Polio: second round of vaccination in Gaza (Reuters) Season 3 for GSK RSV vaccine protection (CIDRAP) Positive data for Arexvy , the respiratory syncytial virus vaccine (GSK) Mpox convicted felon: in Ugandan prison (Reuters) How to stop Marburg virus (Rwanda Biomedical Centre) Marburg virus fact sheet (Rwanda Biomedical Centre) CDC summary of the “Rwanda Marburg Situation” (CDC) 700 doses of a Marburg vaccine from the Sabin Vaccine Institute to Rwanda (CIDRAP) USAID mobilizes Marburg outbreak response in Rwanda (United States Agency International Development) COVID-19 deaths (CDC)
Sun, October 06, 2024
Spillover in stall A
TWiV reviews mask effectiveness against respiratory infections, EEE death in NY State, viruses with zoonotic potential in farmed fur animals, and genetic tracing of market wild life and viruses at the Huanan Seafood Market, the epicenter of the COVID-19 pandemic. Hosts: Vincent Racaniello , Alan Dove , and Rich Condit Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Review confirms mask effectiveness ( original article ) EEE death in Ulster County NY (CBS News) EEE on TWiV 1145 Viruses of farmed fur animals (Nature) Tracing of wildlife and viruses at COVID-19 epicenter (Cell) Letters read on TWiV 1155 Timestamps by Jolene . Thanks! Weekly Picks Rich – Immunize.org, Vaccineinformation.org, National Network of Immunization Coalitions Alan – Birdcast Vincent – A universal framework for inclusive 15-minute cities Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.
Sat, October 05, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the Marburg virus outbreak in Rwanda, the lack of immune durability following pertussis vaccination, recommendations for maternal vaccination and antibody therapy to protect against infant RSV, vaccine security for Mpox, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how to put on and take off PPE to avoid contamination, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, the lack of immune durability elicited by mRNA vaccine and the finding of how SARS-CoV-2 infection impacts memory, cognition and reduces grey matter volume. Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Rwanda: Marburg virus disease (WHO) Passport required?…..Marburg virus commutes to Germany (CIDRAP) Outbreak of whooping cough/pertussis …..no lifelong immunity following vaccination? (Bloomberg Protection of infants by maternal antibodies against RSV by either vaccination or nirsevimab (MMWR) WHO recommendations for RSV: maternal vaccination and antibody shot (Reuters) Ziresovir for RSV hospitalized infants (NEJM) Crawling to effective anti-RSV countermeasures (NEJM) The $800 million pledge for African mpox response (Reuters) COVID-19 <a href= "https://covid.cdc.gov/covid-
Sun, September 29, 2024
Viruses that (can) make you well
From the Viruses of Microbes meeting in Cairns, Australia, TWiV speaks with Krystyna and Rob about their research on using bacteriophages to treat bacterial infections. Hosts: Vincent Racaniello and Jolene Ramsey Guests: Krystyna Dabrowska and Rob Lavigne Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Viruses of Microbes 2024 Immune responses to phages (Front Immunol) Engineering bacteriolytic enzymes (Front Immunol) 100 cases of phage therapy (Nat Micro) Synthetic biology potential of bacteriophages (Nat Micro) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.
Sat, September 28, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin deep dives into the durability of the antibody response following mpox vaccination, vaccine security, global mpox circulation, the origins of SARS-CoV-2, including a list TWiV episodes and combatting scientific misinformation, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if remdesivir + dexamethasone lowers mortality of hospitalized COVID-19 patients and the finding of how SARS-CoV-2 infection impacts memory and cognition. Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode Waning vaccine protection against mpox…..isn’t this the way the humoral immune response works? (CIDRAP) Uncontrollable mpox outbreak in Africa (Reuters) Antibodies elicited by the Jynneos vaccine against mpox contract after 6-9 months….can you believe? (medrxiv) Mpox vaccine for adolescents approved (Pharmaceutical Technology) Clade 1b mpox visiting India (CIDRAP) Mpox clade 1b in Kerala (ANI South Asia’s Leading Multimedia News Agency) US government orders $63M worth of small pox/mpox vaccine (Reuters) Mpox donations boosting global supply (US Department of Health and Human Services) I million mpox vaccine doses for <a href= "https:
Sun, September 22, 2024
Hotel California for Phage
TWiV reviews polio vaccination campaign in Gaza, viruses with zoonotic potential in farmed fur animals, low HPV vaccination in North Texas associated with high rates of cervical cancer, a large flavivirus genome that does not encode error correction machinery, and antiphage defense through inhibition of virion assembly. Hosts: Vincent Racaniello , Dickson Despommier, Alan Dove , and Jolene Ramsey Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Polio vaccination in Gaza (Reuters) Zoonotic viruses in farmed fur animals (Nature) HPV vaccination and cancer rates (JAMA Net Open) 40 kb RNA genome without error correction (PNAS) Stopping the phage tape measure protein (Nat Commun) Tail assembly interference (Nat Commun) Letters read on TWiV 1151 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Digital nature pics winners 2024 Wildlife Photographer of the Year Alan – Adorable story about a Nigerian paralympian couple who are both polio survivors Jolene – <a title="" href= "https://www.thingiverse.com/thing:101373"
Sat, September 21, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin dives into West Nile virus in New Jersey, poliovirus vaccination campaign in Gaza and Afghanistan, California dengue virus infections, children dying from flu, mpox vaccination procurement and antiviral usage, flu circulation in US, before reviewing the recent statistics on SARS-CoV-2 infection, finding a new wasterwater dashboard, if the monovalent XBB.1.5 COVID-19 vaccine is effective against circulating SARS-CoV-2 isolates, the need for nasal mucosal IgA in response to SARS-CoV-2 infection, where to find PEMGARDA, does administration of molnupiravir reduce symptoms in the vaccinated, when to use convalescent plasma, how molnupiravir treatment leads to better outcomes 3 and 6 months after treatment, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if vaccination against SARS-CoV-2 does protect against long COVID, and if those taking the anti-diabetic drug metformin have higher or lower incidences of long COVID. Subscribe (free): Apple Podcasts , RSS , email Become a patron of TWiV! Links for this episode West Nile virus in New Jersey (CBSNews) Poliovirus vaccination 90% coverate (Reuters) Suspension of poliovirus eradication by the Taliban (apnews) California dengue cluster (CIDRAP) Children dying of influenza (CIDRAP) 199 children deaths from flu (CDC) Bavarian Nordic mpox vaccine (Yahoo finances) Prequalification
Sun, September 15, 2024
Mary Estes, a gutsy virologist
From the annual meeting of the American Society for Virology, Kathy and Brianne speak with Mary Estes about her career and the research of her laboratory on viruses that infect the gastrointestinal tract, including rotavirus and norovirus. Hosts: Kathy Spindler and Brianne Barker Guest: Mary Estes Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Diarrhea induced by rotavirus NSP4 (Science) Minimal infective dose of rotavirus (Arch Virol) mRNA release from rotavirus particles (Nat Struct Biol) Norovirus vaccine (Clin Ther) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.
Sat, September 14, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin dives into “pandemic potential” viruses isolated from farmed fur animals, how the mRNA and pox vectored vaccines against mpox spar against each other, how telehealth does managing mpox, and if prophylactic use of the anti-RSV monoclonal for infants is cost-effective before reviewing the recent statistics on SARS-CoV-2 infection, if viral load correlates to one vaccination status, where to find PEMGARDA, does administration of molnupiravir reduce symptoms in the vaccinated, when to use convalescent plasma, how molnupiravirs treatment leads to better outcomes 3 and 6 months after treatment, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if vaccination against SARS-CoV-2 does protect against long COVID, and if SARS-CoV-2 during Omicron alters ones’ micriobiota. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Lending you the viruses in my fur (Nature) mRNA or vaccinia based mpox vaccine (Cell) Virtual outpatient management of mpox (OFID) NYC: mpox vaccination finder (NYC) Vaccine, mpox/COVID-19 near you (NYC) Expensive or not expensive anti-RSV monoclonal therapy for infants (American Academy of Pediatrics) COVID-19 deaths (CDC) COVID-19 national and regional trends (CDC) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) Association of vaccination and SARS-CoV-2 <a
Sun, September 08, 2024
Breastmilk paradox for norovirus
TWiV reviews multi-country outbreak of Mpox, first face covering ban in Nassau County NY, case of polio in India, more in US accept vaccine misinformation, other wartime diseases in Gaza besides polio, a new scientist run virus genome database, Mpox epidemiology and vaccine effectiveness in England, and metabolic immaturity and breastmilk bile acid metabolites determine heightened newborn vulnerability to norovirus diarrhea. Hosts: Vincent Racaniello , Rich Condit , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Multi-country Mpox outbreak (WHO) Face covering ban in Nassau County (NBC) Polio case in India (Business Standard) More acceptance of vaccine misinformation (EurekAlert) War in Gaza not just causing polio (Jerusalem Post) Scientist run virus genome database (Science) Mpox epidemiology and vaccine effectiveness (Emerg Inf Dis) Newborn vulnerability to norovirus diarrhea (Cell Host Microbe) Timestamps by Jolene . Thanks! Weekly Picks Brianne – Viral adaptation to climate change <
Sat, September 07, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses seasonal influenza vaccine recommendations from the CDC, polio vaccine campaign securing mpox vaccine for Africa, and donating to reduce food insecurity in mpox affected areas before reviewing the recent statistics on SARS-CoV-2 infection, where to find PEMGARDA, when to use convalescent plasma, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if vaccination against SARS-CoV-2 does protect against long COVID, how fibrin drives thromboinflammation and neuropathology in COVID-19, and an evidence based approach to long COVID. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Recommendations for seasonal influenza prevention and vaccines (MMWR) Gaza: poliovirus RNA in sewage water (Reuters) Success of the polio vaccination campaign in Gaza (Reuters) UNICEF-Gavi-WO-Africa CDC securing mpox vaccines (Gavi) mpox vaccine tender (CIDRAP) What about vaccines ? (Bavarian Nordic) Resolving food insecurity (UNICEF USA) Semaglutide and the SELECT trial(Journal of the American College of Cardiology) COVID-19 <a href= "https://covid.cdc.gov/covid-da
Sun, September 01, 2024
Heartbeats and hoofbeats
TWiV reviews a case of polio in Gaza, more Mpox, COVID-19 boosters, effectiveness of Ebola virus vaccine, measles cases across the US, an endogenous retroviral envelope protein that regulates human cardiomyocyte development, and submergence of an encephalitic alphavirus caused by receptor shifts. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Gaza baby has polio (Times Israel) Monkeypox virus clade Ib in Thailand (CIDRAP) Updated COVID-19 vaccines (FDA) Effectiveness of Ebola virus vaccine (Lancet Inf Dis) Measles cases in Georgia, Oregon (CIDRAP) Retrovirus protein regulates cardiomyocyte development (Cell Stem Cell) Receptor shifts govern submergence of encephalitis arbovirus (Nature) Letters read on TWiV 1145 Timestamps by Jolene . Thanks! Weekly Picks Kathy – Googlegangers and <a href="https://
Sat, August 31, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses Dr. Fauci’s case of West Nile virus, polio vaccine campaign develops in Gaza, disease that associates with Oropouche virus, mpox: vaccines, clinical trial for mpox antiviral and the WHO strategic preparedness and response plan before reviewing the recent statistics on SARS-CoV-2 infection, how to obtain free COVID tests, EUA for updated Novavax COVID vaccine, ISDA support of and where to find PEMGARDA, breakthrough infections when administering PEMGARDA, when to use convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if nirmatrelvir/ritonavir is effective at preventing hospitalization of high risk patients, incidence of mental illness in the vaccinated and unvaccinated, the effect of amubarvimab/romlusevimab on long COVID outcome, having an evidence based approach to long COVID and how fibrin drives thromboinflammation and neuropathology in COVID-19. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Fauci recovering at home from West Nile Virus infection (STAT News) Gaza: poliovirus RNA in sewage water (GPEI) Bombs and polio….. cease fire , Oh my! (Guardian) The variant type 2 poliovirus in Gaza (United Nations: The Question of Palestine) 25 years polio free? (Facebook) 2 doses of nOPV2 = 1.2M vaccines=640,000 children (CNN) More polio……India, two-year-old child in Tikrikilla, Meghalaya (Business Standard) Sloth fever ……Oropouche virus (USA Today) Oropouche virus disease
Sun, August 25, 2024
SARS-CoV-2 gone wild, with a side of rice
TWiV discusses WHO declaration of Mpox as a public health emergency of international concern, Sweden reports first case of clade 1b outside of Africa, can household pets be productively infected with monkeypox virus, widespread exposure to SARS-CoV-2 in wildlife communities, and modulation of plant defenses by insect salivary GAPDH benefits viral transmission. Hosts: Vincent Racaniello , Dickson Despommier, Alan Dove , Rich Condit , and Kathy Spindler Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Mpox outbreak is PHEIC (WHO) Tecovirimat not great against monkeypox virus clade I (NIH) Case of Mpox Clade I in Sweden (PHAS) Mpox and pets in USA (Emerg Inf Dis) SARS-CoV-2 widespread in wildlife communities (Nat Comm) Salivary GAPDH benefits plant virus transmission (Nat Comm) Letters read on TWiV 1143 Timestamps by Jolene . Thanks! Weekly Picks Dickson – NASA Confirms Evidence That Liquid Water Flows on Today’s Mars Kathy – <a title="" href= "https://www.qiagen.com/us/knowledge-and-suppor
Sat, August 24, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses global transmission of mpox, the different clades of the virus and associated pathogenesis, vaccination vs antiviral therapy against mpox and the US’s aid response for controlling the African outbreak before reviewing the recent statistics on SARS-CoV-2 infection, authorization and approval of updated COVID vaccines, the economic benefit of an annual COVID vaccine and if the first updated vaccines against XBB.1.5 were effective, where to find PEMGARDA, breakthrough infections when administering PEMGARDA, when to use convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, and how long COVID differs in children and adolescents. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode mpox epidemic caused by monkeypox clade I in affected African countries (European Centre for Disease Prevention and Control) mpox in Pakistan (Reuters) mpox imported into Pakistan (UNMC Global Center for Health Security) mpox domesticated in Taiwan (Focus Taiwan: CAN English News) clade IIb not Ib in Taiwan (bne Intellinews) WHO : mpox public health emergency of global care (NY Times) Vaccines didn’t turn back mpox…..people did (NY Times) Deadlier mpox version in Thailand (NY Times) Antiviral tecovirimat….<a href= "https://www.nih.gov/news-events/news-releases/antiviral-tecovirimat-safe-did-not-improve-clade-i-mpox-resolution-democratic-republic-congo#:~:text=NIH%2Dcosponsored%20study%20examined%20tecovirimat%20in%20mpox%2Dendemic%20country.&text=The
Sun, August 18, 2024
Being green with the Red Queen
TWiV discusses the spread of monkeypox virus clade 1b in Africa, COVID drops to tenth leading cause of death in the US, response to detection of poliovirus in Gaza, mechanism of MIS-C after SARS-CoV-2 infection, neonatal Fc receptor is a pan-arterivirus receptor, and antiviral immunity in plants mediated by protein arginine methyltransferase 6. Hosts: Vincent Racaniello , Dickson Despommier, Rich Condit , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Mpox widespread in Africa (CIDRAP) Africa declares Mpox emergency (Science) COVID drops to 10th leading cause of US deaths (MMWR) Response to detection of poliovirus in Gaza (WHO) Molecular mimicry in MIS-C (Nature) Neonatal Fc receptor is pan-arterivirus receptor (Nat Comm) Antiviral immunity in plants by protein arginine methytransferase 6 (Cell Host Micr) Letters read on TWiV 1141 Timestamps by Jolene . Thanks! Weekly Picks Brianne – Kate Douglass: Olympian and Statistician ( Swimming in Data ) Dickson – Women of recent note: Kamala Harris (Democratic Party presidential candidate); Katie Ladecky (
Sat, August 17, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the harms of perpetuating the lab leak hypothesis and the recent ACIP recommendations for the RSV vaccine for those individuals over 60, before reviewing the recent statistics on SARS-CoV-2 infection, treatment guidelines for the different phases of COVID, including vaccines, Pemgarda, early treatment with Paxlovid, remdesivir and molnupiravir, steroids at the right time, anticoagulation support, immune modulation in some cases, and a comprehensive definition of long COVID. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Measles transmission after secondary vaccination failure (Emerg Inf Dis) Mpox public health emergency of international concern (WHO) First case of new mpox strain outside of Africa (Reuters) COVID-19 national trend (CDC) COVID-19 deaths (CDC) Where to get pemgarda (Pemgarda CDC Quarantine guidelines (CDC) Early phase of SARs-CoV-2 infection (COVID.gov) Individual monoclonal antibodies against SARS-CoV-2 should be used (CID) NIH COVID-19 treatment guidelines (NIH) <a href= "https://www.idsociety.org/practice-guideline/covid-19-guideline-treatment-and-management/#ExecutiveSummaryandBackg
Sun, August 11, 2024
Long COVID with Dr. Judith Bruchfeld
Vincent travels to the Karolinska Institute in Stockholm on 31 May 2024 to meet with Dr. Judith Bruchfeld and discuss her research on the etiology and treatment of Long COVID. Hosts: Vincent Racaniello Guest: Judith Bruchfeld Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Immune system perturbations in Long COVID (J Immunol) Post-COVID immune system perturbations (J Immunol) Systems disregulation in Long COVID (Sci Rep) Clincal standards for diagnosing, treating, and preventing Long COVID (Intl J Tuberc Lung Dis) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.
Sat, August 10, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the harms of perpetuating the lab leak hypothesis and the recent ACIP recommendations for the RSV vaccine for those individuals over 60, before reviewing the recent statistics on SARS-CoV-2 infection, treatment guidelines for the different phases of COVID, including vaccines, Pemgarda, early treatment with Paxlovid, remdesivir and molnupiravir, steroids at the right time, anticoagulation support, immune modulation in some cases, and a comprehensive definition of long COVID. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Harms of the lab leak hypothesis (Journal of Virology) Lab leak mania (PaulOffit, Substack) This is a special message: pandemic started in nature! (TWiV) RSV vaccine recommendations August 6 2024 (MMWR) COVID-19 national trend (CDC) COVID-19 deaths (CDC) Where to get Pemgarda (Pemgarda) CDC Quarantine guidelines (CDC) Early phase of SARs-CoV-2 infection (COVID.gov) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society) <li
Sun, August 04, 2024
Dengue is not BANAL
TWiV discusses a twice-yearly antiviral for prevention of AIDS, the WHO pandemic plan, West Nile resurgence in the US, the BANAL SARS-CoV-2 related viruses reproduce in human cells but do not transmit among animal hosts, and an amino acid change in dengue virus that enhances midgut replication in mosquitoes but reduces pathogenicity in humans. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server PrEP with HIV-1 capsid inhibitor (NEJM) WHO pandemic plan ( pdf ) West Nile virus resurgence in US (NY Times) Properties of BANAL SARS-CoV-2 like viruses (Nat Micro) BANAL viruses on TWiV 809 Different effect of dengue virus amino acid change in humans and mosquitoes (Sci Transl Med) Eng Ong Ooi on TWiV 633 Letters read on TWiV 1137 Timestamps by Jolene . Thanks! Weekly Picks Kathy – Using big data to improve traffic light timing Rich – Dillo Dirt Alan – <a href= "https://www.youtube.com
Sat, August 03, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses how the pandemic may have effected our trust in physicians and hospitals and if waiting longer to make strain selection for the seasonal influenza vaccine would be advantageous before reviewing the recent statistics on SARS-CoV-2 infection, how different CVODI-19 vaccines effect the cardiovascular system, if the a third of either COVID-19 mRNA vaccine is effective, where to find PEMGARDA, if convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, and the long term consequences of a SARS-CoV-2 infection on human health including incidences of diabetes, respiratory problems, hearing loss and maternal-fetal health. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode In physicians and hospitals, we trust (JAMA Network) Are there benefits for delaying seasonal influenza vaccine selections (JID) Personal protective effect for wearing surgical face masks in public spaces (the BMJ) COVID-19 national trend (CDC) COVID-19 deaths (CDC) Cardiovascular safety of different COVID-19 vaccination(Nature Comm) Effectiveness of a third dose of mRNA-1273 versus BNT162b2 among older adults (Vaccine) Where to get pemgarda (Pemgarda) CDC Quarantine guidelines (CDC) Early phase of SARs-CoV-2 infection (COVID.gov) <a href= "https://www.covid19treatmentguidelines.nih.gov/about-the-guidelines/whats-new/?utm_campaign=+59641584&utm_content=&utm_medium=email&utm_source=govdelivery&utm_term=&utm_source=MarketingCloud&utm_medium=email&utm_campaign=03062024+IDSA+News&ut
Sun, July 28, 2024
Resistance is not always futile
TWiV reviews whats going on with measles and its global resurgence, poliovirus found in Gaza, vaccine hesitancy in a community, 14 year old dies of Nipah, selection of SARS-CoV-2 viruses resistant to nirmatrelvir, and protective but non-neutralizing antibodies from survivors of Crimean-Congo hemorrhagic fever virus. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Brianne Barker , and Angela Mingarelli Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server What’s going on with measles? (J Virol) Poliovirus in Gaza (Science) Sanitation concerns in Gaza (AP) Community vaccine beliefs (PLoS One) 14 year old dies of Nipah in India (Hindustan Times) Selection of nirmatrelvir resistance mutants (Sci Adv) CCHFV monoclonal antibodies (Cell Rep) CCHFV vaccine ( TWiV 565 ) Prometheus Project ( TWiV 578 ) TWiV at USAMRIID ( TWiV 1015 ) Letters read on TWiV 1135 Timestamps by Jolene . Thanks! Weekly Picks Angela
Sat, July 27, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses Merck’s RSV preventative monoclonal antibody Clesrovimab before reviewing the recent statistics on SARS-CoV-2 infection, if previous SARS-COV-2 infections predict the outcome of subsequent infections, if using COVID rapid diagnostic tests is cost effective, if the protein based vaccine NVX-CoV2327 elicits a durable immune response, if combination treatment of vaccine and antiviral drugs effectively protect against hospitalization, where to find PEMGARDA, what do when healthcare workers succumb to SARS-CoV-2 infection, and how COVID-19 may alter the cognitive trajectories of older patients. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Clesrovimab, RSV preventative monoclonal antibody for infants (Merck) COVID-19 national trend (CDC) COVID-19 deaths (CDC) Characterizing SARS-CoV-2 reinfections and long COVID (Communications Medicine) Cost-effectiveness of COVID rapid diagnostic tests (PLoS Medicine) NVX-CoV2373 against pre-Delta and Delta strains of COVID-19 little evidence of waning immune response (CID) Combined Protection of Vaccination and Nirmatrelvir-Ritonavir Against Hospitalization(CID) Pemgarda infusion center locator (Pemgarda) Respiratory virus guidance (CDC) Early phase of SARS-CoV-2 infection (COVID.gov) <a href= "https://www.covid19treatmentguidelines.nih.gov/abou
Sun, July 21, 2024
Gain of function makes us safer
TWiV reviews cases of measles in Brooklyn NY and Washington DC, stalling of global childhood vaccination, licenses H5N1 vaccines protect against circulating strains, viruses traveling without passports. OC43 SARS-CoV- 2 spike replacement virus as an improved BSL-2 proxy virus for SARS-CoV-2 neutralization assays, and deep mutational scanning reveals functional constraints and antibody-escape potential of Lassa virus glycoprotein complex. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Measles in Brooklyn NY (ABC) Measles in Washington DC (DC Health) Global childhood immunization stalls (WHO) Licensed H5N1 vaccines protect against circulating strains (Nat Med) Viruses moving without passports (European CDC) OC42-SARS-CoV-2 replacement spike virus (PNAS) Deep mutational scanning of Lassa virus glycoprotein (Immunity) Letters read on TWiV 1133 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Elemental sulfur found on Mars
Sat, July 20, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr, Daniel Griffin reviews President Biden’s case of COVID, reviews recent statistics on SARS-CoV-2 infection, discusses post-acute sequelae after infection during pregnancy, the use of nirmatrelvir-ritonavir for post-exposure prophylaxis, where to find Pemgarda, effectiveness of combined nirmatrelvir-ritonavir-molnupiravir treatment, effectiveness of Ensitrelvir in reducing severe outcomes in outpatients at high risk for COVID-19, effectiveness of combined nirmatrelvir-ritonavir-molnupiravir treatment in patients hospitalized with COVID-19, CDC update of Long COVID Basics page, postacute sequelae of SARS-CoV-2 infection in the pre-delta, delta, and omicron eras, Long COVID risk has dropped over time but remains substantial, efficacy of antivirals, corticosteroids, and mAbs as acute COVID treatments in reducing the incidence of long COVID, and the interplay between diet and the gut microbiome: implications for health and disease. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode President Biden has COVID ( CNN , USA Today ) COVID-19 national trend (CDC) COVID-19 deaths (CDC) Post–acute sequelae of COVID after infection during pregnancy (OB & Gyn) Oral nirmatrelvir–ritonavir as postexposure prophylaxis for Covid-19 (NEJM) Pemgarda infusion center locator (Pemgarda) Unable to access pemgarda, gotta call Daniel (microbeTV) CDC Quarantine guidelines (CDC) Early phase of SARs-CoV-2 infection (COVID.gov) <a href= "https://www.covid19treatmentguidelines.nih.gov/about-the-guidelines/whats-new/?utm_campaign=+59641584&utm_content=&utm_medium=email&utm_source=govdelivery&utm_term=&utm_source=MarketingCloud&
Sun, July 14, 2024
Mootant influenza H5N1 virus
TWiV reviews the potential impact on science of the Supreme Court ruling in the Chevron decision, measles in New Hampshire and Vermont, new who proposed terminology for respiratory pathogen transmission, and pathogenicity and transmission of bovine H5N1 influenza virus. Hosts: Vincent Racaniello , Dickson Despommier , and Rich Condit Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Articles on Chevron decision ( one , two , three ) Measles in New Hampshire and Vermont (NH DHHS) Pathogenicity and transmission of bovine H5N1 virus (Nature) Letters read on TWiV 1131 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Stockholm Wood City Rich – “The Wide Wide Sea” by Hampton Sides Vincent – Tour de France stage 12 Listener Picks Amy – Earth Forced from the Protective Heliosphere: What Do We know? Intro music is by Ronald Jenk
Sat, July 13, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses H5N1 influenza in the bird and cow communities of Colorado and Michigan and dengue in New York and the US before reviewing the recent statistics on SARS-CoV-2 infection, the absence of association with proton pump inhibitors and COVID-19 severity in children, where to find PEMGARDA, the effectiveness of molnupiravir and dexamethasone, convalescent plasma, what to do when healthcare workers succumb to SARS-CoV-2 infection, a resource of long COVID answers, how the WHO and CDC define long COVID and how it compares to ME/CSF. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode H5N1: birds and cows oh, my…..Michigan and Colorado (CIDRAP) Flu pandemic for the Colorado chicken (Colorado Sun) It’s a disaster: Avian flu in Weld county (Colorado.gov) More 9.7 million dengue cases in US this year: CDC issues warning (Patch.com) Long Island has DENGUE! (Long Island News12) COVID-19 national trend (CDC) COVID-19 deaths (CDC) Association between proton pump inhibitors and COVID-19 susceptibility or severity in children? (Journal of Pediatrics) Where to get pemgarda (Pemgarda) Unable to access pemgarda, gotta call Daniel (microbeTV) CDC Quarantine guidelines (CDC) Early phase of SARs-CoV-2 infection (COVID.gov) <a href= "https://www.covid19treatmentg
Sun, July 07, 2024
You never forget the first time you flu
TWiV reviews measles in Kenya, a trial for a intranasal COVID vaccine, dengue in the Florida Keys and in Central/South America, Spain connecting government with scientists, T cell activation and viral RNA fragments persist for up to 2 years after SARS-CoV-2 infection, and durable cross-reactive and protective antibodies against avian N2 neuraminidases elicited by A(H2N2) and A(H3N2) influenza pandemics. Hosts: Vincent Racaniello and Alan Dove Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Measles in Kenya (WHO) Intranasal COVID vaccine trial (NIH) Dengue in Florida Keys (Florida Health) Dengue rising in Central/South America (NPR) Spain to connect scientists with government (Science) Persistence of T cells and viral RNA after SARS-CoV-2 infection (Sci Transl Med) Influenza pandemics induce cross-reactive antibodies against avian N2 (Nat Comm) Letters read on TWiV 1129 Timestamps by Jolene . Thanks! Weekly Picks Alan – The first few minutes of this video by Roger Barnes Vincent – Billy & Molly: An Otter Love Story <h3 cla
Sat, July 06, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the fourth US case of H5N1 human infection and reminds the audience of the definition of “pasteurization” before reviewing the recent statistics on SARS-CoV-2 infection, where to find PEMGARDA, the effectiveness of molnupiravir and dexamethasone, convalescent plasma, what to do when healthcare workers succumb to SARS-CoV-2 infection, how an EEG can be used to look for signatures of cognitive decline after SARS-CoV-2 infection and what we observed 2 years following SARS-CoV-2 infection for tissue-resident T cell and viral RNA persistence. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Fourth case human infection associated with an ongoing multistate outbreak of A(H5N1) (CDC) Human H5N1 in Colorado and the definition of pasteurization (CIDRAP) Is “raw” milk more risky than pasteurized (Annenberg Public Policy Center) COVID-19 national trend (CDC) COVID-19 deaths (CDC) Winter, spring, summer and fall COVID-19 surges ? (CDC) Where to get pemgarda (Pemgarda) Unable to access Pemgarda, gotta call Daniel (microbeTV) CDC Quarantine guidelines (CDC) Early phase of SARs-CoV-2 infection (COVID.gov) <a href= "https://www.covid19treatmentguidelines.nih.gov/about-the-guidelines/whats-new/?utm_campaign=+59641584&utm_content=&utm_medium=email&utm_source=govdelivery&utm_term=&utm_source=MarketingCloud&utm_medium=email&utm_campaign=03062024+IDSA+News&utm_content=NIH+COVID-19+Treatment+Guidelines+Upda
Sun, June 30, 2024
Giving prions the (zinc) finger
TWiV discusses secret anti-vax campaign run by Pentagon to undermine China during pandemic, NY governor’s subways mask ban proposal, Colorado bat facility sparks outbreak fears, House budget billls suggest ban on gain of function research, evolution of STAT2 resistance to flavivirus NS5, and brainwide silencing of prion protein by AAV-mediated delivery of an epigenetic editor. Hosts: Vincent Racaniello , Dickson Despommier , and Alan Dove Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Pentagan anti-vac campaign to undermine China (Reuters) NY governor subway mask ban (AP News) Colorado bat facility sparks outbreak fears (Science) House NIH budget bans gain of function research (Science) Evolution of STAT2 resistance to flavivirus NS5 (Nat Commun) Brainwide silencing of prion protein by AAV delivered epigenetic editor (Science) Letters read on TWiV 1127 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Mars Odyssey Orbiter is about to make its 100,000th orbit Alan – Local animal shelters and “kitten season.” Vincent – <a href= "https://www.pbs.or
Sat, June 29, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses RSV vaccination recommendations and revisions to guidelines before reviewing the recent statistics on SARS-CoV-2 infection, data suggesting that individuals with high HLA-DQA2 expression (MHC class II) are better at preventing the onset of a sustained viral infection, how moderate coffee intake can reduce risk of COVID-19 severity but cannabis use resulted in more severe disease but reduced risk of mortality, where to find PEMGARDA, if statin use prevented severe COVID-19, the benefit of administering nirmatrelvir and ritonavir after 5 days, convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if fecal microbiota transplants aid in recovery from COVID-19, and the definition of characteristics and clinical patterns for the diagnosis of long COVID. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode CDC ACIP for RSV (CDC) This respiratory virus season everyone age 75 and older receive the RSV vaccine (CDC Newsroom) Revised RSV vaccine recommendations (CIDRAP) COVID-19 national trend (CDC) COVID-19 deaths (CDC) Local and systemic response dynamics to SARS-CoV-2 infection (Nature) Drink more coffee , reduces risk for SARS-C0V-2 infection (Cell & Bioscience) Cannabis, tobacco… smoking in general NOT good for preventing COVID-19 (JAMA Network OPEN) Do older versions of the COVID-19 vaccine still provide any protection (JAMA Internal Medicine) Where to get pemgarda (Pemgarda)
Sun, June 23, 2024
Can pig flu viruses go viral?
TWiV reviews criticism of NIAID monkeypox virus experiments by House Republicans, spread of wild poliovirus across Afghanistan and Pakistan, plan to overhaul NIH by House lawmakers, and the potential pandemic risk of circulating swine H1N2 influenza viruses. Hosts: Vincent Racaniello , Dickson Despommier , Brianne Barker , and Angela Mingarelli Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server 2024 International HBV Meeting House Republicans fault NIH for evasive answers on monkeypox virus study (Science) Report on MPX experiments at NIAID ( pdf ) Wild poliovirus spreads across Pakistan and Afghanistan (Science) Plan to overhaul NIH (Science) Reforming NIH ( pdf ) Potential pandemic risk of circulating swine H1N2 influenza viruses (Nat Comm) Timestamps by Jolene . Thanks! Weekly Picks Angela – <a title="" href= "https://www.nature.com/articles/d41586-023-0
Sat, June 22, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin reviews the recent statistics on SARS-CoV-2 infection, before discussing methods for sterilizing filtering facepieces, an update to the fall COVID boosters, the emergency use application of a pre-exposure prophylactic and where to find it and drug interaction database, convalescent plasma, the effectiveness of the monoclonal antibody sotrovimab against Omicron variants, what to do when healthcare workers succumb to SARS-CoV-2 infection, the need for better nursing resources, how survivors of COVID-19-associated ARDS exhibited sustained elevation in endothelial dysfunction biomarkers, correlating with the severity of impaired gas exchange, reactivation of latent CMV as a consequence of a SARS-CoV-2 infection, identification of variables that might impact or predict a person’s time to recovery from an acute SARS-CoV-2 infection and if COVID-19 patients really have olfactory dysfunction more often than normally smelling individuals. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode COVID-19 national trend (CDC) COVID-19 deaths (CDC) Comparison of methods for sterilizing filtering facepiece respirators (American Journal of Infection Control) Booster update already! KP.2 of JN.1-lineage (FDA) EUA for pemgarda (FDA) Where to get pemgarda (Pemgarda) CDC Quarantine guidelines (CDC) Early phase of SARs-CoV-2 infection (COVID.gov) NIH COVID-19 treatment guidelines (NI
Sun, June 16, 2024
Europic 2024 in Jyväskylä, Finland
Vincent travels to Europic 2024 in Jyväskylä, Finland to speak with Tapani Hovi and Caroline Tapparel about their careers and their research on enteroviruses and elimination of poliomyelitis. Host: Vincent Racaniello Guests: Tapani Hovi and Caroline Tapparel Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Survival of influenza virus on banknotes (Appl Environ Micro) Variant EV-A71 in immunosuppressed patient (Cell Rep) Rhinoviruses and respiratory enteroviruses (Viruses) Isolation of poliovirus in mouse cells producing Pvr (J Clin Micro) Outbreak of paralytic poliomyelitis in Finland (Lancet) Role of environmental poliovirus surveillance in global polio eradication (Epi Infect) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.
Sat, June 15, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses expanded use of the RSV vaccine by GSK, how the youngest member of the MicrobeTV family was hospitalized with RSV, why we are seeing more RSV infections than before the pandemic and how administration of monoclonal antibody therapy does not prevent infection but disease, before reviewing the weekly US COVID update, how SARS-CoV-2 affects neurodevelopment of the fetus and probability of preeclampsia, if giving Paxlovid prevents long COVID, and FDA recommends switching from the XBB.1.5 variant to JN.1 for fall COVID-19 vaccine formulations. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Young “Immune” co-host with RSV (YouTube) RSV on Immune (MicrobeTV) More children hospitalized with RSV after pandemic than before (Pediatrics) France supports Nirsevimab for RSV (Influenza and other respiratory viruses) Protects against disease not infection Nirsevimab (CIDRAP) TWiV tells it likes it is : protects against disease NOT infection (TWiV 695) RSV vaccine access expanded 50-59 (CIDRAP) GSK RSV vaccine expanded use for high risk 50-year olds (GSK) COVID-19 deaths COVID-19 national trend Neurodevelopmental delay in children whose mothers exposed to SARS-CoV-2 (Scientific Reports) P
Mon, June 10, 2024
How the pandemic began in Nature, in 5 key points
TWiV rebuts a recent opinion piece which falsely claims that the COVID-19 pandemic began in a lab (it began in Nature). This material has been extracted from TWiV 1121. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , Brianne Barker , and Jolene Ramsey Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server SARS-CoV-2 origin discussions previously on TWiV: TWiV 1019: Eddie Holmes on SARS-CoV-2 origins TWiV 1017: From Nature, not a lab TWiV 995: Viral origin stories TWiV 940: Eddie Holmes in on viral origins TWiV 876: Spillover market with Michael Worobey TWiV 762: SARS-CoV-2 origins with Robert Garry TWiV 760: SARS-CoV-2 origins with Peter Daszak, Thea Kølsen Fischer, Marion Koopmans TWiV 774: Kristian Andersen, Robert Garry, and the deleted SARS-CoV-2 sequences Why the Pandemic Probably Started in a Lab, in 5 Key Points (NY Times) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.
Sun, June 09, 2024
SARS-CoV2 still didn't come from a lab
TWiV rebuts a recent opinion piece which falsely claims that the COVID-19 pandemic began in a lab (it began in Nature), followed by a discussion of Paride bacteriophage, which has the unsual property of being able to kill dormant, antibiotic-tolerant cells by direct lytic replication. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , Brianne Barker , and Jolene Ramsey Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server 2024 International HBV Meeting Register for ASV Annual Meeting SARS-CoV-2 origin discussions previously on TWiV: TWiV 1019: Eddie Holmes on SARS-CoV-2 origins TWiV 1017: From Nature, not a lab TWiV 995: Viral origin stories TWiV 940: Eddie Holmes in on viral origins TWiV 876: Spillover market with Michael Worobey TWiV 762: SARS-CoV-2 origins with Robert Garry TWiV 760: SARS-CoV-2 origins with Peter Daszak, Thea Kølsen Fischer, Marion Koopmans TWiV 774: Kristian Andersen, Robert Garry, and the deleted SARS-CoV-2 sequences Why the Pandemic Probably Started in a Lab, in 5 Key Points</a
Fri, June 07, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin reports the third case of influenza H5N1 infection in a human, this time with respiratory symptoms, an H5 avian influenza virus wastewater dashboard, FDA approves Moderna’s mRNA vaccine for respiratory syncytial virus, vaccine advisors to FDA recommend switching from the XBB.1.5 variant to JN.1 for fall COVID-19 vaccine formulations, weekly US COVID update, a controlled human exhaled breath aerosol experimental study on the relative efficacy of masks and respirators as source control for viral aerosol shedding from people infected with SARS-CoV-2, systematic review of early use of oral antiviral drugs and the risk of post COVID-19 syndrome, long-COVID autonomic syndrome in working age and work ability impairment, Centers for Disease Control and Prevention estimates that 5.3% of Americans currently have long COVID, and the National Academies of Sciences, Engineering, and Medicine presented a report with a number of conclusions about long-COVID diagnosis, symptoms, and impact on daily function. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Links coming soon Long COVID evidence based review TWiV shout out Contribute to our Floating Doctors fundraiser Letters read on TWiV 1120 Dr. Griffin’s COVID treatment summary ( pdf ) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Sat, June 01, 2024
Gene editing latent herpes
TWiV reviews viral shedding and antibody responses of men with acute monkeypox virus infection, and gene editing for latent herpes simplex virus infection reduces viral load and shedding. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Angela Mingarelli Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress 2024 International HBV Meeting Michelson Prizes: Next Generation Grants Register for ASV Annual Meeting Monkeypox virus shedding (Nat Commun) Gene editing of herpes simplex virus (Nat Commun) Letters read on TWiV 1119 Timestamps by Jolene . Thanks! Weekly Picks Angela – Unconventional Sex Let Anglerfish Conquer the Deep Ocean Kathy – Doonesbury from 5-26-24 . And Publ
Sat, June 01, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin delves into highly pathogenic H5N1 infection of hunting dogs, dairy cattle, humans and alpacas before reviewing the recent statistics on SARS-CoV-2 infection, risks factors associated with the development of severe COVID-19 in pediatric patients, virus transmission on commercial airline flights, the guidelines for spring administration of COVID vaccines boosters, the emergency use application of a pre-exposure prophylactic, a drug interaction database, absence of durability of XBB.1.15 vaccine induced immunity and continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, and discusses why development of long COVID should be included in the development of treatments for acute viral disease, if vaccination effects long COVID, structural impairment of brain during long COVID, how cognitive and respiratory function may be compromised in long COVID. For more information about long COVID-19 listen to TWiV 1088 and for H5N1 in dairy cattle and unpasteurized milk TWiV 1117 . Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Bird dogs infected with high pathogenic avian flu H5N1(AKC) Hunting dogs with antibodies against influenza A (H5N1) (Emerging Infectious Diseases) Dairy cattle and 2 humans infected with highly pathogenic avian influenza A (H5N1) (MMWR) Daisy, are you reading NEJM: cow’s milk infected with highly pathogenic avian influenza A (H5N1)? (NEJM) Better yet, listen TWiV 1117: pol dances with RNA to learn if mice can transmit H5N1 to each other <li
Sat, May 25, 2024
Pol dances with the RNA that brought it
TWiV discusses presence of infectious avian H5N1 influenza virus in raw milk from infected dairy cows. dynamics of measles immunity from birth and following vaccination, and a mechanism for cis-preferential reverse transcription revealed by deep mutational scanning of hepatitis B virus. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress 2024 International HBV Meeting Michelson Prizes: Next Generation Grants Register for ASV Annual Meeting H5N1 influenza virus in raw cow milk infects mice (NIAID News) Dynamics of measles virus immunity from birth (Nat Comm) Mechanism of cis-preferential HBV reverse transcription (Cell) Timestamps by Jolene . Thanks! Weekly Picks Dickson – <a title="" href= "https://www.newscientist.com/article/243
Sat, May 25, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin delves highly pathogenic H5N1 biology including its circulation in New York City, being able to infect cells within mammary glands and why testing is not supported before reviewing the recent statistics on SARS-CoV-2 infection, how vaccination reduced deaths and hospitalizations associated with COVID-19 and how to take off PPE to reduce virus transmission, discussing the guidelines for spring administration of COVID vaccines boosters, the emergency use application of a pre-exposure prophylactic, a drug interaction database and the global phase 3 trail of a novel antiviral, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, reminisces about when available monoclonal antibody therapies were effective, and discusses muscle training/exercise for treatment of PASC/long COVID and the use of RNase for its treatment. For more information about long COVID-19 listen to TWiV 1088 . Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Clade 2.3.4.4b of highly pathogenic H5N1 in NYC (J Vi) Avian and human influenza A receptors in bovine mammary glands (bioRxiv) Where livestock infected with HPAI live (USDA) Another dairy worker contracted bird flu (NY Times) Reluctance to test for H5N1 (STAT News) COVID-19 national trend (CDC) COVID-19 deaths (CDC) Estimates of hospitalization and deaths prevaccination era (Emerg Inf Dis) <a href= "https://www.cidrap.umn.edu/covid-19/study-vacci
Sun, May 19, 2024
Calling the CoPs on flu
TWiV reviews results of a phase 3 trial of a self-amplifying mRNA COVID-19 vaccine, and the finding that baseline innate and T cell populations are correlates of protection against symptomatic influenza virus infection independent of serology. Hosts: Dickson Despommier , Alan Dove and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Michelson Prizes: Next Generation Grants Immunogenicity and safety of self-amplifying mRNA COVID-19 vaccine (Lancet Inf Dis) First self-amplifying mRNA vaccine approved in Japan (Science) Rise of the RNA machines (Trends Biochem) Innate and T cell populations correlates of protection against influenza (Nat Immunol) Timestamps by Jolene . Thanks! Weekly Picks Dickson - Nitrogen-fixing organelle in a marine alga Brianne – Mapping a lost branch of the Nile Alan – Interactive version of the updated USDA gardening zone map on NPR. Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, May 18, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin delves into discussing drinking “raw” milk possessing H5N1 influenza virus, if the virus can reproduce in the human gut, and the meaning of finding viral RNA in wastewater samples before reviewing the recent statistics on SARS-CoV-2 infection, the guidelines for spring administration of COVID vaccines boosters, withdrawal of AstraZeneca’s SARS-CoV-2 vaccine from the European market, discusses the emergency use application of a pre-exposure prophylactic, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if administration of colchicine for the management of COVID-19, compares and provides information for the enrollment into the NIH clinical trials of long COVID and its effects on sleep, exercise intolerance and the cognitive profile in multiple sclerosis and post-COVID, exercise intolerance and post-exertional malaise. For more information about cow and milk infection by H5N1 listen to the discussion with Richard Webby on TWiV 1113 and for long COVID-19 listen to TWiV 1088 . Dr. Griffin also provides a list of apps for monitoring one’s health including brain health. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Who demands milk infected with H5N1 ? (Futurism) Uncowed by milk possessing H5N1 (LA Times) Cow flu flying around for 4 months (CNN) The unpasteurized raw milk institute (Raw Milk Institute) Infection and reproduction of H5N1 in the human gut (JID) Wastewater samples identified H5N1 in 9 cities (medrxiv) Richard Webby , is H5N1 a concern? (TWiV 1113) COVID-19 n
Sun, May 12, 2024
Influenza virus H5N1 in cows' milk with Richard Webby
Richard Webby joins TWiV to review the history of avian H5N1 influenza virus, the recent change in epidemiological patterns, infection of dairy cattle in the US, and the risk of an outbreak in humans. Hosts: Vincent Racaniello , Alan Dove, and Brianne Barker Guest: Richard Webby Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Webby research laboratory H5N1 virus in dairy cattle and cats (Emerg Inf Dis) Emergence of H5N1 virus in dairy cattle (bioRxiv) Spillover potential of H9N2 bat virus (Nat Commun and TWiV 1111 ) Letters read on TWiV 1113 Timestamps by Jolene . Thanks! Weekly Picks Brianne – The Little Researcher (from Bioss ) Alan – Global Polio Eradication Initiative’s OPV switch was “ unqualified failure .” Vincent – Errant Science Listener Picks Moragh – Paper Cuts Podcast Intro music is by Ronald Jenkees <
Sat, May 11, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin deep dives into infections of dairy cattle with high pathogenic influenza H5N1, how long virus has been circulating and if known anti-influenza antivirals can reduce secondary attack rates, before reviewing the recent statistics on SARS-CoV-2 infection, the guidelines for spring administration of COVID vaccines boosters, whether COVID booster takes associates with long COVID prevalence, discusses the emergency use application of a pre-exposure prophylactic, if administration of oral antiviral therapies can prevent the onset of post-acute sequelae following SARS-CoV-2 infection, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, compares and contrasts the cognitive profile in multiple sclerosis and post-COVID, exercise intolerance following SARS-CoV-2 infection and the epidemiology of the pandemic in a Kenyan refugee camp. For more information about this body of work, listen to TWiV 1088 . Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Technical reports on high path avian influenza (CDC) High path cow influenza H5N1 clade 2.3.4.4b (Emerging Infectious Diseases) Cow flu flying around for 4 months (CNN) Interstate commerce: high path avian influenza in dairy cattle (bioRxiv) Oseltamivir and baloxavir marboxil treatment for influenza in household index cases (Influenza and other respiratory viruses) COVID-19 national trend (CDC) COVID-19 deaths (CDC) Spring vaccine advice (CIDRAP) <
Sun, May 05, 2024
Taming of the flu
TWiV reviews viruses in the news: Chinese scientist who released the SARS-CoV-2 genome sequence sleeps in the street, a case of measles in Haifa, spread of waterborne infectious diseases in Gaza, interstate spread of avian influenza A(H5N1) in dairy cattle, and an orangutan heals himself with medicinal plants, followed by identification of a cell receptor for parechoviruses, and blockade of necroptosis prevents lung injury in severe influenza. Hosts: Vincent Racaniello , Dickson Despommier , and Alan Dove Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV ( asv.org ) The New City by Dickson Despommier ( blog post ) International Conference on Pandemic Preparedness Chinese virologist sleeps on street (Nature) Measles in Haifa (Jerusalem Post) Waterborne illness spreads in Gaza (Reuters) Interstate spread of H5N1 virus in dairy cattle (bioRxiv) Orangutan uses medicinal plants (Science) Parechovirus cell receptor identified (Nat Comm) Necroptosis blockade prevents lung injury in influenza (Nature) Necroptosis, pyrop
Sat, May 04, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin begins with discussing if the antibiotic neomycin is really a pan-antiviral countermeasure, then reviews the recent statistics on SARS-CoV-2 infection before deep diving into if shedding and the rapid antigen test results correlate, the guidelines for spring administration of COVID vaccines boosters, whether COVID booster associates with the long COVID prevalence, discusses the emergency use application of a pre-exposure prophylactic, revised guidelines for how to treat respiratory viral infection guidelines by the CDC, the caveats for improper use of antibiotics to treat SARS-CoV-2 (a viral infection), continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if administration of an anti-immunoglobulin E monoclonal antibody can be used for COVID-19 treatment, if inhibiting T-cell activation will reduce secretion and production of inflammatory cytokines including IL-6, if changes in the gut microbiome associate with post -acute COVID-19 syndrome, and the pulmonary and neurologic determinants of long COVID-19 such as the presence of neurofilament light chain in plasma. For more information about this body of work, listen to TWiV 1088 . Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Intranasal antibiotic evokes antiviral response (PNAS) COVID-19 national trend (CDC) COVID-19 deaths (CDC) SARS-CoV-2 shedding vs rapid antigen test performance (MMWR) Spring vaccine advice (CIDRAP) Older adult spring booster available (CDC) Advisory committee for immunization practices sli
Sun, April 28, 2024
A protein flew out and a bat flu in
TWiV reviews avian H5N1 influenza virus in the US, measles at highest levels in England, positive selection underlies repeated knockout of ORF8 in SARS-CoV-2 evolution, and cross-species spill-over potential of the H9N2 bat influenza A virus. Hosts: Vincent Racaniello , Dickson Despommier , and Alan Dove Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV ( asv.org ) The New City by Dickson Despommier ( blog post ) International Conference on Pandemic Preparedness Bird flu in humans (NY Times) H5N1 genome sequences (USDA) Measles cases and outbreaks (CDC) Latest measles statistics (UK) Positive selection underlies ORF8 loss (Nat Comm) Spillover potential of bat H9N2 influenza virus (Nat Comm) Letters read on TWiV 1109 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Journey to the Andromeda Galaxy , <a title="" href= "https://youtube.com/shorts/e_JiW
Sat, April 27, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles, and H51 influenza infection of birds, poultry and cows before and SARS-CoV-2 circulation, before discussing if the original monovalent SARS-CoV-2 vaccine was effective in children and adolescents, how to use words to properly describe respiratory pathogens the guidelines for spring administration of COVID vaccines boosters, discusses the emergency use application of a pre-exposure prophylactic, revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if administration of remdesivir reduces mortality, long COVID, persistence of virus infection during long COVID and it prevalence. For more information about this body of work, listen to TWiV 1088 . Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Measles tracking (CDC) Cows, chickens and birds H5N1….oh, my (USDA) Evolution of circulating H5N1 (CIDRAP) COVID-19 national trend (CDC) COVID-19 deaths (CDC) Original monovalent mRNA vaccine effectiveness in children and adolescents (MMWR) Updated terminology for pathogens transmitted through the air (WHO) Are these <a href= "https://www.nytimes.com/2024/04/18/health/who-airbo
Sun, April 21, 2024
Uncoating some envelopes
It has been a long time since TWiV has released an all listener email episode, and if you have been waiting for one, then this episode is for you! (and everyone else of course). Hosts: Vincent Racaniello , Alan Dove , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV ( asv.org ) The New City by Dickson Despommier ( blog post ) International Conference on Pandemic Preparedness Letters read on TWiV 1107 Timestamps by Jolene . Thanks! Weekly Picks Brianne – Cats Are Perfect. An Evolutionary Biologist Explains Why Alan – Bardcore music by Hildegard von Blingin’ Vincent – A quote from Georgia O’Keefe: “I think it’s so foolish for people to want to be happy. Happy is so momentary – you’re happy for an instant and then you start thinking again. Interest is the most important thing in life; happiness is temporary, but interest is continuous”. From the dailyphilosopher Listener Picks Julia – Recent success in troubleshooting autoclave challenges Charmaine – <a title="" href= "https://www.youtube.com/watch?v=ABb7uodJRC
Sat, April 20, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles before addressing results of Pfizer’s phase 3 RSV vaccine clinical trial for adults under 60, RSV, influenza and SARS-CoV-2 circulation, differences between rural and urban communities dealing with SARS-CoV-2 infections, the latest statistics on influenza and COVID-19 circulation, restates the guidelines for spring administration of COVID vaccines boosters, discusses the emergency use application of a pre-exposure prophylactic. revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, how long COVID affects the brain and associates with an increase in allergic incidents as well as if post SARS-CoV-2 infected patients are unable to exercise or have functional limitations. For more information about this body of work, listen to TWiV 1088 . Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Measles tracking (CDC) Influenza risk factors for potential severe outcomes (OFID) COVID-19 national trend (CDC) Does SARS-CoV-2 infection influence sperm quality (Scientific Reports) Spring COVID-19 booster recommendations (CIDRAP) Older adult spring booster available (CDC) Advisory committee for immunization practices slides (CDC) Advisory committee for immunization practices spring 2024
Sun, April 14, 2024
All the T and B in China
TWiV reviews influenza H5N1 in North American cows and in birds throughout New York City, polio health emergency extended, ChatGPT to control vaccine hesitancy, increasing viral hepatitis worldwide, dengue public health alert in Puerto Rico, cherry trees drowning in Washington DC, death of iron lung Paul, origin and dispersal history of hepatitis B virus in Eastern Eurasia, and antibody-independent protection against heterologous SARS-CoV-2 challenge. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV ( asv.org ) The New City by Dickson Despommier ( blog post ) Navigating the U.S. Immigration System webinar International Conferene on Pandemic Preparedness Avian influenza in dairy cows North Carolina and South Dakota H5N1 clade 2.3.4.4 Pathogenic flu throughout NYC Polio from Afghanistan to Pakistan extending public health emergency CHAT GPT to combat vaccine hesitancy <a href= "https://www.who.int/news/item/09-0
Sat, April 13, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles before addressing results of Pfizer’s phase 3 RSV vaccine clinical trial for adults under 60, RSV, influenza and SARS-CoV-2 circulation, differences between rural and urban communities dealing with SARS-CoV-2 infections, the latest statistics on influenza and COVID-19 circulation, restates the guidelines for spring administration of COVID vaccines boosters, discusses the emergency use application of a pre-exposure prophylactic. revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, how long COVID affects the brain and associates with an increase in allergic incidents as well as if post SARS-CoV-2 infected patients are unable to exercise or have functional limitations. For more information about this body of work, listen to TWiV 1088 . Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Measles tracking (CDC) Measles just this year (MMWR) ABRYSVO phase 3 results (Pfizer) RSV surveillance (CDC) Influenza/flu surveillance (CDC) Provisional deaths due to COVID-19 (CDC) COVID-19 national trend (CDC) COVID-19 wastewater testing (biobot) Variant tracker (CDC)
Sun, April 07, 2024
Jason 'Spike' McLellan
Vincent travels to the University of Texas in Austin to speak with speak with Jason McLellan about his career and his research on the SARS-CoV-2 spike protein, including the effect of adding two proline residues, its effect on other viral spike glycoproteins, and general approaches to vaccine design. Hosts: Vincent Racaniello and Rich Condit Guest: Jason McLellan Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV ( asv.org ) The New City by Dickson Despommier Prefusion-stabilized SARS-CoV-2 spikes (Science) Structure-based vaccine design (Curr Opin Immunol) Prefusion-stabilized SARS-CoV-2 S2-only antigen (Nat Comm) Stabilized coronavirus spike stem elicits broadly protective antibody (Cell Rep) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, April 06, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles and influenza before addressing Vincent’s comment on measles inclusion in the clinical respiratory PCR panel, the latest statistics on influenza and COVID-19 circulation, if inflammatory cytokines and anti-viral antibody function synergistically, if administration of peptide agonists of the glucagon-like or sodium-glucose pump can reduce disease severity, restates the guidelines for spring administration of COVID vaccines boosters, discusses the emergency use application of a pre-exposure prophylactic. revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound, revised guidelines for SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if remdesivir or paxlovid can reduce cardiovascular adverse events and the first finding of the two-year longitudinal study on long COVID. For more information about this body of work, listen to TWiV 1088 . Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Measles tracking (CDC) What happens when measles is included in commercial syndromic PCR panels (MMWR) Influenza/flu surveillance (CDC) Influenza on the Texas ranch (Statnews) Sequence analysis of highly pathogenic avian influenza from Texas (CDC) Influenza/flu map (CDC) COVID-19 hospital admissions (CDC) COVID-19 national trend (CDC) COVID-19 <a href= "ht
Sun, March 31, 2024
It's not over 'til it's Offit
Paul Offit joins TWiV to discuss his latest book, “Tell Me When It’s Over”, an insider’s guide to deciphering COVID myths and navigating our post-pandemic world. Hosts: Vincent Racaniello , Dickson Despommier , and Brianne Barker Guest: Paul Offit Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV ( asv.org ) The New City by Dickson Despommier Tell Me When It’s Over by Paul Offit Navigating the U.S. Immigration System (webinar) Classifying Viral Subspecies (Workshop) Options XII for the Control of Influenza (Meeting) Letters read on TWiV 1101 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Astronomers Unveil Strong Magnetic Fields Spiraling at the Edge of Milky Way’s Central Black Hole Brianne – Inside the AI Competition That Decoded an Ancient Herculaneum Scroll Vincent – biotech.
Sat, March 30, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles influenza and SARS-CoV-2, before discussing the development of new monoclonal antibody therapy, if vaccines and antivial drugs can used effectively together. revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound including that after administration of the “oral remdesivir”, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if one can predict the loss infectivity of healthcare workers with mild COVID-19 disease and the dynamics of household transmission of the virus in children. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Measles tracking (CDC) Influenza/flu surveillance (CDC) Influenza/flu map (CDC) COVID-19 hospital admissions (CDC) COVID-19 national trend (CDC) COVID-19 wastewater testing (biobot) Variant tracker (CDC) Variant hospital admissions (CDC) What new monoclonal antibody therapy? (FDA) A New pre-exposure prophylaxis for COVID-19? (Invivyd) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Really COVID-19 rebound after N
Sun, March 24, 2024
Volker Lohmann, as persistent as his viruses
Vincent travels to the University of Heidelberg to speak with Volker Lohmann about his career and the research of his laboratory on hepatitis C virus, hepatitis A virus, and norovirus. Host: Vincent Racaniello Guests: Volker Lohmann Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV ( asv.org ) The New City by Dickson Despommier HCV human challenge studies (Lancet Gastro Hepatol) Comparison of HCV and HAV infections (J Hepatol) HCV cell culture systems (J Med Chem) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, March 23, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin deep dives into recent domestic and global measles and mpox outbreaks, before reviewing recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2, discussing revised guidelines for how to treat respiratory viral infection guidelines by the CDC, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, how much oxygen is necessary for effective treatment of severe disease, how COVID-19 effects the cardiovascular system of children and adolescents with long COVID and how iron metabolism may be altered during long COVID. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Measles tracking (CDC) Measles in Cook County (MMWR) Gaps in measles vaccination drives viral surges (Infectious Disease Advisor) Misinformation impacts public health? Seriously? (ID Society) CDC alert for global and domestic measles cases and outbreaks (CDC) Mpox in Kamituga associated with outbreak in DRB (Eurosurviellance) Mpox in US , 2023 (MMWR) Mpox in DRC , 2024 (reliefweb) CDC
Sun, March 17, 2024
Tiny cells and giant viruses in a castle
Vincent travels to the fifth Giant Virus Meeting in Tegernsee, Germany and speaks with Sheree Yau and Victoria Queiroz about their research on picoeukaryotes (tiny algal cells) and their viruses, pithoviruses, and an educational kit for virology classes. Host: Vincent Racaniello Guests: Sheree Yau and Victoria Queiroz Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV ( asv.org ) The New City by Dickson Despommier 8:16 Virophage control of antarctic algal host-virus dynamics (PNAS) Timestamps by Jolene . Thanks! Virus-host coexistence in phytoplankton through the genomic lens (Sci Adv) Two groups of pithoviruses (J Virol) Educational toolkit for virology classes (J Virol) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, March 16, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin highlights measles outbreaks throughout the continental US, reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing if vaccination protected children from the development of long COVID or cardiovascular diseases associated with virus infection, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, how COVID-19 effects the autonomic nervous system, and if nirmatrelvir-ritonavir protects against adverse cardiovascular effects following SARS-CoV-2 infection. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Measles everywhere (CDC) Respiratory disease surveillance (CDC) RSV surveillance (CDC) RSV national trend (CDC) Estimating niresevimab effectiveness for infants (MMWR) More than 100 children died of influenza (NBS News) Influenza/flu surveillance (CDC) Influenza/flu map (CDC) COVID-19 hospital admissions (CDC) COVID-19 national trend (CDC) COVID-19 wastewater testing (biobot) Variant tracker (CDC) Variant hospital admissions (CDC) Did the <a href= "https://publicat
Sun, March 10, 2024
Monkeys fly and mice exaggerate
TWiV reviews heterosexual transmission of clade I Mpox virus, continued circulation of oropouche virus in South America, herpesviruses in South American fur seals and sea lions, sex-specific differences in physiological responses to SARS-CoV-2 infection, underdetected dispersal and extensive local transmission drove the 2022 mpox epidemic, and a humanized mouse model for adenovirus-associated virus gene therapy. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Angela Mingarelli Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV ( asv.org ) The New City by Dickson Despommier Heterosexual transmission of clade I Mpox virus (Emerg Inf Dis) Continued circulation of oropouche virus (PAHO and WHO) Herpesviruses in fur seals and sea lions (PLoS One) Sex-specific effects of SARS-CoV-2 infection (PLoS One) Drivers of 2022 Mpox virus epidemic (Cell) How AAV gene transfer works (YouTube) Humanized mouse model for AAV gene therapy (Nat Comm) Timestamps by Jolene . Thanks! Weekly Picks Dickson – <a title="" href= "https://youtu.be/HgR7YJpOoPE?si=MCQMQU
Sat, March 09, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing revised guidelines for how to treat respiratory viral infection guidelines by the CDC, effectiveness of the new SARS-CoV-2 vaccines and the combination of vaccination and antiviral therapy against the development of disease, continues to dispel the myth of viral rebound, how to pay for paxlovid, the lack of evidence supporting ivermectin as an antiviral drug, when to use steroids and the benefits of convalescent plasma, how COVID-19 affects cognitive function and the effect of long COVID and how healthcare works have difficulty making the proper diagnosis for long COVID even using a questionnaire. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Respiratory disease surveillance (CDC) RSV surveillance (CDC) RSV national trend (CDC) Influenza/flu surveillance (CDC) Influenza/flu map (CDC) COVID-19 hospital admissions (CDC) COVID-19 national trend (CDC) COVID-19 wastewater testing (biobot) Variant tracker (CDC) Variant hospital admissions (CDC) What to do when you are sick with a respiratory virus (CDC) Basis for respiratory virus guidance (CDC) Effectiveness of updated COVID-19 vaccines (MMWR) CDC Quarantine guidelines (CDC) <a hr
Sun, March 03, 2024
Reservoir bats and jumbo phage
TWiV discusses effectiveness of this season’s flu vaccine, efficacy of Pfizer RSV vaccine, nOPV2 in the US, dengue in Peru, measles in Michigan and Indiana, how coordinated inflammatory responses dictate control of Marburg virus by reservoir bats, and tRNA acquisition in phages driven by degradation of host translational machinery. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , Brianne Barker, and Jolene Ramsey Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV ( asv.org ) The New City by Dickson Despommier Effectiveness of flu vaccine ( MMWR , Eurosurveill ) Efficacy of Pfizer RSV vaccine (Pfizer) Understanding six types of vaccine technologies (Pfizer) nOPV in US? (CDC) Dengue in Peru (Peruvian State) Measles in Michigan and Indiana Marburg virus control by reservoir bats (Nat Commun) <a title="" href= "h
Sat, March 02, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing new vaccine guidelines released by the advisory committee on immunization practices, and reviews the CDC guidelines for quarantine/ isolation following SARS-CoV-2 infection, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, the role of IFN-g in long COVID, if the brain-blood-barrier is compromised in long COVID, meaning of persistent community SARS-CoV-2 RNA findings, and the effects of hyperbaric oxygen on post COVID neurocognition. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Respiratory disease surveillance (CDC) RSV surveillance (CDC) RSV national trend (CDC) RSV vaccination stats (CIDRAP) Influenza/flu surveillance (CDC) Influenza/flu map (CDC) COVID-19 hospital admissions (CDC) COVID-19 national trend (CDC) COVID-19 wastewater testing (biobot) Variant tracker (CDC) Variant hospital admissions (CDC) ACIP COVID vaccination for seniors recommendations (CIDRAP) Additional vaccine doses for older adults (CDC) Evidence based advice from the ACI
Sun, February 25, 2024
Skeeter poo and obelisks too
TWiV reviews resurgence of Lassa fever in West Africa, at least 3 paralytic cases of cVDPV2 in Zimbabwe, CWD from eating prion-laden plants, measles in New Orleans and Broward County Florida, failure of Florida Surgeon General to support vaccination, a measles variant in Switzerland, SARS-CoV-2 persistent infections, leaky blood-brain-barrier for long COVID brain fog, West Nile virus transmitted among mosquitoes by the excreta, and viroid-like colonists of human microbiomes. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit and Kathy Spindler Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV ( asv.org ) Research assistant position in Rosenfeld Lab CBER/FDA ( pdf ) The New City by Dickson Despommier Viruses of Microbes 2024 Resurgence of Lassa fever (Science) cVDPV2 in Zimbabwe (UNICEF) CWD from eating plants (CIDRAP) Measles in New Orleans (LA Dept Health) SARS-CoV-2 persistent infections (Nature) Leaky BBB for brain fog of long COVID (Nat Neurosci) <a title="" href= "https://wsvn.com/news/local/br
Sat, February 24, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of respiratory syncytial virus before discussing uptake of the RSV vaccine Abrysvo or the monoclonal anti-RSV antibody nirsevimab to prevent severe disease following RSV infection in infants 8 months or younger before going over this week’s influenza virus and SARS-CoV-2 virus statistics, including all circulating variants in the US, examines if self-testing is more accurate than clinician administered Binax rapid diagnostic tests for SARS-CoV-2 infection, if N95 masks need a yearly fitting, how SARS-CoV-2 vaccination impacts the prevalence of long COVID, reviews the CDC guidelines for quarantine/ isolation following SARS-CoV-2 infection, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, why determining the exact number of long COVID incidences is challenging, how the incidence and predictors for fatiguing illness following SARS-CoV-2 infection may used to reenforce the need for public health actions to prevent virus infection and the risks of respiratory pathologies including lung cancer associate with SARS-C0V-2 infection. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Respiratory disease surveillance (CDC) RSV surveillance (CDC) RSV national trend (CDC) RSV vaccination stats (CIDRAP) Abrysvo vaccine stats (Axios) RSV vaccination dashboard (CDC) Influenza/flu surveillance (CDC) Influenza/flu map (CDC) COVID-19 hospital admissions (CDC) COVID-19 <a href= "https://www.cdc.gov/nwss/rv/COVID19-nationalt
Sun, February 18, 2024
Shoot out at the Circle-T ranch
TWiV reviews a fatal Alaskapox case, MERS in Kenya, diagnostic tests for Nipah and Lassa diseases, HPV vaccination rates in the US, cases of measles in Arizona and Minnesota, hepatitis C virus-derived RNA circles in infected cells, and prevention of respiratory virus transmission by resident memory CD8+ T cells. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV ( asv.org ) Research assistant position in Rosenfeld Lab CBER/FDA ( pdf ) The New City by Dickson Despommier Viruses of Microbes 2024 Fatal case of Alaskapox (AK Beacon) MERS in Kenya (Emerg Inf Dis) Diagnostic tests for Nipah and Lassa (CEPI) Measles in Arizona and Minnesota HCV-derived circular RNAs (PNAS) Resident memory CD8 T cells prevent respiratory virus transmission (Nature) Letters read on TWiV 1087 1:24:33 Timestamps by <a href= "https://ramseylab.vercel
Sat, February 17, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the use of monoclonal antibody therapy to prevent RSV hospitalization of infants and use of GSK’s RSV vaccine Arexy to prevent severe disease following RSV infection in adults between 50-59 years before he reviews recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, discusses if how the influenza vaccine is manufactured can reprogram the antibody response, cardiovascular consequences of influenza infection, mortality of chikungunya virus infection, if an alternative vaccination schedule impacts the anti-SARS-CoV-2 immune response, dispels the myth that increased mortality correlated with the first vaccine dose, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, how manage long COVID including prevent burnout and compassion fatigue of caring for long COVID patients, whether the CDC or WHO definition of long COVID is beneficial or the use of directed questions, baselines test and listening to the patient tell their story are beneficial in making a long COVID diagnosis. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Nirsevimab immunoprophylaxis to prevent RSV hospitalization (Eurosurveillance.) Arexvy given Priority Review in US for the prevention of RSV disease in adults aged 50-59 (GSK) Respiratory disease surveillance (CDC) RSV surveillance (CDC) RSV national trend (CDC) Can antibodies be redirected from egg adapted epitopes using recombinant or cell cultured based influenza vaccines (Nat) Can influenza infection lead to cardiovascular events (JID) <a href= "https://www.thelancet.com/journals/lani
Sun, February 11, 2024
Should old infections be forgot
TWiV reviews rhinovirus complications in infants, a new influenza antiviral drug, Oropouche fever in Brazil, measles in Maryland and Ohio, effect of eliminating non-medical vaccine exemptions in NY, foot-and-mouth disease in Europe, severe primary and secondary dengue infections, and therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Angela Mingarelli Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV ( asv.org ) Research assistant position in Rosenfeld Lab CBER/FDA ( pdf ) The New City by Dickson Despommier Viruses of Microbes 2024 Infant rhinovirus bronchiolitis contribution to hospital bed and vent use (JAMA Net Open) Onradivir new influenza antiviral (Lancet) Oropouche fever in Brazil (PAHO) Maryland and Ohio measles Repealing school vaccination exemptions (JAMA New Open) Increases risk of FMDV entry into Europe (pig333) Severe primary and secondary <a tit
Sat, February 10, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the how the pandemic influenced the healthcare job market and why people conceal their infectious diseases before he reviews most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, discusses if susceptibility and disease severity are inheritable traits, if vaccination during pregnancy protects neonates or leads to adverse effects, the effectiveness of a monovalent XBB.1.5 against disease resulting from infection with Omicron variants, whether vaccination in the same or opposite arms effect antibody protection, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, how SARS-CoV-2 infection may alter one’s sleep patterns, what the health and economic burdens of mild disease are, and if there are predictors for recovery from fatigue and cognitive deficits following SARS-CoV-2 infection. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Do you want a job in healthcare? (JAMA) Why people don’t tell the truth about infectious diseases (Psychological Science) Respiratory disease surveillance (CDC) RSV surveillance (CDC) RSV national trend (CDC) Influenza/flu surveillance (CDC) Influenza/flu map (CDC) COVID-19 hospital admissions (CDC) COVID-19 national trend (CDC) COVID-19 wastewater testing (biobot) Variant tracker (CDC) <a href= "https://covid.cdc.gov/covid-dat
Sun, February 04, 2024
When macrophages go to alimentary school
TWiV reviews measles outbreaks in England and Europe, 2 fatal Nipah virus cases in Bangladesh, yellow fever outbreak in Sudan, and discuss how the type of immunodeficiency influences the outcome of SARS-CoV-2 infection, and programming of alveolar macrophages by intestinal bacteria that influences severity of respiratory viral infection. Hosts: Vincent Racaniello , Dickson Despommier , and Rich Condit Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV ( asv.org ) Research assistant position in Rosenfeld Lab CBER/FDA ( pdf ) The New City by Dickson Despommier Viruses of Microbes 2024 Pig virus imperils food security in Borneo (Science) Measles outbreaks in UK and Europe (Nature) Fatal Nipah virus infections in Bangladesh (CIDRAP) Yellow fever outbreak in Sudan (Crisis24) COVID-19 influenced by type of immunodeficiency (Sci Transl Med) Intestinal microbiota programming of alveolar macrophages (Cell Host Microbe) Letters read on TWiV 1085 Timestamps by Jolene . Thanks! Weekly Picks</h3
Sat, February 03, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the how the pandemic influenced the healthcare job market before he reviews most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, discusses the safety of the prefusion RSV vaccine, if high or moderate dose of the quadrivalent influenza vaccine is better for protection against hospitalization, summarizes the new WHO COVID guidelines, revisits how to prevent pathogen transmission in healthcare setting, the under use of COVID oral antiviral and what occurs in persistently SARS-CoV-2 infected cells in culture after antiviral treatment, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, how inflammatory markers change correlate with death when in ICU and if cognitive slowing is part of long COVID-19. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Do you want a job in healthcare? (JAMA) Respiratory disease surveillance (CDC) RSV surveillance (CDC) RSV national trend (CDC) Efficacy and safety of RSV vaccine after 2 seasons (CID) High vs moderate dose o f quadrivalent influenza vaccine (CMI) Influenza/flu surveillance (CDC) Influenza/flu map (CDC) COVID-19 hospital admissions (CDC) COVID-19 national trend (CDC) COVID-19 wastewater testing (biobot) Var
Sun, January 28, 2024
AI builds better viruses
TWiV reviews global measles outbreaks, toilet-generated aerosols that spread viruses, highly effective prevention of invasive cervical cancer by HPV vaccination, and design of improved adenovirus-associated viral vectors using machine learning. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Rich Condit Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV ( asv.org ) Research assistant position in Rosenfeld Lab CBER/FDA ( pdf ) The New City by Dickson Despommier Jay Nelson obituary Measles outbreak in Europe and Central Asia (UNICEF) Closing the toilet lid doesn’t reduce virus aerosols (Am J Inf Control) NASA’s ingenuity helicopter mission ends (NASA) HPV vaccine prevents invasive cervical cancer (J NCI) Designing AAV vectors with machine learning (Sci Adv) Letters read on TWiV 1083 Timestamps by Jolene . Thanks! We
Sat, January 27, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin reviews most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, before discussing viral transmission to adults in healthcare setting, the recently EUA approved protein based COBREVAX vaccine, reviews quarantine guidelines, the use of simnotrelivr for mild to moderate COVID-19, how viral RNA may persist in your cell culture dish following antiviral therapy, continues to dispel the myth of viral rebound, how to pay for Paxlovid, , when to use steroids and the benefits of convalescent plasma, how Paxlovid may prevent long COVID and how complement dysfunction may lead to thromboinflammation during long COVID. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Articles and graphs cited in TWIV CU 1080 Respiratory disease surveillance (CDC) RSV surveillance (CDC) RSV national trend (CDC) Influenza/flu surveillance (CDC) Influenza/flu map (CDC) COVID-19 hospital admissions (CDC) COVID-19 national trend (CDC) COVID-19 wastewater testing (biobot) Variant tracker (CDC) Variant hospital admissions (CDC) Transmission in healthcare setting (CID) <a href= "https://www.prnewswire.com/news-releases/corbevax-a-covid19-vaccine-developed-by-bio-e-india-based-on-the-rbd-protein-antigen-technology-from-texas-childrens-hospital-center-for-vaccine-development-receives-world-health-organization-emergency-use-listing-appr
Sun, January 21, 2024
I opened the pig sty and in flew enza
TWiV reviews the latest virology news, how infection with a plant virus causes insect to grow long wings, and reverse zoonoses of 2009 H1N1 pandemic influenza viruses in US swine. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , Brianne Barker , and Angela Mingarelli Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV ( asv.org ) Research assistant position in Rosenfeld Lab CBER/FDA ( pdf ) The New City by Dickson Despommier Midwife gave children pellets instead of vaccines (NY Times) Vaccine derived poliovirus circulation in Indonesia (WHO) 9th case of measles in Philadelphia (City of Philadelphia) Measles exposure warning northern Virginia (Virginia DOH) China lab sequenced SARS-CoV-2 genome 2 weeks before release (WSJ) Wisconsin bill to restrict gain of function experiments (Science) Virus infection of insects causes long wings (PNAS) Reverse zoonoses of influenza H1N1 virus in swine (PLoS Path) Ti
Sat, January 20, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin reviews most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus in the US before discussing vaccine effectiveness in children and adolescents, how the pandemic impacted the socioemotional development of infants and toddlers, continues to dispel the myth of viral rebound, how to pay for Paxlovid, reviews quarantine guidelines, when to use steroids and the benefits of convalescent plasma, examines the role of immune aberrations in long COVID and how vaccination may protect against developing long COVID. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Respiratory disease surveillance (CDC) RSV surveillance (CDC) RSV national trend (CDC) Influenza/flu surveillance (CDC) Influenza/flu map (CDC) COVID-19 hospital admissions (CDC) COVID-19 national trend(CDC) COVID-19 wastewater testing (biobot) Variant tracker (CDC) Remember when COVID was bad ? (Wired) Children and adolescents hospitalized with SARI (Pediatrics) COVID-19 vaccines are effective for adolescents (Pediatrics) Vaccine effectiveness against <a href= "https://publications.aap.org/pediatrics/article/doi/10.1542/peds.2023-064446/196419/Vaccine-Effectiveness-Against-Long-COVID-in?autologincheck=redirected%20https://www.cidrap.umn.edu/covid-19/study-covid-19-vacci
Sat, January 13, 2024
Rock of phages
TWiV reveals how viruses participate in the organomineralization of travertines, and how neutralizing antibodies evolve to exploit vulnerable sites in the hepatitis C virus envelope glycoprotein E2 and mediate clearance of infection. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV ( asv.org ) Research assistant position in Rosenfeld Lab CBER/FDA ( pdf ) The New City by Dickson Despommier Global dengue cases rise markedly (WHO) Measles outbreak in Philadelphia (Phil Health Dept) Viruses and organomineralization of travertine (Sci Rep) Neutralizing antibodies and clearance of HCV infection (Immunity) Letters read on TWiV 1079 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Global climate highlights 2023 and 7 new songs you should hear Brianne – Stuff you s
Sat, January 13, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin reviews recent measles outbreaks, prequalification of nOPV2 by the WHO and most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus in the US before discussing COVID-19 deaths linked to SNPs in C-reactive protein, spread of recent viral variants, how early vaccination reduced hospitalization of those infected with XBB.1.5, reviewed quarantine guidelines, how oral antivirals reduce hospitalizations, dissociation of antiviral treatment from infection rebound, and long COVID, deaths due to administration of hydroxychloroquine, muscle abnormalities and extreme fatigue in individuals with long COVID-19 and how the economics of where you live make long COVID-19 more severe. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode A national measles campaign (CDC) A nation of measles (CDC) The measles unvaccinated in NY (CNN) Philadelphia’s measles story (Phila gov) January’s measles outbreak (CNN) Prequalify of nOPV2 by WHO (GPEI) Did you prequalify for the novel poliovirus vaccine (CIDRAP) Respiratory disease surveillance (CDC) RSV surveillance (CDC) RSV national trend (CDC) Influenza/flu surveillance (CDC) Influenza/flu map (CDC) COVID-19 hospital admissions (CDC) COVID-19 <a href= "https://www.c
Sun, January 07, 2024
EtOH and viruses at McGill
Vincent travels to McGill University in Montreal, Canada to join Angela for a discussion of the careers and the research of two faculty members, Corinne Maurice and Jesse Shapiro, and their PhD trainees Anshul Sinha and Sana Naderi. Hosts: Vincent Racaniello and Angela Mingarelli Guests: Corinne Maurice , Jesse Shapiro , Anshul Sinha and Sana Naderi Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV ( asv.org ) Research assistant position in Rosenfeld Lab CBER/FDA ( pdf ) The New City by Dickson Despommier Phage and colitis (Microbiome) Origins and evolution of Lassa virus (Cell) Phage replication in human gut microbiota (iScience) Phages in infant gut (ISME J) Early SARS-CoV-2 transmissions in Quebec (Genome Med) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, January 06, 2024
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin highlights global circulation of Mpox virus, reviews the most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus in the US, and discusses the clinical outcome of hospitalized children under 5 years infected with SARS-CoV-2, the perinatal and neonatal outcomes including adverse effects of SARS-CoV-2 infection and virus transmission in Italy between early 2020 and 2022, the guidelines to improve home ventilation, the safety and efficacy of the oral anti-viral molnupiravir and the use of convalescent plasma as a long term treatment as well as treatment specifically for the immune compromised, the ineffectiveness of antibiotics for treating COVID-19, the association of olfactory dysfunction and the administration of corticosteroids and the safety of the RSV vaccines licensed last year. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Articles and graphs cited in TWIV CU 1076 Global mpox circulation (WHO) Mpox in the Americas and Europe (CIDRAP) Respiratory disease surveillance (CDC) RSV surveillance (CDC) RSV national trend (CDC) Influenza/flu surveillance (CDC) Influenza/flu map (CDC) COVID-19 hospital admissions (CDC) COVID-19 national trend (CDC) COVID-19 wastewater testing (biobot) Vaccine-Eligible Children Under- 5 Years (PIDJ) Pre-school cohort <a href= "https://www.cidrap.umn.edu/covid-19/less-5-us-preschool-cohort-hospitalized-covid-were-fully-vaccinated-study-finds
Sun, December 31, 2023
Fit viruses, parasites, sick chickens
For the last episode of 2023, TWiV describes how ancient chicken remains reveal the increase of fitness and virulence of Marek’s disease virus, and the diversity and dissemination of Leishmania virus in the pathogenic protozoan Leishmania braziliensis . Hosts: Vincent Racaniello , Dickson Despommier , Kathy Spindler , Brianne Barker and Angela Mingarelli Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV ( asv.org ) Research assistant position in Rosenfeld Lab CBER/FDA ( pdf ) The New City by Dickson Despommier Ancient chickens and Marek’s disease virus (Science) Diversity and dissemination of Leishmania virus and L. braziliensis (Nat Comm) Letters read on TWiV 1074 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Addictive Mandelbrot video and Gore slams COP28 summit Angela – 10 top-trending health questions you had for Dr. Google in 2023 Brianne – Tomato lost in space has been found Kathy – <a href= "https://sos.noaa.gov/catalog/datasets/earthquakes-of-the-20th-ce
Sat, December 30, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the outcomes of SARS-CoV-2, influenza and respiratory syncytial virus infection in pediatric communities under the age of 18 years, the treatment of infants with the human monoclonal anti-respiratory syncytial virus antibody to prevent hospitalizations, most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus in the US, how the SARS-CoV-2/COVID-19 pandemic affected school attendance and child healthcare, how exposure length influenced transmission of SARS-CoV-2, how the durability of the anti-SARS-CoV-2 antibody response to protect against virus re-infection, if administration of oral antiviral therapy affected viral rebound in either the unvaccinated or vaccinated populations, as well as a reminder of the ineffectiveness of antibiotics for treating COVID-19 and the effect of vaccination on post-COVID conditions in children between 5-17 years old. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Pediatric outcomes SARS-CoV-2, flu, RSV (JAMA Peds.) SARS-CoV-2 vs Flu (Wired) Anti-RSV antibody treatment for infants (NEJM) Respiratory disease surveillance (CDC) RSV surveillance (CDC) RSV national trend (CDC) Influenza/flu surveillance (CDC) COVID-19 hospital admissions (CDC) COVID-19 national trend (CDC) COVID-19 wastewater testing (biobot) COVID-19 school attendance (JPEIDS) COVID-19 pandemic effects <a href= "https://academic.oup.com
Sun, December 24, 2023
Taming the shrew and barring Epstein-Barr virus
TWiV explains a study showing that ost traits shape virome composition and virus transmission in wild bats, rodents, and shrews, and development of a gB nanoparticle vaccine that elicits a protective neutralizing antibody response against Epstein-Barr virus. Hosts: Vincent Racaniello , Dickson Despommier , and Kathy Spindler Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV ( asv.org ) Research assistant position in Rosenfeld Lab CBER/FDA ( pdf ) The New City by Dickson Despommier Brett Lindenbach passes (Yale Medicine) Virome of small mammals (Cell) Epstein-Barr virus nanoparticle vaccine (Cell Host Micr) Letters read on TWiV 1073 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Summary of Global Climate Action at COP 28 and Notable Deaths 2023: Music Kathy – Two APODS Winter solstice, 183 Days in the Sun and the <a href= "https://apod.nasa.gov/apod/ap231
Sat, December 23, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses the annual economic burden of respiratory syncytial virus in adults in the US, recombinant or standard-dose influenza vaccine in adults under 65 years of age, maternal vaccine effectiveness against influenza-associated hospitalizations and emergency department visits in iInfants, influenza positive tests reported to CDC by US clinical laboratories, update on COVID-19, risk of severe maternal morbidity associated with SARS-CoV-2 infection during pregnancy, COVID-19 rapid antigen tests with self-collected vs health care worker–collected nasal and throat swab specimens, optimal timing of nirmatrelvir/ritonavir treatment after COVID-19 symptom onset or diagnosis: target trial emulation, long-term outcomes following hospital admission for COVID-19 versus seasonal influenza: a cohort study, and risk of arrhythmias following COVID-19: nationwide self-controlled case series and matched cohort study. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode RSV economic burden , US (J Inf Dis) Recombinant or standard dose influenza vaccine (NEJM) Maternal vaccine effectiveness against influenza in Infants (JAMA Ped) Weekly influenza surveillance report (MMWR) COVID data tracker ( hospital admissions , national trend ) Risk of severe maternal morbidity associated with SARS-CoV-2 infection (J Inf Dis) COVID-19 rapid antigen tests with nasal and throat swab specimens (JAMA Net Open) Optimal timing of <a title="" href
Sun, December 17, 2023
Giant viruses and virophages with Matthias Fischer
Vincent visits the Max Planck Institute for Medical Research in Heidelberg, Germany to speak with Matthias Fischer about his career and his research on giant viruses, virophages, and their plankton hosts. Host: Vincent Racaniello Guest: Matthias Fischer Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Research assistant position in Rosenfeld Lab CBER/FDA ( pdf ) C. roenbergensis giant virus (PNAS) Virophage at origin of large DNA transposons (Science) Host genome integration and giant virus-induced reactivation of virophage mavirus (Nature) Invasion of protist genomes by DNA viruses (PNAS) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, December 16, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses monkeypox and chickenpox co-infection in southern Nigeria, vaccine effectiveness against influenza A, SARS-CoV-2 neutralizing antibody titers in maternal blood, umbilical cord blood, and breast milk, COVID-19 rapid antigen tests with self-collected vs health care worker–collected nasal and throat swab specimens, four methods for monitoring SARS-CoV-2 and Influenza A virus activity in schools, efficacy and safety of Baricitinib for the treatment of hospitalized adults with COVID-19, a synbiotic preparation (SIM01) for post-acute COVID-19 syndrome in Hong Kong, consistent absence of cerebrospinal fluid biomarker abnormalities in patients with neurocognitive post-COVID complications, and risk of new-onset long COVID following reinfection with SARS-CoV-2. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Monkeypox and chickenpox co-infection in southern Nigeria (JID) Vaccine effectiveness against influenza A (CID) SARS-CoV-2 neutralizing antibody titers in maternal blood, umbilical cord blood, and breast milk (JOP) COVID-19 rapid antigen tests with self-collected vs health care worker–collected nasal and throat swab specimens (JAMA) Four methods for monitoring SARS-CoV-2 and influenza A virus activity in schools (JAMA) Efficacy and safety of Baricitinib for the treatment of hospitalized adults with COVID-19 (EJMR) A synbiotic preparation (SIM01) for post-acute COVID-19 syndrome in Hong Kong (The Lancet) <a href= "https://academic.oup.com/jid/advance-article
Sun, December 10, 2023
European CDC with Eeva Broberg
From the European Society for Clinical Virology meeting in Milan, Vincent speaks with Eeva Broberg about her career and her work at the European Centre for Disease Prevention and Control. Hosts: Vincent Racaniello and Heli Harvala Guest: Eeva Broberg Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Global Scholar Travel Awards (ASV) Research assistant position in Rosenfeld Lab CBER/FDA ( pdf ) European Centre for Disease Prevention and Control Emerging echovirus 30 in Europe (Emerg Inf Dis) RSV surveillance (Eur Resp J) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, December 09, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses developmental impairment in children exposed during pregnancy to maternal SARS-COV2, vagus nerve dysfunction in the post-COVID-19 condition, and humoral immunity to an endemic coronavirus is associated with postacute sequelae of COVID-19 in individuals with rheumatic diseases, incidence and burden of long COVID in Africa. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Developmental impairment in children exposed during pregnancy to maternal SARS-COV2 (IJID) Vagus nerve dysfunction in the post-COVID-19 condition (CMI) Humoral immunity to an endemic coronavirus is associated with postacute sequelae of COVID-19 in those with rheumatic diseases (STM) Incidence and burden of long COVID in Africa (Nature) Contribute to our MicrobeTV fundraiser at PWB Dr. Griffin’s COVID treatment summary ( pdf ) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Sun, December 03, 2023
Heads or tails, you win a phage lunch
On this all-bacteriophage episode, TWiV explains the ‘vampire phage’, and and how mammalian cells internalize phage particles and utilize them to enhance cell growth and survival. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Jolene Ramsey Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Global Scholar Travel Awards (ASV) Research assistant position in Rosenfeld Lab CBER/FDA ( pdf ) The New City by Dickson Despommier Gerd Sutter passes (LMU) Avian influenza A (H5N1) Cambodia (WHO) CWD expands in Montana (CIDRAP) National Wastewater Surveillance System (CDC) Vampire phage paper (ISME J) UMBC phage hunters (UBMC) Vampire viruses prey on other viruses (Conversation) Phage internalized by mammalian cells (PLoS Biol) Phage uptake by mammalian cells (iScience) Phage-mammalian cell <a title="" href= "https://www.annualreviews.org/doi/10.1146/annure
Sat, December 02, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses a microbiologist who was harassed during COVID pandemic sues university, use of inactivated poliovirus vaccine for poliovirus outbreak response, safety and immunogenicity of bivalent rsvpref vaccine coadministered with seasonal inactivated influenza vaccine in older adults, coffee as a dietary strategy to prevent SARS-CoV-2 infection, enrollment of pediatric patients in COVID-19 interventional trials, vaccination, immunity, and the changing impact of COVID-19 on infant health, COVID-19 vaccine effectiveness against post- COVID -19 condition among 589722 individuals in Sweden, repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting, protection conferred by COVID-19 vaccination, prior SARS-CoV-2 infection, or hybrid immunity against Omicron-associated severe outcomes among community-dwelling adults, the Novavax heterologous COVID booster demonstrates lower reactogenicity than mRNA vaccines, T cell responses to SARS-CoV-2 infection and vaccination are elevated in B cell deficiency and reduce risk of severe COVID-19, oral VV116 versus placebo in patients with mild-to-moderate COVID-19 in China, and how COVID-19 convalescent plasma therapy decreases inflammatory cytokines, therapeutic heparin in non-ICU patients hospitalized for COVID-19 in the ACTIV-4a trial. Click arrow to play Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Microbiologist who was harassed during COVID pandemic sues university (Nature) Use of inactivated poliovirus vaccine for outbreak response (The Lancet) Safety and immunogenicity of bivalent RSVpreF vaccine coadministered with Influenza vaccine (CID) Coffee as a dietary strategy to prevent SARS-CoV-2 infection (BMC) Enrollment of pediatric patients in COVID-19 interventional trials (JAMA) Vaccination, immunity, and the changing <a href= "https://www.pnas
Sun, November 26, 2023
Cat coronavirus gains function in Cyprus
TWiV reviews ban on gain-of-function research by the House, chronic wasting disease in Tennessee deer, nOPV2 causing paralysis in children, and an outbreak of feline infectious peritonitis in Cyprus caused by a new recombinant coronavirus. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Global Scholar Travel Awards (ASV) Research assistant position in Rosenfeld Lab CBER/FDA ( pdf ) The New City by Dickson Despommier House approves ban on gain-of-function research (Science) Virology under the microscope (J Virol) CWD detected in another Tennessee county (CIDRAP) Polio eradication : Do no harm (Science) nOPV2 causes polio (MMWR) How is nOPV2 doing? (Polioeradication.org) Feline infectious peritonitis caused by recombinant coronavirus (bioRxiv) New feline coronavirus <a title="" href= "https://www.science.org/content/article/new-fe
Sat, November 25, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses progress toward measles elimination, risk of severe coronavirus disease 2019 despite vaccination in patients requiring treatment with immune-suppressive drugs, symptoms, viral loads, and rebound among COVID-19 outpatients treated with nirmatrelvir/ritonavir compared to propensity score matched untreated individuals, late administration and corticosteroid usage explain inefficacy in COVID-19 convalescent plasma trial, higher-dose fluvoxamine and time to sustained recovery in outpatients with COVID-19, recombinant C1 inhibitor in the prevention of severe COVID-19, and Epstein-Barr virus reactivation is not causative for post-COVID-19-syndrome in individuals with asymptomatic or mild SARS-CoV-2 disease course. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Progress toward measles elimination (CDC) Risk of severe COVID-19 despite vaccination in patients using immune-suppressive drugs (TID) Symptoms, viral loads, and rebound among COVID-19 outpatients treated with nirmatrelvir/ritonavir compared to untreated individuals (CID) Late administration and corticosteroid usage explain inefficacy in COVID-19 convalescent plasma trial (JID) Higher-dose fluvoxamine and time to sustained recovery in outpatients with COVID-19 (JAMA) Recombinant C1 inhibitor in the prevention of severe COVID-19 (FII) Epstein-Barr virus reactivation is not causative for post-COVID-19-syndrome in individuals with SARS-CoV-2 disease course (BMC) Contribute to our <a href= "https://parasiteswit
Sun, November 19, 2023
Childhood paralysis with Kevin Messacar
Kevin Messacar visits the Incubator to discuss his career as a pediatric infectious disease physician, and his work on enteroviruses that are associated with acute flaccid myelitis and other diseases. Host: Vincent Racaniello Guest: Kevin Messacar Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Global Scholar Travel Awards (ASV) Research assistant position in Rosenfeld Lab CBER/FDA ( pdf ) Emergence of EV-D68 (Microbio Spectr) 2014 outbreak of EV-D68 (J Med Virol) EV-D68 shedding in households (Emerg Inf Dis) EV-A71 outbreak in Colorado (Lancet Inf Dis) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, November 18, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses coverage with selected vaccines and exemption from school vaccine requirements among children in kindergarten, seasonality of endemic COVID-19, mRNA SARS-CoV-2 vaccination before vs during pregnancy and omicron infection among infants, extracting symptoms from free-text responses using ChatGPT among COVID-19 cases in Hong Kong, SARS-CoV-2 virologic rebound with nirmatrelvir–ritonavir therapy, optimization of antiviral therapy in immunocompromised COVID-19 patients, a study to learn about the study medicines (nirmatrelvir plus ritonavir) in people aged 12 years or older with COVID-19 and a compromised immune system, evaluation of the safety profile and therapeutic efficacy of Remdesivir in children with SARS-CoV-2 infection, effect of neutralizing monoclonal antibody treatment on early trajectories of virologic and immunologic biomarkers in patients hospitalized with COVID-19, and SARS-CoV-2 virologic rebound with nirmatrelvir–ritonavir therapy. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Coverage with selected vaccines and exemption from school vaccine requirements among (CDC) Seasonality of endemic COVID-19 (Virology) mRNA SARS-CoV-2 vaccination before vs during pregnancy and Omicron infection among infants (JAMA) Extracting symptoms from responses using ChatGPT among COVID-19 cases (CMI) SARS-CoV-2 virologic rebound with nirmatrelvir–ritonavir therapy (AIM) Optimization of antiviral therapy in immunocompromised COVID-19 patients (ClinicalTrials) A study to learn about nirmatrelvir/ritonavir in people with COVID-19 and a compromised immune system (ClinicalTrials) Evaluation of the safety profile and therapeutic efficacy o
Sun, November 12, 2023
Seasonal COVID and a niche for cervical cancer
TWiV reveals a prediction of the expected endemic seasonality of COVID-19, based on circulation of human coronaviruses, and ecological clearance of vaccine-targeted human papillomaviruses and an increase in circulation of non-targeted virus types. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Global Scholar Travel Awards (ASV) Research assistant position in Rosenfeld Lab CBER/FDA ( pdf ) The New City by Dickson Despommier Seasonality of endemic COVID-19 (mBio) Diversity of non-vaccine targeted HPVs (Cell Host Microbe) Wart’s up doc? ( TWiV 126 ) Letters read on TWiV 1061 Timestamps by Jolene . Thanks! Weekly Picks Dickson – 2023 expected to be hottest year on record after warmest October ever Kathy – You can see the ISS toolbag with binoculars , Billy Collins wikipedia , What dogs think (probably) Al
Sat, November 11, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses CDC expanding testing of international air traveler samples to include flu, RSV, and other respiratory viruses, missed opportunities for preventing congenital syphilis, intrinsic and effective severity of COVID-19 cases infected with the ancestral strain and omicron BA.2 variant in Hong Kong, T-cell immunity against severe acute respiratory syndrome coronavirus 2 measured by an interferon-γ release assay is strongly associated with patient outcomes in vaccinated persons hospitalized with delta or omicron variants, masks during pandemics caused by respiratory pathogens, behavioral factors and SARS-CoV-2 transmission heterogeneity within a household cohort in Costa Rica, convalescent plasma for Covid-19–induced ARDS in mechanically ventilated patients, and olfactory and gustatory function 3 years after mild COVID-19. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode CDC expands testing of international air traveler samples to include flu RSV, and other respiratory viruses (CDC) Missed opportunities for preventing congenital syphilis (CDC) Intrinsic and effective severity of COVID-19 case infected with BA.2 variant (JID) Masks during pandemics caused by respiratory pathogens (JAMA) Behavioral factors and SARS-CoV-2 transmission within a household cohort (Nature) Convalescent plasma for Covid-19–induced ARDS in mechanically ventilated patients (NEJM) Olfactory and gustatory function 3 years after mild COVID-19 (JAMA) Contribute to our MicrobeTV fundraiser at PWB <a href= "https://www.
Sun, November 05, 2023
Keeping poliovirus out and Ebolavirus in
On this episode of TWiV we discuss unusual properties of monoclonal antibodies: one that that binds the receptor attachment site and blocks infection with all three poliovirus serotypes, and others that inhibit Ebolavirus spread from cell to cell. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Angela Mingarelli Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Global Scholar Travel Awards (ASV) Research assistant position in Rosenfeld Lab CBER/FDA ( pdf ) Monoclonal antibody neutralizes all three poliovirus serotypes (Nat Comm) Blocking Ebolavirus intercellular spread (Cell Rep) Letters read on TWiV 1059 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Climate Science Angela – Spider Ballooning ( Wikipedia ) Kathy – Richard Harris Art Collection Rich – “The Murderbot Diaries” by Martha Wells Alan – Old Gods of Appalachia Vincent – Poetry Foundation
Sat, November 04, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses health worker–perceived working conditions and symptoms of poor mental health, Mpox neutralizing antibodies at 6 months from mpox infection or MVA-BN vaccination, newborn and early infant outcomes following maternal COVID-19 vaccination during pregnancy, duration of SARS-CoV-2 culturable virus shedding in children, prescribing outcomes in outpatients treated with nirmatrelvir–ritonavir for COVID-19 in an interdisciplinary community clinic, Nirmatrelvir and molnupiravir and post-COVID-19 condition in older patients, optimal duration of systemic corticosteroids in COVID-19 treatment, association between Guillain-Barré syndrome and COVID-19 infection and vaccination, SARS-CoV-2 infection correlates with male benign prostatic hyperplasia deterioration, Transplanting candidates with COVID-19, and favorable experience of transplant strategy including liver grafts from COVID-19 donors. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Routine vaccination coverage (CDC) Outbreak of invasive Group A Streptococcus in children (PIDS) Nirmatrelvir/ritonavir use in pregnant women with SARS-CoV-2 (Nature) Outcomes of SARS-CoV-2 omicron variant infections compared with seasonal influenza and RSV infections in adults (CID) Remdesivir is associated with reduced mortality in COVID-19 patients requiring oxygen (OFID) Effectiveness of nirmatrelvir/ritonavir against the development of Post–COVID-19 conditions among U.S. veterans (AIM) Contribute to our MicrobeTV fundraiser at PWB <a title="" href= "https://www.mi
Sun, October 29, 2023
CMV-based HIV vaccine with Klaus Früh
Klaus Früh visits the Incubator to discuss his career and his work on cytomegalovirus-vectored vaccines which are unique in their ability to persistently maintain an immune shield of effector memory T cells, including highly unconventional MHC-II and MHC-E restricted CD8+ T cells. Host: Vincent Racaniello , Rich Condit , and Brianne Barker Guest: Klaus Früh Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Spike shirts at vaccinated.us (promo code Microbetv) Research assistant position in Rosenfeld Lab CBER/FDA ( pdf ) HCMV-based attenuated vaccine platform (Sci Rep) HLA-E-restricted, Gag-specific CD8+ T cells suppress HIV-1 infection (Sci Immunol) RhCMV/SIV vaccine shows long-term efficacy against SIV challenge (Sci Transl Med) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, October 28, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses health worker–perceived working conditions and symptoms of poor mental health, Mpox neutralizing antibodies at 6 months from mpox infection or MVA-BN vaccination, newborn and early infant outcomes following maternal COVID-19 vaccination during pregnancy, duration of SARS-CoV-2 culturable virus shedding in children, prescribing outcomes in outpatients treated with nirmatrelvir–ritonavir for COVID-19 in an interdisciplinary community clinic, Nirmatrelvir and molnupiravir and post-COVID-19 condition in older patients, optimal duration of systemic corticosteroids in COVID-19 treatment, association between Guillain-Barré syndrome and COVID-19 infection and vaccination, SARS-CoV-2 infection correlates with male benign prostatic hyperplasia deterioration, Transplanting candidates with COVID-19, and favorable experience of transplant strategy including liver grafts from COVID-19 donors. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Health worker –perceived working conditions and symptoms of poor mental health (CDC) Neutralizing antibodies at 6 months from mpox infection or MVA-BN vaccination (The Lancet) Newborn and early infant outcomes following maternal COVID-19 vaccination during pregnancy (JAMA) Duration of SARS-CoV-2 culturable virus shedding in children (JAMA) Prescribing outcomes in outpatients treated with PAXLOVID for COVID-19 (PLOS ONE) Nirmatrelvir and molnupiravir and post–COVID-19 condition in older patients (JAMA) Optimal duration of systemic corticosteroids in COVID-19 treatment (OFID) Intravenous vitamin C for patients hospitalized with COVID-19 (JAMA) <a href= "https://n.neurology.org/content/early/2023/10/18/WNL.0000000000
Sun, October 22, 2023
Vermont viridae
Vincent travels to the University of Vermont to speak with Jason, Emily, Jessica, and Dimitry about their careers and their work on SARS-CoV-2, hantaviruses, poliovirus, influenza virus, and the involvement of viruses in the autoimmune disease multiple sclerosis. Host: Vincent Racaniello Guests: Jason Botten , Emily Bruce , Jessica Crothers , and Dimitry Krementsov Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Spike shirts at vaccinated.us (promo code Microbetv) Research assistant position in Rosenfeld Lab CBER/FDA ( pdf ) Lab worker contamination with SARS-CoV-2 plasmid DNA (J Clin Micro) Fractional dose poliovirus vaccine (Vaccine) No SARS-CoV-2 RNA in Vermont wildlife (Sci Rep) Predicting SARS-CoV-2 infectivity from RT-PCR (EMBO Mol Med) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, October 21, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses high Influenza incidence and disease severity among children and adolescents aged Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode High Influenza incidence and disease severity among children and adolescents aged Neurologic effects of SARS-CoV-2 transmitted among dogs (EID) Effectiveness of mRNA vaccines against Omicron XBB infection in Singaporean children (JAMA) Effectiveness of COVID-19 vaccine in the prevention of post-COVID conditions (ASHE) Incidence and impact of acute pericarditis in hospitalized patients with COVID‐19 (JAHA) Serotonin reduction in post-acute
Sun, October 15, 2023
Bird flu in Baltimore
From the Centers for Excellence in Influenza Research and Response meeting in Baltimore, Vincent speaks with Ron Fouchier, Rafael Medina, and Louse Moncla about recent changes in the epidemiology of avian H5N1 influenza virus and the threat to humans and other animals. Host: Vincent Racaniello Guests: Ron Fouchier , Rafael Medina , and Louise Moncla Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Spike shirts at vaccinated.us (promo code Microbetv) Research assistant position in Rosenfeld Lab CBER/FDA ( pdf ) Centers for Influenza Research and Response Network Transatlantic spread of avian H5N1 influenza virus (Sci Rep) In-host diversity of influenza H5N1 virus (PLoS Path) Influenza H5N1 virus and mass mortality in sea lions (Vet Q.) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, October 14, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses disease severity of RSV compared with COVID-19 and Influenza among hospitalized adults aged ≥60 years, antiviral efficacy of Molnupiravir versus ritonavir-boosted nirmatrelvir in patients with early symptomatic COVID-19, Nirmatrelvir-Ritonavir and COVID-19 mortality and hospitalization among patients with vulnerability to covid-19 complications, antibiotic use among hospitalized patients with COVID-19 in the United States, one week of oral Camostat vs Placebo in nonhospitalized adults with mild-to-moderate COVID-19, assessment of the available therapeutic approaches for severe COVID-19, optimal duration of systemic Corticosteroids in COVID-19 treatment, effect of monovalent COVID-19 vaccines on viral interference between SARS-CoV-2 and several DNA viruses in patients with long-COVID syndrome, local budesonide therapy in the management of persistent hyposmia in suspected non-severe COVID-19 patients, and the safety profile and clinical and virological outcomes of Nirmatrelvir-Ritonavir treatment in patients with advanced chronic Kidney disease and COVID-19. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Disease severity of RSV compared with COVID-19 and Influenza among hospitalized adults Antiviral efficacy of molnupiravir vs ritonavir-nirmatrelvi r in patients with symptomatic COVID-19 (The Lancet) Nirmatrelvir-Ritonavir and COVID-19 mortality and hospitalization among patients with vulnerability to complications (JAMA) Antibiotic use among hospitalized patients with COVID-19 (OFID) One week of oral Camostat vs placebo in non-hospitalized adults with COVID-19 Assessment of the available therapeutic approaches for severe COVID-19 (Nature) Optimal duration of systemic Corticosteroids in COVID-19 treatment
Sun, October 08, 2023
Like SARS-CoV-2 in the headlights
TWiV reviews the 2023 Nobel Prize in Physiology or Medicine awarded to Katalin Karikó and Drew Weissman for their identification nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19, and accelerated mutation of SARS-CoV-2 in white-tailed deer. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Angela Mingarelli Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Spike shirts at vaccinated.us (promo code Microbetv) Research assistant position in Rosenfeld Lab CBER/FDA ( pdf ) 2023 Nobel Prize Physiology or Medicine (Nobelprize.org) Evading a toll on the road to mRNA vaccines ( TWiV 860 ) Katalin Karikó ‘s overlooked work (Wired) Accelerated mutation of SARS-CoV-2 in deer (Nat Comm) Letters read on TWiV 1051 Timestamps by Jolene . Thanks! Weekly Picks Dickson – The New City. How to Build Our Sustainable Urban Future Angela – 2023 Nobel Peace Prize Alan – The Ruin of All Witches , by Malcolm Gaskill Vincent – <a href= "https://www.agriculture.com/france-kicks-off-bird-flu-vaccin
Sat, October 07, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the effectiveness of maternal mRNA COVID-19 vaccination during pregnancy against COVID-19–associated hospitalizations in infants aged Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Effectiveness of maternal mRNA COVID-19 vaccination during pregnancy against COVID-19–associated hospitalizations in infants (CDC) COVID-19 vaccination recommendations and practices for women of reproductive age (CDC) Molnupiravir for intra-household prevention of COVID-19 (JOI) Delayed peak SARS-CoV-2 viral loads relative to symptom onset and implications for COVID-19 testing programs Viral kinetics of sequential SARS-CoV-2 infections (Nature) FDA authorizes updated Novavax COVID-19 vaccine (FDA) Antiviral efficacy of molnupiravir vs r
Sun, October 01, 2023
Long COVID's book of homeostatic cats
TWiV explains how immune profiling was used to identify distinguishing features of Long COVID, and how a co-opted feline endogenous retroviral envelope promotes cell survival by controlling copper transport and homeostasis in cats. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Spike shirts at vaccinated.us (promo code Microbetv) Research assistant position in Rosenfeld Lab CBER/FDA ( pdf ) Features of Long COVID (Nature) ERV envelope mediates feline copper homeostasis (Cell Rep) Letters read on TWiV 1049 Timestamps by Jolene . Thanks! Weekly Picks Brianne – Webb spots a building block of life on Jupiter’s moon Europa Rich – Are we really made of ‘star stuff?’ Learn about your body’s elements Alan – Avian flu has reached the Galàpagos Vincent – Why the US can’t have nice things Listener Pick Az – Free solo Intro music is by <a href= "http://w
Sat, September 30, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses a molnupiravir-associated mutational signature in global SARS-CoV-2 genomes, inhaled fluticasone furoate for outpatient treatment of COVID-19, optimal duration of systemic corticosteroids in COVID-19 treatment, early antibody treatment, inflammation, and risk of post-COVID conditions, autonomic dysregulation in long-term patients suffering from post-COVID-19 syndrome assessed by heart rate variability, and multiorgan MRI findings after hospitalization with COVID-19 in the UK. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Molnupiravir -associated mutational signature in global SARS-CoV-2 genomes (Nature) Inhaled fluticasone furoate for outpatient treatment of COVID-19 (NEJM) Optimal duration of systemic corticosteroids in COVID-19 treatment (OFID) Distinguishing features of Long COVID identified through immune profiling (Nature) Early antibody treatment , inflammation, and risk of post-COVID conditions (mBIO) Autonomic dysregulation in long-term patients suffering from post COVID-19 syndrome (SR) Multiorgan MRI findings after hospitalization with COVID-19 in the UK (The Lancet) Contribute to our Floating Doctors fundraiser at PWB Letters read on TWiV 1048 Dr. Griffin’s COVID treatment summary ( pdf ) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Sun, September 24, 2023
Long COVID and avian flu in ferrets
TWiV explains a study of postacute sequelae of COVID-19 at 2 years, and respiratory droplet transmission of human-isolated avian H3N8 influenza virus between ferrets. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Research assistant position in Rosenfeld Lab CBER/FDA ( pdf ) 4:20 Postacute sequelae of COVID-19 at 2 years (Nat Med) Disability-adjusted life years ( DALYs ) (WHO) Respiratory droplet transmission of H3N8 virus (Cell) Letters read on TWiV 1047 Timestamps by Jolene . Thanks! Weekly Picks Dickson – UN Climate Action and California sues oil companies for exacerbating climate change Brianne – COVID Drugs are a Miracle Cure for Cats Rich – American Prometheus by Kai Bird and Martin J. Sherwin Vincent – Free Carl Zimmer writings <h3
Sat, September 23, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses wastewater surveillance data as a complement to emergency department visit data for tracking the incidence of influenza A and RSV, chatbot-delivered online intervention to promote seasonal Influenza vaccination during the COVID-19 pandemic, temporal assessment of disparities in California COVID-19 mortality by industry, modeling the impact of a high-uptake bivalent booster scenario on the COVID-19 burden and healthcare costs in New York City, can high COVID-19 vaccination rates in adults help protect unvaccinated children, Nirmatrelvir/Ritonavir use and hospitalizations or death in previously uninfected non-hospitalized high-risk population with COVID-19, Optimal duration of systemic corticosteroids in COVID-19 treatment, and vaccination after developing long COVID. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Wastewater surveillance data as a complement to tracking incidence of influenza A and RSV (CDC) Chatbot-delivered online intervention to promote seasonal influenza vaccination (JAMA) Temporal assessment of disparities in California COVID-19 mortality by industry (AOE) CDC/HICPAC’s plan to weaken guidance for health care respiratory protection and infection control (NNU) Modelling the impact of a high-uptake bivalent booster scenario on COVID-19 burden (The Lancet) Can high COVID-19 vaccination rates in adults help protect unvaccinated children ? (ES) P
Sun, September 17, 2023
Less Lassa, CRISPR RNA viruses
TWiV reviews a Lassa virus mRNA vaccine that confers protection against disease without inducing neutralizing antibodies, and a CRISPR-based method for engineering the genome of RNA viruses. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , Brianne Barker , and Angela Mingarelli Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Research assistant position in Rosenfeld Lab CBER/FDA ( pdf ) Virologist Bob Lamb dies (Northwestern Now) Lassa virus mRNA vaccine (Nat Commun) CRISPR engineering of RNA viruses (Sci Adv) Letters read on TWiV 1045 Timestamps by Jolene . Thanks! Weekly Picks Angela – More than 5,000 new species discovered in Pacific deep-sea mining hotspot ( journal article ) Brianne – <a href= "https://www.nytimes.com/2023/09/02/opinion/cosmology-crisis-webb-telescope.html?unlocked_article_code=5ijCc7GrAzdUwFzDyu-QhdxjMq7N8n315dd73BiB5HOgeKkpB2k62pBrALEAvALQpPsoSUjlN6F4c9krEfF8QCEHn-956Bh5btgaanCQDXpQEHfkyolqS5CN_yPc0bXwv2_hu9t4LBQkJSkGqOMtJipve8gSaRMJCn86Aeeq-Q8W7PsR8nQyIBVLN2ko-uki-1MRSr9FMsfiDHi--NGGT0SGVJdLR06n_UtONG0qdqTtFBeryYEnpQonXwGskRWPV7kFJKM9q_0usQMaLRthUUY4bZs_6
Sat, September 16, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the immunogenicity and reactogenicity of coadministration of COVID-19 and Influenza vaccines, interim effectiveness estimates of 2023 southern hemisphere influenza vaccines in preventing Influenza-associated hospitalizations, genome-wide association study of susceptibility to RSV hospitalization in young children Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Immunogenicity and reactogenicity of coadministration of COVID-19 and Influenza vaccines (JAMA) Effectiveness estimates of Influenza vaccines in preventing associated hospitalizations (CDC) Genome-wide association study of susceptibility to RSV hospitalization in children (JID) Performance of rapid antigen tests to detect SARS-CoV-2 infection (AIN) Safety and immunogenicity of XBB.1.5-containing mRNA vaccines (medRxiv) C.D.C. director explains why you should get the latest Covid booster (Nytimes) Opti
Sun, September 10, 2023
Marion Koopmans on COVID-19, Mpox, H5N1, polio and One Health
From the European Society for Clinical Virology meeting in Milan, Vincent speaks with Marion Koopmans about COVID-19, Mpox, H5N1 and polio, and the promise of a One Health approach to prevent outbreaks, epidemics, and pandemics. Host: Vincent Racaniello Guest: Marion Koopmans Click arrow to play Download TWiV 1043 (45 MB .mp3, 62 min) Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Research assistant position in Rosenfeld Lab CBER/FDA ( pdf ) SARS-CoV-2 variants in Rotterdam wastewater (Sci Tot Environ) SARS-CoV-2 in mink and other animals (Transbound Emerg Dis) Mpox in Netherlands (EuroSurveill) Divergent SARS-CoV-2 in immunocompromised patient (Emerg Inf Dis) Accelerated SARS-CoV-2 evolution in deer (Nat Commun) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, September 09, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses China’s health authorities fighting surge in cases of Mpox unknown origin, analysis of seasonal variation of antibiotic prescribing for respiratory tract diagnoses in primary care practices, prevalence and associated outcomes of co-infection between SARS-CoV-2 and influenza, comparison of bivalent and monovalent mRNA vaccine boosters, optimal duration of systemic corticosteroids in COVID-19 treatment, acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization, temporal changes in fecal microbiota of patients infected with COVID-19, and long-term survival after intensive care for COVID-19. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode China’s health authorities fight surge in cases of unknown origin (BMJ) Analysis of seasonal variation of antibiotic prescribing for respiratory tract diagnoses (ASHE) Prevalence and outcomes of co-infection between SARS-CoV-2 and influenza (IJID) Comparison of bivalent and monovalent mRNA vaccine boosters (CID) Optimal duration of systemic corticosteroids in COVID-19 treatment (OFID) Acute blood biomarker profiles predict cognitive deficits after COVID-19 hospitalization (Nature) Temporal changes in fecal microbiota of patients infected with COVID-19 (BMC) Long-term survival after intensive care for COVID-19 (AIC) Contribute to our Floating Docto
Sun, September 03, 2023
Novel oral polio vaccine? with Raul Andino and Kostya Chumakov
Vincent speaks with Raul and Kostya about the development of novel oral polio vaccine from the Sabin type 2 strain, its deployment in over 600 million children, and whether it can lead to eradication of poliomyelitis. Host: Vincent Racaniello Guests: Raul Andino and Kostya Chumakov Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Research assistant position in Rosenfeld Lab CBER/FDA ( pdf ) Engineering OPV (Cell Host Microbe) Poliopolis (Lancet) nOPV2 (Polioeradication.org) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, September 02, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the public health significance of finding autochthonous melioidosis cases in the continental United States, human neural larva migrans caused by Ophidascaris robertsi ascarid, Project nextgen awards over $1.4 billion to develop the future of COVID-19 vaccines and therapeutics, excess all-cause mortality in China after ending the zero COVID policy, international pediatric COVID-19 severity over the course of the pandemic, differences in SARS-CoV-2 specific humoral and cellular immune responses after contralateral and ipsilateral COVID-19 vaccination, Pfizer and BioNTech receive positive CHMP opinion for Omicron XBB.1.5-adapted COVID-19 vaccine in the European Union, clinical antiviral efficacy of Remdesivir in COVID-19, optimal duration of systemic corticosteroids in COVID-19 treatment, clinical outcomes associated with overestimation of oxygen saturation by pulse oximetry in patients hospitalized with COVID-19, risk of autoimmune diseases following COVID-19 and the potential protective effect from vaccination. Click arrow to play Download TWiV 1040 (19 MB .mp3, 27 min) Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Public health significance of finding autochthonous melioidosis cases (PLOS) Human neural larva migrans caused by Ophidascaris robertsi ascarid (EID) Project nextgen awards over $1.4 billion to develop the future of COVID-19 vaccines and therapeutics (HHS) Excess all-cause mortality in China after ending the zero COVID policy (JAMA) International pediatric COVID-19 severity over
Sun, August 27, 2023
Landmines for phages, a mouthful of redondoviruses
TWiV describes how a viral capsid protein activates a bacterial innate immune system that interferes with protein synthesis, and human-associated redondoviruses that infect the commensal protozoan Entamoeba gingivalis . Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , Kathy Spindler , and Jolene Ramsey Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Research assistant position in Rosenfeld Lab CBER/FDA ( pdf ) Anti-phage defense via capsid detection (Nature) Redondoviruses infect commensal amoebae (Cell Host Micro) A host for redondoviruses (Nat Rev Micro) Letters read on TWiV 1039 Timestamps by Jolene . Thanks! Weekly Picks Dickson – “ Cosmic Time Machine ” Netflix documentary Kathy – Antarctican accents Rich – Cymothoa exigua, or the tongue-eating louse , Week of wonder: The case for preserving parasites Jolene – Perspectiv
Sat, August 26, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses modeling poliovirus transmission and responses in New York State, FDA approves first vaccine for pregnant individuals to prevent RSV in infants, prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices, Nirmatrelvir resistance – de novo E166V/L50V mutations in an immunocompromised patient treated with prolonged nirmatrelvir/ritonavir monotherapy leading to clinical and virological treatment failure, incidence of new-onset hypertension post–COVID-19: comparison with influenza, and post-acute sequelae of COVID-19 at 2 years. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Modeling poliovirus transmission and responses in New York State (JID) FDA approves first vaccine for pregnant individuals to prevent RSV in infants (FDA) Prevention and control of seasonal influenza with vaccines (CDC) De novo E166V/L50V mutations in an immunocompromised patient treated with nirmatrelvir/ritonavir (CID) Incidence of new-onset hypertension post–COVID-19 (Hypertension) Postacute sequelae of COVID-19 at 2 years (Nature Medicine) Contribute to our Floating Doctors fundraiser at PWB Letters read on TWiV 1038 Dr. Griffin’s COVID treatment summary ( pdf ) Timestamps by Jolene . Thanks! Intro mu
Sun, August 20, 2023
Antibodies, the good (CoV), the bad (Ad), the beautiful
TWiV reviews evidence that symptomatic adenovirus infection leads to thrombocytopenia, thrombosis, and production of anti-platelet factor 4 antibodies similar to the rare disorder seen after immunization with adenoviral vectored COVID-19 vaccines, and a monoclonal antibody isolated from a SARS survivor, following vaccination with a SARS-CoV-2 spike mRNA vaccine, that neutralizes a broad collection of ACE2-binding sarbecoviruses. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Research assistant position in Rosenfeld Lab CBER/FDA ( pdf ) VITT-like disorder after adenovirus infection (NEJM) The clot thickens ( TWiV 842 ) Lessons from VITT (Nat Rev Immunol) Pan-sarbecovirus neutralizing mAb (Sci Adv) Letters read on TWiV 1037 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Rho Ophiuchi nebula showing massive star formation. James Webb Space Telescope Brianne – Question Mark in Space? <br /
Sat, August 19, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses Florida local transmission of dengue cases reported in Broward and Miami-Dade counties, infants admitted to US intensive care units for RSV infection during the 2022 seasonal peak, long-term risk of death and readmission after hospital admission with COVID-19 among older adults, safety profile and clinical and virological outcomes of Nirmatrelvir-Ritonavir treatment in patients with advanced chronic kidney disease and COVID-19, Fluvoxamine vs placebo for outpatients with symptomatic COVID-19, the effect of corticosteroids, antibiotics, and anticoagulants on the development of post-COVID-19 syndrome in COVID-19 hospitalized patients 6 months after discharge, long COVID and significant activity limitation among adults, incidence of diabetes following COVID-19 vaccination and SARS-CoV-2 infection in Hong Kong, and diabetes following SARS-CoV-2 infection: Incidence, persistence, and implications of COVID-19 vaccination. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Florida local transmission of dengue cases (Outbreak News) Infants admitted to US ICU for RSV infection (JAMA) Long term risk of death and readmission after hospital admission with COVID-19 (BMJ) Outcomes of Nirmatrelvir-Ritonavir Treatment in patients with Kidney disease and COVID-19 (CID) Fluvoxamine vs placebo for outpatients with symptomatic COVID-19 (OFID) The effect of corticosteroids, antibiotics, and anticoagulants on the development of post-COVID-19 syndrome in hospitalized patients (CEM) Long COVID and significant activity limitati
Sun, August 13, 2023
Poxvirus wars, warp speed COVID-19 vaccine rollout
TWiV dissects a study of COVID-19 vaccination which shows that the timing of initial rollout affects disease outcomes more substantially than final coverage or degree of socioeconomic disparity, and discovery of a novel cellular defense comprising a nuclease that is activated by poxvirus infection and cleaves a specific tRNA molecule to inhibit protein synthesis. Hosts: Vincent Racaniello , Rich Condit , Alan Dove , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Research assistant position in Rosenfeld Lab CBER/FDA ( pdf ) Impact of COVID-19 vaccination trends (Sci Adv) Poxvirus-activated anticodon nuclease (Sci Adv) Letters read on TWiV 1035 Timestamps by Jolene . Thanks! Weekly Picks Brianne – Project Hail Mary Rich – Bird Buddy Alan – Blood, Sweat, and Pixels and Press Reset <s
Sat, August 12, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the immunogenicity, safety, and preliminary efficacy evaluation of OVX836, a nucleoprotein-based universal influenza A vaccine candidate, association between nose picking and SARS-CoV-2 incidence, a cohort study in hospital health care workers; effect of COVID-19 vaccination and booster on maternal-fetal outcomes, dynamics of inflammatory responses after SARS-CoV-2 infection by vaccination status in the USA, does monoclonal antibody treatment for COVID-19 impact short and long- term outcomes in a large generalizable population, persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation, core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Immunogenicity, safety, and preliminary efficacy evaluation of OVX836, a influenza A vaccine candidate (The Lancet) Association between nose picking and SARS-CoV-2 incidence (PLOSONE) Effect of COVID-19 vaccination and booster on maternal-fetal outcomes (Lancet Digital Health) Dynamics of inflammatory responses after SARS-CoV-2 infection by vaccination status (The Lancet) Does monoclonal antibody treatment for COVID-19 impact short and long-term outcomes (BMJ) Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and inflammation (Angiogenesis) Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts (STM) Contribute to our Floating Doctors fundraiser at PWB Letters re
Fri, August 11, 2023
Toppling the anti-vaxxer pyramid with "flu-shot cheerleader" Desiree Townsend
Vincent speaks with Desirée Townsend about how she felt used and indoctrinated by the anti-vaxx movement, the science surrounding her autoimmune disorder, and why she is no longer the “flu shot cheerleader,” but a cheerleader for flu shots. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Desiree on Instagram and LinkedIn ‘Flu-shot cheerleader’ speaks out (NBC) ‘Flu-shot cheerleader’ back with a warning (NBC) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, August 06, 2023
Freediving with nanobodies and interferon
TWiV notes the passing of Harald zur Hausen, dengue breaking records in the Americas, inhibition of SARS-CoV-2 infection and inflammation by modulation of type I IFN, and an armed nanobody that protects mice against influenza A and B disease. Hosts: Vincent Racaniello , Kathy Spindler , and Angela Mingarelli Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Position in Rosenfeld Laboratory ( pdf ) Paul and the Mosquitos ( pdf , English) Other childrens books (SMVIROLOGIA) Dengue breaking records in Americas (Nature) Harald zur Hausen , 1936-2023 (Nature) Vincent interviews zur Hausen (ASM) COVID-19 and modulation of IFN (Sci Immunol) Burning down the mouse ( TWiV 900 ) Armed nanobody protects against influenza (Sci Immunol) Click chemistry Nobel prizes (The Nobel Prize) Letters read on TWiV 1033 Timestamps by Jolene . Thanks! Weekly Picks Angela – The Deepest Breath Kathy – <a href= "https://w
Sat, August 05, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses predicting COVID-19 incidence using wastewater surveillance data, use of wastewater metrics to track COVID-19 in the US, wastewater-based epidemiology predicts COVID-19-induced weekly new hospital admissions in over 150 USA counties, association between duration of SARS-CoV-2 positivity and long COVID, rapid direct detection of SARS-CoV-2 aerosols in exhaled breath at the point of care, effectiveness of oral Nirmatrelvir/Ritonavir vs. intravenous three-day Remdesivir in preventing progression to severe COVID-19, NIH launching of several phase 2 long-COVID treatment trials. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Predicting COVID-19 incidence using wastewater surveillance data (CDC) Use of wastewater metrics to track COVID-19 in the US (JAMA) Wastewater-based epidemiology predicts COVID-19-induced new hospital admissions (Nature) Association between duration of SARS-CoV-2 positivity and long COVID (JID) Rapid direct detection of SARS-CoV-2 aerosols in exhaled breath at the point of care (ACS) Effectiveness of oral Nirmatrelvir/Ritonavir vs. intravenous three-day Remdesivir in preventing COVID-19 progression (Viruses) NIH has launched several phase 2 long-COVID treatment trials (NIH) Fatigue can shatter a person (Atlantic) Contribute to our Floating Doctors fundraiser at PWB <
Sun, July 30, 2023
Death on the West Nile
TWiV notes the passing of virologist Michael BA Oldstone, a study to assess the performance of rapid antigen tests to detect symptomatic and asymptomatic SARS-CoV-2 infection, and the presence of antibodies to type I interferons in ~40% of patients with West Nile virus encephalitis. Hosts: Vincent Racaniello , Rich Condit , and Alan Dove Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Position in Rosenfeld Laboratory ( pdf ) XKCD on antivaxxers RFK Jr. CDC or FDA head ? (Politico) Performance of rapid antigen tests (Ann Int Med) Guidance on rapid antigen tests (FDA) Autoantibodies to IFN in West Nile virus encephalitis (JEM) Letters read on TWiV 1031 Timestamps by Jolene . Thanks! Weekly Picks Rich – The Final Covid-19 Grand Rounds: What Have We Learned? Alan – Teaching biology to Tibetan Buddhist monks Vincent – I got it from Agnes by Tom Lehrer and Why Oppenheimer has i
Sat, July 29, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the use of RSV vaccines in older adults: recommendations of the advisory committee on immunization practices, case report of leprosy in Central Florida, blood group A enhances SARS-CoV-2 infection, predicting COVID-19 incidence using wastewater surveillance data, a common allele of HLA associated with asymptomatic SARS-CoV-2 infection, prevalence of low-frequency, antiviral resistance variants in SARS-CoV-2 isolates in Ontario, Canada, viral resistance analyses from the Remdesivir phase 3 adaptive COVID-19 treatment trial-1, impact of Molnupiravir treatment on patient-reported COVID-19 symptoms in the phase 3 move-out trial, Molnupiravir for treatment of adults with mild or moderate COVID-19, delayed intubation associated with in-hospital mortality in patients with COVID-19 respiratory failure who fail heated and humified high flow nasal canula, relationship between azithromycin and cardiovascular outcomes in unvaccinated patients with COVID‐19 and preexisting cardiovascular disease, and the effects of COVID-19 on cognitive performance in a community-based cohort, clinical phenotypes and quality of life to define post-COVID-19 syndrome. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Use of RSV vaccines in older adults (CDC) Case report of leprosy in Central Florida (EID) Blood group A enhances SARS-CoV-2 infection (Blood) Predicting COVID-19 incidence using wastewater surveillance data (EID) Common allele of HLA associated with asymptomatic SARS-CoV-2 infection (Nature) Prevalence of low-freque
Thu, July 27, 2023
David Tuller on Long COVID and ME/CFS
David Tuller returns to TWiV to provide an update on ME/CFS, the PACE trial, developments related to the NICE guidelines, and how similar practices and ideologies are being applied to long COVID. Host: Vincent Racaniello Guest: David Tuller Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server David Tuller at virology blog CFS, a long tangled tale (virology blog) Request for Correction of Prevalence Rates Cited in FND Paper (virology blog) Estimates of long COVID prevalence (virology blog) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, July 23, 2023
Asymptomatic SARS-CoV-2 infection and T cells
TWiV reviews approvals of the first gene therapy for severe hemophilia A in adults and a monoclonal antibody to prevent RSV respiratory disease in babies and toddlers, and a common allele of HLA that mediates asymptomatic SARS-CoV-2 infection through pre-existing T cell immunity due to previous exposure to common cold coronaviruses. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server First gene therapy for hemophilia A approved (FDA) Luxurna, gene therapy for vision loss (FDA) Anti-RSV monoclonal antibody approved (FDA) Trial of single-dose Nirsevimab (NEJM) Letters read on TWiV 1028 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Phoenix hits 110 degrees for the 19th day in a row, setting national record Brianne – James Webb Telescope One Year Anniversary Photo Kathy – Drone awards photos <b
Sat, July 22, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the transmission of SARS-CoV-2 in free-ranging white-tailed deer in the United States, Omicron subvariant BA.5 efficiently infects lung cells, COVID-19 scent dog research highlights and synthesis during the pandemic of December 2019, T-Cell Immunity against SARS-CoV-2 measured by an interferon-γ release assay is strongly associated with patient outcomes in vaccinated persons hospitalized with Delta or Omicron variants, a common allele of HLA is associated with asymptomatic SARS-CoV-2 infection, and the immunology of long COVID. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Transmission of SARS-CoV-2 in white-tailed deer in the United States (Nature) Omicron subvariant BA.5 efficiently infects lung cells (Nature) COVID-19 scent dog research highlights during the pandemic of December 2019 (JOM) T-Cell Immunity against SARS-CoV-2 measured by an interferon-γ release assay is strongly associated with patient outcomes (JID) Common allele of HLA is associated with asymptomatic SARS-CoV-2 infection (Naure) Immunology of long COVID (Nature) Contribute to our FIMRC fundraiser at PWB Letters read on TWiV 1027 Dr. Griffin’s COVID treatment summary ( pdf ) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Sun, July 16, 2023
Debunking RFK Jr.’s vaccine funk with Dan Wilson
Dan Wilson returns to TWiV to debunk vaccine misinformation by RFK Jr. during his recent appearance on the Joe Rogan Experience. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , Kathy Spindler , and Brianne Barker Guest: Dan Wilson Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Joe Rogan’s worst misinformation yet, with RFK Jr. (YouTube) Every first vaccine has been tested in placebo-controlled trials before going to market. Polio Measles HPV COVID-19 HepB Haemophilus influenzae B Pertussis Diphtheria Tetanus Pneumococcal Mumps Meningococcal Chickenpox <a title="" href= "https://www.nejm.org/doi/10.1056/NEJM1992081332
Sat, July 15, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the new risk assessment for the H5N1 avian flu viruses, the development of monoclonal antibody-based blocking ELISA for detecting SARS-CoV-2 exposure in animals, repeated antibiotic exposure and risk of hospitalization and death following COVID-19 infection, COVID-19 rebound study: a prospective cohort study to evaluate viral and symptom rebound differences in participants treated with Nirmatrelvir plus Ritonavir versus untreated controls, exaggerated blood pressure elevation in response to orthostatic challenge a post-acute sequelae of SARS-CoV-2 infection (PASC) after hospitalization, long term follow-up of a multicenter cohort of COVID-19 patients with pulmonary embolism, and risk of cardiovascular disease after COVID‐19 diagnosis among adults with and without diabetes. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode New risk assessment for H5N1 avian flu viruses (CDC) Development of monoclonal antibody-based blocking ELISA for detecting SARS-CoV-2 exposure (Virology) Repeated antibiotic exposure and risk of hospitalization and death following COVID-19 infection (eClinicalMedicine) COVID-19 Rebound Study (CID) Exaggerated blood pressure elevation in response to orthostatic challenge (AN) Long term follow-up of a multicenter cohort of COVID-19 patients with pulmonary embolism (TR) Risk of Cardiovascular disease after COVID‐19 diagnosis among adults with and without Diabetes (JAHA) Contribute to our FIMRC fundraiser at PWB Letters read on TWiV 1025 Dr. Griffin’s COVID treatment summary (<a hr
Fri, July 14, 2023
The Chumakoviridae
Vincent speaks with Kostya Chumakov about his career: raised by two virology parents in Moscow, trained in virology by Vadim Agol, then moving to the US FDA where he developed a molecular test for measuring production consistency of oral poliovirus vaccine. Host: Vincent Racaniello Guest: Kostya Chumakov Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Mikhail Chumakov (Wikipedia) MAPREC (WHO pdf ) Kostya Chumakov Symposium (YouTube) Maprec and monkey neurovirulence of OPV (PNAS) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, July 09, 2023
Covering science with Katherine Wu
Katherine joins TWiV to discuss her career in science writing, from not liking science at all, to a PhD in microbiology and immunology, and writing for Nova, the NY Times, and The Atlantic, and how the COVID-19 pandemic has impacted her craft. Host: Vincent Racaniello , Kathy Spindler , and Brianne Barker Guest: Katherine Wu Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server All Katherine’s articles at The Atlantic Vaccines still blocking severe disease (The Atlantic) Calling Omicron mild is wishful thinking (The Atlantic) Tattoos do odd things to the immune system (The Atlantic) The Story Collider Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, July 08, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses autochthonous leprosy in the United States, a systematic review to identify novel clinical characteristics of Mpox virus infection and therapeutic and preventive strategies to combat the virus, two-year duration of immunity of inactivated poliovirus vaccine, evaluation of novel oral polio vaccine type 2 SIA impact in a large outbreak of circulating vaccine-derived poliovirus in Nigeria, performance of rapid antigen tests to detect symptomatic and asymptomatic SARS-CoV-2 Infection, effectiveness of the COVID-19 bivalent vaccine, oral Nirmatrelvir and Ritonavir for COVID-19 in vaccinated, non-hospitalized adults ages 18-50 years, genome-wide association study of long COVID, vaccination ameliorates cellular inflammatory responses in SARS-CoV-2 breakthrough infections, and high incidence of autonomic dysfunction and postural orthostatic tachycardia syndrome in patients with long-COVID. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Autochthonous leprosy in the United States (NEJM) Systematic review to identify novel clinical characteristics of Monkeypox (Archives of Virology) Two-year duration of immunity of inactivated poliovirus vaccine (JID) Evaluation of novel oral polio vaccine type 2 SIA impact in a outbreak of vaccine-derived poliovirus in Nigeria (IDSA) Performance of rapid antigen tests to detect symptomatic and asymptomatic SARS-CoV-2 (AIM) Effectiveness of the COVID-19 bivalent vaccine (OFID) Oral Nirmatrelvir and Ritonavir for COVID-19 in vaccinated, non-hospitalized adults (CID) Genome-wide association study of <a href= "https://www.
Sun, July 02, 2023
Nextstrain with Trevor Bedford
From ASV 2023 in Athens, Georgia, Vincent, Kathy and Brianne speak with Trevord Bedford about his career, the development of Nextstrain.org for real-time tracking of pathogen evolution, and evolution of SARS-CoV-2 from January 2020 through Omicron. Host: Vincent Racaniello , Kathy Spindler , and Brianne Barker Guest: Trevor Bedford Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Nextstrain Household influenza testing (Influenza Other Resp Viruses) SARS-CoV-2 outbreak Washington (Sci Transl Med) SARS-CoV-2 surveillance , Washington (Emerg Inf Dis) S1 changes drive SARS-CoV-2 clade success (Cell Host Micro) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, July 01, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses guidance on measles during the summer travel season, the Infectious Diseases Society of America guidelines on the diagnosis of COVID-19: antigen testing, SARS-CoV-2 variants and age-dependent infection rates among household and nonhousehold contacts, effect of COVID-19 vaccination on household transmission of SARS-COV-2 in the Omicron era, incidence of myopericarditis after mRNA COVID-19 vaccination, intrinsic and effective severity of COVID-19 cases infected with the ancestral strain and Omicron BA.2 variant in Hong Kong, safety, immunogenicity and protection of heterologous boost with an aerosolized Ad5-nCoV after two-dose inactivated COVID-19 vaccines in adults, awake prone positioning for non-intubated patients with COVID-19-related acute hypoxic respiratory failure, melatonin effects on sleep quality of COVID-19 patients, female reproductive health impacts of Long COVID and associated illnesses including ME/CFS, POTS, and connective tissue disorders, and incident autoimmune diseases in association with SARS-CoV-2 infection. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Guidance on measles during the summer travel season (CDC) Infectious Diseases Society of America guidelines on the diagnosis of COVID-19 (CID) SARS-CoV-2 variants and infection rates among household and nonhousehold contacts (CDC) Effect of COVID-19 vaccination on household transmission of SARS-CoV-2 in the Omicron era (IJID) Incidence of myopericarditis after mRNA COVID-19 vaccination (Science Direct) Intrinsic and effective severity of COVID-19 cases infected with the ancestral strain and Omicron BA.2 variant (JID) Safety, immunogenicity and protection of heterologous boost with Ad5-nCoV after two-dose inactivated COVID-19 vaccines (The Lancet) Aw
Sun, June 25, 2023
Eddie Holmes on SARS-CoV-2 origins
From ASM Microbe in Houston, Texas, Vincent speaks with Eddie Holmes about the evidence that SARS-CoV-2 spilled over into humans in the Huanan Market in Wuhan, absence of evidence for other origins, and his work on the virosphere. Host: Vincent Racaniello Guest: Eddie Holmes Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Huanan Seafood Market early COVID-19 epicenter (Science) SARSr-CoV-2 in Malayan Pangolins (PLoS Path) Zoonotic risk of farmed animals (Cell) Virusea at bat-tick interface (Microb Genom) Influenza H3N8 virus in southern China (J Virol) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, June 24, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the CDC vaccine advisory group recommending the newly approved RSV vaccines, association of culturable-virus detection and household transmission of SARS-CoV-2, prevention of COVID-19 following a single intramuscular administration of Adintrevimab, real-world effectiveness of Nirmatrelvir/Ritonavir on COVID-19, and COVID-19 convalescent plasma outpatient therapy to prevent outpatient hospitalization. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode CDC vaccine advisory group recommends RSV vaccines Association of culturable-virus detection and household transmission of SARS-CoV-2 (JID) Prevention of COVID-19 following intramuscular administration of Adintrevimab (OFID) Real-world effectiveness of Nirmatrelvir/Ritonavir on COVID-19 (CID) COVID-19 convalescent plasma outpatient therapy to prevent hospitalization (CID) Contribute to our FIMRC fundraiser at PWB Letters read on TWiV 1018 Dr. Griffin’s COVID treatment summary ( pdf ) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Sun, June 18, 2023
From Nature, not a lab
Vincent travels to the University of Pennsylvania to meet up with Susan, Rick, Gigi and David to discuss the origin of SARS-CoV-2, how the FBI might have reached its conclusion on the matter, and public and political perception of scientific risk. Host: Vincent Racaniello Guests: Susan Weiss , Rick Bushman , Gigi Gronvall , and David Joanson Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Huanan Seafood Market early COVID-19 epicenter (Science) Spillover market with Michael Worobey ( TWiV 876 ) Unclassified intelligence on SARS-CoV-2 origins (IC) Conspiracy theories about COVID-19 (Foreign Policy) COVID-19 not from lab leak (Globe and Mail) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, June 17, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses surveillance to track progress toward poliomyelitis eradication, genetic stabilization of attenuated oral vaccines against poliovirus types 1 and 3, evaluation of Oseltamivir used to prevent hospitalization in outpatients with Influenza, viral emissions into the air and environment after SARS-CoV-2 human challenge, has COVID-19 threatened routine childhood vaccination, successful treatment of persistent symptomatic COVID-19 infection with extended duration Nirmatrelvir/Ritonavir, anemia as a risk factor for disease progression in patients admitted for COVID-19, impact of fatigue as the primary determinant of functional limitations among patients with post-COVID-19 syndrome, post-COVID condition in patients with inflammatory rheumatic diseases, outpatient treatment of COVID-19 and incidence of post-COVID-19 condition over 10 months, metformin reduces SARS-CoV-2 in a Phase 3 randomized placebo controlled clinical trial, persistent serum protein signatures define an inflammatory subcategory of long COVID, and the relevance of pacing strategies in managing symptoms of post-COVID-19 syndrome. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Surveillance to track progress toward poliomyelitis eradication (CDC) Genetic stabilization of attenuated oral vaccines against poliovirus types 1 and 3 (Nature) Evaluation of Oseltamivir to prevent hospitalization in outpatients with Influenza (JAMA) Viral emissions into air and environment after SARS-CoV-2 human challenge (The Lancet) Has COVID-19 threatened routine childhood vaccination (Health Affairs) <a href= "https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofad306/7190863?searchresult=1&login=false&utm_source=MarketingCloud&utm_medium=email&utm_campaign=0610
Sun, June 11, 2023
Soldiers & Scientists at USAMRIID
Vincent and Rich travel to Ft. Detrick to visit USAMRIID and speak with Todd, Crystal, John and Jay about their careers, their research, and the mission of the US Army Medical Institute of Infectious Diseases. Host: Vincent Racaniello and Rich Condit Guests: Todd Bell , Crystal Burke , John Dye , and Jay Hooper Opinions, interpretations, conclusions, and recommendations are those of the panelists and no official endorsement by the U.S. Army should be inferred. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server USAMRIID Mpox virus in testes of nonhuman primates (Nat Micro) Efficacy of equine encephalitis virus-like particle vaccine (Viruses) Prophylaxis with SARS-CoV-2 mAb (Antimicrob Agents Chemother) Needle-free jet injection of DNA vaccine (PLoS One) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, June 10, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses estimates of SARS-CoV-2 seroprevalence and incidence of primary SARS-CoV-2 infections among blood donors, by COVID-19 vaccination status, smart thermometer–based participatory surveillance to discern the role of children in household viral transmission during the COVID-19 pandemic, COVID-19 vaccine mandates, changing severity and epidemiology of adults hospitalized with COVID-19 in the United States after introduction of COVID-19 vaccines, effectiveness of COVID-19 treatment with Nirmatrelvir–Ritonavir or Molnupiravir among U.S. veterans, national trends in anticoagulation therapy for COVID-19 hospitalized adults in the United States, development of a definition of postacute sequelae of SARS-CoV-2 infection, neuroinflammation after COVID-19 with persistent depressive and cognitive symptoms, long COVID clinical phenotypes up to six months after infection identified by latent class analysis of self-reported symptoms, and coronary microvascular health in symptomatic patients with prior COVID-19 infection. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Estimates of SARS-CoV-2 seroprevalence and incidence of infections among blood donors, by vaccination status (CDC) Smart thermometer–based surveillance to discern the role of children in household viral transmission during the COVID-19 pandemic (JAMA) COVID-19 vaccine mandates (GOV) Changing epidemiology of adults hospitalized with COVID-19 after introduction of vaccines (CID) Effectiveness of COVID-19 treatment with Nirmatrelvir–Ritonavir or Molnupiravir among U.S. Veterans (ACP Journals) National trends in Anticoagulation therapy for COVID-19 (IDSA) <a href= "https://jamanetwork.com/journals/jama/fullarticle/2805540?guestAccessKey=1f
Sun, June 04, 2023
Bird flu around the world
TWiV reviews remarkable changes in the epidemiology of avian H5N1 influenza virus leading to previously uninfected areas, involvement of previously unaffected wild birds, and devastating outbreaks in farmed poultry, and isolation of a monoclonal antibody against the influenza virus neuraminidase that inhibits infection with a wide range of A and B isolates. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , Kathy Spindler , and Angela Mingarelli Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Register for ASV 2023 Research assistant position at FDA ( pdf ) MicrobeTV Discord Server Avian influenza H5N1 (Eurosurveillance) Pan-influenza NA antibody (Nature) World Animal Health Information System Timestamps by Jolene . Thanks! Weekly Picks Angela – May’s best science images – Nature Kathy – Historical reasons for resistance to recognizing airborne transmission Rich – Scan of Titanic reveals wreck as never seen before – BBC News Alan – Science Education in an Age of Misinformation Vincent – Equity, Diversity and Inclusion: When communication all changed Intro music is by Ronald Jenkees
Sat, June 03, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the potential for recurrent Mpox outbreaks among gay, bisexual, and other men who have sex with men, association between SARS-CoV-2 variants and frequency of acute symptoms, prospective study of key correlates for household transmission of SARS-CoV-2, Pfizer’s PAXLOVID™ receiving FDA approval for adult patients at high risk of progression to severe COVID-19, efficacy and safety of antimicrobial stewardship prospective audit and feedback in patients hospitalized with COVID-19, development of a definition of postacute sequelae of SARS-CoV-2 infection, COVID-19 and risk for mental disorders among adults in Denmark, risk of new post-COVID mental disorders higher only in older patients. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Potential for recurrent Mpox outbreaks among men who have sex with men (CDC) Association between SARS-CoV-2 variants and frequency of acute symptoms (OFID) Key correlates for household transmission of SARS-CoV-2 (OFID) PAXLOVID receiving FDA approval for patients at high risk of severe COVID-19 (Pfizer) Efficacy and safety of antimicrobial stewardship prospective audit and feedback in patients with COVID-19 (The Lancet) <a href= "https://cdn.jamanetwork.com/ama/content_public/journal/jama/0/joi230062supp3_prod_1684937534.95554.pdf?Expires=1688067977&Signature=DxaWrbEmeCwe~5-TIbuLlcNrNNSnUtziS1LCcOKYkIgUA3l9wlU0BZWMdSPggILIV4EHueYNP4UIS5M1F0d0~4UPXw4nhr-RbrXQpTVMgGA4c2qy1yIYNH5J8iD0yHFBy2ezh6JWrtahAm8~r5i34h9w9AHx5J
Sun, May 28, 2023
Aquatic viruses
Vincent travels to Québec City, Canada and the 11th Aquatic Virus Workshop, where he speaks with Fred Aylward and Jed Furman about the research of their laboratories on the ecology and evolution of aquatic viruses and their microbial communities. Host: Vincent Racaniello Guests: Fred Aylward and Jud Fuhrman Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server 11th Aquatic Virus Workshop Endogenization of giant virus genomes in green algae (Nature) Red Queen dynamics in marine viruses (Nature) Biogeography of marine giant viruses (ISME Commun) Marine prokaryotic community structure (Nat Commun) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, May 27, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the CDC HIV surveillance report, FDA voted in favor of approving the Abrysvo vaccine, canine olfactory detection of SARS-CoV-2-infected humans, safety of the BNT162b2 COVID-19 vaccine in children aged 5 to 17 years, and statement on the antigen composition of COVID-19 vaccines. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode HIV surveillance report (CDC) FDA voted in favor of approving Abrysvo vaccine (Pfizer) Canine olfactory detection of SARS-CoV-2-infected humans (Annals of Epidemiology) Safety of the BNT162b2 COVID-19 vaccine in children (JAMA) Statement on the antigen composition of COVID-19 vaccines (WHO) Contribute to our FIMRC fundraiser at PWB Letters read on TWiV 1010 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Sun, May 21, 2023
Nidovirus on the water
Vincent travels to Montreux, Switzerland and the 16th International Nidovirus Symposium, where he speaks with Maria von Kerkhove, the face of COVID-19 for the World Health Organization, and Kanta Subbarao, Director of the WHO Collaborating Centre on Influenza in Melbourne. Host: Vincent Racaniello Guests: Kanta Subbarao and Maria von Kerkhove Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Nidovirus Symposium , Montreux WHO Collaborating Centre for Influenza , Melbourne Maria von Kerkhove (Wikipedia) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, May 20, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses variant specific clinical performance of a SARS-CoV-2 rapid antigen test with focus on omicron VOC, ventilation in buildings, COVID-19 mortality among selective serotonin reuptake inhibitor users, risk of post-acute sequelae of SARS-CoV-2 infection associated with pre-coronavirus disease obstructive sleep apnea diagnoses, trajectories of the evolution of post COVID-19 condition, and efficacy of cognitive behavioral therapy targeting severe fatigue following COVID-19. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Virus variant clinical performance of a SARS-CoV-2 rapid antigen test (CID) Ventilation in buildings (CDC) COVID-19 mortality among SSRI users (CMI) Risk of post-acute sequelae of SARS-CoV-2 infection associated with sleep apnea (SLEEP) Trajectories of the evolution of post COVID-19 condition (IJID) Efficacy of cognitive behavioral therapy targeting fatigue following COVID-19 (CAD) Contribute to our FIMRC fundraiser at PWB Letters read on TWiV 1008 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Sun, May 14, 2023
Fragile DNA, viruses, cancer
TWiV explains genetic changes in nOPV2 strains that paralyzed children, outbreak of raccoon distemper in Toronto, EcoHealth Alliance gets its NIH grant back, and breakage at chromosomal fragile sites caused by the EBNA1 protein of Epstein-Barr virus as a mechanism for carcinogenesis. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Angela Mingarelli Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Register for ASV 2023 Research assistant position at FDA ( pdf ) MicrobeTV Discord Server nOPV2 after two years (Polioeradication) Raccoon distemper in Toronto (CityNews Everywhere) NIH reinstates EcoHealth grant (Nature) Chromosomal breakage by EBNA1 (Nature) Agent of chromosomal instability (Nature) Timestamps by Jolene . Thanks! Weekly Picks Angela – Night Science Kathy – Kermit, Jim Henson, Rainbow Connection Rich – Alexander Skarsgård Explains the Answer to Everything Vincent – Beyond the Noise with Dr. Paul Offit Intro music is by <a href= "http://www.ronaldjen
Sat, May 13, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses immunogenicity and tolerability of a bivalent virus-like particle norovirus vaccine candidate in children from 6 months up to 4 years of age, influenza hemagglutinin stem nanoparticle vaccine induces cross-group 1 neutralizing antibodies in healthy adults, COVID-19 surveillance after expiration of the public health emergency declaration, provisional mortality data, targeted vaccine messaging to promote COVID-19 vaccines for children and youth, vaccines and related biological products advisory committee meeting June 15, 2023 announcement, how to overhaul the CDC, impact of SARS-CoV-2 variants on inpatient clinical outcome, prevalence of post-coronavirus disease condition 12 weeks after Omicron infection compared with negative controls and association with vaccination status, gut bacteria cocktail helps long COVID, and gut microbiota‐derived symbiotic formula (SIM01) as a novel adjuvant therapy for COVID‐19. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Immunogenicity and tolerability of a bivalent norovirus vaccine in children (HVI) Influenza hemagglutinin stem nanoparticle vaccine induces neutralizing antibodies in healthy adults (STM) COVID-19 surveillance after expiration of the public health emergency declaration (CDC) Provisional mortality data (CDC) Targeted messaging to promote COVID-19 vaccines for children and youth (Pediatrics) Vaccines and biological products advisory committee meeting announcement (FDA) How to overhaul the C.D.C (NYTIMES) Impact of <a
Sun, May 07, 2023
COVID T vax and a virus from the blue
TWiV reveals plankton-infecting relatives of herpesviruses in the sunlit oceans, and a vaccine encoding non-spike T cell antigens that protects animals from severe SARS-CoV-2 infection. Hosts: Vincent Racaniello , Alan Dove , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Register for ASV 2023 Research assistant position at FDA ( pdf ) MicrobeTV Discord Server Mirusviruses link herpesvirus to giant viruses (Nature) Tara Oceans expeditions T cell vaccine protects against severe COVID (Cell) Letters read on TWiV 1005 Timestamps by Jolene . Thanks! Weekly Picks Brianne – Immune #67: Can T cells Live Forever? Kathy – Hazel Scott, Trinidad Jazz star Alan – The Last Navigator , Steve Thomas Vincent – Nasal Spray Covid Vaccines: Hope or Hype? Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, May 06, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the U.S. Food and Drug Administration approving Arexvy: the first respiratory syncytial virus (RSV) vaccine approved for use in the United State, association between SARS-CoV-2 and metagenomic content of samples from the Huanan Seafood Market, researchers disagree over how bad it is to be reinfected and whether COVID-19 can cause lasting changes to the immune system, virtual care and emergency department use during the COVID-19 pandemic among patients of family physicians in Canada, vaccination with BCG-Denmark did not result in a lower risk of COVID-19 among health care workers than placebo, NVX-CoV2373 vaccine efficacy against hospitalization, comparative effectiveness of the SARS-COV-2 vaccines during Delta dominance, assessment of gender-specific COVID-19 case fatality risk per malignant neoplasm type, clinical outcomes following treatment for COVID-19 with Nirmatrelvir/Ritonavir and Molnupiravir among patients living in nursing homes, timing of intubation and ICU mortality in COVID-19 patients, real-life experience with Remdesivir for treatment of COVID-19 among older adults, and how long COVID brain fog and muscle pain are associated with longer time to clearance of SARS-CoV-2 RNA from the upper respiratory tract during acute infection. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode FDA approves Arexvy , the first RSV vaccine approved in the US (FDA) Association between SARS-CoV-2 and content of samples from the Huanan Seafood Market (bioRxiv) Researchers disagree over how bad it is to be reinfected with COVID-19 and lasting changes to the immune system (Nature) Virtual care and emergency department use during the COVID-19 Pandemic among patients of family physicians (JAMA) Vaccination with BCG-Denmark did not result in a lower risk of COVID-19 among health care workers (NEJM) NVX-CoV2373 vaccine efficacy against hospitalization (V
Sun, April 30, 2023
Going clinically viral
Vincent and Kathy travel to Atlanta for APHL ID Lab Con, a conference focused on the latest developments in detection and characterization of infectious diseases of public health concern, and speak with Megan, Ryan, and Kirsten about the workings of public health and clinical laboratories. Hosts: Vincent Racaniello and Kathy Spindler Guests: Megan Crumpler , Ryan Relich , and Kirsten St. George Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server APHL Lab ID CON Association of Public Health Laboratories Orange County Public Health Laboratory Division of Clinical Microbiology , Indiana University Health Virology Laboratory , NYSDOH Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, April 29, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses completeness and spin of medRxiv preprints and associated published abstracts of COVID-19 randomized clinical trials, lessons learned from a COVID-19 dog screening pilot in California K-12 schools, SARS-CoV-2 reinfection and severity of the disease, effectiveness of COVID-19 bivalent vaccine, Molnupiravir and risk of post-acute sequelae of COVID-19, risk of new-onset long Covid following reinfection with SARS-CoV-2, low vitamin D levels associated with long COVID syndrome in COVID-19 survivors, and clinical experience with the α2A-adrenoceptor agonist, guanfacine, and N-acetylcysteine for the treatment of cognitive deficits in “Long-COVID19”. Click arrow to play Download TWiV 1002 (27 MB .mp3, 44 min) Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Completeness and spin of medRxiv preprint and published abstracts of COVID-19 randomized clinical trials (JAMA) Lessons learned from a COVID-19 dog screening pilot (JAMA) SARS-CoV-2 reinfection and severity of the disease (Viruses) Effectiveness of COVID-19 bivalent vaccine (medRxiv) Molnupiravir and risk of post-acute sequelae of COVID-19 (BMJ) Risk of new-onset long Covid following reinfection with SARS-CoV-2 (medRxiv) Low vitamin D levels are associated with Long COVID in COVID-19 survivors (JCEM) Clinical experience with the α2A-adrenoceptor agonist, guanfacine, and N-acetylcysteine for treatment of Long-COVID19 (NIH) Contribute to our ASTMH fundraiser at PWB Le
Sun, April 23, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses an update on vaccine-derived poliovirus outbreaks, how the dream of wiping out polio might need a rethink, risk of death in patients hospitalized for COVID-19 vs seasonal Influenza in fall-winter, French Mpox cluster includes fully vaccinated patients, two individuals with potential Mpox virus reinfection, epidemiologic and clinical features of Mpox-associated deaths, FDA authorizes changes to simplify use of bivalent mRNA COVID-19 vaccines, SARS-CoV-2 during Omicron variant predominance among infants born to people with SARS-CoV-2, severe maternal morbidity and mortality of pregnant patients with COVID-19 infection during the early pandemic period in the US, sickness presenteeism in healthcare workers during the COVID-19 pandemic, ventilation improvements among k–12 public school districts, risk factors and vectors for SARS-CoV-2 household transmission, SARS-CoV-2 neutralizing antibodies after bivalent versus monovalent, durability of bivalent boosters against Omicron subvariants, Nirmatrelvir and risk of hospital admission or death in adults with COVID-19, evolving real-world effectiveness of monoclonal antibodies for treatment of COVID-19, effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support–free days in patients hospitalized with COVID-19, efficacy and safety of Anakinra plus standard of care for patients with severe COVID-19, higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support, risk of autoimmune diseases in patients with COVID-19, definition of post–COVID-19 condition among published research studies, and sleep disturbance severity and correlates in post-acute sequelae of COVID-19. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Update on vaccine-derived poliovirus outbreaks (CDC) The dream of wiping out polio might need a rethink (NPR) Risk of death in patients hospitalized for COVID-19 vs influenza (JAME) French mpox cluster includes
Sun, April 23, 2023
Live from New York, 1k epitopes of virology
The entire TWiV team gathers at a theatre in New York City to celebrate a milestone in science podcasting, to reminisce how they joined the show, and to play a game of TWiV Jeopardy. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler , Brianne Barker , Daniel Griffin , and Angela Mingarelli Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode TWiV #1: West Nile virus TWiV #100: TWiV catches a big fish TWiV #200: Threading the NEIDL TWiV #300: So happy together TWiV #400: Harold ‘400’ Varmus, a scientist for all seasons TWiV #500: Keep virology weird Randal Despommier Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, April 09, 2023
Vaccinated to the nines
TWiV notes Ashish Jha’s call for doctors to combat a vacuum of medical information while ignoring our contributions, China CDC’s surveillance of SARS-CoV-2 at the Huanan Seafood Market, and an experimental infectious attenuated COVID-19 vaccine that elicits superior mucosal and systemic immunity in hamsters. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Register for ASV 2023 MicrobeTV Discord Server Jha ignores TWiV contribution to disseminating science information (STAT) Surveillance of SARS-CoV-2 at the Huanan Market (Science) Pandas in the Huanan Market? (ArsTechnica) Infectious attenuated COVID-19 vaccine candidate (Nature Micro) Virus attenuation by codon pair deoptimization (Cell Rep) Timestamps by Jolene . Thanks! Weekly Picks Dickson – Jazz Project: Conductor/composer: Gill Evans. Produced Sketches of Spain, Porgy And Bess . Quincey Jones. Numerous albums, all kinds of music. Duke Ellington. Prolific musician, pianist, and composer. Antonio Carlos Jobim. Signature album: Sound track from the film – Black Orpheus . Si
Sat, April 08, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the White House COVID adviser calling on doctors to combat a vacuum of medical information, adeno-associated virus type 2 in US children with acute severe hepatitis, genomic investigations of unexplained acute hepatitis in children, surveillance of SARS-CoV-2 at the Huanan seafood market, vaccine effectiveness against hospitalization among adolescent and pediatric SARS-CoV-2 cases between May 2021 and January 2022 in Canada, effectiveness of BNT162b2 after extending the primary series dosing interval in children and adolescents aged 5–17, prevalence and characteristics associated with post–COVID-19 condition among non-hospitalized adolescents and young adults, within-host genetic diversity of SARS-CoV-2 lineages in unvaccinated and vaccinated individuals, live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters, Fc-γR-dependent antibody effector functions are required for vaccine-mediated protection against antigen-shifted variants of SARS-CoV-2, COVID-19 convalescent plasma utilization in the United States, FDA authorizes Gohibic (vilobelimab) injection for the treatment of COVID-19, anti-C5a antibody IFX-1 (vilobelimab) treatment versus best supportive care for patients with severe COVID-19 (PANAMO), anti-C5a antibody (vilobelimab) therapy for critically ill, invasively mechanically ventilated patients with COVID-19, triple combination therapy with two antivirals and monoclonal antibodies for persistent or relapsed SARS-CoV-2 infection in immunocompromised patients, and the breadth of the neutralizing antibody response to original SARS-CoV-2 infection is linked to the presence of long COVID symptoms. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode White House COVID adviser calls on doctors to combat medical information (STAT) Adeno-associated virus type 2 in US children with acute severe hepatitis (Nature) Genomic investigations of unexplained acute hepatitis in children (Nature) Surveillance of SARS-CoV-2 at the Huanan Seafood Market (ChinaXiv) <a href= "https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0283715"
Sun, April 02, 2023
Inside Omicron with Mohsan Saeed
Mohsan joins TWiV to discuss the work of his laboratory showing that spike and nsp6 are determinants of Omicron attenuation, and why the work was widely misinterpreted by the press and the public. Hosts: Vincent Racaniello , Alan Dove , and Rich Condit Guest: Mohsan Saeed Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode •Register for ASV 2023 • MicrobeTV Discord Server • Spike and nsp6 determinants of Omicron attenuation (Nature) •China releases genomic data from Wuhan market (Science) •Timestamps by Jolene . Thanks! Weekly Picks Rich – For pianist Dan Tepfer, improvisation is the mother of Bach’s Inventions Alan – HMS Victory 3D animated tour Vincent – The Fight Over Penn Station and Madison Square Garden Listener Picks Douglas – How’s Your City Doing? Ask the Honeybees . Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, April 01, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses how antibiotics don’t reduce risk of death from viral respiratory infections, norovirus infections continue to rise in the US, ABO blood types and SARS-CoV-2 infection assessed using seroprevalence data in a large population-based sample, maternal third dose of BNT162b2 mRNA vaccine and risk of infant COVID-19 hospitalization, association of treatment with Nirmatrelvir and the risk of Post–COVID-19 condition, mechanically ventilated patients with COVID-19 had a higher chance of in-hospital death if treated with high-flow nasal cannula oxygen before intubation, high-flow nasal cannula and outcomes in COVID-19, severe infection and risk of Cardiovascular disease, and the risk factors associated with post−COVID-19 condition. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Antibiotics don’t reduce risk of death from viral respiratory infections (CIDRAP) ABO blood types and SARS-CoV-2 infection (Nature) Maternal third dose of BNT162b2 mRNA vaccine and risk of infant COVID-19 hospitalization (Nature Medicine) Association of treatment with Nirmatrelvir and risk of post–COVID-19 (JAMA) Ventilated patients with COVID-19 had a higher chance of in-hospital death with usage of nasal cannula oxygen (IARS) High-flow nasal cannula and outcomes in COVID-19 (IARS) Severe infection and risk of cardiovascular disease (AHA) Risk factors associated with post−COVID-19 condition (JAMA) Contribute to our ASTMH fundraiser at PWB
Sun, March 26, 2023
Viral origin stories
TWiV discusses genetic evidence of susceptible wildlife in SARS-CoV-2 positive samples at the Huanan Wholesale Seafood Market, polio cases in African linked to a new polio vaccine that was designed to not cause the disease, and structural conservation of hepatitis B virus capsid proteins over millions of years despite a shift from a naked to an enveloped capsid. Click arrow to play Download TWiV 995 (74 MB .mp3, 123 min) Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode •Register for ASV 2023 • MicrobeTV Discord Server • More evidence for SARS-CoV-2 spillover (Zenodo) •Polio cases linked to nOPV2 ( Science ; GPEI statement ) •nOPV2 on TWiV 756 •Engineering OPV to prevent reversion to neurovirulence (Cell Host Microbe) • Stability of nOPV2 in children (npj Vaccines) •2A changes compensate for 5′-UTR disruptions (Virology) •HBV shifts from naked to enveloped (Nat Comm) • Letters read on TWiV 995 •Timestamps by Jolene . Thanks! Weekly Picks Dickson – Jazz Project: Bass: Ray Brown, Ron Carter, Percy Heath Angela – The nervous system may play a role in severe allergic reactions through immune cell (mast cells) cross-talk with neurons Brianne – <a href= "https://www.nytimes.com/2023/03/23/science/science-museums-onlin
Sat, March 25, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the detection of circulating vaccine-derived poliovirus type 2 in Burundi and the Democratic Republic of the Congo, the novel oral polio vaccine type 2 story, prior COVID-19 infection associated with increased risk of newly diagnosed erectile dysfunction, adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection, correlates of protection against COVID-19 infection and intensity of symptomatic disease in vaccinated individuals exposed to SARS-CoV-2 in households in Israel, effectiveness of Nirmatrelvir–Ritonavir in preventing hospital admissions and deaths in people with COVID-19, projected COVID-19 mortality reduction from Paxlovid rollout, and SARS-CoV-2 mRNA vaccines decouple anti-viral immunity from humoral autoimmunity. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode cVDPV2 detections in Burundi and the DRC (PGEI) Novel oral polio vaccine type 2 story (The Lancet) Prior COVID-19 infection associated with risk of diagnosed erectile dysfunction (IJIR) Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection (BMJ) Protection against COVID-19 infection and intensity of symptomatic disease in vaccinated individuals (The Lancet) <a style= "font-family: -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, Oxygen
Sun, March 19, 2023
COVID-19 drives autoimmunity
TWiV reveals how treatment with remdesivir for COVID-19 resolved a chronic poliovirus infection in an immunocompromised patient, and the finding that infection with SARS-CoV-2 leads to an increase in new and preexisting autoantibodies. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode •Register for ASV 2023 • MicrobeTV Discord Server •Janet Sinsheimer on TWiV 653 •Clearance of chronic poliovirus infection by remdesivir (Front Immunol) • Autoimmunity induced by SARS-CoV-2 infection (Nat Comm) • Letters read on TWiV 993 •Timestamps by Jolene . Thanks! Weekly Picks Brianne – Xkcd: Lymphocytes Kathy – A brief history of Parafilm with video Alan – Mapping and exploring the USS Monitor wreck Vincent – Skype a Scientist Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, March 18, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses clearance of longstanding, immune-deficiency-associated, vaccine-derived poliovirus infection following remdesivir therapy for chronic SARS-CoV-2 infection, SARS-CoV-2 exposure in New York City rats, clinical characteristics and outcomes of children with SARS-CoV-2 infection during the Delta and Omicron variant-dominant periods in Korea, exhaled breath aerosol shedding of SARS-CoV-2 variants, outpatient treatment of COVID-19 and the development of long COVID over 10 months, Nirmatrelvir and the risk of post-acute sequelae of COVID-19, assessment of the risk of venous thromboembolism in nonhospitalized patients with COVID-19, and the optimal duration of systemic corticosteroids in COVID-19 treatment. Click arrow to play Download TWiV 992 (19 MB .mp3, 32 min) Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Clearance of vaccine-derived poliovirus following remdesivir therapy for SARS-CoV-2 infection (Frontiers) SARS-CoV-2 exposure in Norway rats from New York City (mBio) Clinical characteristics and outcomes of children with SARS-CoV-2 Infection in Korea (JKMS) Exhaled breath aerosol shedding of SARS-CoV-2 variants (CID) Outpatient treatment of COVID-19 and the development of Long COVID (The Lancet) Nirmatrelvir and the risk of post-acute sequelae of COVID-19 (medRxiv) Risk of venous thromboembolism in nonhospitalized patients with COVID-19 (JAMA) Optimal duration of systemic corticosteroids in COVID-19 treatment (OFID) Contribute to our AST
Sun, March 12, 2023
The cancer mRNA shot
On this episode of TWiV, the observation that the 1918 influenza virus is not lethal in nonhuman primates and implications for studies on viral virulence, and mRNA vaccines that control and resolve human papillomavirus-associated cancers in mice. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode •Register for ASV 2023 • MicrobeTV Discord Server •1918 influenza virus not lethal in nonhuman primates (J Virol) •mRNA vaccines control HPV-associated tumors (Sci Trans Med) • Letters read on TWiV 991 •Timestamps by Jolene . Thanks! Weekly Picks Dickson – Jazz Project: Piano: Art Tatum/Thelonius S. Monk/Dave Brubeck/Bill Evans/George Shearing/Herbie Hancock/Chick Corea/Keith Jarret/Diana Krall/Eliane Elias/Horace Silver. Honorable mention: Oscar Peterson/Erroll Garner/Ramsey Lewis/Dr. John/Duke Ellington Rich – Protein synthesis: an epic on the cellular level Alan – Thomas Was Alone Vincent – I called for more research on the COVID ‘lab leak theory.’ Here’s what I found out Listener Pick Carol – The Exceptions: Nancy Hopkins, MIT, and the fight for Women in Science Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, March 11, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses confronting the evolution and expansion of anti-vaccine activism in the USA in the COVID-19 era, the effectiveness of maternal Influenza vaccination in Peru, characteristics and predictors of persistent symptoms post-COVID-19 in children and young people, parental nonadherence to health policy recommendations for prevention of COVID-19 transmission among children, community-onset bacterial coinfection in children critically ill with SARS-CoV-2 infection, bivalent booster effectiveness against severe COVID-19 outcomes in Finland, viral kinetics of sequential SARS-CoV-2 infections, risk of COVID-19 associated pulmonary aspergillosis based on corticosteroid duration in intensive care patients, immunomodulators for severe COVID19 in transplant patients: do they increase the risk of secondary infection, long-term cardiovascular outcomes in COVID-19 survivors among non-vaccinated population, cardiac abnormalities in Long COVID 1-year post-SARS-CoV-2 infection, one-year adverse outcomes among us adults with Post–COVID-19 condition vs those without COVID-19 in a large commercial insurance database, and long-term gastrointestinal outcomes of COVID-19. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Confronting the evolution and expansion of anti-vaccine activism (The Lancet) Effectiveness of maternal influenza vaccination in Peru (OFID) Characteristics and predictors of persistent symptoms post-COVID-19 (BMJ) Parental nonadherence to health policy recommendations for prevention of COVID-19 (JAMA) Community-onset bacterial coinfection in children ill with SARS-CoV-2 infection (OFID) Bivalent booster effectiveness against severe COVID-19 outcomes (medR
Sun, March 05, 2023
Antibody cross-reactivity is metal
TWiV to explains a study on presence of COVID-19 vaccine mRNA in the blood, and the isolation of cross-protective monoclonal antibodies against common endemic respiratory viruses. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode •Register for ASV 2023 • MicrobeTV Discord Server • Paul Berg obituary •Spike mRNA in blood (J Path Micro Imm) •Spike mRNA in blood (Biomedicine) • Cross-protective mAbs against respiratory viruses (Nat Comm) •RSV prefusion F protein vaccine in older adults (NEJM) • Ad26.RSV.preF–RSV preF protein vaccine (NEJM) • Letters read on TWiV 989 •Timestamps by Jolene . Thanks! Weekly Picks Dickson – Jazz Project: Drums: Sunny Payne (Count Basie Orchestra); Buddy Rich (Count Basie Orchestra); Rufus Jones (Maynard Ferguson Orchestra); Joe Morello (Dave Brubeck Quartet). Brianne – A Scientific Investigation of ‘The Last of Us’ Fungal Pandemic Kathy – “That’s What They Say” podcast about pronunciation of “primer.” Rich – Slow motion art: 1 and 2 Vincent – Grammarly Listener Pick Charles – <a title="" href= "https://www.npr.org/2023/03/01/1159798950/psychologist-daniel-levitin-dissects-pink
Sat, March 04, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses FDA authorizing the first over-the-counter at-home test to detect both influenza and COVID-19, monoclonal antibody for the prevention of respiratory syncytial virus infection in infants and children, epidemiologic characteristics of SARS-CoV-2 recombinant variant XBB.1.5, COVID-19 vaccines vs pediatric hospitalization, maternal SARS-CoV-2 vaccination and infant protection against SARS-CoV-2 during the first six months of life, immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children, fatal fulminant cerebral edema in six children with SARS-CoV-2 Omicron BA.2 infection in Taiwan, certifying deaths due to COVID-19, efficacy of first dose of COVID-19 vaccine vs no vaccination on symptoms of patients with long COVID, and the effect of COVID-19 vaccination on long COVID. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode FDA authorizes over-the-counter at-home test to detect both Influenza and COVID-19 (FDA) Monoclonal antibody for the prevention of RSV in infants and children (JAMA) Epidemiologic characteristics of SARS-CoV-2 variant XBB.1.5 (CDC) COVID-19 vaccines vs pediatric hospitalization (Cell) Maternal SARS-CoV-2 vaccination and infant protection during the first six months of life (Nature) Immunoglobulin, glucocorticoid, or combination therapy for MIS in children (The Lancet) Fatal <a href= "https://academic.oup.com/jpids/a
Sun, February 26, 2023
Convalescing with Casadevall
Arturo Casadevall returns to TWiV to explain the use of convalescent serum to treat COVID-19 patients, and the need to support virology at a time when more regulation of experiments is envisioned. Hosts: Vincent Racaniello , Alan Dove , and Rich Condit Guest: Arturo Casadevall Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Register for ASV 2023 MicrobeTV Discord Server Early treatment of COVID-19 with convalescent plasma (NEJM) Neutralization of SARS-CoV-2 by convalescent plasma (Nat Comm) Convalescent COVID-19 plasma for immunocompromised patients (JAMA Net Open) Virology under the microscope (mSphere) Virology in peril (mSphere) Emil von Behring Nobel Lecture Letters read on TWiV 987 Timestamps by Jolene . Thanks! Weekly Picks Rich - Flammarion engraving Alan - What Remains of Edith Finch Vincent - The CDC’s Long-Covid Deception Listener Pick Bill - General Relativity For Babies Intro music is by Ronald
Sat, February 25, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses the efficacy and safety of two RSV vaccines in older adults, health care vaccine mandate remains as some push for an end, past SARS-CoV-2 infection protection against re-infection, a third vaccine dose equalizes the levels of effectiveness and immunogenicity of heterologous or homologous COVID-19 vaccine regimens, Sotrovimab retains activity against SARS-CoV-2 Omicron variant BQ.1.1 in a non-human primate model, effect of higher-dose Ivermectin for 6 Days vs placebo on time to sustained recovery in outpatients with COVID-19, viral burden rebound in hospitalized patients with COVID-19 receiving oral antivirals in Hong Kong, serological response to vaccination in post-acute sequelae of COVID, sex differences in cardiovascular complications and mortality in hospital patients with COVID-19, association of COVID-19 vaccination with risk for incident diabetes after COVID-19, postacute sequelae of SARS-CoV-2 in university setting, the CDC’s long-Covid deception, and podcast companies, once walking on air, feel the strain of gravity. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode RSV prefusion F protein vaccine in older adults (NEJM) Efficacy and safety of an Ad26.RSV.preF–RSV preF protein vaccine (NEJM) Health care vaccine mandate remains as some push for an end (AP) Past SARS-CoV-2 infection protection against re-infection (The Lancet) A third vaccine dose equalizes the levels of effectiveness and immunogenicity of COVID-19 vaccine regimens (medRxiv) Sotrovimab retains activity against SARS-CoV-2 Omicron variant in primate model (bioRxiv) Effect of higher-dose Ivermectin for 6 days vs placebo in patients with COVID-19 (JAMA) Viral burden rebound in patients with COVID-19 receiving <a href= "https://www.thelancet.com
Sun, February 19, 2023
Bambi's revenge
TWiV reviews an outbreak of Marburg hemorrhagic fever in Equatorial Guinea, wild poliovirus type 3 shedding from a laboratory in the Netherlands, and white-tailed deer as a reservoir for previous SARS-CoV-2 variants of concern. Hosts: Vincent Racaniello , Dickson Despommier , and Rich Condit Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode •Register for ASV 2023 • MicrobeTV Discord Server • Marburg virus disease outbreak in Equatorial Guinea (WHO) • Wild-type poliovirus type 3 from laboratory (Eurosurveillance) •Extinct SARS-CoV-2 VOC in white-tailed deer (PNAS) • Letters read on TWiV 985 •Timestamps by Jolene . Thanks! Weekly Picks Dickson – Jazz Project: Vibraphone: Lionel Hampton/Gary Burton/Cal Jader. Lionel Hampton: Signature album: The Classics Album Collection , Signature song: Flying Home . Gary Burton: Signature album: A Genuine Tong Funeral . Signature song: General Mojo’s Well Laid Plan. Cal Jader: Signature album: Latin Kick . Signature song: Soul Sauce (Wachi Wara). Milt Jackson (a member of the Modern Jazz Quartet). Signature song: Ice Skating in Central Park. Rich – The American Phage Group: Founders of Molecular Biology by William C. Summers Vincent – DJ Miss Monique aka Olesia Arkusha Listener Pick Megan – <a title="" href= "https://slate.com/podcasts/one-year/s4/1942/e3/recording-ban-1942-james-c-petrillo-the-american
Sat, February 18, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses the political polarization of COVID-19 treatments among physicians and laypeople in the United States, seven alternatives to evidence-based medicine, Malawi’s cholera death toll crosses 1,300 in its deadliest outbreak on record, impact of coronavirus infections on pediatric patients at a tertiary pediatric hospital, maternal mRNA COVID-19 vaccination during pregnancy and delta or omicron infection or hospital admission in infants, yes masks reduce the risk of spreading infection, despite a review saying they don’t, COVID-19 and airborne transmission: science rejected, lives lost. can society do better, what were the historical reasons for the resistance to recognizing airborne transmission during the COVID-19 pandemic, a randomized trial comparing Omicron-containing boosters with the original COVID-19 vaccine mRNA-1273, SARS-CoV-2 neutralizing antibodies after bivalent vs. monovalent booster, the impacts of SARS-CoV-2 vaccine dose separation and targeting on the COVID-19 epidemic in England, intra-host evolution provides for the continuous emergence of SARS-CoV-2 variants, real-world use of Nirmatrelvir–Ritonavir in outpatients with COVID-19 during the era of Omicron variants including BA.4 and BA.5 in Colorado, viral burden rebound in hospitalized patients with COVID-19 receiving oral antivirals in Hong Kong, and guidance on the use of convalescent plasma to treat immunocompromised patients with COVID-19. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode The political polarization of COVID-19 treatments in the United States (PNAS) Seven alternatives to evidence-based medicine (BMJ) Malawi’s cholera death toll crosses 1,300 (CBC) Impact of coronavirus infections on pediatric patients (JHI) Maternal mRNA COVID-19 vaccination during pregnancy (BMJ) Yes, masks reduce the risk of spreading COVID (TVO) <a href= "https://academic.oup.com/cid/advance-article/doi/10.109
Sun, February 12, 2023
One flu vaccine for them all with Scott Hensley
Scott returns to TWiV to explain the development of an experimental mRNA vaccine that encodes hemagglutinin antigens against all known influenza A virus subtypes and influenza B virus lineages, and why he is worried about avian H5N1 influenza virus. Hosts: Vincent Racaniello , Dickson Despommier , and Brianne Barker Guest: Scott Hensley Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode •Research assistant position at FDA ( pdf ) •Register for ASV 2023 • MicrobeTV Discord Server •Multivalent influenza mRNA vaccine (Science) •Influenza virus mRNA vaccines circumvent egg adaptation problems (J Virol) • Letters read on TWiV 983 •Timestamps by Jolene . Thanks! Weekly Picks Dickson – Jazz Project: Guitar. Django Reinhardt; Pat Metheny. Signature album: Still Life Talking. Signature song: Last Train Home; Joe Pass (Ella Fitzgerald’s favorite guitar accompanist). Signature album: V irtuoso . Signature song: Round Midnight . Brianne – HHMI Virus Explorer Vincent – Chris Luno Listener Picks John – White-tail deer density and SARS-CoV-2 in white-tail deer Jessica – Classic cases revisited: Oscar the cat and predicting death Intro music is by Ronald Jenkees Send your virology que
Sat, February 11, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses the consistency of COVID-19 trial preprints with published reports and impact for decision making, the negative effect of preexisting immunity on Influenza vaccine responses transcends the impact of vaccine formulation type and vaccination history, highly pathogenic avian influenza A(H5N1) virus infection in farmed minks in Spain, Peru confirms H5N1 avian flu in marine mammals, prior vaccination enhances immune responses during SARS-CoV-2 breakthrough infection with early activation of memory T cells followed by production of potent neutralizing antibodies, bacillus Calmette-Guérin vaccine for prevention of COVID-19 and other respiratory tract infections in older adults with comorbidities, incidence of chronic spontaneous urticaria following receipt of the COVID-19 vaccine booster in Switzerland, relationship between immune response to SARS-CoV2 vaccines and development of breakthrough infection in solid organ transplant recipients, early treatment with pegylated interferon lambda for COVID-19, and how long-term high-dose immunoglobulin successfully treats long COVID patients with pulmonary, neurologic, and cardiologic symptoms. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Consistency of COVID-19 trial preprints with published reports (BMI) Negative effect of preexisting immunity on Influenza vaccine (JID) Highly pathogenic avian influenza infection in farmed minks (Eurosurveillance) Peru confirms H5N1 avian flu in marine mammals (CIDRAP) Prior vaccination enhances immune responses during SARS-CoV-2 infection (bioRxiv) Bacillus Calmette-Guérin vaccine for prevention of COVID-19 and respiratory infections (CM
Sun, February 05, 2023
Tastes like chikungunya
TWiV explains the recent meeting of the National Science Advisory Board for Biosecurity (NSABB) where stricter guidelines for research involving human, animal, and plant pathogens were considered, and how the consumption of viruses by small protists returns energy to food chains. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode •Research assistant position at FDA ( pdf ) •Register for ASV 2023 • MicrobeTV Discord Server •NSABB proposed oversight framework ( pdf ) • Stricter US guidelines for research (Nature) •Information on NSABB (NIH) • Consumption of viruses by protists (PNAS) • Letters read on TWiV 981 •Timestamps by Jolene . Thanks! Weekly Picks Dickson – Jazz Project: Trombone: Steve Turre/Conrad Herwig; Steve Turre; Curtis Fuller; J.J. Johnson and Kai Winding. Steve Turre: Signature album: Sanctified Shells . Signature song: Sanctified Shells . Conrad Herwig. Signature album: A Jones For Bones Tones . Signature song: Slide’s Routine ; Curtis Fuller: Signature album: BLUES ette . Signature song: <
Sat, February 04, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses prevalence and clinical outcomes of respiratory syncytial virus versus influenza virus in adults hospitalized with acute respiratory Illness, reconsideration of antinucleocapsid IgG antibody as a marker of SARS-CoV-2 infection postvaccination for mild COVID-19 patients, assessment of COVID-19 as the underlying cause of death among children and young people aged 0 to 19 years in the US, information for persons who are immunocompromised regarding prevention and treatment of SARS-CoV-2 Infection in the context of currently circulating Omicron sublineages, association of culturable-virus detection and household transmission of SARS-CoV-2, effectiveness of bivalent boosters against severe Omicron infection, Covid vaccines and playing the long game, efficacy and safety of antimicrobial stewardship prospective audit and feedback in patients hospitalized with COVID-19, and severe fatigue and persistent symptoms at three months following SARS-CoV-2 Infections during the pre-Delta, Delta, and Omicron time periods. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Prevalence and clinical outcomes of RSV vs influenza in adults (CID) Reconsideration of antinucleocapsid IgG antibody as a marker of SARS-CoV-2 infection (OFID) Assessment of COVID-19 as the underlying cause of death among children and young people (JAMA) Information for persons who are immunocompromised regarding prevention and treatment of SARS-CoV-2 infection (CDC) Association of culturable-virus detection and household transmission of SARS-CoV-2 (JID) Effectiveness
Fri, February 03, 2023
One COVID vaccine for them all with Paul Offit
Paul Offit returns to TWiV to unpack the recent FDA Advisory Panel on COVID vaccines, with discussions on giving everyone the same bivalent vaccine, simplifying the immunization schedule, and how to know when the vaccine should be updated. Hosts: Vincent Racaniello and Rich Condit Guest: Paul Offit Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode FDA briefing document ( pdf ) Effectiveness of bivalent booster against severe infection (NEJM) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, January 29, 2023
Flushing out the viroids
TWiV gives an update on poliovirus in wastewater, and reveals a vast world of viroids that infect a wide range of host species in diverse ecosystems. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode •Research assistant position at FDA ( pdf ) •Register for ASV 2023 • MicrobeTV Discord Server • Nick Muzyczka passes •CDC planning wastewater testing for polio (CDC) •Wastewater testing for poliovirus (MMWR) •NY state poliovirus wastewater surveillance (NYSDOH) •CDC wastewater poliovirus surveillance in select communities (CDC) •Vast world of viroid-like RNAs (Cell) •Timestamps by Jolene . Thanks! Weekly Picks Kathy – 3B new Milky Way objects , Green comet Rich – Virology under the Microscope—a Call for Rational Discourse Alan – Indie story-driven games series #3: Valiant Hearts: The Great War
Sat, January 28, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses co-detections of other respiratory viruses among children hospitalized with COVID-19, preprint review should form part of PhD programs and postdoc training, early and increased Influenza activity among children, COVID-19 vaccines versus pediatric hospitalization, SARS-CoV-2 variant-related abnormalities detected by prenatal MRI, protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the Omicron variant and severe disease, protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the omicron variant and severe disease, persistent COVID-19 Symptoms at 6 months after onset and the role of vaccination before or after SARS-COV-2 infection, effect of Dexamethasone use on viral clearance among patients with COVID-19, and the impact of vaccination on post-acute sequelae of SARS CoV-2 infection in patients with rheumatic diseases. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Codetections of other respiratory viruses among children with COVID-19 (Pediatrics) Preprint review should form part of PhD programmes and postdoc training (Nature) Early and increased Influenza activity among children (CDC) COVID-19 vaccines versus pediatric hospitalization (Cell) SARS-CoV-2 variant abnormalities detected by prenatal MRI (The Lancet) Protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity (The Lancet) Persistent COVID-19 symptoms at 6 months and role of vaccination (JAMA) <a href
Sun, January 22, 2023
Ageing is infectious
TWiV covers a study of SARS-CoV-2 persistence at multiple sites in the human body, and the role of endogenous retroviruses in ageing and senescence. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Brianne Barker , and Angela Mingarelli Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode •Research assistant position at FDA ( pdf ) •Register for ASV 2023 • MicrobeTV Discord Server • Persistence of SARS-CoV-2 (Nature) •Endogenous retroviruses and senescence (Cell) •Timestamps by Jolene . Thanks! Weekly Picks Dickson – Baritone Saxophone: Gerry Mulligan. No one else comes close Signature song : Bernie’s Tune Angela – World’s Longest Animal Brianne – Green Comet to Pass By Earth for first time in 50,000 years Alan – Indie games series: Golf Club Wasteland Vincent – Bivalent Covid-19 Vaccines — A Cautionary Tale Listener Picks Lisa – The River and the Wall Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, January 21, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses China reporting almost 60,000 Covid-related deaths after abrupt shift in policy, detection of SARS-CoV-2 IgA and IgG in human milk and breastfeeding infant stool 6 months after maternal COVID-19 vaccination, effect of Fluvoxamine vs placebo on time to sustained recovery in outpatients with mild to moderate COVID-19, hyperimmune globulin for severely immunocompromised patients hospitalized with COVID-19, long COVID outcomes at one year after mild SARS-CoV-2 infection, long COVID: major findings, mechanisms and recommendations, a systematic review of trials currently investigating therapeutic modalities for post-acute COVID-19 syndrome and registered on World Health Organization international clinical trials platform, and the effect of using a structured pacing protocol on post-exertional symptom exacerbation and health status in a longitudinal cohort with the post-COVID-19 syndrome. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode China records almost 60,000 COVID-related deaths (SCMP) Detection of SARS-CoV-2 IgA and IgG in human milk and breastfeeding infant stool (Nature) Effect of Fluvoxamine vs placebo in outpatients with COVID-19 (JAMA) Hyperimmune Globulin for immunocompromised patients with COVID-19 (JID) Long COVID outcomes at one year after mild infection (BMJ) Major findings, mechanisms and recommendations for Long COVID (Nature) Review of trials investigating therapeutic modalities for post-acute COVID-19 (CMI) Effect of using a structured pacing protocol (JMV) Contribute to our MicrobeTV fundraiser at PWB <
Sun, January 15, 2023
Crossing the Ts with Daniela Weiskopf
Daniela joins TWiV to discuss her career and her research on T cells, their role in infection with SARS-CoV-2, T cell epitopes and why a variant that evades T cell immunity is not likely to emerge. Hosts: Vincent Racaniello , Alan Dove , and Brianne Barker Guest: Daniela Weiskopf Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode •Research assistant position at FDA ( pdf ) •Register for ASV 2023 • Cross reactive T cells to SARS-CoV-2 (Science) •SARS-CoV-2 exposure history and T cell response (Cell Rep Med) •Spike T cells cross- recognize Omicron (Nature) •Ancestral SARS-CoV-2 T cells recognize Omicron (Nature) • NVX-CoV2373 induces T cell responses (J Clin Inves) • Letters read on TWiV 975 •Timestamps by Jolene . Thanks! Weekly Picks Brianne – Video of viral attachment (based on this article ) Alan – Starting a series of innovative indie video games. First up: The Longing . Vincent – The Amy Papers and Calendar for live events Listener Picks Judy
Sat, January 14, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses poliovirus returns to New York wastewater, COVID-19 is more widespread in animals than we thought, increasing ventilation reduces SARS-CoV-2 airborne transmission in schools, the use of carbon dioxide monitoring to assess ventilation at a national infectious diseases conference, effectiveness of the bivalent mRNA vaccine in preventing severe COVID-19 outcomes, 7-month duration of SARS-CoV-2 mucosal immunoglobulin-A responses and protection, and long COVID outcomes at one year after mild SARS-CoV-2 infection. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode COVID-19 more widespread in animals than thought (Nat Geo) Increasing ventilation reduces airborne transmission in schools (Frontiers) Carbon dioxide monitoring to assess ventilation at a NID conference (CID) Paxlovid patient eligbiliity screening checklist (FDA) Effectiveness of bivalent mRNA vaccine in preventing severe COVID-19 (Lancet) Duration of SARS-CoV-2 mucosal immunoglobulin-A responses and protection (Lancet) Long COVID outcomes at one year after mild SARS-CoV-2 infection (BMJ) Contribute to our MicrobeTV fundraiser at PWB Dr. Griffin’s treatment guide ( pdf ) Letters read on TWiV 974 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Se
Sun, January 08, 2023
Crouching virus, hidden triggers with Felicia Goodrum
Felicia joins TWiV to discuss her career and her research on human cytomegalovirus, which infects most of us for our entire lives yet mainly causes disease in the immunosuppressed. Hosts: Vincent Racaniello , Alan Dove , and Brianne Barker Guest: Felicia Goodrum Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode •Research assistant position at FDA ( pdf ) • The loss of binary (Curr Clin Micro Rep) • Virology in Peril (mBio) •Letters read on TWiV 973 •Timestamps by Jolene . Thanks! Weekly Picks Brianne – “Leukocyte” immunology video parody Alan – West Point Removing Confederate Monuments , and Ty Seidule’s book on that subject Vincent – The works of Haruki Murakami – South of the Border, West of the Sun ; also short stories (First Person Singular, particularly Confessions of a Shinagawa Monkey; and Men Without Women , partic
Sat, January 07, 2023
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses the infectiousness of SARS-CoV-2 breakthrough infections and reinfections during the Omicron wave, virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants, antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants, comparative effectiveness of third doses of mRNA-based COVID-19 vaccines in US veterans, time to negative PCR conversion among high-risk patients with mild-to-moderate Omicron BA.1 and BA.2 COVID-19 treated by Sotrovimab or Nirmatrelvir, COVID drug Paxlovid was hailed as a game-changer, what happened?, the Fc-effector function of COVID-19 convalescent plasma contributes to SARS-CoV-2 treatment efficacy in mice, SARS-CoV-2 infection and persistence in the human body and brain at autopsy, long-term cardiovascular outcomes of COVID-19, and how heart-disease risk soars after COVID — even with a mild case. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Infectiousness of breakthrough infections & reinfections during Omicron wave (Nature) Virological characteristics of the SARS-CoV-2 XBB variant (bioRxiv) Antibody evasion properties of BQ and XBB subvariants (Cell) Comparative effectiveness of third doses of mRNA vaccines in US veterans (Nature) Time to negative PCR conversion among high-risk patients treated by Sotrovimab or Nirmatrelvir (CMI) Paxlovid patient eligbiliity screening checklist (FDA) COVID drug Paxlovid was hailed as a game-changer. What happened? (Nature) Fc-effector function of COVID-19 convalescent plasma contributes to treatment efficacy (Cell) SARS-CoV-2 i
Sun, January 01, 2023
Another year is viral
In the first epitope of 2023, TWiV reviews our coverage of virology in 2022, including favorite story arcs, episodes, show titles, and much more. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Our favorite 2022 virology stories: •Vincent: Paul Offit on bivalent boosters (TWiV 917 , 942 , Special ) •Dickson: Interviews with Paul Offit and Andy Slavitt •Rich: TWiV 948: Breathless with David Quammen •Kathy: TWiV 915: Mouse mouth to mouse mom •Brianne: Spillovers (TWiV 923 and 876 ) •Vincent: Giant viruses (TWiV 873 , 906 , 968 ) •Dickson: TWiV 960 – Getting Funky with Dan Wilson •Rich: TWiV 927: Merchlinsky vs monkeypox •Kathy: TWiV 958: Pass the RNA and have some venison pi •Brianne: TWiV 869: Epstein-Barr virus and MS, a perfect storm • Twiverse •Letters read on TWiV 968 •Timestamps by Jolene . Thanks! Weekly Picks Dickson – Jazz Project: Tenor saxophone: John Coltrane/Dexter Gordon/St
Sat, December 31, 2022
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses modelling the adjustment of COVID-19 response and exit from dynamic zero-COVID in China, canine real-time detection of SARS-CoV-2 infections in the context of a mass screening event, two masks can be worse than one: N95 respirator failure caused by an overlying face mask, airflow patterns in double-occupancy patient rooms may contribute to roommate-to-roommate transmission of severe SARS-CoV-2, clinical validation of a novel T-Cell receptor sequencing assay for identification of recent or prior SARS-CoV-2 infection, antibody-dependent cellular cytotoxicity against SARS-CoV-2 Omicron sub-lineages is reduced in convalescent sera, regardless of the infecting variant, VV116 versus Nirmatrelvir–Ritonavir for oral treatment of Covid-19, Nirmatrelvir plus Ritonavir for early COVID-19 in a U.S. health system, Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes, higher dose corticosteroids in hospitalized COVID-19 patients with hypoxia but not requiring ventilatory support, FDA approves Roche’s Actemra (tocilizumab) for the treatment of COVID-19 in hospitalized adults, structural brain changes in post-acute COVID-19 patients with persistent olfactory dysfunction, persistent post–COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium, epidemiology of long COVID in US adults, persistent symptoms and sequelae after SARS-CoV-2 infection not requiring hospitalization, and outpatient treatment of Covid-19 with metformin, ivermectin, and fluvoxamine and the development of Long Covid over 10-month follow-up. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Modeling the adjustment of COVID-19 response and exit in China (Nature) Canine real-time detection of SARS-CoV-2 infections in mass screening events (BMJ) N95 respirator failure caused by an overlying face mask (ICHE) <a href= "https://academic.oup.com/cid/ar
Wed, December 28, 2022
Carl Zimmer on COVID-19
Carl Zimmer visits the Incubator to record a wide-ranging conversation about COVID-19, including origins, vaccines, public health responses, and impact on society. Host: Vincent Racaniello Guest: Carl Zimmer Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, December 25, 2022
A spillover waiting in the wings
TWiV reviews eukaryotic viruses recovered from ancient permafrost, a mistake made by scientists on Omicron origins, and close relatives of MERS-CoV from bats that bind ACE2 for entry into cells. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt ( Vaccinated.us ) with promo code MicrobeTV Positions with the Mosquito and Vector Control Division in Harris County Public Health ( one and two ) Ancient eukaryotic viruses from permafrost (bioRxiv) We made a mistake (Science) Bat MERS-like CoV bind ACE2 (Nature) Letters read on TWiV 968 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Alto Saxophone: Paul Desmond/Cannonball Adderley/Charlie Parker/Randal Despommier: Paul Desmond: Signature album: Paul Desmond:The Complete RCA Victor Recordings (1961-1965). Signature song: Take Five (Dave Brubeck Quartet). Cannonball Adderley: Signature album: The Cannonball Adderley Quintet: Mercy, Mercy, Mercy . Signature song: Mercy, Mercy, Mercy . Charlie Parker (Bird): played in many groups: Signature album: Dizzy Gillespie and His Allstars . Signature song: A Night In Tunisia ; Randal Despommier: Signature album: A Midsummer Odyssey. Signature song : I Hope It’s Spring For You. Brianne
Sat, December 24, 2022
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses how immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection, prevalence of SARS-CoV-2 and influenza coinfection and clinical characteristics among children and adolescents aged Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Immunological dysfunction persists for 8 months following SARS-CoV-2 infection (Nature) Prevalence of SARS-CoV-2 and Influenza coinfection and clinical characteristics (CDC) WHO estimates of excess mortality associated with the COVID-19 pandemic (Nature) Reconsideration of anti-nucleocapsid IgG antibody as a marker of SARS-CoV-2 infection (OFID) Impact of SARS-CoV-2 v
Fri, December 23, 2022
1918 influenza with Jeffery Taubenberger
Vincent travels to the NIH campus to speak with Jeffery Taubenberger about his career, the 1918 influenza pandemic, deciphering the genome sequence of the virus from tissues of disease victims and using it to rescue infectious virus. Host: Vincent Racaniello Guest: Jeffery Taubenberger Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt ( Vaccinated.us ) with promo code MicrobeTV Influenza 1918 pandemic questions answered (Sci Transl Med) Reconstructed 1918 influenza virus (Science) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, December 18, 2022
Asking Esper Kallas for some I.D.
Brazilian infectious diseases physician Esper Kallas returns to TWiV to discuss the state of viral diseases in his country, including those cause by Zika, dengue, and yellow fever viruses, MPOX, and SARS-CoV-2. Hosts: Vincent Racaniello and Alan Dove Guest: Esper Kallas Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt ( Vaccinated.us ) with promo code MicrobeTV International Scientific Coordinator Position (agajewski at icsnicaragua.org for more info) Viral kinetics in sylvatic yellow fever (J Inf Dis) Safety and efficacy of Butanan-DV (Lancet Inf Dis) Immune responses to CoronaVac (Front Immunol) Timestamps by Jolene . Thanks! Weekly Picks Alan – A Voyage for Madmen Vincent – Some favorite holiday cookies: pignoli cookies and pfeffernusse Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, December 17, 2022
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses Dr. Griffin discusses progress toward poliomyelitis eradication in Afghanistan, reduced risk for Mpox after receipt of 1 or 2 doses of JYNNEOS vaccine compared with risk among unvaccinated persons, reduced airborne transmission of SARS-CoV-2 BA.1 Omicron virus in Syrian hamsters, authorized updated (Bivalent) COVID-19 vaccines for children down to 6 months of age, low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1, and XBB.1 by parental mRNA vaccine or a BA.5-bivalent booster, efficacy of antiviral agents against omicron subvariants BQ.1.1 and XBB, incidence of viral rebound after treatment with Nirmatrelvir-Ritonavir and Molnupiravir, and the effectiveness of coronavirus disease 2019 (COVID-19) vaccine in the prevention of post–COVID-19 conditions. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Progress toward Poliomyelitis eradication in Afghanistan (CDC) Reduced risk for Mpox after receipt of 1 or 2 Doses of JYNNEOS vaccine (CDC) Reduced airborne transmission of BA.1 Omicron virus in Syrian hamsters (PLOS) Authorized bivalent vaccines for children down to 6 months of age (FDA) Low neutralization of BA.2.75.2, BQ.1.1, and XBB.1 by parental mRNA vaccine (Nature) Efficacy of antiviral agents against Omicron subvariants BQ.1.1 and XBB (NEJM) Viral rebound after treatment with Nirmatrelvir-Ritonavir and Molnupiravir (JAMA) Paxlovid patient eligbiliity screening checklist (FDA) <a href= "https://www.cambridge.org/core/journals/antimicrobial-stewardship-and-healthcare-epidemiology/article/effectiveness-of-coronavirus-disease-2019-covid19-vaccine-in-the-pre
Wed, December 14, 2022
Feline coronavirus with Gary Whittaker
Vincent travels to Cornell University to speak with Gary Whittaker about regulation by proteolytic processing of the fusion activity of the spike protein of SARS-CoV-2, and feline coronavirus transmission, replication and disease. Hosts: Vincent Racaniello Guest: Gary Whittaker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode SARS-CoV-2 spike and its furin cleavage site (Lancet Microbe) TMPRSS2 inhibitor blocks SARS-CoV-2 reproduction (Nature) Distinct spike proteins of feline coronaviruses (Viruses) Feline coronavirus and feline infectious peritonitis (J Zoo Wild Med) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Mon, December 12, 2022
TWiV Special: Bivalent boosters with Paul Offit
Paul Offit returns to TWiV to discuss why the bivalent booster dosing story should be a cautionary tale of how not to move forward in this pandemic. Hosts: Vincent Racaniello and Rich Condit Guest: Paul Offit Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Antibody responses to bivalent booster (bioRxiv) Immunogenicity of bivalent vaccine (bioRxiv) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, December 11, 2022
Chiara Mingarelli takes the pulse of the universe
Astrophysicist Chiara Mingarelli joins TWiV to discuss her career and her work using pulse timing arrays to study the gravitational wave background, ripples in the fabric of spacetime that are caused by events such as the merging of black holes. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Angela Mingarelli Guest: Chirara Mingarelli Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt ( Vaccinated.us ) with promo code MicrobeTV International Scientific Coordinator Position (agajewski at icsnicaragua.org for more info) Seeing the gravitational wave universe (Science) Timestamps by Jolene . Thanks! Weekly Picks Angela – OpenAI Playground and Nature Milestones: T cells Chiara – The Biggest Ideas in the Universe by Sean Carroll Kathy – Recycling PVC and here and here Rich – Brome Bird Care Squirrel Buster Plus (Bonus pick: 1971 Volvo 142 Commercial – With John Cameron Swayze ) Vincent – Journey to the Microcosmos Intro music is by Ronald Jenkees Send your virology quest
Sat, December 10, 2022
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses Mpox (formerly monkeypox) in women: epidemiological features and clinical characteristics of mpox cases in Spain, April to November 2022, triage of patients with Ebola virus disease, SARS-CoV-2 serology and self-reported infection among adults, serological markers of SARS-CoV-2 infection; anti-nucleocapsid antibody positivity may not be the ideal marker of natural infection in vaccinated individuals, sensitivity of anti-SARS-CoV-2 nucleocapsid protein antibody for breakthrough infections during the epidemic of the Omicron variants, effect of wearing glasses on risk of infection with SARS-CoV-2 in the community, and data-driven identification of post-acute SARS-CoV-2 infection subphenotypes. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Mpox in women: Epidemiological features and clinical characteristics of cases (Eurosurveillance) Triage of patients with Ebola virus disease (The Lancet) SARS-CoV-2 serology and self-reported infection among adults (CDC) Serological markers of SARS-CoV-2 infection (JID) Sensitivity of anti-SARS-CoV-2 nucleocapsid protein antibody (Journal of infection) Effect of wearing glasses on risk of infection with SARS-CoV-2 in the community (JAMA) Paxlovid patient eligbiliity screening checklist (FDA) Data-driven identification of post-acute SARS-CoV-2 infection subphenotypes (Nature) Contribute to our MicrobeTV fundraiser at PWB Dr. Griffin’s treatment guide ( pdf) Letters read on TWiV 961 <
Sun, December 04, 2022
Getting funky with Dan Wilson
Dan Wilson of Debunk the Funk joins TWiV to explain why he decided to take on science misinformation and how he critiques people who promulgate incorrect information. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Brianne Barker Guest: Dan Wilson Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt ( Vaccinated.us ) with promo code MicrobeTV International Scientific Coordinator Position (agajewski at icsnicaragua.org for more info) Debunk the Funk (YouTube) Letters read on TWiV 960 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Jazz Project: InstrumentalTrumpet: Clifford Brown/Miles Davis/Winton Marsalis. Clifford Brown: Signature album: Study In Brown , Signature song: Sandu ; Miles Davis: Signature albums: Kind Of Blue; Sketches Of Spain; Porgy And Bess; Miles. Signature song: Time After Time . Wynton Marsalis: Signature album: Standard Time . Signature song: Do You Know What It Means To Miss New Orleans Brianne – Physicists Create a Wormhole Rich – Dec 1 APOD: Artemis 1 Flight Day 13 Vincent – An Ancient Language, Once on the Brink, Is a British Isle’s Talk of the Town Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, December 03, 2022
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses effectiveness of influenza vaccination of pregnant women for prevention of maternal and early infant Influenza-associated hospitalizations in South Africa, a multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes, single and 2-dose vaccinations with modified vaccinia Ankara-Bavarian Nordic induce durable B cell memory responses comparable to replicating smallpox vaccines, whether the risk of still and preterm birth is affected by the timing of symptomatic SARS-CoV-2 infection during pregnancy, medical masks versus N95 respirators for preventing COVID-19 among health care workers, alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants, real-world evidence of novel treatments for COVID-19 on mortality: a nationwide comparative cohort study of hospitalized patients in the 1 st , 2 nd , 3 rd and 4 th wave in the Netherlands, and effectiveness and safety of extended thromboprophylaxis in post-discharge patients with COVID-19. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Effectiveness of Influenza vaccination in pregnant women (OFID) Multivalent nucleoside-modified mRNA vaccine against Influenza subtypes (Science) Single and 2-dose vaccinations with modified vaccinia Ankara-Bavarian Nordic (JID) Is the risk of still and preterm birth affected by the timing of symptomatic SARS-CoV-2 infection ? (AJOG) Medical masks versus N95 respirators for preventing COVID-19 among health care workers (ACP) Bebtelovimab fact sheet for providers (FDA) Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants (bioRxiV) Paxlovid patient eligbiliity screening checklist (FDA) Real-world evidence of <a href=
Sun, November 27, 2022
Pass the RNA and have some venison pi
The TWiV team reveals a variant SARS-CoV-2 that emerged in deer with deer-to-human transmission, and hybrid virus particles produced by co-infection with influenza virus and respiratory syncytial virus particles. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt ( Vaccinated.us ) with promo code MicrobeTV Testing and evaluation specialist (Harris County Public Health) Oveta Fuller tribute (YouTube) Divergent SARS-CoV-2 in deer (Nat Micro) Hybrid influenza virus and respiratory syncytial virus particles (Nat Micro) Letters read on TWiV 958 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Jazz Project: Vocals Best female vocalists: Ella Fitzgerald/Billie Holiday, Betty Carter Best Male Vocalists: Mel Tormé/Joe Williams/Tony Bennett Brianne – ASV Curriculum Guidelines for Virology Courses Kathy – The Snow Cruiser Alan – Rescuing bats in Ukraine Vincent – Woodpeckers: The Hole Story PBS Listener Picks Florencia – W
Sat, November 26, 2022
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses human monkeypox virus infection in women and non-binary individuals during the 2022 outbreaks, changes in population immunity against infection and severe disease from SARS-CoV-2 Omicron variants in the United States, updates on COVID-19–related mortality, impact of community masking on COVID-19, effectiveness of the COVID-19 vaccines against hospitalization with Omicron sub-lineages BA.4 and BA.5 in England, cardiovascular outcomes after Tixagevimab and Cilgavimab use for pre-exposure prophylaxis against COVID-19, how Paxlovid is associated with decreased hospitalization rate among adults with COVID-19, inside the mind of an anti-paxxer, and angiotensin receptor blockers for the treatment of COVID-19. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Human monkeypox virus infection in women and non-binary individuals (The Lancet) Changes in population immunity against infection and severe disease from variants (Medrxiv) Updates on COVID-19 related mortality (CDC) Impact of community masking on COVID-19 (Science) Effectiveness of the COVID-19 vaccines against hospitalization (The Lancet) Cardiovascular outcomes after tixagevimab and cilgavimab use for pre-exposure prophylaxis (CID) Bebtelovimab fact sheet for providers (FDA) Paxlovid associated with decreased hospitalization among adults (CDC) Inside the mind of an <a href= "https://www.theatlantic.com/health/archive/2022/11/paxlovid-covid-drug-hesita
Sun, November 20, 2022
A domesticated viral envelope with Cedric Feschotte and John Anthony Frank
Cedric and John join TWiV to discuss their research showing that a human protein derived from an ancient retrovirus infection can protect against infection by other retroviruses. Hosts: Vincent Racaniello , Rich Condit , and Kathy Spindler Guest: Cedric Feschotte and John Anthony Frank Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt ( Vaccinated.us ) with promo code MicrobeTV Cedric on TWiV 935 Antiviral retroviral protein (Science) Stealing genes , facing consequences (Science) Letters read on TWiV 956 Timestamps by Jolene . Thanks! Weekly Picks Kathy – Wastewater Dashboard Rich – Artemis I Mission ; Artemis I launch ; Artemis I Map Vincent – Pasta Grammar Listener Picks Rich – Watch a virus in the moments before it attacks Justin –
Sat, November 19, 2022
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses the four things to know about RSV, the burden of respiratory syncytial virus in healthy term-born infants in Europe, the diagnostic accuracy of rapid diagnostic tests for Ebola virus disease, evaluating the accuracy of self-collected swabs for the diagnosis of monkeypox, tecovirimat is effective against human monkeypox virus in vitro at nanomolar concentrations, acute and postacute sequelae associated with SARS-CoV-2 reinfection, clinical course of SARS-CoV-2 infection and recovery in lung transplant recipients, effectiveness of a third BNT162b2 mRNA COVID-19 vaccination during pregnancy, maternal antibody response and transplacental transfer following SARS-CoV-2 infection or vaccination in pregnancy, impact of community masking on COVID-19, Lifting Universal Masking in Schools – Covid-19 Incidence among Students and Staff, systematic review of the clinical effectiveness of Tixagevimab/Cilgavimab for prophylaxis of COVID-19 in immunocompromised patients, comparative effectiveness of sotrovimab and molnupiravir for prevention of severe COVID-19 outcomes in patients in the community, early adoption of anti–SARS-CoV-2 pharmacotherapies among us veterans with mild to moderate COVID-19, evaluation of viral and symptom rebound differences between Paxlovid and untreated COVID-19 participants, monoclonal antibodies for treatment of SARS-CoV-2 infection during pregnancy, twice daily oral zinc in the treatment of patients with COVID-19, cognitive deficits in long Covid-19, severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration, and long-lasting symptoms after an acute COVID-19 infection and factors associated with their resolution. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Four things to know about RSV (Gates Foundation) The burden of RSV in healthy term-born infants in Europe (The Lancet) Diagnostic accuracy of rapid tests for Ebola (CMI) Accuracy of self-collected swabs for diagnosis of <a href= "https://academic.oup.com/cid/advance-art
Sun, November 13, 2022
Speculating sarbecovirus spillovers with Michael Letko
Michael Letko joins TWiV to discuss his research on understanding cell receptors required for sarbecovirus entry, including an ACE2-dependent isolate from Russian bats that is resistant to vaccine-induced antibodies. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , Kathy Spindler , and Brianne Barker Guest: Michael Letko Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt ( Vaccinated.us ) with promo code MicrobeTV Cell entry of SARS-CoV-2 and other sarbecoviruses (Nat Micro) ACE2-dependent sarbecovirus in Russian bats (PLoS Path) Letters read on TWiV 954 Timestamps by Jolene . Thanks! Weekly Picks Brianne – Sometimes This Octopus is So Mad it Just Wants to Throw Something or The Cosmic Bat Nebula Kathy – APODs Jupiter , Lunar Eclipse Blood Moon, Ice Giant Rich – Mirror-image T7 transcription of chirally inverted ribosomal and functional RNAs ( Wiki: Mirror Life ) Vincent – The 2022-2023 Respiratory Virus Season Hits Early and Hard: Part 1 <
Sat, November 12, 2022
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses high demand for Amoxicillin causing shortages amid child RSV surge, epidemiologic and clinical features of children and adolescents aged Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode High demand for Amoxicillin causing shortages amid RSV surge (Washington Post) Epidemiologic and clinical features of children & adolescents with monkeypox (CDC) Low risk of SARS-Cov2 transmission by fomites (IDSA) Nucleocapsid Antigenemia Is a marker of acute SARS-CoV-2 Infection (JID) Impact of community masking on COVID-19 (Science) Remdesivir fact sheet for providers (Veklury) Protection against Omicron from vaccination & previous infection in prison system (NEJM) Nirmatrelvir and the risk of post-acute sequelae of COVID-19 (medRxiv) <l
Sun, November 06, 2022
Jake Scott put the ID in COVID-19
Infectious Disease physician Jake Scott joins TWiV to provide a west coast clinical perspective on the evolution of the COVID-19 pandemic with respect to the impact of vaccines, antivirals, variants of concern and mortality. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Guest: Jake Scott Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt ( Vaccinated.us ) with promo code MicrobeTV Omicron variant reproduction ex vivo (Nature) Clinical outcomes with Omicron (Nat Med) Low neutralizing antibodies induced by bivalent booster (NEJM) Antibody responses to bivalent booster (bioRxiV) Spike T cell responses not enhanced by bivalent booster (Sci Immunol) Pandemic end will not be televised (BMJ) Conflation of infection and disease (Twitter) Timestamps by Jolene . Thanks! Weekly Picks Kathy – 10 moments for Jazz at Lincoln Center Orchestra Residency (Item 7) and Alan’s pick from TWiV 931 The Kissing Bug by Daisy Hernandez Rich – <a href= "https://wilderness-safaris.com/photo-compe
Sat, November 05, 2022
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses Influenza incidence and vaccine effectiveness during the southern hemisphere influenza season in Chile, Nirsevimab for prevention of RSV infection in healthy late-preterm and term infants, severe Monkeypox in hospitalized patients, reinfections with different SARS-CoV-2 Omicron subvariants, impact of community masking on COVID-19 in Bangladesh, unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses, antibody responses to Omicron BA.4/BA.5 bivalent mRNA vaccine booster shot, immunogenicity of bivalent mRNA vaccine boosters, long-term gastrointestinal sequelae following COVID-19, evaluation of an automated text message–based program to reduce use of acute health care resources after hospital discharge, and how in adults with COVID-19, melatonin was assessed for effects on inflammatory markers, clinical signs and symptoms, and mortality. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Influenza incidence and vaccine effectiveness (CDC) Nirsevimab for prevention of RSV (NEJM) Severe Monkeypox in hospitalized patients (CDC) Reinfections with different SARS-CoV-2 Omicron subvariants (CDC) Impact of community masking on COVID-19 (Science) Vaccine elicits protective immunity against sarbecoviruses (Science) Antibody responses to <a href= "https://www.biorxiv.org/content/10.1101/2022
Sun, October 30, 2022
Prion diseases with Richard Knight
From the European Society for Clinical Virology 2022 Conference in Manchester UK, Vincent speaks with Richard Knight about prion diseases and the outbreak of bovine spongiform encephalitis that led to cases of variant Creutzfeldt-Jakob disease in humans. Host: Vincent Racaniello Guest: Richard Knight Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode National CJD Research and Surveillance Unit Clinical diagnosis of human prion disease (Prog Mol Biol Trans Sci) Variant Creutzfeldt-Jakob disease (Handbook Clin Viral) Creutzfeldt-Jakob disease (Adv Exp Med Biol) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, October 29, 2022
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses progress toward poliomyelitis eradication in Pakistan, polio by the numbers , influenza and COVID-19 vaccination coverage among health care personnel, phase 1/2a safety and immunogenicity of an adenovirus 26 vector RSV vaccine encoding prefusion F in adults 18–50 years and RSV seropositive children 12–24 months, receipt of first and second doses of JYNNEOS vaccine for prevention of Monkeypox, distinguishing SARS-CoV-2 persistence and reinfection, Novavax NVX-COV2373 triggers potent neutralization of Omicron sub-lineages, association between regular physical activity and the protective effect of vaccination against SARS-CoV-2 in a South African case, COVID-19 outcomes in solid organ transplant recipients who received Tixagevimab-cilgavimab Prophylaxis and/or Bebtelovimab treatment, Omicron sublineage BA.2.75.2 exhibits extensive escape from neutralizing antibodies, and Tocilizumab versus Baricitinib in hospitalized patients with severe COVID-19. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Progress toward Poliomyelitis eradication (CDC) Polio by the numbers (JID) Influenza & COVID-19 vaccination coverage among health care personnel (CDC) Phase 1/2a Safety & Immunogenicity of an adenovirus RSV Vaccine (JID) Receipt of first & second doses of JYNNEOS vaccine (CDC) <a href= "https://academic.oup.com/cid/advance-article/doi/10.1093/cid/
Sun, October 23, 2022
Breathless with David Quammen
David Quammen returns to TWiV to discuss how he wrote his new book ‘Breathless’, a story about the science and the scientists behind the race to understand the pandemic coronavirus SARS-CoV-2. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Guest: David Quammen Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Boston Quammens ( TWiV 408 ) Breathless by David Quammen Spillover by David Quammen Song of the Dodo by David Quammen Timestamps by Jolene . Thanks! Weekly Picks David – Shepherd Brianne – Adventure Aquarium Kathy – DART results ( Narrative , images ) Rich – “Elementary” TV series Vincent – Stop passing the buck on intro science Listener Pick Rich – Consensus Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, October 22, 2022
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses the prediction of upcoming global infection burden of influenza seasons after relaxation of public health and social measures during the COVID-19 pandemic, severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters, and how successful immunomodulators for treatment of COVID-19 have opened the pathway for comparative trials. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt at Vaccinated.US Prediction of upcoming global infection burden of Influenza (The LANCET) Severe COVID-19 outcomes after full vaccination (The LANCET) Successful immunomodulators for treatment of COVID-19 (CMI) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) PAXLOVID patient eligibility screening checklist (FDA) Dr. Griffin’s treatment guide ( pdf ) Contribute to Floating Doctors fundraiser at PWB Letters read on TWiV 947 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Sun, October 16, 2022
Poo versus flu
Angela Mingarelli joins TWiV to discuss whether the gut microbiota of bats confers tolerance to influenza virus infection in mice, and primate hemorrhagic fever-causing arteriviruses that can reproduce in human cells and might be capable of infecting humans. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guest: Angela Mingarelli Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Research assistant position at FDA ( pdf ) Support MicrobeTV with a Spike t-shirt ( Vaccinated.us ) Bat gut microbiota and flu infection in mice (Transbound Emerg Dis) Primate hemorrhagic fever-causing arteriviruses (Cell) Timestamps by Jolene . Thanks! Weekly Picks Dickson – Jazz pics: #5. Small group. Art Blakey and the Jazz Messenger: Art Blakey, Drums; Lee Morgan, Trumpet; Benny Golson, Tenor saxophone; Bobby Timmons, Piano; Jymie Merrit, Bass (1958-1964). Signature album: Art Blakey And The Jazz Messengers: Blues March: Signature song: Blues March Brianne – Why Chimps and Gorillas Form Rainforest Friendships Rich – Fly Water – FPV to New Depths Alan – The Seven Words You Can’t Say on Television , by George Carlin, and its repercussions Angela – Nature’s Inspiring Women in Science Award Vincent
Sat, October 15, 2022
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses a healthcare-associated infection with Monkeypox virus, air and surface sampling for monkeypox virus in a UK hospital, misrepresentation and nonadherence regarding COVID19 public health measures, tolerability and immunogenicity of an intranasally-administered adenovirus-vectored COVID-19 vaccine, clinical, virologic, and immunologic evaluation of symptomatic rebound following Nirmatrelvir/Ritonavir treatment, early outpatient treatment with Eemdesivir in patients at high risk for severe COVID-19, Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes, and outcomes among confirmed cases and a matched comparison group in the long-COVID in Scotland. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Research assistant position with Amy Rosenfeld ( pdf ) Support MicrobeTV with a Spike t-shirt at Vaccinated.US A healthcare-associated infection with monkeypox virus (OFID) Air and surface sampling for monkeypox virus (The Lancet) Misrepresentation & nonadherence in COVID-19 public health measures (JAMA) Tolerability and immunogenicity of a COVID-19 vaccine (The Lancet) PAXLOVID patient eligibility screening checklist (FDA) Evaluation of symptomatic disease rebound following PAXLOVID (CID) Outpatient treatment with Remdesivir in patients at high risk (OFID) <a href= "https://www.vekluryhcp.com/?utm_id=iw_sa_11453738585_111635246813&utm_medium=cpc&u
Sun, October 09, 2022
Hacking through Borneo with Kathryn Hanley
Kathryn Hanley joins TWiV to discuss her career and the research in her laboratory on the molecular biology, evolution and ecology of emerging RNA viruses and their insect vectors. Hosts: Vincent Racaniello , Rich Condit , and Kathy Spindler Guest: Kathryn Hanley Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Research assistant position at FDA ( pdf ) Support MicrobeTV with a Spike t-shirt ( Vaccinated.us ) One bite is all it takes ( TWiV 587 ) CREATE-NEO Shifts in Borneo mosquito diversity (Ecosphere) VSV surveillance along Rio Grande (PLoS Path) Virulence a trade-off between transmission and clearance (Viruses) West Nile virus disease indicators (Viruses) Identify mosquito meals by barcoding (Trop Med Inf Dis) SkitoSnack (Sci Rep) Neal Nathanson dies (Baltimore Sun) VRR interview with Neal Nathanson (YouTube) Letters read on TWiV 944 Timestamps by Jolene . Thanks! Weekly Picks Kathy – Car Talk Puzzler Archive Rich – The Molecular Biologist Who Exposed the Soviet U
Sat, October 08, 2022
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses high points of the multi-national monkeypox outbreaks, monkeypox virus genome mutations, possible occupational infection of healthcare workers with monkeypox virus, rates of monkeypox cases by vaccination status, protection of SARS-CoV-2 infection against reinfection, Paxlovid significantly reduces COVID-19 hospitalizations and deaths, and rebound in COVID19 with and without Paxlovid treatment. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Research assistant position with Amy Rosenfeld ( pdf ) Support MicrobeTV with a Spike t-shirt at Vaccinated.US Multi-National Monkeypox outbreak (CDC) Mutation of the Monkeypox Virus (Nature) Occupational infection of Healthcare workers with Monkeypox (CDC) Rates of Monkeypox cases by vaccination status (CDC) Protection of SARS-CoV-2 natural infection against reinfection (CMI) PAXLOVID patient eligibility screening checklist (FDA) Paxlovid reduces COVID19 hospitalizations & deaths (EPIC) Paxlovid rebound in COVID19 (NEJM) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for provider
Tue, October 04, 2022
Public Health with Laurie Garrett: Wastewater Testing
Laurie Garrett discusses the role of wastewater testing in public health and her idea of a device that could be used by anyone to analyze water samples. This podcast is not an episode of TWiV, but I thought it would be of interest to listeners. Laurie Garrett and Vincent Racaniello Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt ( Vaccinated.us ) Coliform testing of water in Florida (YouTube) Declining cost of genome sequencing (Illumina) National wastewater surveillance system (CDC) Advances in detection of viruses in wastewater (Med Express) Wastewater monitoring comes of age (Nature) Monitoring monkeypox virus in wastewater (Med Express) Poliovirus wastewater surveillance in NY (Dept of Health) Wastewater surveillance in NYS (Dept of Health) Estimating norovirus infections through wastewater (Water Res) Estimating antimicrobial resistant bacteria through latrine water (Antimicro Res Inf Control) Intro music is by Ronald Jenkees Send your questions and comments to twiv@microbe.tv
Sun, October 02, 2022
Omicron boosters with Paul Offit
Paul Offit returns to TWiV for a discussion of SARS-CoV-2 bivalent boosters containing ancestral and Omicron spike mRNAs, including their composition, why they are being recommended by CDC, and who would benefit the most from them. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , Kathy Spindler , and Brianne Barker Guest: Paul Offit Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Research assistant position at FDA ( pdf ) Support MicrobeTV with a Spike t-shirt ( Vaccinated.us ) CDC oversells bivalent booster (Wall St Journal) FDA authorizes bivalent COVID-19 booster Letters read on TWiV 942 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Jazz favorites: Small group #4: Gerry Mulligan Quartet with Chet Baker: Gerry Mulligan, Baritone saxophone; Carson Smith, Bass; Larry Bunker, Drums, Chet Baker, Trumpet. Signature album: The Best Of The Gerry Mulligan Quartet With Chet Baker : Signature song: My Funny Valentine . Second pick: Wonder: Childhood and the Lifelong love of Science . Frank C. Keil. Brianne – A Devious Cellular Trick Cancers Can Use to Escape Your Immune Syst
Sat, October 01, 2022
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses increased acute respiratory illnesses among children and adolescents, estimates of monkeypox incubation period, generation time, and reproduction number, rapid increase in suspected SARS-CoV-2 reinfections, interim infection prevention and control recommendations for healthcare personnel during COVID-19, SARS-CoV-2 secondary attack rates in vaccinated and unvaccinated household contacts during replacement of delta with omicron variant, breakthrough infection by SARS-CoV-2 delta and omicron variants elicited immune response comparable to mRNA booster vaccination, interval between prior SARS-CoV-2 infection and booster vaccination impacts magnitude and quality of antibody and B cell responses, further humoral immunity evasion of emerging SARS-CoV-2 BA.4 and BA.5 subvariants, short-course early outpatient Remdesivir prevents severe disease due to COVID-19 in organ transplant recipients during the Omicron BA.2 wave, effectiveness of Molnupiravir in high risk patients, and primary care and a distinct symptom pattern for long COVID. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Research assistant position with Amy Rosenfeld ( pdf ) Support MicrobeTV with a Spike t-shirt at Vaccinated.US Increase in Acute Respiratory illnesses among children and adolescents (CDC) Estimates of Monkeypox incubation period , generation time, reproduction number (CDC) Rapid increase in suspected SARS-CoV-2 reinfections (CDC) Infection pre
Wed, September 28, 2022
Eddie Holmes in on viral origins
Eddie Holmes joins TWiV to discuss his role in the first release of the SARS-CoV-2 genome sequence, what really happened during the infamous Fauci teleconference, and evidence that the virus came from Nature and not from a lab. Hosts: Vincent Racaniello and Dickson Despommier Guest: Eddie Holmes Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Research assistant position at FDA ( pdf ) Support MicrobeTV with a Spike t-shirt ( Vaccinated.us ) Novel 2019 coronavirus genome (Virological) Proximal origins of SARS-CoV-2 ( Virological and Nature versions) Original paper on new CoV in China that led to genome sequence release (Nature) Reporting on Fauci teleconference (USA Today) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, September 25, 2022
From lizards to Lassa with Tom Monath
Tom Monath joins TWiV to discuss his wide-ranging career that includes medicine, field work and vaccine development while working for the US government, the US military, and multiple biotechnology companies. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Rich Condit Guest: Tom Monath Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Research assistant position at FDA ( pdf ) Support MicrobeTV with a Spike t-shirt ( Vaccinated.us ) Fever by John Fuller (Amazon) Crozet BioPharma Timestamps by Jolene . Thanks! Weekly Picks Dickson – Jazz – Small Group #3: Dave Brubeck Quartet. Dave Brubeck, Piano; Joe Morello, Drums, Paul Desmond, Alto Saxophone, Eugene Wright, Bass: Signature Album: Time Out. Signature Song: Take Five . Rich – Wilderness Safaris ( wiki ) Alan – Madhouse at the End of the Earth , by Julian Sancton Vincent – Raymond Chandler and his protagonist Philip Marlowe. Listener Picks Philip – Students bitten by bats inside college residence hall Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, September 24, 2022
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin reviews the public health response to poliovirus in New York, impact of mandatory influenza vaccination, monkeypox in a young infant, health care worker exposure to monkeypox virus, monkeypox testing delays, transmission potential of monkeypox virus, TPOXX trial for monkeypox, detection of SARS-CoV-2 subgenomic mRNA, mucosal IgA against SARS-CoV-2, BNT262b2 against Omicron, awareness and use of SARS-CoV-2 antivirals, comparable outcomes for Bebtelovimab and Nirmatrelvir, and COVID-19 and Alzheimer's disease. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support MicrobeTV with a Spike t-shirt at Vaccinated.US Research assistant position with Amy Rosenfeld ( pdf ) Public health response to polio in New York (MMWR) Impact of mandatory influenza vaccination (Cambridge Core) Monkeypox in young infant (MMWR) Health care worker exposure to monkeypox virus (MMWR) Monkeypox <a href= "https://www.cambridge.org/core/journals/infection-control-and-hospital-epidemiology/article/monkeypox-testing-delays-the-need-for-drastic-expansion-of-education-and-testing-for-monkeypox-virus/72690C69D7FD2C4EC9994AF79D6FDF85?utm_source=SFMC&%3Butm_medium=email&%3Butm_content=Article&%3Butm_campaign=New%2520Cambridge%2520Aler
Sun, September 18, 2022
Pediatric hepatitis with Emma Thomson
From the European Society for Clinical Virology 2022 Conference in Manchester UK, Vincent speaks with Emma Thomson about the recent outbreak of pediatric hepatitis of unknown etiology and the finding that it is linked to infection by adenovirus-associated virus 2. Hosts: Vincent Racaniello Guest: Emma Thomson Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Thomson laboratory Emma on TWiV 188 and TWiV 341 AAV2-associated pediatric hepatitis (bioRxiv) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, September 17, 2022
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses detection of a highly divergent type 3 vaccine-derived poliovirus in a child with a severe primary immunodeficiency disorder, severe respiratory illnesses associated with rhinoviruses and/or enteroviruses including EV-D68, effects of vaccination and previous infection on Omicron infections in children, COVID-19-associated hospitalizations among vaccinated and unvaccinated adults 18 years or older in 13 US states, effectiveness of COVID-19 vaccines over time prior to Omicron emergence in Ontario, Canada, nasal IgA wanes 9 months after hospitalization with COVID-19 and is not induced by subsequent vaccination, resistance of SARS-CoV-2 Omicron subvariant BA.4.6 to antibody neutralization, persistent circulating SARS-CoV-2 spike associated with post-acute COVID-19 sequelae, and impact of COVID-19 vaccination on the risk of developing long-covid and on existing long-covid symptoms. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Detection of poliovirus in immunosuppressed child (CDC) Severe respiratory illnesses associated with rhinoviruses and/or enteroviruses (CDC) Effects of vaccination and previous Omicron infection in children (NEJM) COVID-19 hospitalizations among vaccinated and unvaccinated adults (JAMA) Effectiveness of vaccines prior to Omicron (IDSA) Nasal iga wanes 9 months after COVID hospitalization (medRxiv) Resistance of Omicron subvariant to antibody neutralization (BioRxiv) PAXLOVID patient eligibility screening checklist (FDA) <a href= "https://www.vekluryhcp.com/?utm_id=iw_sa_11453738585_111635246813&utm_medium=cpc&utm_term=medicine+remdesivir&gclid=CjwKCAjwj42UBhAAEiwACIhADocodyE-OQCnF5PXs6x5nuFnH230Tc-4V3iFulmtEoxHgYAY1Tr
Sun, September 11, 2022
Mobile DNA with Cedric Feschotte
Vincent travels to Cornell University to speak with Cedric about his career and his research on mobile genetic elements such as transposons and endogenous viruses and how they have shaped the evolution of nearly all organisms. Hosts: Vincent Racaniello Guest: Cedric Feschotte Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Feschotte laboratory Field guide to transposable elements (Ann Rev Genetics) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, September 10, 2022
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses variant influenza virus infections: recommendations for identification, treatment, and prevention for summer and fall 2022, low levels of monkeypox virus neutralizing antibodies after MVA-BN vaccination in healthy individuals, using the right tools at the right time for SARS-COV-2 infection, onset and window of SARS-COV-2 infectiousness and temporal correlation with symptom onset, transmission of SARS-COV-2: a review of viral, host, and environmental factors, antibody persistence and safety through 6 months after heterologous orally aerosolized Ad5-nCoV in individuals primed with two-dose vaccine, timely administration of tocilizumab improves outcome of hospitalized COVID-19 patients, administration of anti–SARS-COV-2 monoclonal antibodies after US Food and Drug Administration deauthorization, and clinical and genetic risk factors for acute incident venous thromboembolism in ambulatory patients with COVID-19. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode 2022 recommendations for Influenza infections (CDC) Low levels of monkeypox neutralizing antibodies after vaccination (medRxiv) Using the right tools during SARS-CoV-2 infection (ESMED) Onset and window of SARS-CoV-2 infectiousness with symptom onset (The LANCET) Transmission of SARS-COV-2 (ACP Journals) PAXLOVID patient eligibility screening checklist (FDA) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) Administration of anti–SARS-COV-2 <a href= "https://jamanetwork.com/journals/ja
Sun, September 04, 2022
Island-hopping bats
TWiV discusses a new henipavirus from fruit bats in Madagascar, and attenuation of SARS-CoV-2 Omicron disease in mice caused by genome mutations outside of the spike protein coding region. Hosts: Vincent Racaniello , Dickson Despommier , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Research assistant position at FDA (pdf) Beijerinck virology prize (KNAW) Nipah virus vaccine ( TWiV 618 ) Novel henipavirus from Madagascar (J Viral) Spike-independent Omicron attenuation in mice (Cell Rep) Letters read on TWiV 933 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Small groups: 3. Modern Jazz Quartet. Signature song: Skating in Central Park . Signature album: Django . Brianne – To Prevent a Martian Plague, NASA Needs to Build a Very Special Lab Kathy – Physics Girl – Overnight in the Most Remote Camp on Earth Vincent – Lab leaders wrestle with paucity of postdocs Listener Picks Gary – Stan Kenton Orchestra Miguel – Microsoft Premonition Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, September 03, 2022
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses vaccine effectiveness against influenza illness in children, clinical manifestations of infection with poliovirus, spike protein-independent attenuation of SARS-CoV-2 Omicron variant in laboratory mice, concordance of SARS-CoV-2 results in self-collected nasal swabs vs swabs collected by health care workers in children and adolescents, probable animal-to-human transmission of SARS-CoV-2 causing a pet shop-related outbreak, laboratory-confirmed COVID-19–associated hospitalizations among adults during BA.2 variant, SARS-CoV-2 specific T-cells and antibodies, Nirmatrelvir use and outcomes during the Omicron surge, real-world effectiveness of early Molnupiravir or Nirmatrelvir–ritonavir in hospitalized patients, and distinguishing features of long COVID. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Vaccine effectiveness against Influenza illness in children (CID) Clinical manifestations of infection with Polio (JAMA) Characteristics of deaths among fully vaccinated persons with Coronavirus (CID) Spike protein attenuation of Omicron Variant in lab mice (Cell Reports) Concordance of SARS-CoV-2 results in nasal swabs self-collected vs healthcare collected (JAMA) Probable animal-to-human transmission of Sars-Cov-2 (CID) PAXLOVID patient eligibility screening checklist (FDA) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) COVID-19–associated hospitalizations
Sun, August 28, 2022
Driven to immunodistraction
TWiV reviews the genetic characterization of a new strain of type 2 oral polio vaccine and its implications for eradication, and how a polymorphism in humans comprising a single amino acid change in an antibody molecule regulates vaccine elicitation of broadly neutralizing antibodies against influenza virus HA. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Characterization of novel OPV2 from humans (MMWR) Engineering nOPV2 (TWiV 756) Genome sequence of Rockland County NY OPV2 isolate (Genbank) Allelic polymorphism and vaccine induction of influenza virus bnAbs (Immunity) Letters read on TWiV 931 Timestamps by Jolene . Thanks! Weekly Picks Dickson - Small groups: 1. Miles Davis Quintet. Signature album: Kind Of Blue . Signature song: So What . Brianne - World Excel Championships Kathy - L yre bird background and video Alan – <a hr
Sat, August 27, 2022
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses antibody response against nonpoliovirus enteroviruses, clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain, object and surface contamination with monkeypox virus, monkeypox virus infection in humans across 16 countries, clinical characteristics of ambulatory and hospitalized patients with monkeypox virus infection, compassionate use of Tecovirimat for the treatment of monkeypox infection, monitoring of Pfizer-BioNTech vaccine among children, Pfizer and BioNTech announce updated vaccine data supporting efficacy in children, direct capture of neutralized RBD enables rapid point-of-care assessment of SARS-CoV-2 neutralizing antibody titer, Pfizer and BioNTech submit application for bivalent vaccine, and Oral Nirmatrelvir and Ritonavir in non-hospitalized vaccinated patients with COVID-19. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Antibody response against nonpoliovirus enteroviruses (ASM) Clinical presentation of Monkeypox cases in Spain (The Lancet) Object and surface contamination with Monkeypox virus infection (CDC) Environmental persistence of Monkeypox virus (Emerg Inf Dis) Monkeypox virus infection across 16 countries (NEJM) Clinical characteristics of hospitalization patients with Monkeypox (CMI) Usage of Tecovirimat for treatment of Monkeypox infection (JAMA) PAXLOVID patient eligibility screening checklist (FDA) Remdesivir fact sheet for
Sun, August 21, 2022
Empathyology with Andy Slavitt
Andy Slavitt joins TWiV to discuss his book, Preventable and how failures in leadership, politics, and selfishness doomed the U.S. response to SARS-CoV-2. Hosts: Vincent Racaniello , Dickson Despommier , Kathy Spindler , and Brianne Barker Guest: Andy Slavitt Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode In the Bubble podcast Preventable (Amazon) Letters read on TWiV 929 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Best big band #5: 1. Glenn Miller’s Orchestra -1940-1944: Signature song: In The Mood. Signature album: An Album Of Outstanding Arrangements Brianne – Cross-stitched Microbes Kathy – Time trials for bottle emptying Alan – Meow Parlor Vincent – VIRUS x1,000,000 (2022) by Drew Berry wehi.tv Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, August 20, 2022
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses the public health response to a polio case in a unvaccinated NY state resident, human to dog transmission of monkeypox virus, Tecovirimat and the treatment of monkeypox, detection of asymptomatic monkeypox virus infections among male sexual health clinic attendees in Belgium, what to do if you are exposed to SARS-CoV-2 and isolation and precautions for people with COVID-19, risk of SARS-CoV-2 infection in health care workers, effectiveness of HEPA filters at removing infectious SARS-CoV-2 from the air, Pfizer reports additional data on Paxlovid, hospitalization encounters for infection after Paxlovid, a randomized trial of Metformin, Ivermectin, and Fluvoxamine, and readmissions, post-discharge mortality and sustained recovery among patients admitted to hospital with COVID-19. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Response to Polio case in an unvaccinated person in New York (CDC) Human to dog transmission of Monkeypox virus (The Lancet) Tecovirimat for the treatment of Monkeypox (NEJM) Detection of asymptomatic Monkeypox among Belgian men (Nature Medicine) Exposure to disease and precautions (CDC) Risk of infection in healthcare workers (JAMA) Effectiveness of HEPA filters (ASM) PAXLOVID patient eligibility screening checklist (FDA) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) Pfizer
Sun, August 14, 2022
Merchlinsky vs monkeypox
Michael Merchlinsky joins TWiV to discuss the development of two smallpox antiviral drugs and two smallpox vaccines and their uses during the monkeypox outbreak. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Kathy Spindler Guest: Michael Merchlinsky Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Michael on Anything but academic ( TWiM 145 ) Development of Tecoviromat (TPOXX) (Antiviral Res) Use of Jynneos vaccine (MMWR) Limitations of Tecoviromat (NEJM) Poliovirus in NYC wastewater (NY Times) Letters read on TWiV 927 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Duke Ellington and his Orchestra. Signature song: Take The A Train ; Signature album: Black, Brown, And Beige and Herding Cats: Harlem 1958 Kathy – How the US Postal Service reads terrible handwriting Rich – JWST/chorizo gag Vincent – Bat Conservation Trust Listener Picks Bill – The End of Manual Transmission
Sat, August 13, 2022
Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses guidance for prevention and treatment of monkeypox, post-infectious symptoms among children and adolescents, profiling post-infectious syndromes of different variants, comparison of vaccine Ankara vs intradermal routes of administration, infection in vaccinated individuals treated with or without PAXLOVID, duration of symptoms with positive rapid antigen after infection, epidemiologic characteristics of monkeypox, and sequelae of post-acute infection. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Guidance for prevention & treatment of Monkeypox (CDC) Post-infection symptoms among children and adolescents (CDC) Profiling post-infection syndromes in different variants (medRxiv) Comparison of vaccinia Ankara (MVA) vs intradermal routes of administration (NIH) PAXLOVID patient eligibility screening checklist (FDA) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) Infection in vaccinated individuals treated with or without PAXLOVID (medRxiv) Duration of symptoms with positive rapid antigen after infection (J Virological Methods) Epidemiologic characteristics of Monkeypox (CDC) Sequelae of post-acute
Sun, August 07, 2022
First kisses and second doses
TWiV discusses monkeypox virus, poliovirus in NY, Marburg virus in Ghana, ancient herpes simplex virus type 1 genomes, and immunogenicity of different combinations of SARS-CoV-2 vaccines. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode How monkeypox virus spreads (CDC) Vaccination against monkeypox virus (CDC) Monkeypox case trends (CDC) Polio in New York State (NY Dept of Health) Poliovirus in NY wastewater (NBC New York) Marburg disease in Ghana (WHO) Ancient herpesvirus genomes (Sci Adv) Combinations of SARS-CoV-2 vaccines (Cell Rep Medicine) Timestamps by Jolene . Thanks! Weekly Picks Brianne – Everyone Loses on Jeopardy Eventually Kathy – Climate spiral followed by Carl Sagan Rich – Most Popular Desktop Browsers 1993 – 2022 Alan – <a href= "https://alandove.itch.io
Sat, August 06, 2022
TWiV clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses Tecovirimat for treatment of monkeypox, the safety and acceptance of vaccination after multisystem inflammatory syndrome, variants in solid organ transplant recipients, masks for prevention of respiratory virus infections, pre-exposure prophylaxis with Evusheld, the association between Evusheld administration and infection, if repeat administration of casirivimab and imdevimab is well-tolerated, viral and symptom rebound in untreated infection, extended Remdesivir infusion for persistent infection, Baricitinib in patients admitted with infection, and cognitive impairment 13 months after hospitalization. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Armchair Expert with Malcolm Gladwell Tecovirimat for treatment of monkeypox (OFID) Safety and acceptance of vaccination after MIS (JPID) Is variant less virulent in solid organ transplant recipients (Transplant Infectious Disease) Masks for prevention of respiratory virus infections (Annals of Internal Medicine) Pre-exposure prophylaxis with Evusheld (CMI) Association between Evusheld administration and infection (CID) Repeat administration of casirivimab and imdevimab well-tolerated (ISID) PAXLOVID patient eligibility screening checklist (FDA) Remdesivir fact sheet for providers (Veklury
Sun, July 31, 2022
If a bat pees in a forest, does anyone care?
From The Third International Symposium on Infectious Diseases of Bats in Ft. Collins, Colorado, TWiV speaks with Vincent Munster and Raina Plowright about their careers and their research on bats, bat viruses, bat ecology and spillover events. Hosts: Vincent Racaniello and Brianne Barker Guests: Vincent Munster and Raina Plowright Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Novel Hendra virus variant in Australia (Emerg Inf Dis) Nipah virus detection after spillover events (Emerg Inf Dis) Want to prevent pandemics? Stop spillovers (Nature) Ecological countermeasures to prevent zoonoses (Restor Ecol) Land-use induced spillovers (Lancet Planet Health) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, July 30, 2022
TWiV clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses monkeypox infection in humans across 16 countries, pregnancy outcomes after SARS-CoV-2 infection by trimester, vaccination intent and belief, antiviral drug treatment for non-severe disease, the association of smoking with infected hospitalized patients, the association of Paxlovid on negative conversion rates among high-risk patients with COVID-19, safety and efficacy of Molnupiravir, usage of enoxaparin for primary thromboprophylaxis, statin and aspirin as therapy in infected patients, post-COVID-19 conditions among children 90 days after SARS-CoV-2 Infection, and symptoms and risk factors for long COVID in non-hospitalized adults. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Monkeypox infection in humans (NEJM) Pregnancy outcomes after infection (PLOS ONE) Vaccination intent and belief (Emerging Infectious Diseases) Antiviral drug treatment for non-severe disease (CMAJ) Smoking association with infected hospitalized patients (PLOS ONE) Impact of Paxlovid on negative conversion rates (CID) PAXLOVID patient eligibility screening checklist (FDA) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) Safety and efficacy of Molnupiravir (J
Sun, July 24, 2022
Science will break your heart
From ASV 2022 in Madison, Wisconsin, TWiV speaks with Pamela Bjorkman and Andy Mehle about their careers and their research on influenza virus, HIV-1, SARS-CoV-2, and influenza virus. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Guests: Pamela Bjorkman and Andy Mehle Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Bjorkman laboratory Mehle laboratory Finding the groove (Nat Immunol) Structure of HLA-A2 (Nat Immunol) Mosaic RBD nanoparticles (Science) Influenza virus PB2 627 (J Virol) ANP32B or not to be (eLife) Influenza virus compartmentalization (Nat Commun) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, July 23, 2022
COVID-19 clinical update #124 with Dr. Daniel Griffin
In COVID-19 clinical update #124, Dr. Griffin discusses the results of a variant vaccine booster trial, the neutralization of variant sub-lineages by Novavax, the CDC’s recommendation of Novavax’s COVID-19 vaccine in adults, Paxlovid in patients who are immunocompromised and hospitalized, and inhaled fluticasone for outpatient treatment. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Variant vaccine boosters trial (medRxiv) Novavax triggers neutralization of variant sub-lineages (bioRxiv) CDC recommends Novavax (CDC) Paxlovid in patients who are immunocompromised and hospitalized (The Lancet) Inhaled Fluticasone for outpatient treatment (medRxiv) PAXLOVID patient eligibility screening checklist (FDA) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) Contribute to FIMRC fundraiser at PWB Dr. Griffin’s treatment guide ( pdf ) Letters read on TWiV 921 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Sun, July 17, 2022
Motivated by volatiles
TWiV reviews the FDA decision to update COVID-19 vaccine boosters in the fall, the meaning of fatigue with respect to long COVID, and a skin volatile induced by flavivirus reproduction that attracts mosquitoes to the infected host. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode COVID-19 vaccine booster composition (FDA) Settling in for the long haul (Crooked Timber) Flavivirus-induced skin volatile attracts mosquitoes (Cell) Letters read on TWiV 919 Timestamps by Jolene . Thanks! Weekly Picks Brianne – Redactle Kathy – Kirigami paper replacing plastic bubble wrap Rich – First Images from the James Webb Space Telescope ( Gravitational lens ; Einstein ring ) Vincent – Spotted lanternfly Listener Picks Ann – NASA Engineer Who Made the James Webb Space Telescope Work Sonrisa – Aloft – the pleasures and risks of flying Intro
Sat, July 16, 2022
COVID-19 clinical update #123 with Dr. Daniel Griffin
In COVID-19 clinical update #123, Dr. Griffin discusses rapid diagnostic testing in response to the monkeypox outbreak, leading causes of death in the US during the COVID-19 pandemic, antibody evasion by subvariants, broadly-neutralizing antibodies against emerging variants, factors associated with severe outcomes among hospitalized immunocompromised adults, measurement of the burden of hospitalizations during the pandemic, parental vaccine hesitancy in diverse communities, evaluating saliva sampling to improve access to diagnosis in low-resource settings, oral sabizabulin for high-risk hospitalized adults, lower-risk of multisystem inflammatory syndrome in children, and neurovascular injury with complement activation and inflammation during infection. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Monkeypox outbreak rapid testing response (CDC) Leading causes of death during pandemic (JAMA) FDA recommends vaccine update (FDA) Antibody evasion by subvariants (Nature) Broadly-Neutralizing antibodies against variants (Frontiers in Immunology) Severe outcomes factors in immunocompromised adults (CDC) Measurement of the burden of hospitalizations (OFID) Vaccine hesitancy among parents (Academic Pediatrics) PAXLOVID patient eligibility screening checklist (FDA) Remdesivir fact sheet for providers (Veklury)
Sun, July 10, 2022
Boosters on, Paul Offit
Paul Offit returns to TWiV to discuss why, during the recent FDA advisory committee meeting, he voted against releasing revised COVID-19 vaccines containing an Omicron component, and the reasons why children must be vaccinated against the disease. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Kathy Spindler Guest: Paul Offit Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode 28 June 2022 VRBPAC meeting materials (FDA) Don’t rush to change COVID vaccines (STAT) Monkeypox situation report #1 (WHO) Letters read on TWiV 917 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Woody Herman and his orchestra. 1955-1965. Signature song: The Preacher . Signature album: Woody Herman and His Orchestra (1956) Kathy – Solargraphic analemmas Rich – Windy ( desktop ; app ) Vincent – Why monkeypox is mostly hitting men who have sex with men Listener Picks Mark – Hand Wash Dance – NHK WORLD-JAPAN Intro music is by <
Sat, July 09, 2022
COVID-19 clinical update #122 with Dr. Daniel Griffin
In COVID-19 clinical update #122, Dr. Griffin discusses vaccine availability and coverage among children, post-infection health impairments in children and adolescents, infection detection using salvia and nasopharyngeal samples, effectiveness of vaccines during delta dominance, durability of vaccine against severe outcomes, concern in the postvaccination era, infection rebound after Paxlovid & Molnupiravir, lack of improvement after adding ivermectin to standard care, duration of shedding of virus, how thromboprophylaxis reduces thromboembolism but increases major bleeding, multi-lineage neural and myelin dysregulation caused by infection, and the association between vaccination and post-acute infection. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode The next epidemic may be here (STAT) Vaccine availability and coverage among children (CDC) Post-infection health impairments in children & adolescents (Pediatrics) Infection detection using saliva & nasopharyngeal samples (Journal of Medical Virology) Effectiveness of vaccines during Delta dominance (The Lancet) Durability of vaccine against severe outcomes (The Lancet) Don’t rush to change COVID vaccines (STAT) Concern in the postvaccination era (Immunity, Inflammation and Disease) Infection rebound after Paxlovid & Molnupiravir (medRxiv) No improvement after <a href= "https://webapi.acponline.org/Account/Logi
Sun, July 03, 2022
Mouse mouth to mouse mom
TWiV discusses the recent decision by an FDA advisory committee to update COVID vaccines for the fall, the monkeypox virus outbreak, and the finding that enteric viruses infect the salivary glands and are transmitted through saliva. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , Kathy Spindler , and Brianne Barker. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Postdoctoral position in the Kielian Laboratory ( pdf ) COVID vaccine update for fall (WaPo) Don’t rush to change COVID vaccines (STAT) Materials from 28 June FDA advisory meeting (FDA) Monkeypox cases US and Global (CDC) Enteric viruses transmit via saliva (Nature) Letters read on TWiV 915 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Jazz big bands #2: Maynard Ferguson : Signature song: Theme From Rocky : Signature album: Color Him Wild Brianne – Origami antibody
Sat, July 02, 2022
COVID-19 clinical update #121 with Dr. Daniel Griffin
In COVID-19 clinical update #121, Dr. Griffin discusses age as a risk factor for severe disease, updated vaccine boosters for the fall, pediatric infection and antibody seroprevalence in Arkansas over the first year of the COVID-19 pandemic, all-cause maternal mortality in the United States before and during the pandemic, and the effect of 2-week interruption in methotrexate treatment and how it impacts vaccine immunity. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Age as a risk factor for severe disease (NY Times) Omicron boosters for the fall (NPR) Pediatric infection and antibody seroprevalence in Arkansas (PIDS) All-cause US maternal mortality during pandemic (JAMA) Effect of 2-week interruption in methotrexate treatment (The Lancet) PAXLOVID patient eligibility screening checklist (FDA) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) PAXLOVID drug interaction checker (IDSA) Contribute to FIMRC fundraiser at PWB 35:42 Dr. Griffin’s treatment guide ( pdf ) Letters read on TWiV 914 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Sun, June 26, 2022
Twinkle twinkle little SARS
TWiV explains the meaning of vaccine-derived poliovirus found in London sewage, risk of long COVID after infections with Delta or Omicron variants of SARS-CoV-2, and enhancers of innate immune signaling as broad-spectrum antivirals. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler . Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Poliovirus in UK sewage ( ProMedMail and Science ) Poliovirus eradication effort (Science) Long COVID after Delta and Omicron (Lancet) How common is long COVID? (Nature) Immune enhancers as antivirals (Cell Chem Biol) Letters read on TWiV 913 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Count Basie: April in Paris Kathy – Bird aerodynamics & inertia: lay article , video , Nature Rich – NASA Gateway (Thanks Ellis) Alan – Polio Eradication
Sat, June 25, 2022
COVID-19 clinical update #120 with Dr. Daniel Griffin
In COVID-19 clinical update #120, Dr. Griffin discusses outcomes of SARS-CoV-2 reinfection, CDC recommendation for vaccines in young children, neurodevelopment outcomes in infants of mothers testing positive for COVID during pregnancy, efficacy of monoclonal antibodies and antivirals in hamsters, rebound phenomenon after PAXLOVID in high-risk persons, hospitalization for infection after PAXLOVID treatment, and risk of long COVID with different variants. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Reinfection outcomes (Research Square) CDC recommends vaccine for young children (CDC) Neurodevelopment outcomes in infants post-infection (JAMA) Efficacy of monoclonal antibodies/antivirals in hamsters (Nature) PAXLOVID patient eligibility screening checklist (FDA) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) PAXLOVID drug interaction checker Rebound phenomenon after PAXLOVID in high-risk persons (IDSA) Hospitalization for infection after PAXLOVID treatment (CDC) Risk of post acute infection with <a href= "https://www.thelancet.
Sun, June 19, 2022
Antibody can get vaccinated now
TWiV provides an update on hepatitis of unknown etiology in children, an experimental nanoparticle vaccine for Epstein-Barr virus, and minimal impact of bamlanivimab therapy on antiviral antibodies induced by vaccination. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Hepatitis of unknown etiology (MMWR) Clinical recognition of monkeypox (CDC) Epstein-Barr virus nanoparticle vaccine (Cell Rep Med) Minimal impact of mAb therapy on COVID vaccine induced antibodies (Sci Trans Med) Letters read on TWiV 911 Timestamps by Jolene . Thanks! Weekly Picks Brianne – A Frog So Small, It Could Not Frog Kathy – A Grand Night In: The Story of Aardman Rich – Archive Vincent – Bandwagoning by Heran Darwin Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, June 18, 2022
COVID-19 clinical update #119 with Dr. Daniel Griffin
In COVID-19 clinical update #119, Dr. Griffin reviews tixagevimab for infection prevention, ivermectin for outpatient infection treatment, symptom rebound after PAXLOVID treatment, bamlanivimab minimally impacting immune response to vaccination, in-hospital mortality among infection patients, residual viral antigen in patients following infection, usage of Casirvimab/Imdevimab and Remdesivir in infected patients with depleted B-cells, and rheumatic symptoms following infection. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Tixagevimab-Cilgavimab for infection prevention (NEJM) Ivermectin for outpatient infection treatment (medRxiv) Symptom rebound after PAXLOVID treatment (IDSA) Bamlanivimab minimally impacts immune response to vaccination (Sci Transl Med) In-hospital morality among infected patients (IDSA) Casirvimab/Imdevimab & Remdesivir for infected B-cell depleted patients (IDSA) PAXLOVID patient eligibility screening checklist (FDA) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) Residual viral antigen in patients post infection (IDSA) Rheumatic symptoms following infection (IDSA) Contribute to <a href= "https://parasiteswithou
Thu, June 16, 2022
Art of science
From ASM Microbe 2022 in Washington DC, Vincent and Michael speak with science artists Michele Banks and Jane Hartman about their work and their inspiration. Hosts: Vincent Racaniello and Michael Schmidt Guests: Michele Banks and Jane Hartman Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Trilobite Glassworks (Jane Hartman) Artologica (Michele Banks) Science art with Michele Banks ( TWiV 352 ) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, June 12, 2022
When the cats and mice are away, the viruses play
TWiV discusses the situation with monkeypox, risk factors for SARS-CoV-2 infections of cats and dogs, and a lineage-tracing mouse model for studying papillomavirus infections. Hosts: Vincent Racaniello , Rich Condit , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Monkeypox update (CDC) SARS-CoV-2 infection of cats and dogs (Emerg Inf Dis) Mouse papillomavirus identification (Vet Patrol) Mouse model for papillomavirus infection (eLife) Vincent interviews Harald zur Hausen (virology blog) Letters read on TWiV 907 Timestamps by Jolene . Thanks! Weekly Picks Brianne – Microbes Rule! at Liberty Science Center Rich – Artemis I update: Mission diagram , mission in photos , launch dates Vincent – Eco-sustainable 3D printed house – Tecla Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, June 11, 2022
COVID-19 clinical update #118 with Dr. Daniel Griffin
In COVID-19 clinical update #118, Dr. Griffin discusses management of hair loss after infection, FDA announcements on vaccine schedule and recommendations, Moderna announcement on bivalent booster candidate, association between vaccination and infection during pregnancy, population-level implications of Israel’s booster campaign, PAXLOVID outcomes during recent infection surge, efficacy and safety of Tixagevimab-cilgavimab, diagnostic accuracy of infection by canines, efficacy of colchicine in hospitalized patients, and factors associated with hospital readmission. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Management of hair loss after infection (NIH) FDA announces vaccine schedule meeting (FDA) FDA advisory committee recommends NOVAVAX vaccine (Novavax) Moderna announces bivalent booster candidate (Moderna) Association of vaccination and infection during pregnancy (JAMA) Implications of Israeli booster campaign (Science Translational Medicine) PAXLOVID patient eligibility screening checklist (FDA) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) PAXLOVID outcomes during <a href= "https://assets.researchsquare.com/files/rs-1705061/v1/ed7100f4-9db
Sun, June 05, 2022
Long COVID, giant viruses, and smallish pox
TWiV reviews human monkeypox infections, evidence for human Mimivrus infections, and incidence of long COVID in post-vaccine SARS-CoV-2 infections. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Monkeypox update (ProMedMail) Multi-country monkeypox outbreak (WHO) Monkeypox new global threat (Science) Monkeypox outbreak 9 US states (MMWR) Mimivirus in human respiratory samples (Sci Rep) Long COVID after post-vaccination infection (Nat Med) Letters read on TWiV 906 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Lake Mead water level very low Brianne – Transplantation of a 3D printed ear made out of human cells Rich – nderstanding Vaccine Safety and the Roles of the FDA and the CDC and The Facts About Vaccine Safety Vincent – My new favorite backpack Listener Pick Greg – Aga
Sat, June 04, 2022
COVID-19 clinical update #117 with Dr. Daniel Griffin
In COVID-19 clinical update #117, Dr. Griffin discusses duration of virus shedding, association between pre-exposure to steroids and infection outcome, post-infection subtypes, rehabilitation for post-acute infection, Tixagevimab/Cilgavimab for infection prevention, antibody prophylaxis and vaccination in kidney transplant recipients, remdesivir and bebtelovimab fact sheets for providers, the updated guidelines on treatment with Famotidine, Paxlovid rebound symptom characterizations, antigen test positivity duration, viral dynamics of variants and isolation, association of inflammation in CS fluid, and transmission dynamics in Ghana. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Duration of virus shedding (NIH) Association between pre-exposure to steroids and infection outcome (CMI) Post-infection subtypes (medRxiv) Rehabilitation for post-acute infection syndrome (MDPI) Tixagevimab/Cilgavimab for infection prevention (medRxiv) Antibody prophylaxis & vaccination in kidney transplant recipients (Kidney International) Guideline on treatment with Famotidine (IDSA) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) PAXLOVID rebound symptom characterization (medRxiv) Antigen test <a href= "https://www.medrxiv.org/content/10.1101/2022.05.19.22274
Sun, May 29, 2022
50 years of reverse transcriptase
Vincent travels to Cold Spring Harbor Laboratory to speak with David Baltimore, John Coffin, and Harold Varmus about the discovery in 1970 of retroviral reverse transcriptase and its impact on life sciences research. Hosts: Vincent Racaniello Guests: David Baltimore , John Coffin , and Harold Varmus Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Fifty Years of Reverse Transcriptase (Cold Spring Harbor Laboratory) 50th Anniversary of RT discovery (Mol Biol Cell) RT in virions of Rous sarcoma virus – Temin (Nature) RNA-dependent DNA polymerase in tumor virus particles – Baltimore (Nature) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, May 28, 2022
COVID-19 clinical update #116 with Dr. Daniel Griffin
In COVID-19 clinical update #115, Dr. Griffin discusses croup association with infection surge, rhinovirus co-circulation in children, shedding following vaccination, high vaccine efficacy in children 6 mo-5 yr, vaccine protection for hospitalized patients, convalescent plasma as post-exposure prophylaxis, real-world effectiveness of PAXLOVID, effectiveness of PAXLOVID in reducing hospitalization, infection rebound after PAXLOVID, relapse of symptomatic infection after PAXLOVID, remdesivir and bebtelovimab fact sheets for providers, guidelines on usage of anticoagulation drugs, long covid symptoms after vaccination, excess mortality in MA, infection sequelae and immunity, and post infection conditions among adults. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Croup association with infection surge (PIDS) Rhinovirus co-circulation in children (Science Direct) Infection shedding following vaccination (MedRxiV) High vaccine efficacy in children 6 months to 5 years (Pfizer) Protection of vaccine against hospitalized patients (IDSA) Convalescent plasma as post-exposure prophylaxis (IDSA) Real-world effectiveness of PAXLOVID in Hong-Kong (MedRxiV) Effectiveness of PAXLOVID in reducing hospitalization (The Lancet) Infection rebound after PAXLOVID (CDC) Relapse of symptomatic infection after PAXLOVID (Research Square) <a href= "https://www.vekluryhcp.com/?utm_id=iw_sa_11453738585_111635246813&utm_medium=cpc&utm_
Thu, May 26, 2022
Monkeypox clinical update with Dr. Daniel Griffin
In this special episode, Dr. Griffin answers questions about the recent cases of monkeypox including their origin, clinical presentation, diagnosis, treatment, and overall risk. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Monkeypox multi-country outbreak risk assessment ( pdf , ECDC) Monkeypox update (ProMedMail) Monkeypox virus genome sequences (Nextstrain) Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Sun, May 22, 2022
Autoantibodies drive severe COVID-19
TWiV reviews recent cases of monkeypox, presence of SARS-CoV-2 RNA but not infectious virus in feces, and the association of autoantibodies to interferons with severe COVID-19. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Monkeypox in MA (ProMed Mail) Possible monkeypox in NYC (NY Times) Occupational monkeypox, Wisconsin (Emerg Inf Dis) SARS-CoV-2 in feces (Nature) IFN autoantibodies and severe COVID-19 (PNAS) Letters read on TWiV 902 Timestamps by Jolene . Thanks! Weekly Picks Dickson – How to grow food on the moon Brianne – APod May 16: Milky Way over French Alp Hoodoos Kathy – Covid Nationwide data visualization Rich – NIH All of Us Research Program Vincent – Physicians Spreading Misinformation on Social Media — Do Right and Wrong Answers Still Exist in Medicine? Listener Pick Lisa – E.H. Danner Museum of Telephony Intro music is by Ronald Jenkees <br /
Sat, May 21, 2022
COVID-19 clinical update #115 with Dr. Daniel Griffin
In COVID-19 clinical update #115, Dr. Griffin reviews cross-variant immunity without vaccination, EUA for boosters in 5-11 year olds, B.1.1.529 attack rate, scent dogs, Omicron and pets, Paxlovid, Veklury, Fluvoxamine, antigen positivity after isolation, inflammasome activation and severe disease, and GI persistence and fecal shedding. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Limited cross-variant immunity without vaccination (Nature) EUA for boosters in 5-11 year olds (FDA) Stages of COVID-19 (AIDS Rev) B.1.1.529 attack rate in Australia (JID) Scent dogs (BMJ) Does Omicron affect pets? (CVMBS News) Paxlovid eligibility checklist (FDA) Supratherapeutic tacrolimus with nirmatrelvir/ritonavir (Op For Inf Dis) Is longer Paxlovid needed? (Reuters) How about Veklury ? (Gilead) Fluvoxamine declined (FDA) Antigen positivity after isolation (MMWR) Inflammasome activation drives COVID-19 pathology ( TWiV 900 , <
Sun, May 15, 2022
Burning down the mouse
TWiV celebrates 900 episodes, Vincent gives the Richard R. Ernst lecture, and we discuss why inflammasome activation in infected macrophages drives severe COVID-19. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Richard R. Ernst Lecture Infected macrophages drives severe COVID-19 (Nature) Timestamps by Jolene . Thanks! Weekly Picks Brianne – The Milky Way’s Black Hole Comes to Light Kathy – River dolphins playing with anaconda Rich – Smallpox vaccination techniques; from knives and forks to needles and pins Alan – Vacuum Tubes: a Modern Aladdin’s Lamp Vincent – Books by Pamela Jane Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, May 14, 2022
COVID-19 clinical update #114 with Dr. Daniel Griffin
In COVID-19 clinical update #114, Dr. Griffin discusses early treatment with ivermectin, procalcitonin not a reliable biomarker, vaccine in 6-11 year olds, FDA limits use of Janssen vaccine, does site of vaccine booster matter, sniffer dogs, monoclonals for hospitalized patients, risk assessment for public events, Paxlovid eligibility, and persistence of pediatric anosmia. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Effects of early treatment with Ivermectin (NEJM) Procalcitonin not a reliable biomarker (IDSA) Evaluation of vaccine in children 6 to 11 years (NEJM)) FDA limits use of Janssen vaccine (FDA) Recall of b cell memory on vaccination location (Science Immunology) Persistence screening using sniffer dogs (Journal of Clinical Trials) Tixagevimab/Cilgavimab for treatment of hospitalized patients (Lancet) Infection detection by canine olfaction (OFID) Diagnostic utility to differentiate patients (IDSA) Prevalence of anosmia in pediatric cases (Pediatric Infectious Disease Journal) <a href= "htt
Sun, May 08, 2022
Immunity is skin deep
TWiV explains why the concept of herd immunity might not apply to COVID-19, and the observation that smallpox vaccination causes an increase in skin bacteria that promote pathology and influence the immune response. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Herd immunity may not apply to COVID-19 (J Inf Dis) Smallpox vaccination increases skin bacteria (PLoS Path) The invinceable TWiV ( TWiV 145 ) By the pricking of my thumbs… ( TWiV 284 ) Letters read on TWiV 898 Timestamps by Jolene . Thanks! Weekly Picks Brianne – Bacteria and Me Coloring Book Kathy – Smarter 3D printing Rich – Big Ben Restoring the Worlds Most Famous Clock 2021 Vincent – Scientific review articles as antivaccine disinformation Listener Pick Suellen – Your Fantastic Mind Season 3 Ep 2: Long COVID and Making of a Brain Surgeon (Full Episode) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, May 07, 2022
COVID-19 clinical update #113 with Dr. Daniel Griffin
In COVID-19 clinical update #113, Dr. Griffin discusses tocilizumab use in hospitalized Patients, IL-6 inhibitors and mortality, Baricitinib in hospitalized patients, post-infection neurological sequelae, comparative effectiveness of Pfizer and Moderna vaccines, phase 2/3 study of Paxlovid, infection relapse following Paxlovid, pre-hospital administration of Remdesivir, and hospitalization with different variants. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Timing of Tocilizumab Use in Hospitalized Patients (NIH) Interleukin-6 inhibitors reduce mortality (European Journal of Internal Medicine) Treatment Effect of Baricitinib on Hospitalized Patients (IDSA) Post Infection Neurological Sequelae (Res Square) Comparative Effectiveness of Pfizer and Moderna Vaccines (Nature Commun) Results from Phase 2/3 Study of Paxlovid (Pfizer) Infection Relapse Following Suppression by Paxlovid (Res Square) Update on Paxlovid Usage (FDA) Availability and Use of Treatments in Outpatients (CDC) Pre-Hospital Administration of Remdesivir (IDSA) Remdesivir and three other drugs for Hospitalized Patients (Lancet) Guidelines on Usage of Anticoagulants (Am Soc Hematol) Different Variants Hos
Sun, May 01, 2022
Memory B cells, the way we were
TWiV explains a study of how climate change is predicted to increase cross-species viral transmission risk, and increased memory B cell potency and breadth after a SARS-CoV-2 mRNA vaccine boost. Hosts: Vincent Racaniello , Dickson Despommier , and Amy Rosenfeld Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Climate change and viral zoonosis risk (Nature) COVID-19 mRNA boost effect on memory B cells (Nature) Letters read on TWiV 896 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Toots Thilelemans Amy – Largest comet ever identified Vincent – Scientific review articles as antivaccine disinformation Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, April 30, 2022
COVID-19 clinical update #112 with Dr. Daniel Griffin
In COVID-19 clinical update #112, Dr. Griffin reviews seroprevalence of infection-induced antibodies, Moderna filing for vaccine authorization in young children, public health impact of vaccines in US, FDA approval of first treatment for young children, phase 2 data for Sabizabulin, and post infection inflammation. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Seroprevalence of Infection-Induced Antibodies (CDC) Authorization for Vaccine in Young Children Filed (Moderna) Public Health Impact of Vaccines in US (BMJ) FDA authorizes first approved treatment for children (FDA) Phase 2 Data for Sabizabulin (Veru Pharma) Clinical Characteristics of Post Infection Inflammation (The Lancet) Fact Sheet for Providers on Evusheld (FDA) Fact Sheet for Providers on Paxlovid (FDA) Provider Referral for EvuSheld (Northwell Health) Contribute to ASTMH fundraiser at PWB Dr. Griffin’s treatment guide (pdf) Lette
Thu, April 28, 2022
Dinner with the TMPRSS family
TWiV explains what is known about cases of acute, severe hepatitis of unknown origin in children, and discovery of an inhibitor of TMPRSS2 protease that blocks SARS-CoV-2 infection. Hosts: Vincent Racaniello , Alan Dove , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Severe hepatitis in children (WHO) TMPRSS2 inhibitor (Nature) Omicron less dependent on TMPRSS2 ( TWiV 879 ) Letters read on TWiV 894 Timestamps by Jolene . Thanks! Weekly Picks Brianne – Apple AirTag Kathy – Dental art/sculpture/mobile/chandelier Alan – Vintage Radio and Communications Museum of Connecticut Vincent – For the Love of Enzymes by Arthur Kornberg Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, April 24, 2022
Yellow fever virus escapes antibodies
Kartik, Denise, and Gorka join TWiV to discuss their finding that changes in the surface glycoprotein of South American yellow fever virus lead to reduced neutralization by antibodies induced by the vaccine, which is derived from an African isolate. Hosts: Vincent Racaniello , Dickson Despommier , and Brianne Barker Guests: Kartik Chandran , Denise Haslwanter , and Gorka Lasso Cabrera Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Prometheus project ( TWiV 578 ) Reduced neutralization of South American yellow fever virus (Cell Host Microbe) Letters read on TWiV 893 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Earth Day and Earth Day History Brianne – XKCD: Family Reunion Vincent – Tokaido: A Journey (DVD) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, April 23, 2022
COVID-19 clinical update #111 with Dr. Daniel Griffin
In COVID-19 clinical update #111, Dr. Griffin discusses vaccine coverage and mortality in Hong Kong, immune response to boosters in kids, hospitalization of kids, breath based diagnostic test, viral co-infections, bivalent mRNA vaccine, intramuscular Evusheld, and global long COVID. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Vaccine coverage and mortality, Hong Kong (MMWR) Kids behind on routine vaccinations (Politico) Immune response to booster , 5-11 year olds (Pfizer) Children and vaccination (AAP) Hospitalization of 5-11 year olds (MMWR) Test using breath samples (FDA) Influenza virus, adenovirus, RS virus co-infections (Lancet) Booster crystal ball ( TWiV 890 ) Bivalent vaccine (Res Square) Bivalent vaccine in mice (bioRxiv) Intramuscular Evusheld (NEJM) Global PASC (J Inf Dis) Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 8
Thu, April 21, 2022
LLOV in the time of Ebola
Elke, Adam, and Gabor join TWiV to discuss their work on Lloviu virus, a filovirus, including recovery of infectious virus from a DNA copy of the genome and from Schreiber’s bats in Hungary. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Guests: Elke Muhlberger , Adam Hume , and Gabor Kemenesi Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Elke on TWiV 200 and Threading the NEIDL Infectious Lloviu virus from bats in Hungary (Nat Commun) Infectious Lloviu virus from DNA (PloS Path) Letters read on TWiV 891 Timestamps by Jolene . Thanks! Weekly Picks Brianne – APod Stars and Globules in the Running Chicken Nebula Kathy – BioRender Poster Builder Rich – The Sins of Our Fathers: An Expanse Novella (The Expanse) by James S. A. Corey Vincent – Baumgartner Restoration Listener Pick J – Time, Einstein, and the coolest stuff in the Universe Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, April 17, 2022
Looking into a booster crystal ball
This episode of TWiV is focused on COVID-19 vaccines and antibodies: who should get boosters, whether a variant matched mRNA vaccine is superior to a historical vaccine, and how the interval between vaccination and infection influences the quality of the antibody response. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode What next for COVID-19 boosters? (NEJM) Boosting with historical or variant mRNA vaccines (Cell) Vaccination-infection interval determines antibody breadth (Cell Med) Letters read on TWiV 890 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Webb Telescope’s coldest instrument reaches operating temperature Brianne – Video of a CTL killing a tumor cell Rich – Our Unfinished Pandemic ( On the Media Podcast ) Vincent – Lý Thị Ca Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, April 16, 2022
COVID-19 clinical update #110 with Dr. Daniel Griffin
In COVID-19 clinical update #110, Dr. Griffin covers hospital admissions during variant outbreaks, viral load in vaccinated and unvaccinated individuals, predictive capacity of symptoms in children, comparison of antigen tests, incidence of myocarditis after vaccination, steroids during replication phase, Paxlovid efficacy and safety, fluvoxamine, sabizabutin, colchicine, and prevalence of infection in Africa. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Hospital admissions during Omicron and Delta variant outbreaks (Lancet) Viral load in unvaccinated and vaccinated individuals (Nat Med) Predictive Capability of symptoms in children (Clin Inf Dis) Comparison of antigen tests (medRxiv) Incidence of Myocarditis after COVID19 and non-COVID19 vaccination (Lancet) Steroids during viral replication phase (Resp) Paxlovid efficacy and safety (Pfizer) Fluvoxamine & Outpatient Management (JAMA) Sabizabutin efficacy and safety (Veru) Colchicine and lack of benefit (Lancet) SARS-CoV-2 prevalence in Africa (medRxiv) Contribute to ASTMH fundraiser at PWB Dr. Griffin’
Thu, April 14, 2022
Molnupiravir with Richard Plemper
Richard joins TWiV to discuss the SARS-CoV-2 antiviral drug Molnupiravir , including how it was discovered, its mechanism of action, whether it is a mutagen for cells, and the future of drugs for treatment of COVID-19. Hosts: Vincent Racaniello , Alan Dove , and Brianne Barker Guest: Richard Plemper Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Richard on TWiV 636 Molnupiravir in ferrets (Nat Micro) Oral prodrug of Remdesivir in ferrets (Nat Commun) Letters read on TWiV 888 Timestamps by Jolene . Thanks! Weekly Picks Brianne – BioRender Poster Builder Alan – Hexbug cat toys Vincent – US Mint 2019 American Innovation Coin – PA – Polio Vaccine Listener Picks Sue – American Visionary Art Museum Frazer – Vaccine trial for killer elephant virus Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, April 10, 2022
Bonfire of the monocytes
TWiV explains why this season’s influenza vaccine is not protecting against mild to moderate disease caused by H3N2 virus, and that antibody-dependent entry of SARS-CoV-2 into monocytes is a major contributor to severe COVID-19. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Amy Rosenfeld Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Seasonal influenza vaccine effectiveness (MMWR) Properties of a dominant H3N2 variant (bioRxiv) Scott Henley on influenza vaccine growth in eggs ( TWiV 480 ) Fc receptor dependent entry of SARS-CoV-2 into monocytes (Nature) Timestamps by Jolene . Thanks! Weekly Picks Dickson – Ketanji Brown Jackson confirmed to US Supreme Court Amy – Some threats just keep coming in waves Rich – Lady Bird Johnson Wildflower Center Vincent – Martijn Doolaard Listener Picks Ann – Immunological memory to SARS-CoV-2 infection and vaccines Chris – Isoplexis Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, April 09, 2022
COVID-19 clinical update #109 with Dr. Daniel Griffin
In COVID-19 clinical update #109, Daniel Griffin discusses cardiac complications after infection or vaccination, long COVID in children, fourth vaccine dose in Israel, no need for fourth vaccine dose in EU, dexamethasone dosing, immunomodulation therapy, MIS outcomes in children, US long COVID effort launched, and herd immunity. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Cardiac complications after infection or vaccination (MMWR) Long COVID in children (Future Med) Fourth vaccine dose in Israel (NEJM) No need for fourth vaccine dose (Eur Med Agency) Dexamethasone dosing (Intensive Care Med) Actemra priority review (Roche) Guidelines on anticoagulation therapy (American Soc Hematol) MIS outcomes in children in children (JAMA) Biden launches long COVID effort (USA Today) Herd immunit y and COVID (J Inf Dis) Contribute to ASTMH fundraiser at PWB Dr. Griffin’s treatment guide ( pdf ) Letters read on TWiV 886 Timestamps by Jolene . Thanks! Intro music is by <a href= "http://ww
Thu, April 07, 2022
Russian bats and Ankara vectors
TWiV reveals an ACE2-dependent sarbecovirus from Russian bats that is not inhibited by anti-SARS-CoV-2 antibodies, and a modified vaccinia virus Ankara vectored vaccine that protects nonhuman primates from Delta infection. Hosts: Vincent Racaniello , Rich Condit , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Sarbecovirus from Russian bat (bioRxiv) MVA vectored COVID vaccine (Sci Immunol) Letters read on TWiV 885 Timestamps by Jolene . Thanks! Weekly Picks Brianne – The Search for a Model Octopus That Won’t Die After Laying Its Eggs Rich – Vaccine Pioneers and Opponents with Paul Offit (Podcast: Connected by Controversy by Chris White ) and The Cutter Incident by Paul Offit Vincent – Simply Put: Vaccines Save Lives Listener Picks Rich – ‘Stolen’ Charles Darwin notebooks left on library floor in pink gift bag Neva – Elin Thomas, UK textile artist Viki – History of English Podcast Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, April 03, 2022
Cytokines and viral mimicry
Vincent and Amy explain how asthmatic bronchial smooth muscle increases rhinovirus replication in the bronchial epithelium, and mimicry of IL-17 by the ORF8 protein of SARS-CoV-2. Hosts: Vincent Racaniello and Amy Rosenfeld Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Asthmatic bronchial smooth muscle and rhinovirus (Cell Rep) SARS-CoV-2 ORF8 mimics IL-17 (mBio) Letters read on TWiV 884 Timestamps by Jolene . Thanks! Weekly Picks Amy – Ben Franklin by Ken Burns Vincent – Thoughts on a second booster: Offit and Krause/Borio Listener Picks Philip – History of Clemson Blue Cheese Jack – Pipeline and A Special Report on Polio Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, April 02, 2022
COVID-19 clinical update #108 with Dr. Daniel Griffin
In COVID-19 clinical update #107, Daniel Griffin reviews vaccine booster doses, at-home testing, transmission in ferrets, improving indoor air quality, trials of BCG, ivermectin, and fluvoxamine, vaccination during pregnancy, mRNA vaccines and Fc functions, anti-platelet and aspirin therapy and a trial of prone positioning. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode FDA authorizes second booster (FDA) Second booster and mortality (Res Square) Booster effectiveness vs hospitalization (MMWR) SARS-CoV-2 confections (Lancet) At-home testing (MMWR) Transmission study in ferrets (PLoS Path) Improving indoor air quality (EPA) BCG vaccine no effect on viral infections (Clin Inf Dis) Vaccination during pregnancy (JAMA) mRNA vaccines and different Fc functions (Sci Transl Med) Ivermectin clinical trial (NEJM) Fluvoxamine clinical trial (Lancet) <
Thu, March 31, 2022
Elispot on about T cells and lipids
Vincent and Brianne review the need to better understand T cell responses to SARS-CoV-2 infection to better inform public health decisions, and how IL-1 and IL-1ra are important regulators of the inflammatory response to RNA vaccines. Hosts: Vincent Racaniello and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Understanding T cell responses during COVID-19 (Science Immunol) IL-1 and IL-1ra are keys to inflammation after RNA vaccination (Nature Immunol) Letters read on TWiV 882 Timestamps by Jolene . Thanks! Weekly Picks Brianne – Covid restrictions prevented dengue in hundreds of thousands of people in 2020 Vincent – Scotch Dual Lock 250 Reclosable Fastener Listener Picks Erin – JWT Preparation and Xploration Outer Space Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, March 27, 2022
50 ways to zap your virus
TWiV describes the identification of a monoclonal antibody that provides broad protection against a variety of hantaviruses, and development of an oral remdesivir-like antiviral that ameliorates viral disease in mice. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Amy Rosenfeld Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Monoclonal antibody provides broad hantavirus protection (Sci Transl Med) Prometheus Project ( TWiV 578 ) Oral antiviral related to Remdesivir (Sci Transl Med) Letters read on TWiV 881 Timestamps by Jolene . Thanks! Weekly Picks Dickson – World’s tallest wooden building Amy – Virus hunter in the Wuhan market Rich – WorldPop ( example ) Vincent – Karst Stone Paper Listener Picks Neva – Can we vaccinate against EBV? and Paul Sutter reading a science paper Intro music is by <a href= "http://www.ronaldjenk
Sat, March 26, 2022
COVID-19 clinical update #107 with Dr. Daniel Griffin
In COVID-19 clinical update #107, Daniel Griffin discusses Moderna vaccine results in children, hospitalization by ethnicity, BA.2 severity in children, placentitis and thrombohematoma during pregnancy, predictive value of symptoms for diagnosis, Evusheld activity against BA.1 and BA.2, Remdesivir resistance, Ivermectin with and without strongyloidiasis, inhaled ciclesonide, home telemonitoring, pulse oximetry for remote monitoring, effectiveness of anti-platelet therapy, and deaths in Zambia. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Moderna vaccine results in children (Moderna) Delta/Omicron hospitalization by ethnicity (MMWR) Intrinsic BA.2 severity in unvaccinated children (Lancet) Children and COVID state-level data (AAP) Placentitis and thrombohematoma during pregnancy (JAMA) Predictive value of symptoms for diagnosis (Clin Inf Dis) FDA to discuss booster strategy (FDA) Evusheld activity against BA.1 and BA.2 ( AstraZeneca and bioRxiv ) Remdesivir resistance in immunocompromised patient (Nature Comm) Ivermectin for COVID <a href= "https://jamanetwork.com/journals/jamanetworkopen/fullart
Thu, March 24, 2022
Indolent, resistant, and losing our TMPRSS
TWiV reviews the emergence of remdesivir-resistant SARS-CoV-2 during treatment of a persistently infected immunocompromised patient, and how altered TMPRSS2 utilization by the Omicron variant influences infectivity and fusion. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV 2022 Emergence of remdesivir resistance (Nature Comm) How to stall a copy machine ( TWiV 819 ) Omicron altered TMPRSS2 usage (Nature) Timestamps by Jolene . Thanks! Weekly Picks Brianne – NSURP 2022 Kathy – Virology Jobs Rich – 10 Steps from Seed to Cup ( Graphic ) Alan – Fathoms: The World in The Whale , by Rebecca Giggs Vincent – Worldwaterday.org Listener Picks Jeremy – Archaeology of Light Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, March 20, 2022
Shape matters sometimes
TWiV revisits chronic wasting disease of cervids and the ability of the prions to infect meadow voles and raccoons, and the suggestion that stochastic assembly of influenza virus particles may play a role in phenotypic diversity. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Amy Rosenfeld Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode CWD in meadow voles and raccoons (Emerg Inf Dis) Unusual infectious agents (Virology Live) Low fidelity influenza virus assembly (Cell) Shape-shifting viruses (TWiV 743) From variolous effluvia to VLPs (TWiV 170) A pox on your horse (TWiV 478) Letters read on TWiV 878 Timestamps by Jolene . Thanks! Weekly Picks Dickson – James Webb Space Telescope and Nature Conservancy Photo Contest Amy – A new strategy for staying one step ahead of the virus Rich – Searching for the origin of the smallpox vaccine: Edward Jenner and his little-known horsepox hypothesis Vincent – Blacktail Studio Listener Picks Richard – Water Structure and Science</a
Sat, March 19, 2022
COVID-19 clinical update #106 with Dr. Daniel Griffin
In COVID-19 clinical update #106, Daniel Griffin covers failure of ivermectin to improve hospitalization, increased hospitalization of children with Omicron, seroconversion of children versus adults, effectiveness of Pfizer mRNA vaccine in children, high vaccine effectiveness in Finland against Omicron, distinct long COVID clinical phenotypes, and estimating worldwide excess mortality. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Ivermectin did not reduce hospitalizations (Wall St J) Increased hospitalization of children with Omicron (MMWR) Seroconversion of children vs adults (JAMA) Effectiveness of Pfizer-BioNTech vaccine in children (MMWR) High vaccine effectiveness in Finland (medRxiv) Distinct long COVID clinical phenotypes (Open Forum Inf Dis) Estimating excess mortality (Lancet) Contribute to ASTMH fundraiser at PWB Letters read on TWiV 877 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Thu, March 17, 2022
Spillover market with Michael Worobey
Michael Worobey joins TWiV to explain evidence that SARS-CoV-2 emerged via the wildlife trade and that the Huanan market was the unambiguous epicenter of the COVID-19 pandemic. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Guest: Michael Worobey Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Early COVID-19 cases in Wuhan ( TWiV 833 ) Huanan market was epicenter of COVID-19 (Zenodo) Two spillover events launched COVID-19 pandemic (Zenodo) Robert Malone and Peter McCullough: A litany of untruths (Decoding the Gurus) Timestamps by Jolene . Thanks! Weekly Picks Brianne – Kartchner Caverns (info from Wikipedia here ) Kathy – Laminar flow and turbulent flow Rich – Wikipedia Vincent – The Human Lake by Carl Zimmer Listener Picks Brad – NASASpaceflight Intro music is by Ronald Jenkees <
Sun, March 13, 2022
Animal house
TWiV discusses the virome of game animals in China, and the finding that binding of sarbecoviruses to ACE2 is an ancestral and evolvable trait. Hosts: Vincent Racaniello , Dickson Despommier , and Amy Rosenfeld Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode WHO declaration of COVID-19 pandemic Virome of China game animals (Cell) ACE2 binding is ancestral and evolvable (Nature) Letters read on TWiV 875 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Ship found at the bottom of the sea Amy – Vaccinating kids has never been easy Vincent – State data and CDC data on children and COVID-19 Listener Picks Andrew – Books by Randall Munroe Intro music is by Ro
Sat, March 12, 2022
COVID-19 clinical update #105 with Dr. Daniel Griffin
In COVID-19 clinical update #105, Daniel Griffin discusses changes in brain structure after infection, dementia in patients with pneumonia, Paxlovid in children, mask effectiveness in schools, host factors and severe disease, post-acute symptoms, and the mission of CEPI. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Infection and changes in brain structure (Nature) Dementia among pneumonia survivors (Open Forum Inf Dis) Narrative dynamics around COVID-19 vaccines (FSI) Children and COVID (AAP) Paxlovid in pediatric patients (Pfizer) Mask effectiveness in schools (MMWR) Host factors and severe disease (Nature) Antiviral efficacy against BA.2 (NEJM) Post-acute symptoms , Denmark (medRxiv) Risk of sequelae after infection (BMJ) CEPI ( TWiV 612 ) Contribute to ASTMH fundraiser at PWB <a href="https://www.microbe.tv
Sun, March 06, 2022
Pig viruses and big viruses
TWiV reviews the six known coronaviruses that infect pigs and what can be learned about human infections, and how the giant Mimivirus DNA genome is organized into a nucleocapsid. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Brianne Barker Click arrow to play Download TWiV 873 (128 MB .mp3, 107 min) Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ABRCMS ePoster Spring Symposium for Emerging Scientists Porcine coronaviruses (Virol Sin) Mimivirus nucleocapsid (bioRxiv) Letters read on TWiV 873 Timestamps by Jolene . Thanks! Weekly Picks Brianne – The Dinosaur Age May Have Ended in Springtime Alan – The Track of the Typhoon , and me reading it . Rich – 12 Monkeys Vincent – Anna Mason’s Art Channel Listener Picks Richard – SARS-CoV-2 in animals: Situation report #9 Jason – Counting App and CountThings from Photos</a
Sat, March 05, 2022
COVID-19 clinical update #104 with Dr. Daniel Griffin
In COVID-19 clinical update #104, Daniel Griffin reviews effectiveness of mRNA vaccines among children, number of children affected by disease, accuracy of rapid antigen tests, CDC guidance for prevention strategies, monoclonal antibody effectiveness, predicting progression to severe respiratory failure from pneumonia, risk of long COVID after two vaccine doses, and peripheral neuropathy in long COVID. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Vaccine effectiveness 5-11 year olds (medRxiv) Vaccine effectiveness vs ED and UCE 5-12 year olds (medRxiv) Children affected by COVID (Lancet) Accuracy of rapid antigen tests (medRxiv) COVID community levels (CDC) Therapeutics guidelines (WHO) Mortality among SOT (Clin Inf Dis) Long COVID after two vaccine doses (medRxiv) Peripheral neuropathy in COVID patients (Neurology) Letters read on TWiV 872 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Sun, February 27, 2022
If the ACE2 fits, ferret
TWiV discusses whether or not Omicron should be designated a new serotype of SARS-CoV-2, and the finding that amino acid changes that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway. Hosts: Vincent Racaniello , Alan Dove , and Rich Condit Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ABRCMS ePoster Spring Symposium for Emerging Scientists ASV Annual Meeting Registration (ASV) Microbiology & Immunology at LSU Health Is Omicron a new serotype ? (Nat Rev Micr) Adaptation of SARS-CoV-2 to mink/ferret (Cell Rep) Letters read on TWiV 871 Timestamps by Jolene . Thanks! Weekly Picks Alan – Which Immune Cell Are You? and Michaeleen Doucleff’s article Rich – Vaccinated: One Man’s Quest to Defeat the World’s Deadliest Diseases by Paul A. Offit Vincent – Ebola on Canvas Listener Picks Les – Ologies podcast Intro mus
Sat, February 26, 2022
COVID-19 clinical update #103 with Dr. Daniel Griffin
In COVID-19 clinical update #102, Daniel Griffin covers immunocompromised people, hospitalization of children, vaccine usage update, Omicron and cross-reactive neutralizing antibodies, reinfection prevents disease in hamsters, repeated infections with endemic coronaviruses, global burden of antimicrobial resistance, ivermectin not protective in hamsters, and Omicron evades therapeutic monoclonals. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode What does society owe immunocompromised people (Atlantic) Prevalence of immunosuppression in US (JAME) Hospitalizations of children (MMWR) Clinical considerations for vaccines (CDC) Sanofi seeks vaccine approval (Sanofi) Omicron triggers cross-reactive neutralization (medRxiv) Reinfection prevents disease in hamsters (Cell) Repeated infections with endemic CoV (J Inf Dis) Global burden of antimicrobial resistance (Lancet) Ivermectin not protective in hamsters (bioRxiv) Omicron evades therapeutic monoclonals (bioRxiv) Letters read on TWiV 870 Timestamps by <a hr
Sun, February 20, 2022
Epstein-Barr virus and MS, a perfect storm
TWiV reviews epidemiological and experimental evidence that infection with Epstein-Barr virus leads to the production of antibodies against a viral protein that cross-react with a human protein, leading to multiple sclerosis. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ABRCMS ePoster Spring Symposium for Emerging Scientists ASV Annual Meeting Registration (ASV) Microbiology & Immunology at LSU Health Viremia in human poliomyelitis (J Exp Med) EBV associated with MS (Science) MS antibodies Bind EBV EBNA1 and GlialCAM (Nature) Letters read on TWiV 869 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Rapid intensification of the emerging southwestern North American megadrought in 2020–2021 Brianne – Which Immune Cell Are You? Rich – Nikola Tesla – 3D Anamorphosis <strong
Sat, February 19, 2022
COVID-19 clinical update #102 with Dr. Daniel Griffin
In COVID-19 clinical update #102, Daniel Griffin reviews children and COVID, effectiveness of maternal vaccination, vaccines for immunocompromised, primary care physicians and vaccination rates, booster safety among adults, placentitis, azithromycin, oral Nirmatrelvir, Omicron antibody evasion, EUA for bebtelovimab, IL-1 blocking agents, thromboprophylaxis, effectiveness of vaccines against long COVID, and risks of mental health outcomes. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Children and COVID state data (AAP) Effectiveness of maternal vaccination (MMWR) Vaccines for immunocompromised (CDC) PCP and vaccination rates (JAMA) Booster safety among adults (MMWR) Placental tissue destruction and placentitis (Arch Path Lab Med) Azithromycin meta-analysis (J Antimicrob Chemo) Oral Nirmatrelvir for high-risk, nonhospitalized adults (NEJM) Omicron antibody evasion (bioRxiv) EUA for bebtelovimab (FDA) IL-1 <a title="blocking agents" href= "http
Thu, February 17, 2022
I love the smell of vaccines in the morning
TWiV reviews an experimental, intranasally administered SARS-CoV-2 vaccine that utilizes adenovirus vectors to deliver three viral proteins and induces immunity to ancestral and variant isolates. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Dorothy Horstmann (Wikipedia) Intranasal SARS-CoV-2 experimental vaccine (Cell) t-SNE (Wikipedia) Timestamps by Jolene . Thanks! Weekly Picks Kathy – 477-mile-long megaflash lightning in Seattle Times ( originally Washington Post ) and extra info from Rich World Meteorological Org Rich – NIAID Global Research ( Mali ) Alan – New method for recycling electric car batteries Vincent – Q&A with A&V Listener Picks Addie – Vaccine Podcast Jennie – <a href= "https://yourlocal
Sun, February 13, 2022
EV antibodies rEVolutionize our thinking
Amy returns to TWiV to discuss her work on the identification of cross-reactive antibody responses among diverse enteroviruses, and the implications for our understanding of viral pathogenesis and seroprevalence studies. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit Brianne Barker , and Amy Rosenfeld Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ABRCMS ePoster Spring Symposium for Emerging Scientists Cross-reactive enterovirus antibodies (mBio) Poliovirus receptor transgenic mice (virology blog) Timestamps by Jolene . Thanks! Weekly Picks Dickson – European scientists set new record in production of nuclear fusion energy Amy – Alfredo’s Magic Wand Brianne – What Happened After the Chicken-Pox Vaccine? Rich – Year Three of COVID-19: Harsh Truths, Realities, and Glimmers of Hope Vincent – Economists Are Fueling the War Against Public Health Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, February 12, 2022
COVID-19 clinical update #101 with Dr. Daniel Griffin
In COVID-19 clinical update #101, Daniel Griffin discusses children and COVID, human challenge study results, effectiveness of mask use, Omicron boost in macaques, mucosal vaccine candidate, long-term cardiovascular outcomes, and global vaccine perceptions. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Children and COVID state data (AAP) Human challenge study (Res Sq) Effectiveness of mask use (MMWR) Omicron boost in macaques (bioRxiv) Mucosal vaccine candidate (Cell) Long-term cardiovascular outcomes (Nat Med) Global vaccine perceptions (PLoSNTD) Letters read on TWiV 865 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Fri, February 11, 2022
Sea Sawdust
Mark Martin returns to TWiM for a discussion of the frightening global burden of bacterial antibiotic resistance, and a solution to the problem of daylight nitrogen fixation in a cyanobacterium, despite the incompatibility of nitrogenase with oxygen produced during photosynthesis. Become a patron of TWiM. Links for this episode: Global bacterial antimicrobial resistance (Nat Micro) Cancer moon shot (NCI) When antibiotics don’t work (TED) Cyanobacterium buoyancy (Nat Micro) Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe.tv
Thu, February 10, 2022
A game of thrones
Monica, John, David, and Marc join TWiV to discuss their work on identifying cryptic SARS-CoV-2 lineages in New York City wastewater, and understanding whether they were shed from humans or other animals. Hosts: Vincent Racaniello , Rich Condit , and Brianne Barker Guests: John Dennehy , Marc Johnson , Davida Smyth , and Monica Trujillo Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode SARS-CoV-2 in NYC wastewater ( TWiV 737 ) Cryptic SARS-CoV-2 in NYC wastewater (Nat Comm) Timestamps by Jolene . Thanks! Weekly Picks Brianne – When scientific conferences went online, diversity and inclusion soared Rich – Traffic flow measured on 30 different 4-way junctions Vincent – A Slot Machine, a Broken Test Tube by S.E. Luria Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, February 06, 2022
Does this challenge study pass the smell test?
TWiV reviews the results of a study in which 36 volunteers were infected with SARS-CoV-2, and what was learned about the kinetics of virus reproduction in the nose and throat, development of symptoms, and reliability of lateral flow antigen assays. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Vaccine Town Hall ( ASV ) Columbia University BSL-3 Manager position 3:27 UK SARS-CoV-2 challenge study (Res Sq) U of Pennsylvania smell test (Wikipedia) Letters read on TWiV 863 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Webb team begins aligning telescope Brianne – Our Solar System in True Color Is Really Something Else Rich – When the International Space Station retires, it will plunge into the ocean to die Vincent – Gateway Program and What One Really Expensive Means to US Train Travel <h3 id=
Sat, February 05, 2022
COVID-19 clinical update #100 with Dr. Daniel Griffin
In COVID-19 clinical update #100, Daniel Griffin, from Accra, Ghana, reviews the challenges in evaluating Omicron severity, over 800 deaths in children, Pfizer vaccine EUA application for under 5 year olds, false positives from soft drinks, Novavax vaccine EUA application, childhood experiences and vaccine hesitancy, fourth vaccine dose in Israel, effects of antivirals and monoclonals against Omicron, and multiple factors associated with PASC. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Omicron severity challenges (NEJM) Children and COVID data (AAP) Vaccine EUA for under 5 year olds (Pfizer) B cell boot camp ( Immune 52 ) Soft drink and LFA false positives (medRxiv) EUA application for Novavax vaccine (Novavax) Childhood experiences and vaccine hesitancy (BMJ Open) Fourth vaccine dose in Israel (medRxiv) Antibodies and antivirals vs Omicron (NEJM) Paxlovid and Omicron (Pfizer) Multiple factors and PASC (Cell) Internship at Parasites Without Borders (<a href= "https://www.microbe.tv
Fri, February 04, 2022
Rough draft of Omicron origins
Nels joins TWiV to discuss hypotheses for the origins of Omicron, including that it came from mice or arose during chronic infection of an immunocompromised patient. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Guest: Nels Elde Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Vaccine Town Hall ( ASV ) Columbia University BSL-3 Manager position Did Omicron come from mice? (J Genet Genomics) Persistent SARS-CoV-2 infection (SSRN) Letters read on TWiV 861 Timestamps by Jolene . Thanks! Weekly Picks Brianne – Groundhogs Emerge From the Scientific Shadows Kathy – Zig-zag Coast Guard search pattern Rich – Moon Phases 2022 ( Lunar Reconnaissance Orbiter ) Vincent – Kevin Cowtan’s Book of Fourier and Live Fourier Transformation Nels – Biology versus bias Listener Picks Dusty – Fighting bias in space Intro music is by Ronald Jenkees Send your virology questions and comments to t
Sun, January 30, 2022
Evading a Toll on the road to RNA vaccines
TWiV reviews a seminal paper showing that chemically modified bases in RNAs suppress recognition by Toll-like receptors, a finding that that was essential for the development of COVID-19 mRNA vaccines. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Kathy Spindler Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Vaccine Town Hall ( ASV ) Columbia University BSL-3 Manager position RNA modifications suppress innate recognition (Immunity) Critical contribution of pseudouridine (Front Cell Dev Biol) Rich Condit reminisces (YouTube) Letters read on TWiV 860 Timestamps by Jolene . Thanks! Weekly Picks Dickson - NASA Research Launches a New Generation of Indoor Farming Kathy - How Pfizer scientists transformed an old drug lead into a COVID-19 antiviral Rich - Fermi paradox Vincent - Racism not Race by Joe Graves Listener Picks Jay – <a href= "https://www.youtube
Sat, January 29, 2022
COVID-19 clinical update #99 with Dr. Daniel Griffin
In COVID-19 clinical update #99, Daniel Griffin discusses Omicron disease severity, neurologic manifestations in children, testing outcomes during multiple infections, boosters improve VE and VD, booster efficacy for ED and UC encounters, vaccines induce cross-protective T cell memory, and indications for monoclonal antibody therapy.C Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Omicron disease severity (MMWR) Neurologic manifestations in children (Pediatric Neurol) Respiratory virus interference (Emerg Inf Dis) Hospitalization by vaccination status (CDC) Third vaccine dose VE (MMWR) Vaccination induces cross-reactive T cells (Cell) Limitations for monoclonal antibody use for Omicron (FDA) Internship at Parasites Without Borders ( pdf ) 42:40 Letters read on TWiV 859 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Fri, January 28, 2022
The vax of life with John Mascola
John Mascola joins TWiV to discuss the history and mission of the NIH Vaccine Research Center, how it prepared for devising pandemic vaccines, and development of the COVID-19 vaccines. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Brianne Barker Guest: John Mascola Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Accelerated COVID-19 vaccine development (Immunity) Letters read on TWiV 858 Timestamps by Jolene . Thanks! Weekly Picks Brianne – How Sesame Street is Handling the Pandemic Rich – Zamboni: How it works Alan – How lightning starts Vincent – Buon-A-Petitti Listener Picks Meika – Wordle Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, January 23, 2022
Not just antibody, Jon Yewdell
Jon Yewdell returns to TWiV to discuss how antibodies are made, vaccination against SARS-CoV-2, antigenic variation of the virus, booster shots, and more. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Brianne Barker Guest: Jon Yewdell Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Jon Yewdell on TWiV 208 , 467 , 597 , 620 Letters read on TWiV 857 Timestamps by Jolene . Thanks! Weekly Picks Jon – The Premonition by Michael Lewis Dickson – Nature photographer of the year 2021 Brianne – Should BioBank Volunteers Be Warned About Mutations? Rich – Czech singer Hanka Horká dies after intentionally getting infected by the coronavirus and Dena Dietrich Dies at 91 Vincent – Cuore di Cioccolato Listener Picks Bronwen – Schools must stay open John – Pandemic humor Intro music is by Ronald Jenkees Send your virology questions and c
Sat, January 22, 2022
COVID-19 clinical update #98 with Dr. Daniel Griffin
In COVID-19 clinical update #98, Daniel Griffin reviews COVID-19 in South Africa, recognition of Omicron by ancestral T cells, booster effectiveness against disease, infection and vaccination in pregnant women, early Remdesivir to prevent progression to severe disease, management of hospitalized adults, Tocilizumab in hospitalized patients, vaccination and long COVID, and the true toll of the pandemic. Click arrow to play Download TWiV 853 (58 MB .mp3, 48 min) Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode COVID-19 in South Africa ( pdf ) Ancestral T cells recognize Omicron (Nat Med) Booster effectiveness against COVID-19, England (Nat Med) Cases and hospitalization by vaccination status (MMWR) Infection and vaccination in pregnant women , Scotland (Nat Med) Early Remdesivir to prevent progression to severe disease (NEJM) Management of hospitalized adults (NIH) Tocilizumab in hospitalized patients (Resp Care) Vaccination and long COVID in Israel (medRxiv) Pandemic true death toll (Nature) Internship at Parasites Without Borders ( pdf ) Letters read on TWiV 856 Timestamps by <a href= "ht
Fri, January 21, 2022
T time with Alessandro Sette
Alessandro Sette returns to TWiV to discuss the observation that SARS-CoV-2 vaccination induces T cells that are able to cross-recognize variants Alpha to Omicron. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Guest: Alessandro Sette Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Travel Award Applications ( ASV ) 3:20 Impact of variants on T cells (Cell Rep Med) Timestamps by Jolene . Thanks! Letters read on TWiV 855 Weekly Picks Brianne – 75 years of research on human diseases in 1 minute Kathy – 10 second video of COVID-19 spread Rich – Diffraction spike Vincent – John’s Furniture Repair and Transcend Furniture Gallery Listener Picks Alison – FDA drug shortages Ingrid – One woman’s mission to get vaccines to her rural Alabama town Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, January 16, 2022
Omicron is evasive
TWiV reviews findings that increased fitness of the Omicron variant is due to immune evasion, not an increase in intrinsic transmissibility, and determination of infectious viral load in patients infected with wild type, Delta and Omicron viruses reveals lack of correlation with RNA loads determined by RT-PCR, similar levels of shedding among Delta and Omicron, and greatly reduced shedding in vaccinated people. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Travel Award Applications ( ASV ) 2:11 Omicron transmission in Danish households (medRxiv) Infectious viral load in vaccinated and unvaccinated patients (medRxiv) Fred Murphy on TWiV 625 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Favorite Science Photos of 2021 Brianne – Viruses, Vaccines, and COVID-19 videos from American Museum of Natural History Kathy – Klompas et al. “Current insights into respiratory virus transmission…” Rich – Leviathan Falls by James S.A. Corey Vincent – Ebola (1996) by David Molesky at The Incubator Listener Picks Randall – Robert Malone & Peter McCullough: A litany of untruths Suellen – <a href= "https://evolution.ber
Sat, January 15, 2022
COVID-19 clinical update #97 with Dr. Daniel Griffin
In COVID-19 clinical update #97, Daniel Griffin covers immunity after infection recognized by CDC, outcomes before and after Omicron, infectious viral load in Delta vs Omicron, PCR vs rapid antigen tests, booster interval shortened to 5 months, risk factors for severe outcomes in vaccinated, cross-reactive memory T cells, vaccine effectiveness vs MIS-C, and Rivaroxiban for thromboprophylaxis. Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Quarantine and isolation (CDC) Outcomes before and after Omicron (medRxiv) Infectious viral load in Delta vs Omicron infections (medRxiv) PCR vs rapid antigen test (medRxiv) Booster interval to 5 months (FDA) Cross-reactive memory T cells (Nat Comm) Risk factors for severe outcomes in vaccinated (MMWR) Vaccine effectiveness vs MIS-C (MMWR) Cross-reactive T cells to Omicron from vaccines (medRxiv) Rivaroxiban for thromboprophylaxis (Lancet) Letters read on TWiV 853 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Thu, January 13, 2022
Tree man syndrome
A TWiV threesome explains the observation that humans with inherited T cell CD28 deficiency are susceptible to severe warts driven by human papilloma virus infection, but are otherwise healthy. Hosts: Vincent Racaniello , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Vaccine Town Hall ( ASV ) Travel Award Applications ( ASV ) CD28 deficiency and severe warts (Cell) Vincent interviews Harald zur Hausen (virology blog) Letters read on TWiV 853 Timestamps by Jolene . Thanks! Weekly Picks Brianne – Every Pore on Your Face Is a Walled Garden Rich – “On Warts” by Lewis Thomas (Pdf) Vincent – Cells at Work Code Black 1 Listener Picks Chris – Ria Lina on the Guilty Feminist podcast Duncan – Meet the green kleptos of the animal kingdom Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, January 09, 2022
Questions are tricky
The TWiV team reviews the observation that infection with the SARS-CoV-2 Omicron variant causes reduced reproduction and pathogenesis in mice and hamsters. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , Brianne Barker , and Amy Rosenfeld Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Vaccine Town Hall ( ASV ) Travel Award Applications ( ASV ) Omicron infection in mice and hamsters (Res Square) Letters read on TWiV 851 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Engineering the James Webb Space Telescope Amy – T cells might be our bodies’ best shot against Omicron Brianne – Where is Webb? Rich – First U.S. vaccine mandate in 1809 launched 200 years of court battles Vincent – The Secret of Life by Howard Markel Listener Picks Jen – Antidote David – Rosie Revere, Engineer Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, January 08, 2022
COVID-19 clinical update #96 with Dr. Daniel Griffin
In COVID-19 clinical update #96, Daniel Griffin reviews Omicron in South Africa, rapid antigen tests, viral coinfections, isolation and quarantine, saliva preferred for Omicron, risk factors for severe disease in vaccinated, Paxlovid dosing, and long COVID. Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Variant proportions (CDC) Omicron in South Africa (JAMA) Transmission of SARS-CoV-2 (Ann Int Med) Diagnostics for COVID-19 (Lancet) Comparison of rapid antigen tests (J Clin Med) Rapid antigen tests to reduce isolation (medRxiv) Frequency of viral confections (MMWR) Isolation and quarantine (CDC) Saliva preferred for Omicron (medRxiv) Risk factors for severe COVID in vaccinated (MMWR) Paxlovid dosing (Pfizer) Fatigue and cognitive impairment (Brain, Behavior, Immune) Letters read on TWiV 850 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Fri, January 07, 2022
Arc of the epitope
TWiV kicks off 2022 with a review of the virology highlights of 2021, from three virologists, one immunologist, a science writer, and a partridge in a pear tree. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode COVID vaccines: TWiV 708, 715, 718, 844 Non-CoV papers: TWiV 763 , 784 , 819 , 822 , 740 , 848 Immune correlates of protection: TWiV 791, 799, 835 , 832, <a
Sun, January 02, 2022
On Dasher, on Dancer, on Corona and Lassa
For the final episode of 2021, TWiV reviews an experimental infectious attenuated Lassa fever vaccine based on a codon-deoptimized glycoprotein gene, and SARS-CoV-2 infection of free-ranging white-tailed deer. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Codon-deoptimized Lassa fever vaccine (mBio) Attenuation of dengue virus by codon deoptimization ( TWiV 351 ) Codon deoptimization of poliovirus and RS virus ( TWiV 740 ) Codon deoptimization of DNA viruses ( TWiV 362 letters ) CEPI on TWiV 612 SARS-CoV-2 in white-tailed deer (Nature) Letters read on TWiV 847 Timestamps by Jolene . Thanks! Weekly Picks Dickson – EO Wilson ( Ants and The Conversation ) Brianne – The Best Fun Science Stories of 2021 Kathy – Using sound for data analysis; chemotactic bacteria and Moo loo story Alan – Owls of the Easern Ice , by Jonathan Slaght Vincent – TWiV 9: Fever!
Sat, January 01, 2022
COVID-19 clinical update #95 with Dr. Daniel Griffin
In COVID-19 clinical update #95, Daniel Griffin discusses new CDC guidelines for isolation and quarantine, EUA for Molnupiravir, children and COVID, vaccine safety in 5-11 year olds, Omicron outbreaks in Nebraska and Denmark, Baylor's COVID vaccine, and COVID-OUT for ivermectin. Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Isolation and quarantine guidance (CDC) EUA for Molnupiravir (FDA) Children and COVID state data (AAP) Vaccine safety in 5-11 year olds (MMWR) Omicron and antigen tests (FDA) Omicron in Nebraska (MMWR) Omicron in Danish households (medRxiv) Baylor COVID vaccine (TCH) COVID-OUT for ivermectin (U Minn) Letters read on TWiV 848 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Sun, December 26, 2021
Beta was stirring, and now in a mouse
TWiV explores the impact of the intestinal virome on seroconversion after rotavirus vaccination, and implications of the ability of the SARS-CoV-2 beta variant to infect wild-type laboratory mice. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Impact of enteric virome on rotavirus vaccine (Cell Host Micr) Beta variant infects wild type mice (Sig Transd Targ Ther) Timestamps by Jolene . Thanks! Weekly Picks Brianne – XKCD on Immune Responses and Immunity Kathy – UVA Rotunda astrophotograph with Heart and Soul Nebulae by Brennan Gilmore Rich – James Webb Space Telescope Videos: 29 Days On The Edge ; Launch And Deployment Alan – Sokobond puzzle game Vincent – International Space Station shines in gorgeous fly-around photos by Crew Dragon astronauts Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, December 25, 2021
COVID-19 clinical update #94 with Dr. Daniel Griffin
In COVID-19 clinical update #94, Daniel Griffin reviews the FDA EUA for Paxlovid, test to stay in school, immunity after infection, variants and therapeutics, quarantine and isolation guidelines, Molnupiravir in non-hospitalized patients, and convalescent serum in outpatients. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode FDA EUA for Paxlovid ( pdf ) Children and COVID-19 ( pdf ) Evaluation of test to stay in school , IL (MMWR) Evaluation of test to stay in school , LA (MMWR) Update on mRNA vaccine in under 5 yo (Pfizer) CDC endorses preference for mRNA vaccines (CDC) Natural immunity and protection against delta (Clin Inf Dis) Cross-neutralization post-vaccination infection (JAMA) Variants and therapeutics (NIH) Quarantine and isolation (CDC) Molnupiravir in non-hospitalized patients (NEJM) Convalescent serum for outpatients (medRxiv) <
Sun, December 19, 2021
Paul Offit on children, COVID, and boosters
Paul Offit returns to TWiV to discuss new CDC guidance on J&J vaccine, why children should be immunized against COVID-19, and whether or not booster doses are scientifically justified. Hosts: Vincent Racaniello , Dickson Despommier , and Brianne Barker Guest: Paul Offit Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Paul Offit on TWiV 720 Are COVID-19 vaccine boosters needed? (virology blog) Letters read on TWiV 844 Timestamps by Jolene . Thanks! Weekly Picks Brianne - Virus snowflakes Dickson - The Year in Pictures 2021 Vincent - Our Life is Plasticized Listener Picks Gerry - Dan Barouch: COVID-19 Vaccine Development Louise - Pandora's Lab by Paul Offit Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, December 18, 2021
COVID-19 clinical update #93 with Dr. Daniel Griffin
In COVID-19 clinical update #93, Dr. Griffin summarizes Omicron fitness, S-gene target failure, monoclonal efficacy against Omicron, vaccination, monoclonals, and disease in children, persistence of memory B cells in the elderly, infection and vaccine induced immunity, protection against severe illness and death by a third mRNA vaccine dose, high flow oxygen versus intubation, and therapeutic anticoagulation. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Variant updates (CDC) List of diagnostic kits (Global Fund, pdf ) B1.1.529 escapes most antibodies (bioRxiv) mRNA vaccine third dose and Omicron (medRxiv) Outpatient strategies children and adolescents (AAP) Memory B cells persist in elderly (J Clin Invest) mRNA booster effect against Delta (Clin Inf Dis) Azithromycin meta-analysis (J Antimicrob Chemo) High-flow oxygen vs intubation (JAMA) Therapeutic anticoagulation (Ann Int Med) Africa cases surge (CIDRAP) Letters read on TWiV 843 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Thu, December 16, 2021
The clot thickens
TWiV reviews the results of serum neutralization assays which show that a third vaccine dose restores neutralization of the Omicron variant, and interaction of platelet factor 4 with the adenovirus capsid, suggesting a mechanism for thrombosis with thrombocytopenia syndrome. Hosts: Vincent Racaniello , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Third vaccine dose improves Omicron neutralization (medRxiv) ChAdOX1 interacts with PF4 (Sci Adv) Timestamps by Jolene . Thanks! Weekly Picks Brianne – Vaccine Scientists: Time’s 2021 Heroes of the Year Kathy – Snake dietary diversity Vincent – Alfred Wegener Institute on Instagram Listener Picks Niclas – Once upon a time… Life Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, December 12, 2021
Unmasking immunity
TWiV provides an update on immunity to Omicron, results of a randomized controlled trial of face masks, and a study of correlates of protection against respiratory syncytial virus infection in the upper and lower respiratory tract of nonhuman primates. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Amy Rosenfeld Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Omicron escape from serum antibodies ( pdf ) Pfizer/BioNTech update on Omicron (Pfizer) Randomized trial of masking for COVID-19 (Science) Upper and lower respiratory tract correlates of protection for RS virus (Cell Host Micr) Timestamps by Jolene . Thanks! Weekly Picks Dickson – Cities at Night Amy – I’m an E.R. Doctor in Michigan, Where Unvaccinated People Are Filling Hospital Beds Rich – International Dark Sky Association Vincent – SARS-CoV-2 variants Listener Picks Keith – Ventusky Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, December 11, 2021
COVID-19 clinical update #92 with Dr. Daniel Griffin
In COVID-19 clinical update #92, Dr. Griffin reviews emerging data on the Omicron variant, much information about monoclonal antibody treatment, including expansion of EUA for Lilly’s cocktail, FDA EUA for pre-exposure prophylaxis, outcomes after treatment, and investigation of subcutaneous or intramuscular administration; effect of adding immunomodulatory agents to usual care on thromboembolic events, and long COVID following infection in previously vaccinated individuals. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Risk associated with Omicron (medRxiv) Expansion of monoclonal EUA (FDA) Neutralization of Omicron by sera (medRxiv) Third dose sera neutralize Omicron (Pfizer) Monoclonals authorized for PreP (FDA) Patient outcomes after monoclonals (Open Forum Inf Dis) Subcutaneous or intramuscular monoclonals (medRxiv) WHO does not recommend convalescent serum (WHO) Immunomodulation and thromboembolic risk (J Clin Med) Long COVID after infection of vaccinated (medRxiv) Letters read on TWiV 840 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel
Thu, December 09, 2021
The long and the short of it: get vaccinated
TWiV reviews the impact of vaccination on SARS-CoV-2, the latest information on Omicron, West Nile virus transmission by organ transplantation, and why a 16 week interval between doses of BNT162b2 vaccine is better than a shorter interval. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Coronavirus in the US (NY Times) Omicron variant (NY Times) West Nile virus transmission by organ transplantation (Emerg Inf Dis) Stronger antibody response after 16 week mRNA dose (Cell Host Micr) Higher antibody response with 7 week dosing (Clin Inf Dis) Immune response after recovery and 1 vaccine dose (Sci Transl Med) Booster guidance in Canada ( pdf ) Timestamps by Jolene . Thanks! Weekly Picks Kathy – CDC U-M flu report ( lay version, MMWR ) Rich – Thagomizer Alan – Descent into Darkness by Edward Raymer Vincent – Funding: Blinding peer review Listener Picks Lynne – <a href= "https://www.cell.com/molecular-therapy-family/molecular-th
Sun, December 05, 2021
The magic virus bus
The New York City Virus Hunters join TWiV to reveal how local students engage in safe virus surveillance and conduct science research right in their neighborhoods, followed by an update on variant of concern Omicron. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Brianne Barker Guests: Teresa Bautista, Isabel Francisco, Jesus Gonzales, Joel Gonzalez, Florian Krammer , and Christine Marizzi , Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Biobus Wild Bird Fund FluLab B1.1.529 (COVID-19-lineages) Report on Omicron spike changes (virological) Omicron (Wikipedia) Timestamps by Jolene . Thanks! Weekly Picks Dickson – Plant Habitat-04 Brianne – The Coronavirus in a Tiny Drop Rich – Prophet in Purgatory by Jon Cohen Vincent – “ ’—All You Zombies—’ ” by Robert A. Heinlein ( pdf ) Listener Picks Mike – The Coronavirus in a Tiny Drop Intro music is by Ronald Jenkees Send your virology questions and comm
Sat, December 04, 2021
COVID-19 clinical update #91 with Dr. Daniel Griffin
In COVID-19 clinical update #91, Dr. Griffin discusses final results of molnupiravir trial, Omicron variant of concern, outcomes in B-cell depleted patients, recovery in T-cell depleted macaques, peptide for induction of T cell immunity, high respiratory viral RNA loads in infants, IgA and T cells transferred to breast milk after vaccination, sensitivity and specificity of ID NOW, post-acute sequelae at 12 months, disease in low and middle income countries. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Update on Molnupiravir results (Merck) Omicron (Wikipedia) P681H and IFN resistance (bioRxiv) Synthetic DMARDS and disease severity (Ann Rheum Dis) Recovery in T cell depleted macaques (mBio) T-cell inducing peptide (Nature) Respiratory viral RNA load in infants (J Inf Dis) IgA and T cells in breast milk (Cell Rep) ID NOW specificity and sensitivity (J Clinical Viral) Risk prediction algorithm (Thorax) PASC in adults at 12 months (Front Med) Letters read on TWiV 837 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your que
Thu, December 02, 2021
OMG, Omicron!
TWiV reveals all that we know so far about the variant of concern B.1.1.529, also called Omicron, and describes a study on the ability of the alpha, beta, and delta variants to reproduce in cells in culture and induce membrane fusion. Hosts: Vincent Racaniello , Alan Dove , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Omicron genome changes (Covariants) Omicron shared changes with other variants (Covariants) Update on Omicron (WHO) Spike polymutant PMS20 (bioRxiv) Syncytium formation of variants of concern (EMBO J) Variants as super cell fusers (EMBO J) Letters read on TWiV 836 Timestamps by Jolene . Thanks! Weekly Picks Brianne – Immune Kathy – Elizabeth Lee Hazen and Rachel Fuller Brown, discoverers of nystatin one and two Alan – Four Lost Cities by Analee Newitz Vincent – Deadly Choices by Paul Offit Listener Picks Ryan – Ronny Jackson ( one and two ) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe
Sun, November 28, 2021
Giving thanks for antibodies
TWiV reviews why children should be vaccinated against COVID-19, increased risk of infection with SARS-CoV-2 Beta, Gamma, and Delta variant compared to Alpha variant in vaccinated but not recovered individuals, and immune correlates of protection from the mRNA-1273 vaccine efficacy trial. Hosts: Vincent Racaniello , Dickson Despommier , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode COVID-19 vaccines for children (Science) Risk of infection with variants (medRxiv) Immune correlates of mRNA-1273 (Science) Letters read on TWiV 835 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Pee Wee Herman aka Paul Rubens Brianne – APOD: Pleiades Vincent – A History of Poliomyelitis by JR Paul Listener Picks Richard – Let’s talk about a familiar problem and a new tactic…. Sherri – Have the New Jab Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, November 27, 2021
COVID-19 clinical update #90 with Dr. Daniel Griffin
In COVID-19 clinical update #90, Dr. Griffin covers FDA expansion for booster doses, 3 more at home antigen tests approved by FDA, immune correlates analysis of mRNA-1273 vaccine, risk for stillbirth, PROVENT prophylaxis trial results, fluvoxamine recommendations, advice on molnupiravir, automated text messaging service for monitoring illness, and long COVID-19 after vaccination and infection. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Expanded eligibility for booster doses (FDA) More rapid antigen tests approved (FDA) Immune correlates for mRNA-1273 (Science) Risk for still birth with and without COVID-19 (MMWR) PROVENT phase III prophylaxis trial (AstraZenica) Fluvoxamine guidelines (IDSA) COVID-OUT trial (Univ Minnesota) Monoclonal antibody treatment in vaccinated infected (J Inf Dis) Steroid use in non-oxygen requiring patients (QJM) Doxycycline trial (Lancet) Efficacy of inhaled ciclesonide (JAMA) Advise on use of molnupiravir (EMA) Text messaging for monitoring disease (Ann Int Med) Long COVID after <a href= "https://www.resear
Thu, November 25, 2021
Grand theft kinesin
TWiV reviews Michael Worobey’s dissection of the early COVID-19 cases in Wuhan, and the discovery that herpesviruses assimilate cellular kinesin to produce motorized virus particles. Hosts: Vincent Racaniello , Alan Dove , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Early COVID-19 cases in Wuhan (Science) Herpesviruses assimilate kinesin (Nature) Letters read on TWiV 833 Timestamps by Jolene . Thanks! Weekly Picks Kathy – Power of poop Alan – Under the Sky We Make , by Kimberly Nicholas Vincent – Enzymatic amplification of beta-globing sequences Listener Picks Paula – Reasons to be Cheerful and The Night Witches by Bruce Myles Grant – George Carlin – Germs, Immune System Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, November 21, 2021
Heavy metal flu fighters
TWiV reviews the vials labeled smallpox that were not, re-emergence of enterovirus D68 in Europe, efficacy of inactivated SARS-CoV-2 vaccine, and cellular correlates of protection for an oral influenza virus vaccine. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condi t , and Amy Rosenfeld Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Smallpox vials contain vaccinia virus (6abc.com) European re-emergence of enterovirus D68 (Eurosurveill) Efficacy of inactivated SARS-CoV-2 vaccine (Lancet) Cellular correlates of protection for oral flu vaccine (Cell Host Micr) Timestamps by Jolene . Thanks! Weekly Picks Dickson – Rodney Dangerfield Amy – Calder at MoMA Rich – ‘Useless Specks of Dust’ Turn Out to Be Building Blocks of All Vertebrate Genomes Vincent – Structure of small viruses Listener Picks Charles – It is raining you lied to me Dave – A Whole New Ball Game Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, November 20, 2021
COVID-19 clinical update #89 with Dr. Daniel Griffin
In COVID-19 clinical update #89, Dr. Griffin reviews upcoming meeting on FDA emergency use authorization for molnupiravir, 25% of US cases in children, reinfection associates with presence of antibodies, national surveillance for acute flaccid myelitis in the US, and monoclonal antibody treatment of infection in vaccinated, high-risk individuals. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Scott Hammer on TWiV 52 Meeting for molnupiravir EUA (FDA) SARS-CoV-2 reinfection associates with antibodies (Clinical Inf Dis) AFM surveillance in US (CDC) Monoclonal antibody treatment in high-risk patients (J Inf Dis) Letters read on TWiV 831 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Thu, November 18, 2021
A culture of resistance
TWiV explains that a recent report suggesting that the SARS-CoV-2 spike protein inhibits V(D)J recombination in vitro would not impact immunity after infection or vaccination, and describes the isolation of remdesivir resistant mutants in cells in culture, and the emergence of amino acid changes in the spike protein identical to those in variants of concern, in the absence of immune selection. Hosts: Vincent Racaniello , Alan Dove , Rich Condi t , and Kathy Spindler Click arrow to play Download TWiV 830 (67 MB .mp3, 112 min) Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Spike protein inhibition of V(D)J recombination in vitro (Viruses) Evolutionary predictability of SARS-CoV-2 (PLoS Path) Letters read on TWiV 830 Timestamps by Jolene . Thanks! Weekly Picks Kathy – When do we get back to normal? Maybe now. Rich – The Covid-19 Pandemic Alan – Yaupon Brothers American tea Vincent – Cracking the genetic code (and Niremberg’s account ) Listener Picks Justin – <a href= "https://www.cnn.com/2021/11/14
Sun, November 14, 2021
Antiviral and cytotoxically empowered for COVID-19
A TWiV duo reviews how SARS-CoV-2 attacks the olfactory mucosa but spares the olfactory bulb, vaccination with BNT162b2 induces virus-specific stem cell memory T cells, and development of an oral protease inhibitor for the treatment of COVID-19. Hosts: Vincent Racaniello and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode How SARS-CoV-2 attacks olfactory mucosa (Cell) SARS-CoV-2-specific stem cell memory T cells after mRNA vaccine (Sci Immunol) Oral SARS-CoV-2 protease inhibitor (Science) Paxlovid phase 2/3 trial preliminary results (Pfizer) Letters read on TWiV 829 Timestamps by Jolene . Thanks! Weekly Picks Brianne – Coronavirus Neutralizing Antibodies and mRNA Vaccine Video Vincent – MHC restriction of cytotoxic T cell lysis ( Nobel description ) Listener Picks Lisa – Shall Furnish Medicine Bistra – Saving the World by Julia Alvarez Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, November 13, 2021
COVID-19 clinical update #88 with Dr. Daniel Griffin
In COVID-19 clinical update #88, Dr. Griffin covers vaccine protection among US veterans, absence of long COVID in vaccinated who are infected, single dose of REGEN-COV monoclonal antibody cocktail provides long term protection, and Pfizer protease inhibitor Paxlovid is 89% effective in preventing hospitalization or death. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Vaccine protection of US veterans (Science) Long term protection by REGEN-COV (Regeneron) Pfizer protease inhibitor Paxlovid phase 2/3 results (Pfizer) Letters read on TWiV 828 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Sun, November 07, 2021
A shot to save the world with Greg Zuckerman
Greg Zuckerman joins TWiV to discuss his book that explores the race to produce COVID-19 vaccines, with insights into the companies, scientists, and executives involved and the rivalries, ambitions, ego, and a desire to save the world. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condi t , and Kathy Spindler Guest: Greg Zuckerman Click arrow to play Download TWiV 824 (76 MB .mp3, 127 min) Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode A Shot to Save the World ( Hardcover , Kindle ) Letters read on TWiV 827 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Michael Palin Kathy – Science News Centennial Rich – Diverse variola virus (smallpox) strains were widespread in northern Europe in the Viking Age Vincent – Evidence for somatic rearrangement of immunoglobulin genes (and commentary ) Listener Picks Matt – Clinical evidence that the pandemic from 1889 to 1891 commonly called the Russian flu might have been an earlier coronavirus pandemic Brigitte – <a href= "https://www.pushkin.fm/episode/the-obscure-viru
Sat, November 06, 2021
COVID-19 clinical update #87 with Dr. Daniel Griffin
In COVID-19 clinical update #87, Dr. Griffin reviews PCR cycle threshold and RNA copy number, rapid antigen tests, hospitalization rate after infection or vaccination, allergies and vaccination, community transmission and viral RNA load, early treatment with sotrovimab, meta-analysis of tocilizumab treatment, antibiotic overuse, and guidelines on the use of anticoagulation for thromboprophylaxis. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode CDC vaccine nod to 5-11 year olds (CDC) Sensitivity of rapid antigen tests (Front Micro) COVID-19 among infected or vaccinated (MMWR) Allergy and vaccination symptoms (JAMA) Community transmission and viral RNA load (Lancet) Early treatment with sotrovimab (NEJM) Tocilizumab treatment meta-analysis (Leukemia) Antibiotic overuse in COVID-19 (Am J Trop Med Hyg) Anticoagulants for thromboprophylaxis (Blood Adv) Letters read on TWiV 826 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Mon, November 01, 2021
COVID-19 Q&A with Dr. Daniel Griffin
In this special live-streamed episode of TWiV, Dr. Daniel Griffin fields questions on SARS-CoV-2 and COVID-19 from listeners. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Sun, October 31, 2021
Immunogoblins in the nose and lungs
TWiV explores the properties of the spike glycoproteins of an influenza B virus discovered in the Wuhan spiny eel, and protection against SARS-CoV-2 infection one year after mRNA-1273 vaccination of nonhuman primates. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condi t , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode HA and NA of Wuhan spiny eel influenza virus (Nat Comm) Protection one year after mRNA-1273 vaccination (bioRxiv) Letters read on TWiV 824 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Best of Gilda Radner Brianne – This polio survivor is one of the last still relying on an iron lung Rich – WHO Announces Proposed Members of its Scientific Advisory Group for the Origins of Novel Pathogens (SAGO) ; ( members ) Vincent – Discovery of mRNA (paper one and two ) Listener Picks Doris – History of smallpox and smallpox vaccine Judith – How the immune system works Intro music is by Ronald Jenkees Send your virology que
Sat, October 30, 2021
COVID-19 clinical update #86 with Dr. Daniel Griffin
In COVID-19 clinical update #86, Dr. Griffin discusses virologic features of infection in children, antibody tests should not be used to asses level of protection, test-to-stay programs in schools, FDA authorizes Moderna boosters, results of TOGETHER trial for fluvoxamine, statins and 28 day mortality, and cognitive function in patients. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode 115,000 healthcare worker deaths (Stat News) Virology features of infection in children (J Inf Dis) Antibody tests not for assessing protection (FDA) Infections in vaccinated healthcare workers (NEJM) Flawed science of antibody testing (JAMA) Test-to-stay in school (US News) Vaccination and non-COVID mortality risk (MMWR) EUA for Moderna booster (FDA) Fact sheet for use of casirivimab and imdevimab (FDA) Effect of early treatment with fluvoxamine (Lancet) Statins and 28-day mortality (J Inf Dis) Cognitive function after COVID-19 (JAMA) Routine <a href= "https://www.cdc.gov/mmwr/volumes/70/wr/mm7043a1.htm?s_cid
Thu, October 28, 2021
Viking variola variants
Rich reviews the history of smallpox and the discovery of variola viral genomes in ancient DNA from human remains throughout Northern Europe, which pushes back the earliest date of smallpox virus infection to ~600–1050 CE, overlapping the Viking Age. Hosts: Vincent Racaniello , Alan Dove , Rich Condi t , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Variola virus genomes from Viking era (Science) Hidden history of ancient plagues (Nature) Was smallpox a mild disease? (Science) Smallpox: Ten years gone (Am J Pub Health) Myth of the milkmaid (NEJM) Interview with DA Henderson (ASM) Letters read on TWiV 822 Timestamps by Jolene . Thanks! Weekly Picks Brianne – The Animal Kingdom is Full of Genetic Screwballs Kathy – Science dresses, accessories from Svaha and Rosalind Franklin’s DNA diffraction dress Rich – The Saxon Stories Alan – Cincinnati’s “Old Cunny,” and audiobook version Vincent – <a href= "https://pubmed.ncbi.nlm.nih.go
Sun, October 24, 2021
Public clonotype #1
A TWiV trio reveal the isolation of novel paramyxoviruses from rodents and bats in Arizona, and isolation of naive B cells from seronegative donors that produce germline encoded antibodies which engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses from bats. Hosts: Vincent Racaniello , Rich Condi t , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Bat and rodent paramyxoviruses from Arizona (J Viral) Naive B cells engage SARS-CoV-2 RBD (Science Immunol) Vincent interviews Philip Sharp (ASM) Letters read on TWiV 821 Timestamps by Jolene . Thanks! Weekly Picks Brianne – Apod: The Dolphin Head Nebula Rich – The Tree That Could Help Stop The Pandemic ; Elucidating the Mechanisms of Action of Saponin-Derived Adjuvants Vincent – Discovery of RNA splicing in Sharp and Roberts laboratories Listener Picks Jason – Home Assistant Alena – VirusCraft Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, October 23, 2021
COVID-19 clinical update #85 with Dr. Daniel Griffin
In COVID-19 clinical update #85, Dr. Griffin reviews cases and deaths by vaccination status, mRNA vaccine effectiveness in 12-18 year olds, standard and extended dosing of mRNA vaccines, immune responses after vaccination, Moderna booster dose approved, giving monoclonals at home, no benefit from colchicine, and IFN does not help remdesivir. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Guidelines on COVID-19 drugs (WHO) Holiday celebrations (CDC) COVID-19 cases and deaths by vaccination status (CDC) Effectiveness of Pfizer-BioNTech mRNA Vaccination 12-18 years (MMWR) Rollout of vaccines for 5-11 year olds (WaPo) Standard and extended dosing mRNA vaccine (Cell) Differential kinetics immune responses after vaccination (NEJM) Moderna booster dose approved (FDA) Vertically transferred maternal immune cells (Nat Comm) Giving monoclonals at home (JAMA) No benefit from colchicine (Lancet) IFN does not help remdesivir (Lancet) Letters read on TWiV 820 Timestamps by J
Thu, October 21, 2021
How to stall a copy machine
TWiV explains how remdesivir inhibits the SARS-CoV-2 RNA polymerase: the drug is incorporated into the growing RNA chain and causes synthesis to stall when the drug clashes with an amino acid in the active site. Hosts: Vincent Racaniello , Alan Dove , Rich Condi t , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode How remdesivir stalls the SARS-CoV-2 polymerase (Nat Comm) Movie of polymerase stalling (Nat Comm) Second mechanism of remdesivir inhibition (J Biol Chem) Watson Crick molecular model (Science Museum Group) Letters read on TWiV 819 Timestamps by Jolene . Thanks! Weekly Picks Kathy – Great Lakes Science Center, Cleveland Rich – How to Temporarily Disable Your Keyboard with a Keyboard Shortcut in Windows Alan – How to Make a Slave and Other Essays by Jerald Walker Vincent – A structure for deoxyribose nucleic acid Listener Picks Steve – How the immune system actually works Lise – Lise Meitner: A Life in Physics Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, October 17, 2021
Thor's hammer
The TWiVers review phase 3 efficacy and safety results for the Novavax COVID-19 vaccine, effects on the neonatal immune system caused by maternal infection with SARS-CoV-2, and NHC, the metabolite of molnupiravir, causes mutations in cellular DNA. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condi t , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Efficacy and safety of Novavax vaccine (medRxiv) A floret of spikes with Matt Frieman ( TWiV 729 ) Maternal SARS-CoV-2 infection affects neonatal immunity (Nat Immunol) NHC is mutagenic in mammalian cells (J Inf Dis) Coding for catastrophe (Nat Struct Mol Biol) Molnupiravir development (Nature) Letters read on TWiV 818 Timestamps by Jolene . Thanks! Weekly Picks Dickson – J ohn Clease Brianne – Astronomy Picture of the Day: Swirl in the Southern Sky Kathy – Lise Meitner Statue is at the Humboldt University Rich – Google has the cleanest cloud. Now it’s helping other companies go green Vincent – Discovery of reverse transcriptase by Baltimore and <a href= "https://pubmed.ncbi.
Sat, October 16, 2021
COVID-19 clinical update #84 with Dr. Daniel Griffin
In COVID-19 clinical update #84, Dr. Griffin discusses childrens’ antibody response to vaccination, phase 3 results of Novavax vaccine, heterologous vaccination, antithrombotic therapy, EUA for molnupiravir, phase 3 results of AZD7442, serum ferritin levels and outcomes, heparin therapy, and WHO strategy for global vaccination. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Antibody profiles after mRNA vaccination in children (bioRxiv) Novavax vaccine phase 3 results (medRxiv) Heterologous vaccine boosters (medRxiv) Antithrombotic therapy outcomes (JAMA) Molnupiravir EUA submitted (Merck) AZD7442 phase 3 results (AstraZeneca) Serum ferritin levels and disease outcome (JAMA) Heparin efficacy (JAMA) WHO strategy to vaccinate world (WHO) Letters read on TWiV 817 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Fri, October 15, 2021
Long COVID and ME/CFS with David Tuller
David Tuller returns to TWiV to revisit his work to expose the methodological and ethical problems with the PACE trial, and the post-acute sequelae to SARS-CoV-2 infection, also known as long COVID. Host: Vincent Racaniello Guest: David Tuller Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Call me David Tuller ( TWiV Special ) David writes at virology blog Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, October 10, 2021
MIS-C with Moshe Arditi and Ivet Bahar
Moshe and Ivet join TWiV to discuss their finding that MIS-C is a consequence of a superantigen in the spike protein of SARS-CoV-2 that causes activation of a skewed population of T cell receptor bearing lymphocytes, leading to hyperinflammation. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condi t and Kathy Spindler Guests: Moshe Arditi and Ivet Behar Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MIS-C in US children (NEJM) Superantigen in spike and T cell skewing in MIS-C (PNAS) MIS-C mimics toxic shock syndrome (J Allergy Clin Immunol) Antibody against bacterial superantigen blocks SARS-CoV-2 entry (Structure) Autoimmune signature of MIS-C in children (J Clin Invest) HLA1 associated T cell expansion in MIS-C (J Clin Invest) Passing of Bill Wold ( one , two ) Letters read on TWiV 815 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Mel Brooks Kathy – Dickson’s art show at Fordham Rich – Saildrone captures footage from inside Hurricane Sam Vincent – <a href="htt
Sat, October 09, 2021
COVID-19 clinical update #83 with Dr. Daniel Griffin
In COVID-19 clinical update #83, Daniel Griffin discusses upcoming FDA discussions on vaccines, strategies to prevent transmission at youth camps, outbreaks at summer camps, impact of vaccination on transmission, AZD7442 request for EUA filed, EUA issued for home antigen test, phase 3 data on AZD1222 vaccine, 6 month effectiveness of Pfizer/BioNTech vaccine, estimates of durability of immunity against reinfection, Molnupiravir interim results, optimal time for monoclonal antibody infusion, IVIG plus Infliximab for MIS-C, and effect of vaccination on long COVID. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Preventing transmission at camps (MMWR) Outbreaks at summer camps (MMWR) Impact of vaccination on transmission (medRxiv) AZD7442 r equest for FDA EUA (AstraZeneca) FDA EUA for home antigen test (FDA) Phase 3 results AZD1222 vaccine (NEJM) 6 month effectiveness BNT1`62b2 vaccine (Lancet) Durability of immunity vs reinfection (Lancet) Molnupiravir interim results (Merck) Optimal time for mAb therapy (Inf Dis Advisor) <a href="https://pubmed.ncbi.nlm.nih.gov/345
Thu, October 07, 2021
COVID-19 at the European Society for Clinical Virology
From the 2021 online meeting of the European Society for Clinical Virology, Vincent speaks with meeting speakers on COVID-19 vaccines, immunity, how countries responded to the pandemic, and how to prepare for the next one. Host: Vincent Racaniello Guests: Sarah Gilbert , Florian Krammer , Fausto Baldanti , Thea Fischer , Ron Fouchier , and Catherine Moore Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Correlate of protection needed for COVID-19 vaccines (Nat Med) Simian adenoviruses as vaccine vectors (Future Viral) Early SARS-CoV-2 spread in Lombardy (Nat Comm) SARS-CoV-2 seroprevalence in Denmark (Clin Micro Inf) SARS-CoV-2 testing in an academic center (Nat Biotech) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, October 03, 2021
Bespoke capsids delivered
TWiV considers lessons learned from COVID-19 about emergency drug use during a pandemic, and selection of AAV capsids to produce vectors that efficiently deliver genes to muscle cells. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condi t and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Emergency drug use during a pandemic (Cell) Mus cle-directed AAV capsids (Cell) Designer AAV muscles up (Cell) Letters read on TWiV 812 Timestamps by Jolene . Thanks! Weekly Picks Dickson - Sid Caesar - The German General Brianne - These Sea Slugs Break a Cardinal Rule of Animal Life Rich - Seek by iNaturalist Alan - The hard part of making a game is ... everything Vincent - Columbia Pledges That All Future Campus Construction Will Be Fossil Free Listener Picks Bruce - Bat Superpowers Gary - We’re Already Barreling Toward the Next Pandemic Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv</
Sat, October 02, 2021
COVID-19 clinical update #82 with Dr. Daniel Griffin
In COVID-19 clinical update #82, Daniel Griffin reviews vaccines for 5-12 years old, safety of a third vaccine dose, Oklahoma reinfection data, Regencov outcomes, Pfizer protease inhibitor, impact of Tocilizumab, and incidence of long COVID. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Data on Pfizer-BioNTech in 5-12 year olds (Pfizer) Safety of additional vaccine dose (MMWR) Oklahoma reinfection rates (OK DOH) Regencov outcomes (NEJM) Pfizer protease inhibitor trial (Pfizer) WHO recommends antibody therapy (Hosp Health) Tocilizumab use in hospitalized patients (Resp Care) Long COVID (PLoS Medicine) Letters read on TWiV 811 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Thu, September 30, 2021
Opening Pandora's box
TWiV reviews how a novel technology enabled development of COVID-19 mRNA vaccines, and discovery of a proton gradient and an incomplete TCA cycle in a giant. virus. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode mRNA vaccines, a novel technology (Cell) Proton gradient in giant virus (ISME J) Tomograms of Pandoravirus massiliensis Pandoraviruses are not alive (virology blog) Letters read on TWiV 810 Timestamps by Jolene . Thanks! Weekly Picks Brianne – PhD Comics: Words Said By No Academic Ever Kathy – Bach Cello Suite #1 visualization Rich – Hypnagogia Vincent – Landsat 9 and Wiki Listener Picks Lori – Project Hail Mary by Andy Weir Kevin – Oak Savannahs Intro music is by Ronald Jenke Send your virology questions and comments to twiv@microbe.tv
Sun, September 26, 2021
Vampire vax
TWiV reveals isolation from bats in Laos of a SARS-CoV-2 like virus with a spike protein that allows entry into human cells, and exploration of a herpesvirus vector for immunization of vampire bats against rabies virus. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit and Amy Rosenfeld Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode SARS-CoV-2 like viruses from Laotian bats (Res Sq) Herpesvirus in rabies endemic vampire bats (Nat Comm) Letters read on TWiV 809 Timestamps by Jolene . Thanks! Weekly Picks Dickson – George Carlin: “Stuff” Amy – The best of me by David Sedaris Rich – You could have a secret twin (but not the way you think) Alan – Nuclear powered Gameboy Vincent – No, Vaccinated People Are Not ‘Just as Likely’ to Spread the Coronavirus as Unvaccinated People by Craig Spencer Listener Picks Michael – The tangled history mRNA vaccines Fernando – 1493 by Charles Mann Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, September 25, 2021
Clinical update #81 with Dr. Daniel Griffin
In COVID-19 clinical update #81, Daniel Griffin discusses vaccine boosters, vaccination during pregnancy, mRNA vaccine comparison, J&J vaccine booster, EUA expansion for Lilly monoclonals, remdesivir reduces risk of hospitalization, and anticoagulation regimens. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Pfizer phase III results in 5-11 year olds (Pfizer) FDA authorizes booster (FDA) V-safe vaccine pregnancy registry (CDC) High antibody levels in cord blood (Am J Ob Gyn) mRNA vaccines compared (MMWR) Effectiveness of single shot J&J (medRxiv) J&J booster results (J&J) EUA expansion for Lilly mAbs (Lilly) Remdesivir reduces hospitalization risk (Gilead) DisCoVeRy on Remdesivir (Lancet) Prophylactic anticoagulant dosing (Eur Heart J) Letters read on TWiV 808 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv<
Sun, September 19, 2021
The shot yearned 'round the world with Chadi Saad-Roy and Caroline Wagner
Chadi and Caroline join TWiV to describe the potential epidemiological and evolutionary impacts of vaccine nationalism, and their modeling which emphasizes the importance of rapid equitable vaccine distribution for global control of the pandemic. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit and Brianne Barker Guests: Chadi Saad-Roy and Caroline Wagner Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Vaccine nationalism and control of the pandemic (Science) Vaccine sharing app Dynamics of SARS-CoV-2 simulation Dynamics of vaccination simulation Vaccine effectiveness against hospitalization (MMWR) Letters read on TWiV 807 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Ernie Kovaks-Nairobi Trio Brianne – XKCD Summarizes this Episode Rich – Texas Coronavirus Antibody REsponse Survey (CARES) (Dashboard) Vincent – Elmer Pfefferkorn Listener Picks Catherine – A Life on Our Planet Attila – <a href= "https://youarenotsosm
Sat, September 18, 2021
COVID-19 clinical update #80 with Dr. Daniel Griffin
In COVID-19 clinical update #80, Daniel Griffin reviews infections in children, masking, testing to limit transmission, high barrier for monoclonal antibody escape, are boosters needed, use of steroids, grants for long COVID, and how the pandemic unfolds in Africa. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Hospitalization pre- and post-vaccines (Res Sq) Infection in children (medRxiv) Updated mask guidance (CDC) Transmission to masked and unmasked (MMWR) Daily testing in schools (Lancet) High barrier to mAb escape (bioRxiv) Boosters not needed (Lancet) Distribution system for mAbs (HHS) Steroids in non-oxygen requiring patients (Int J Med) Grants for long COVID (NIH) Genomic surveillance in Africa (Science) Letters read on TWiV 806 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Thu, September 16, 2021
Delta and boosters
The TWiVotopes review current evidence which does not show the need for widespread COVID-19 booster vaccination, and results of experiments to examine the replication and immune evasion of the SARS-CoV-2 delta variant. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV Vaccine Town Halls Vaccine boosters not needed (Lancet) Delta variant replication and immune evasion (Nature) Epidemiologically linked COVID-19 outbreaks (MMWR) Letters read on TWiV 805 Timestamps by Jolene . Thanks! Weekly Picks Brianne – Sloan Foundation Theater Kathy – COVID vaccines work, even if you don’t have side effects lay article primary article Rich – Science Alone Can’t Heal a Sick Society by Jay S. Kaufman Vincent – Sandra Black SciArt Listener Pick Ruth – Radio Lento podcast Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, September 12, 2021
A tangled web of viruses with Mya Breitbart
Virus hunter Mya Breitbart joins TWiV to describe her laboratory’s work on viruses in spiders, insects, millipedes, freshwater springs, seawater, plants, human feces and much more. Hosts: Vincent Racaniello , Alan Dove , and Dickson Despommier Guest: Mya Breitbart Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Viruses of spinybacked orbweavers (J Gen Virol) Viruses of terrestrial arthropods (PeerJ) Pepper mild mottle virus in sewage (PLoS Path) Environmental DNA in marine community (Nat Comm) Viral community of freshwater springs (mBio) Phage puppet masters in the oceans (Nat Micro) Letters read on TWiV 804 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Official-Droodles-Home Alan – The 31st First Annual Ig Nobel Prize Ceremony video (and the text version ) Vincent – Biden’s federal and business vaccine mandates Listener Pick Anonymous – The Ivermectin Episode – Behind the Bastards Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, September 11, 2021
COVID-19 clinical update #79 with Dr. Daniel Griffin
In COVID-19 clinical update #79, Daniel Griffin discusses clinical management guidelines, ER visits and hospitalization among children, infection and vaccine induced seroprevalence in the US, antibodies in Kenyan blood donors, infections after vaccination, anticoagulation for thromboprophylaxis, baracitinib efficacy, long-term symptoms in adults, and sustained symptoms after severe disease. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Overlooked shortcomings of observational studies (Op For Inf Dis) Guidelines for clinical management (Op For Inf Dis) ER visits and hospitalization among children (MMWR) Hospitalization of adolescents (MMWR) Seroprevalence in the US (JAMA) Seroprevalence in Kenya (JAMA) Infections after vaccine (medRxiv) Israel data dashboard Guidelines on anticoagulation for thromboprophylaxis (Blood Adv) Baricitinib efficacy (Lancet) Long term symptoms , US adults (MMWR) Severe disease associated with long term symptoms (medRxiv) <a href="h
Thu, September 09, 2021
Another epitope with Shane Crotty
Shane Crotty returns to TWiV to review the immunology of COVID-19, including differences between infection and vaccination, increased breadth of antibodies after infection followed by vaccination, the roles of T cells, and whether booster vaccinations are needed. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Guest: Shane Crotty Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV Vaccine Town Halls SARS-CoV-2 immune memory 8 months post-infection (Science) SARS-CoV-2 T cell epitopes (Cell Host Microbe) Letters read on TWiV 802 Timestamps by Jolene . Thanks! Weekly Picks Brianne – How the cat gets its stripes Kathy – Kurzgesagt on Giruses (giant viruses) and beautiful APOD Rich – The 1911 Triangle Factory Fire ; Triangle: The Fire That Changed America by David Von Drehle Vincent – Two Top F.D.A. Vaccine Regulators Are Set to Depart During a Crucial Period Listener Picks Debby – River Runner Lin – Your Vaccinated Immune System Is Ready for Breakthroughs Intro music is by Ronald Je Send your virology questions and comments to twiv@microbe.tv
Sun, September 05, 2021
We can hear the coffin
The meteorologicomaniacs discuss the COVID-19 pandemic global death toll, effectiveness of vaccines against the delta variant, and how analysis of ancient viral DNA reveals that two pathogenic human viruses were brought into Mexico during the transatlantic slave trade. Hosts: Vincent Racaniello , Alan Dove , Dickson Despommier , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV Vaccine Town Halls COVID-19 excess mortality (eLife) Tracking pandemic death toll (eLife) COVID-19 vaccines and delta variant (NEJM) Slave trade carries viruses into Mexico (eLife) Letters read on TWiV 801 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Victor Borge, Phonetic Punctuation Brianne – Cat TV Rich – Cochrane review: Ivermectin for preventing and treating COVID‐19 Alan – Cockpit video of flying into Oshkosh Vincent – Medical News Network Morning Medical Update Listener Pick Jody – Human Body Theatre and Plagues: The Microscopic Battlefield Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, September 04, 2021
COVID-19 clinical update #78 with Dr. Daniel Griffin
In COVID-19 clinical update #78, Daniel Griffin covers ivermectin, convalescent plasma, disease in pregnant women, children and COVID, delta outbreak in an elementary school, validation of at-home antigen test, shedding in infected vaccinated people, mRNA vaccine antibody responses compared, AZD7442, fluvoxamine, one year outcomes in hospitalized patients, and post-vaccination disease. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Do not take veterinary ivermectin (FDA) Ivermectin side effects (CDC) Do not use convalescent plasma (IDSA) COVID-19 in pregnant women (JAMA) Children and COVID-19 data (AAP) Long COVID in 11-17 year olds (Res Square) Delta outbreak elementary school (MMWR) Validation of at-home antigen test (JAMA) Shedding in infected vaccinated people (medRxiv) Compared antibody responses after mRNA vaccination (JAMA) AZD7442 PROVENT phase III (AZ) Fluvoxamine trial (medRxiv) One-year outcomes hospital survivors (Lancet) <a href= "https://www.thelancet.com/journals/la
Thu, September 02, 2021
A very model of a modern TWiV
TWiV reviews models for determining correlates of neutralizing antibody protection against COVID-19, and for identifying key vector and host species that drive transmission of zoonotic pathogens. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Correlate of protection needed for COVID-19 vaccines (Nat Med) Neutralizing antibodies predict protection against symptomatic COVID-19 (Nat Med) Host and vector importance for Ross River virus (eLife) Coronavirus in the U.S.: Latest Map and Case Count (NY Times) Letters read on TWiV 799 Timestamps by Jolene . Thanks! Weekly Picks Brianne – A microscopic video shows the coronavirus on the rampage Kathy – Sabin Oral Sundays in Cuyahoga County, 1962 Rich – The Continuing COVID-19 Pandemic: Current Issues and Glimpse Into the Future Vincent – Demand Surges for Deworming Drug for Covid, Despite Scant Evidence It Works Listener Picks Ronald – Immunity to COVID-19 could last longer than you’d think Agnes – Space Shuttle Prints Intro music is by Ronald Jenkees <br
Sun, August 29, 2021
Rats, more coronaviruses!
The TWiV team explains what the Biden report on SARS-CoV-2 origins did not: evidence that the virus came from Nature, not a lab; and reveals new coronaviruses in rodents that inhabit populated areas in southern China. Hosts: Vincent Racaniello , Alan Dove , Dickson Despommier , Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Biden preliminary report on virus origins (NY Times) Window on SARS-CoV-2 origins closing (Nature) WHO Committee members on TWiV 760 Origins of SARS-CoV-2 review (Cell) Comirnaty ? Really Pfizer? (FDA) Why the weird name for Pfizer vaccine (Quartz) US vaccine names (CDC) More coronaviruses from rodents in China (J Viral) Timestamps by Jolene . Thanks! Weekly Picks Dickson – The Brilliant Abyss by Helen Scales Kathy – Solar System ball drop Rich – Dr. Fox effect Alan – Patty Wagstaff virtual airshow cockpit video Vincent</s
Sat, August 28, 2021
COVID-19 clinical update #77 with Dr. Daniel Griffin
In COVID-19 clinical update #77, Daniel Griffin discusses children becoming increasingly infected, virological characteristics of infections in vaccinated health care workers, transmission dynamics among close contacts, licensing of Pfizer mRNA vaccine, cost of hospitalization of unvaccinated patients, 29 times higher hospitalization rates in unvaccinated patients, boost in neutralizing antibody potency and breadth by third vaccine dose, and use of J&J vaccine as second dose. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode COVID-19 false dichotomies (BMC Inf Dis) Virological characteristics of infections (medRxiv) Transmission among close contacts (JAMA) Comirnaty licensed (FDA) Cost of hospitalization of unvaccinated (Health Sys Tracker) 29 times higher hospitalization among unvaccinated (MMWR) Third dose boosts antibody potency and breadth (medRxiv) J&J second dose (J&J) Letters read on TWiV 797 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Sun, August 22, 2021
The vary hungry spike with Paul and Theodora
Paul and Theodora return to TWiV to explain their research on determining the number of neutralizing epitopes on the SARS-CoV-2 spike that are recognized by antibodies, and engineering of a polymutant spike with twenty amino acid changes that demonstrates the high genetic barrier to escape from convalescent serum. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Brianne Barker Guests: Paul Bieniasz and Theodora Hatiziiouannou Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode High genetic barrier for SARS-CoV-2 antibody escape (bioRxiv) Enhanced antibody one year after COVID-19 (Nature) Letters read on TWiV 796 Timestamps by Jolene . Thanks! Weekly Picks Dickson – NIF and Photon Science : fusion reaction generates 1.3 MJ Brianne – The PCR Song Rich – 1) How Boston Dynamics’ Spot Robot Works! 2) Inside the lab: How does Atlas work? 3) Atlas | Partners in Parkour Theodora – Kevin Parry turning into random objects Vincent – Lex Fridman Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, August 21, 2021
COVID-19 clinical update #76 with Dr. Daniel Griffin
In COVID-19 clinical update #76, Daniel Griffin covers association of age and pediatric household transmission, rapid antigen testing in remote communities, shedding of infectious virus in vaccinated individuals, FDA amendment of mRNA vaccine EUA to allow a third dose, new vaccine mandate for NY state, full vaccination suppresses selection of variants, effectiveness of mRNA vaccines in nursing homes, sustained effectiveness of mRNA vaccines against hospitalization, and no benefit from early convalescent serum in high-risk outpatients. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Age and pediatric household transmission (JAMA) Rapid antigen testing in remote communities (MMWR) Shedding of infectious virus from vaccinated individuals (medRxiv) Additional vaccine doses for immunocompromised (FDA) New vaccine mandate for New York (NYS) Vaccination suppresses variant emergence (medRxiv) mRNA vaccine effectiveness in nursing homes (MMWR) Effectiveness of mRNA vaccines against hospitalization (MMWR) mRNA vaccine sustained effectiveness against hospitalization (MMWR) No benefit of convalescent plasma for high-risk outpatients (NEJM) Letters read on TWiV 795 Timestamps by Jolene . Thanks! Intro music is by <a
Sun, August 15, 2021
PAMS spray SARS-CoV-2
TWiV summarizes cases of arbovirus disease during 2019 in the US, and explains a study that estimates infectiousness throughout the SARS-CoV-2 course of infection. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Vaccine Town Halls (ASV) Arboviral illness , US, 2019 (MMWR) Estimating SARS-CoV-2 infectiousness (Science) Timestamps by Jolene . Thanks! Weekly Picks Dickson – Climate Reports | United Nations Brianne – Astronomy Picture of the Day: A Perfect Spiral Rich – COVID-19 false dichotomies Alan – Fixing broken machines Vincent – MKBHD Studio Tour 2021 Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, August 14, 2021
COVID-19 clinical update with Dr. Daniel Griffin
In COVID-19 clinical update #75, Daniel Griffin reviews vaccine effectiveness against transmission, modeling effectiveness of daily antigen tests, updated CDC guidance for fully vaccinated, risk of infection with time after mRNA vaccination, reduced risk of infection after vaccination, therapeutic anticoagulants in critically ill patients, and 6 month outcomes in hospitalized patients. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Vaccine effectiveness against transmission (Euro Surveill) Effectiveness of daily antigen tests (medRxiv) Interim guidance for fully vaccinated people (CDC) Elapsed time since BNT162b2 vaccine and reinfection (medRxiv) Reduced risk of infection after vaccination (MMWR) Therapeutic anticoagulants in critically ill patients (NEJM) 6 month outcomes in hospitalized patients (J Gen Int Med) Letters read on TWiV 793 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Thu, August 12, 2021
Transmission with Jeffrey Shaman
Jeffrey Shaman returns to TWiV to explain how epidemiologists measure SARS-CoV-2 movement among humans, including calculation of the reproductive index, secondary transmission, and what factors affect transmission. Hosts: Vincent Racaniello , Kathy Spindler , and Brianne Barker Guest: Jeffrey Shaman Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode A guide to R (Nature) Epidemiology of three SARS-CoV-2 VOC (medRxiv) Impact of delta variant in India (medRxiv) Letters read on TWiV 792 Timestamps by Jolene . Thanks! Weekly Picks Brianne – The Social Lives of Giraffes Kathy – Saturn’s Iapetus, moon in 3-D Vincent – Arkansas Governor Wants To Reverse A Law That Forbids Schools To Require Masks Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, August 08, 2021
A mad virologists' T party
TWiV reviews SARS-CoV-2 infection of wild white-tailed deer in the US, mRNA vaccine-mediated protection by spike-specific T cells before detection of neutralizing antibodies, and recovery from SARS-CoV-2 infection in T-cell depleted rhesus macaques. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode SARS-CoV-2 in wild deer (bioRxiv) Rapid T cell induction by mRNA vaccine (Nature) T cell depleted macaques recover from SARS-CoV-2 infection (mBio) Letters read on TWiV 791 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Virgin Hyperloop shows off the future Brianne – BioNumbers Rich – Advice will evolve as COVID situation changes Alan – Mars Perseverance-themed geocaching swag Vincent – Mattel’s Barbie Turns Women Of Science, Including COVID Vaccine Developer, Into Dolls Listener Picks Nancy – Vaccines at a Party Jeff – <a href= "https://www.nytimes.com/2021/07/23/nyregion/Co
Sat, August 07, 2021
COVID-19 clinical update #74 with Dr. Daniel Griffin
In COVID-19 clinical update #74, Daniel Griffin covers infections in vaccinated individuals, expansion of Regeneron monoclonal antibody cocktail for prophylaxis, neutralization of variants by antibodies produced by infection or vaccination, longer hospital stays associated with remdesivir treatment, and post-acute sequelae of infection and impact on quality of life 1-6 months after illness. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Outbreak in Barnstable County, MA (MMWR) Kinetics of delta variant infections (medRxiv) Prophlaxis with Regeneron mAbs ( Regeneron ) Subcutaneous mAbs to prevent COVID-19 (NEJM) Variant neutralization by infection or vaccine antibodies (Clin Inf Dis) Remdesivir associated with longer hospital stays (JAMA) Post-acute sequelae (Op For Inf Dis) Letters read on TWiV 790 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Thu, August 05, 2021
Does delta mean a change?
TWiV reviews a leaked CDC document on virulence and spread of the delta variant, and how anti-alphavirus antibodies that do not neutralize infection can nevertheless protect mice from disease. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode NYC first to require vaccination proof (Reuters) Leaked internal CDC document (WaPo) Manuscripts on increased virulence ( one , two , three ) Disease protection by non-neutralizing antibodies (Cell) Timestamps by Jolene . Thanks! Weekly Picks Brianne – Nobel Prize Games Kathy – Snail sensors Rich – In Shock: My Journey from Death to Recovery and the Redemptive Power of Hope by Rana Awdish Vincent – The Provincetown Covid data is actually good news (if you are vaccinated) and I Was the Architect of Operation Warp Speed. I Have a Message for All Americans. Listener Pick Jake – NASA spinoff Peter – Bernard, the Extraordinary Moth Intro music is by <a href= "http://w
Sun, August 01, 2021
neuroCOVID with Kiran Thakur, MD
Kiran joins TWiV to discuss the findings of a team at Columbia University Medical Center on COVID-19 neuropathology, and the conclusion that SARS-CoV-2 does not reproduce in the central nervous system. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Brianne Barker Guest: Kiran Thakur Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode COVID-19 neuropathology (Brain) Infections in vaccinated people (MMWR) Infections in vaccinated people (NEJM) Letters read on TWiV 788 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Simone Biles and Suni Lee Brianne – How Speed and Distance Dictate the Way Olympians Run Rich – CDC reversal on indoor masking prompts experts to ask, ‘Where’s the data?’ Vincent – Paul and the Mosquitos Listener Pick Lin – Your Vaccinated Immune System is Ready For Breakthroughs Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, July 31, 2021
COVID-19 clinical update #73 with Dr. Daniel Griffin
In COVID-19 clinical update #73, Daniel Griffin reviews updated mask guidance from CDC, infections in public school district employees, effectiveness of vaccines against delta variant, antibody response after third vaccine dose in kidney transplant recipients, protection afforded by mRNA vaccines fully vaccinated people with and without prior infections, correlates of protection in nonhuman primates, lack of effectiveness of doxycycline, neurological manifestations of COVID-19, and infection in vaccinated health care workers. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Updated mask guidance (CDC) Infections in public school district employees (MMWR) 10% of positive kids need hospitalization (Houston Chronicle) Effectiveness of vaccines vs delta variant (NEJM) Antibody response after third vaccine dose (JAMA) Severe COVID-19 in kidney transplant patients (Kidney Intl) mRNA vaccine protection with or without prior infection (medRxiv) Doxycycline ineffective (Lancet) Neurological manifestations (Lancet) Infections in vaccinated health care workers (NEJM) Letters read on TWiV 787 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@
Thu, July 29, 2021
You make mucus and you move it
TWiVsters review off-season epidemics of respiratory syncytial virus in Australia after easing of COVID-19 restrictions, and impaired innate immune responses in upper respiratory tract cells from patients with severe COVID-19. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Off-season RSV in Australia (medRxiv) Impaired innate immunity in severe COVID-19 (Cell) Letters read on TWiV 786 Timestamps by Jolene . Thanks! Weekly Picks Brianne – The Science of Swimming Kathy – Talking to the vaccine hesitant and covidactnow.org Rich – The Disinformation Dozen | Center for Countering Digital Hate ( CCDH on wiki ) Vincent – Russia discards Pirs docking port to clear way for new space station module ( IG post ) Listener Pick April – Pemberton Aviation ( Facebook , YouTube ) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Wed, July 28, 2021
COVID-19 Q&A with Dr. Daniel Griffin
In this special episode, Daniel Griffin answers listener questions on COVID-19 vaccines, vaccine misinformation, long COVID, masking and distancing, school safety, and much more. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Letters read on TWiV 785 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Sun, July 25, 2021
Virtually live from ASV
Moriah and Joseph join the nearly complete TWiV team to discuss their work on genetic variation and adaptability in herpes simplex virus, and how rotavirus infection disrupts intracellular calcium homeostasis. Live streamed during the 2021 annual meeting of the American Society for Virology. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , Alan Dove , and Brianne Barker Guests: Joseph Hyzer and Moriah Szpara Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Diversity of HSV2 in neonates (mSphere) Genome of HSV1 from multiple sites in one person (J Inf Dis) Rotavirus disrupts calcium homeostasis (mBio) Rotavirus protein activates calcium sensor (J Virol) Timestamps by Jolene . Thanks! Weekly Picks Dickson – Inside of Mars is not like Earth Brianne – AlphaFold Rich – Tesla motors Alan – Diving for antique beer Vincent – Dolly Parton Tried. But Tennessee Is Squandering a Miracle Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Fri, July 23, 2021
COVID-19 clinical update #72 with Dr. Daniel Griffin
In COVID-19 clinical update #72, Daniel Griffin covers long term symptoms in children, outcomes for MIS-C, recent guidance from the American Academy of Pediatrics, a large well traced outbreak of delta variant, low dose mRNA vaccination generates durable T cell memory and antibodies, protective immunity in recovered patients, assessment of BinaxNOW, no effect of oral azithromycin, post-discharge symptoms in Nigeria, and therapeutics for low and middle income countries. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Long COVID in children (JAMA) Outcomes after MIS-C (Pediatrics) Guidance for school opening (Amer Acad Ped) Infection in well traced delta outbreak (medRxiv) Immune memory 8 months post-infection (Science) Low dose mRNA vaccine enhances T cells (medRxiv) Protection after infection (Lancet) Assessment of BinaxNOW (Sci Rep) Rapid POC antigen tests (Cochrane Rev) Oral azithromycin ineffective (JAMA) Post discharge symptoms in Nigeria (AJTMH) Therapeutics for low and middle income countries (AJTMH) Letters read on TWiV 783 Timestamps by Jolene . Than
Thu, July 22, 2021
An antibody for all sarbecoviruses
On this episode, broadening of immune responses to SARS-CoV-2 after mRNA vaccine booster to ChAdOx1 nCoV-19, five-fold underestimation of the number of cases in the US during the first six months of the pandemic, and a monoclonal antibody that broadly neutralizes many different sarbecoviruses. Hosts: Vincent Racaniello and Amy Rosenfeld Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Immune responses after heterologous COVID-19 vaccine boost (Nat Med) Undiagnosed SARS-CoV-2 infections in US (Sci Transl Med) Broadly neutralizing sarbecovirus antibody (Nature) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, July 18, 2021
My genome is left to tell the tale
The Team with Invincible Values discusses whether dogs or cats passively carry SARS-CoV-2 on hair and foot pads, maternal to fetal transfer of antibodies in infected or vaccinated pregnant women, and evidence that retroviruses infected cetaceans before and after they moved into the oceans. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode SARS-CoV-2 on dogs and cats (Viruses) Maternal to neonatal transfer of SARS-CoV-2 antibodies (J Clin Investîmes) Retroviral evolution in cetaceans and their ancestors (Plos Path( Letters read on TWiV 781 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Current Map | U.S. Drought Monitor Brianne – A comic strip about immune responses Alan – Superliminal game Vincent – Birds are dying in NJ Listener Picks 2listening1 – Renewal Em – Cognitive Surplus Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, July 17, 2021
COVID-19 clinical update #71 with Dr. Daniel Griffin
In COVID-19 clinical update #71, Daniel Griffin reviews updated school and child care guidance from CDC, transmission in schools, accuracy of lateral flow assays, update to J&J/Janssen vaccine EUA to include GBS, interim immunogenicity of Ad.26.CoV2.s, effectiveness of mRNA vaccines to prevent hospitalization, Bamlanivimab plus Etesevimab for mild or moderate disease, and a meta-analysis of ivermectin results. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode School and child care guidance (CDC) Transmission in schools (CDC) Accuracy of lateral flow diagnostics (Lancet) GBS with Ad.26.CoV2.s vaccine (FDA) Ad.26.CoV2.s interim immunogenicity (NEJM) mRNA vaccine effectiveness to prevent hospitalization (medRxiv) Bamlanivimab plus Etesevimab (NEJM) Meta-analysis of ivermectin studies (Clin Inf Dis) Letters read on TWiV 780 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Sun, July 11, 2021
Evolving boosterism
TWiV reviews evidence that COVID-19 mRNA vaccination of both uninfected and previously infected persons elicits cross-variant neutralizing antibodies, and directed evolution of a bacterial protein to form a virus-like capsid that specifically packages its encoding mRNA. Hosts: Vincent Racaniello , Alan Dove , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode mRNA vaccine boosts cross-variant neutralizing Ab (Science) mRNA vaccine boosts variant B and T cell responses (Science) Directed evolution of virus-like nucleocapsid (Science) Letters read on TWiV 779 Timestamps by Jolene . Thanks! Weekly Picks Brianne – The Science of Chocolate Chip Cookies Alan – Keeping Black students in STEM Vincent – Antiviral Program for Pandemics Listener Pick Mark – Curator on the Loose , Classic Airliners and Vintage Pop Culture , Flying Men , Flying Machines , Thai Flying Club Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, July 10, 2021
COVID-19 clinical update #70 with Dr. Daniel Griffin
In COVID-19 clinical update #70, Daniel Griffin discusses efficacy of portable air cleaners, vaccine induced serum neutralizing antibodies against variants, prevention and attenuation of disease with mRNA vaccines, ivermectin to prevent hospitalization, IL-6 antagonists and mortality, and impact of vaccination on long COVID. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Efficacy of portable air cleaners (MMWR) Ad26.COV2.S elicited neutralization of variants (bioRxiv) Prevention of COVID-19 with mRNA vaccines (NEJM) Ivermectin to prevent hospitalization (BMC Inf Dis) IL-6 antagonists and mortality (JAMA) Impact of vaccination on long COVID (Lancet) Letters read on TWiV 778 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Thu, July 08, 2021
SARS-CoV-2 fitness with Ron Fouchier
Ron Fouchier explains why increased transmission of SARS-CoV-2-variants has not been demonstrated, and their ability to displace ancestral variants is due to greater fitness, much like influenza virus antigenic variation leads to better fitness and replacement of previously circulating variants. Hosts: Vincent Racaniello , Kathy Spindler , and Brianne Barker Guest: Ron Fouchier Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Ron Fouchier on TWiV 177 , 291 , 557 Mutations driving H5N1 airborne transmission in ferrets (Cell) SARS-CoV and SARS-CoV-2 transmission among ferrets (Nat Comm) Avian influenza virus transmission among seals (Cell Host Micr) Timestamps by Jolene . Thanks! Weekly Picks Brianne – The Science News Cycle Kathy – mRNA Day Kariko & Weissman lectures and Q&A Vincent – Just Planes Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, July 04, 2021
Yes! We have no pangolins
TWiV reviews an analysis of animal sales from Wuhan wet markets before the COVID-19 pandemic, control of dengue by release of Wolbachia -infected mosquitoes, and fatal dengue acquired in Florida. Hosts: Vincent Racaniello , Alan Dove , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Animal sales from Wuhan markets before COVID-19 (Sci Rep) Dengue control by Wolbachia -infected mosquitoes (NEJM) Fatal dengue in Florida (NEJM) Letters read on TWiV 776 Timestamps by Jolene . Thanks! Weekly Picks Brianne – You Know You’ve Worked Too Long in a Lab When… Alan – Massachusetts vaccine lottery Vincent – Coonhound paralysis Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, July 03, 2021
COVID-19 clinical update #69 with Dr. Daniel Griffin
In COVID-19 clinical update #69, Daniel Griffin covers effectiveness of mRNA vaccines against the delta variant, depression among public health workers, correlates of protection against asymptomatic and symptomatic infection, BNT162b2 in ChAdOx-1-S primed individuals, prior infection rescues B and T cell responses to variants after vaccination, effect of vaccination on household transmission, germinal responses induced by mRNA vaccines, phase 3 results of Novavax vaccine, and long COVID as our next national health disaster. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Worry about human behavior , not variants (NY Times) Moderna and Pfizer vaccines vs delta variant Depression among public health workers (MMWR) Correlates of protection (medRxiv) mRNA vaccine in AZ recipients (Lancet) Prior infection rescues B and T cell responses to variants (Science) Effect of vaccination on household transmission (NEJM) mRNA vaccines induce germinal responses (Nature) Novavax vaccine phase 3 results (NEJM) EUA for tocilizumab (FDA) Long COVID , next national health disaster (NEJM) Letters read on TWiV 775 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenke
Thu, July 01, 2021
Kristian Andersen, Robert Garry, and the deleted SARS-CoV-2 sequences
Kristian Andersen and Robert Garry join TWiV to discuss recovery of deleted deep sequencing data from early in the Wuhan SARS-CoV-2 epidemic, and whether they shed light on the early phase of the outbreak. Hosts: Vincent Racaniello , Kathy Spindler , and Brianne Barker Guests: Kristian Andersen and Robert Garry Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Andersen laboratory Recovery of deleted deep sequencing data (bioRxiv) Animal sales from Wuhan wet markets (Sci Rep) Danielle Anderson on Wuhan Lab (Bloomberg) Timestamps by Jolene . Thanks! Weekly Picks Kathy – STEVE over Copper Harbor, MI Vincent – Human Behavior During the Pandemic Is More Important Than Any Covid Variant Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, June 27, 2021
Laurie Garrett, pandemic prophet
Laurie Garrett, author of The Coming Plague , joins TWiV for a wide-ranging discussion of infectious disease and public health, including emerging infections, the role of wildlife markets in spillovers, and missteps in handling the COVID-19 pandemic. Hosts: Vincent Racaniello , Kathy Spindler , and Brianne Barker Guest: Laurie Garrett Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Lauriegarrett.com The Coming Plague Betrayal of Trust Trump sabotaged coronavirus response (Foreign Policy) ASV Vaccine Town Hall Timestamps by Jolene . Thanks! Weekly Picks Brianne – A Pivotal Mosquito Experiment Could Not Have Gone Better Kathy – Microbiology at the Movies Vincent – When a Good Scientist Is the Wrong Source Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, June 26, 2021
COVID-19 clinical update #68 with Dr. Daniel Griffin
In COVID-19 clinical update #68, Daniel Griffin discusses children acquiring infection at birthday parties, immunogenicity of vaccines in solid organ transplant patients, reinfection rates in recovered patients, lack of efficacy of azithromycin, bacterial and fungal infections in hospitalized patients, effect of monoclonal antibody treatment on clinical outcomes of ambulatory patients, and reduction in mortality of hospitalized patients treated with remedesivir. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode COVID-19 and birthday parties (JAMA) Vaccines in transplant patients (Ann Int Med) Reinfection of recovered patients (Clin Inf Dis) Azithromycin lack of efficacy (Rev Med Virol) Bacterial and fungal infections in hospitalized patients (Op For Inf Dis) mAb treatment of ambulatory patients (Op For Inf Dis) Remdesivir reduction of mortality (Gilead) Letters read on TWiV 772 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Sun, June 20, 2021
Borna hundred million years ago
A TWiV trio reveals the 100 million year old history of bornavirus infections hidden as EVEs in vertebrate genomes, and identification of novel bat coronaviruses that provide evolutionary insight into the origins of SARS-CoV-2. Hosts: Vincent Racaniello , Alan Dove , and Amy Rosenfeld Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV Vaccine Town Hall 2:05 100 million year old bornavirus infections (PNAS) Bornaviruses across geological timescales (PNAS) Bornaviruses previously on TWiV 303 , 347 , 548 Novel bat SARS-CoV-2 related coronaviruses (Cell) Letters read on TWiV 771 Timestamps by Jolene . Thanks! Weekly Picks Amy – A relic from the Jurassic era Alan – World of Wonders , by Aimee Nezhukumatathil Vincent – Tom Buck’s YouTube Channel Listener Pick Victor – Vaccines: A measured response Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, June 19, 2021
COVID-19 clinical update #67 with Dr. Daniel Griffin
In COVID-19 clinical update #67, Daniel Griffin reviews antibodies to the virus early in the US, serology testing of blood donations, MIS-C in children under 21, myocarditis in competitive athletes, ER visits for suspected suicide attempts, delta variant in Scotland, Novavax vaccine phase 3 results, vaccine coverage in pregnant women, early monoclonal administration reduces hospitalization and mortality, casirivimab and imdevimab recovery trial results, and CDC guidance on postacute sequelae. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Antiviral antibodies early in US outbreak (CID) Serologic testing of US blood donations (CID) The virus, what went wrong (PBS) MIS-C in children (JAMA) Myocarditis in competitive athletes (JAMA) ER visits for suspected suicide (MMWR) Delta variant in Scotland (Lancet) Novavax phase 3 results (Novavax) Vaccine coverage in pregnant women (MMWR) Early mAb reduces hospitalization and mortality (CID) Regen-Cov trial results (Regeneron) Guidance on postacute sequelae (CDC) Letters read on TWiV 770 Ti
Thu, June 17, 2021
MIS-C and leaky gut
On this episode of TWiV, Novavax COVID-19 vaccine demonstrates 90% overall efficacy, preventing an antigenically disruptive change during growth of influenza virus vaccine in chicken eggs, and MIS-C is driven by loss of the gut mucosal barrier. Hosts: Vincent Racaniello , Kathy Spindler, and Brianne Barker Click arrow to play Download TWiV 769 (68 MB .mp3, 114 min) Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV Vaccine Town Hall 2:05 Novavax vaccine efficacy reported (Novavax) H3N2 glycosylation in eggs (TWiV 480) Preventing antigenically disruptive HA change in eggs (Cell Host Micr) MIS-C due to leaky gut (J Clin Invest) Letters read on TWiV 769 Timestamps by Jolene . Thanks! Weekly Picks Brianne – Pandemics for Babies , Germ Theory for Babies , and Vaccines for Babies Kathy – Playing with Time Vincent – A Top Virologist in China, at Center of a Pandemic Storm, Speaks Out Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, June 13, 2021
Can nanobody stop these variants?
TWiV describes how human behavior, not increased transmissibility, led to increased spread of a SARS-CoV-2 variant throughout Europe in summer 2020, and nanobodies from camelid mice and llamas that efficiently neutralize variants of concern. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV Vaccine Town Hall Spread of SARS-CoV-2 variant in summer 2020 (Nature) Nanobodies neutralize SARS-CoV-2 variants (Nature) Letters read on TWiV 768 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Hotel Magdalena Brianne – Antibody Song by Raven the Science Maven Alan – How to play Magic: the Gathering Vincent – Steve Gibson’s rant on Security Now Listener Pick David – Coronavirus set to mu Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, June 12, 2021
COVID-19 clinical update #66 with Dr. Daniel Griffin
In COVID-19 clinical update #66, Daniel Griffin covers treatment guidelines from IDSA, hospitalization of adolescents, estimating epidemiological dynamics from viral load distributions, incidence of infection according to baseline antibody status, assessment of reinfection in Italy, need for vaccination in previously infected individuals, assessment of protection against reinfection, antimicrobial use in hospitalized patients, effect of single dose ivermectin, and a trial of aspirin in hospitalized patients. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode COVID-19 treatment guidelines (IDSA) Hospitalization of adolescents (MMWR) Estimating dynamics from viral load (Science) Incidence according to antibody status (Lancet) Reinfections in Italy (JAMA) Need for vaccination in previously infected (medRxiv) Assessment of protection against reinfection (ACC) Antimicrobial use in hospitalized patients (Lancet) Effect of single dose ivermectin (Viruses) Aspirin in hospitalized patients (medRxiv) Letters read on TWiV 767 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees
Thu, June 10, 2021
The CORONA project with David Fajgenbaum
David joins TWiV to relate how his near-death experience with Castleman’s disease motivated him to found the Center for Cytokine Storm Treatment & Laboratory and the CORONA project to identify and track all treatments reported for COVID-19 in an open-source data repository. Hosts: Vincent Racaniello , Kathy Spindler , and Brianne Barker Guest: David Fajgenbaum Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode CORONA project Center for Cytokine Storm Treatment & Laboratory Castleman Disease Collaborative Network Chasing My Cure Letters read on TWiV 766 Timestamps by Jolene . Thanks! Weekly Picks Brianne – How Giraffes Beat High Blood Pressure Kathy – Orangutan optical illusion Vincent – Two quotes from Chasing My Cure by David Fajgenbaum John Paul II: Dear young people, whether you are believers or not, accept the call to be virtuous. This means being strong within, having a big heart, being rich in the highest sentiments, bold in the truth, courageous in freedom, constant in responsibility, generous in love, invincible in hope. David: Never stop questioning and always follow the data. Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, June 06, 2021
Potpourri of COVID-19
TWiV reviews the new nomenclature for SARS-CoV-2 variants, effectiveness of Pfizer/BioNTech vaccine against variants, modified Moderna vaccine against variants, impact of COVID-19 interventions on influenza in China and the US, and binding of RaTG13 spike protein to ACE2 of multiple species. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Updated nomenclature of SARS-CoV-2 variants (WHO) Pfizer-BioNTech vaccine effective against alpha variants (Lancet) Novavax vaccine effective against beta variants (NEJM) Moderna updated vaccine against beta and gamma variants (medRxiv) Impact of COVID-19 interventions against influenza (Nat Comm) RaTG13 spike binding to various ACE2 proteins (Cell) Timestamps by Jolene . Thanks! Weekly Picks Dickson – NASA’s Juno to Get a Close Look at Jupiter’s Moon Ganymede Brianne – Send in the Bugs. The Michelangelos Need Cleaning. Rich – All landers and rovers on Mars animated in video with human scale Alan – Weird case cluster reported in MMWR 40 years ago; <a href= "https
Sat, June 05, 2021
COVID-19 clinical update #65 with Dr. Daniel Griffin
In COVID-19 clinical update #65, Daniel Griffin summarizes effects of non-pharmaceutical interventions, updated summer camp guidance from CDC, serology testing not recommended by FDA, antigen tests during a music event, inhibition of vaccine immunogenicity by methotrexate, phase 3 trial results for colchicine, and small airway disease as a post-acute sequelae. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Effects of vaccines and NPIs (JAMA) Guidance on summer camps (CDC) Antibody testing not recommended (FDA) Antigen testing at a music event (Lancet) Methotrexate and vaccine immunogenicity (Ann Rheum Dis) Colchicine phase 3 results (Lancet Resp Med) Small airway disease a post-acute sequelae (medRxiv) Letters read on TWiV 764 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Thu, June 03, 2021
Cap-snatch fever
TWiV explains how cap-snatching, the priming of viral mRNA synthesis with fragments of host mRNAs, can lead to the synthesis of novel viral proteins. Hosts: Vincent Racaniello , Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Cap-snatching makes new ORFs (Cell) Cap-snatching leads to novel proteins (Cell) Letters read on TWiV 763 Timestamps by Jolene . Thanks! Weekly Picks Kathy – Flat pasta that turns into shapes here and here Rich – Ad Fontes Media Bias Chart ( wiki ) Vincent – Martin Beck police mysteries Listener Picks Greg – Stewart Lee on Loch Ness monster Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, May 30, 2021
SARS-CoV-2 origins with Robert Garry
Robert Garry joins TWiV to explain how the molecular biology of SARS-CoV-2 shows that it came from Nature and not a lab, including the receptor binding domain, the furin cleavage site, and the two lineages circulating in Wuhan wildlife markets. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guest: Robert Garry Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode The proximal origin of SARS-CoV-2 (Nature) Two early genome lineages in Wuhan markets (virological.org) Insights from spike proteins of bat sarbecoviruses (virological.org) Letters read on TWiV 762 Timestamps by Jolene . Thanks! Weekly Picks Dickson – 143 Optical Illusions and Visual Phenomena Brianne – The Arcane Research that Prepared Us for COVID-19 Rich – Hidden Brain podcast Alan – A scientific theory of gist communication Vincent – Divisive COVID ‘lab leak’ debate prompts dire warnings from researchers Listener Picks Jon – <a href= "htt
Sat, May 29, 2021
COVID-19 clinical update #64 with Dr. Daniel Griffin
In COVID-19 clinical update #64, Daniel Griffin covers new guidance from NY on day camps, mitigation and infection rates in schools, testing to sustain in person instruction, Moderna mRNA vaccine highly effective in adolescents, longer storage of Pfizer vaccine, FDA EUA for sotrovimab, and persistent illness in UK children. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Guidance on child camps and day care (NY State) Mitigation and schools (medRxiv) Masks in elementary schools (MMWR) Testing to sustain in person instruction (MMWR) TeenCOVE results (Moderna) Pfizer/BioNTech vaccine handling and storage (CDC) EUA for sotrovimab (FDA) Illness duration in UK schoolchildren (medRxiv) Letters read on TWiV 761 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Thu, May 27, 2021
SARS-CoV-2 origins with Peter Daszak, Thea Kølsen Fischer, Marion Koopmans
Peter Daszak, Thea Kølsen Fischer, and Marion Koopmans, members of the WHO team investigating the origins of SARS-CoV-2 join TWiV to explain the work done by the committee during phase one, their conclusions, and the extent of work that remains to be done in phase two. Hosts: Vincent Racaniello , Rich Condit , and Kathy Spindler Guests: Peter Daszak , Thea Kølsen Fischer , and Marion Koopmans Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Peter on TWiV 615 , 623 Thea on TWiV 576 Marion on TWiV 413 , 548 WHO report on origins of SARS-CoV-2 Timestamps by Jolene . Thanks! Weekly Picks Kathy – My Octopus Teacher Rich – John Wyndam classic Sci Fi: The Chrysalids , The Day of the Triffids Vincent – SARS-CoV-2 Phylogeny and Spatiotemporal Spread ( paper ) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, May 23, 2021
Pork dogs and an evolutionary pickle
TWiV examines spillovers of porcine and canine coronaviruses into humans in Haiti and Malaysia, and how antigenic evolution of measles virus is constrained by multiple co-dominant epitopes on the viral glycoproteins. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Amy Rosenfeld Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV vaccine town halls 15:10 Porcine deltacoronavirus in Haitian children (medRxiv) Canine coronavirus from Malaysian pneumonia patient (Clin Inf Dis) No shift, measles (TWiV 340) The Cancer Thief (TWiV Letters read on TWiV 759 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Ants: workers of the world Amy – Let The Record Show by Sarah Schulman Rich – QAnon resembles the games I design Alan – Librivox Vincent – Stratechery Listener Picks Fernando – The 60-year old scientific screwup that helped COVID kill Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, May 22, 2021
COVID-19 clinical update #63 with Dr. Daniel Griffin
In COVID-19 clinical update #63, Daniel Griffin reviews cases at child care facilities, estimates of mRNA vaccine effectiveness, risk of reinfection in university students, enhanced antibody generation with extended interval of mRNA vaccination, no benefit of convalescent plasma in hospitalized patients, and risk of clinical sequelae after acute infection. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode COVID-19 in child care facilities (MMWR) mRNA vaccine effectiveness (MMWR) Excelsior pass (NYS) Risk of SARS-CoV-2 reinfection in university students (CID) Enhanced antibody production with longer mRNA vaccine interval (medRxiv) Convalescent plasma trial in hospitalized patients (Lancet) Phase 3 data on REGEN-COV (PR Newswire) Clinical sequelae after acute COVID-19 (BMJ) Letters read on TWiV 758 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Thu, May 20, 2021
Supershedders and super vaccines
TWiV reveals that 2% of SARS-CoV-2−positive individuals carry 90% of the virus circulating in a college campus, and a nanoparticle vaccine that induces cross-reactive immunity against multiple pandemic and pre-emergent coronaviruses. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV vaccine town halls 2% of SARS-CoV-2 positives carry most viral RNA (PNAS) Pan-coronavirus nanoparticle vaccine (Nature) Why HIV-1 particles have few spikes (PLoS Path) Letters read on TWiV 757 Timestamps by Jolene . Thanks! Weekly Picks Brianne – Darwin’s Arch Collapses Kathy – The woman who discovered the first coronavirus Rich – “Richard Feynman: The pleasure of finding things out” Vincent – CORONA Project Listener Picks JH – Fungus kills cicadas Alan – Liftoff by Eric Berger Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, May 16, 2021
Precluding problematic polio prophylaxis
TWiV returns to the 2012 brouhaha over transmission experiments with avian H5N1 influenza virus, re-examines the claim of SARS-CoV-2 RNA integration into human DNA, and reviews the engineering and testing of a genetically stable version of the attenuated type 2 Sabin poliovirus vaccine. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Amy Rosenfeld Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV vaccine town halls 3:16 First smallpox vaccine day Revised masking and distancing (CDC) Science vs Spin (Sandman) Artifactual SARS-CoV-2 integration (PNAS) SARS-CoV-2 integration is artifactual (J Virol) Engineering n ew OPV2 (Cell Host Micr) Safety and immunogenicity of nOPV2 (Lancet) Poliopolis (Lancet) Letters read on TWiV 756 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Five Deeps Amy – Premonition by Michael Lewis Alan – The Secret Life of Groceries by Benjamin Lorr Rich – The Way Ferrofluid Floats Above a Supe
Sat, May 15, 2021
COVID-19 clinical update #62 with Dr. Daniel Griffin
In COVID-19 clinical update #62, Daniel Griffin covers outdoor transmission of the virus, safe use of NSAIDS, expansion of Pfizer/BioNTech vaccine to include 12-15 year olds, post-disease Mucormycosis, and hydroxychloroquine treatment associated with increased mortality. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Moderna vaccine safe, effective in teens (AAP news) Review of outdoor transmission (JID) Pfizer/BioNTech vaccine EUA 12-15 year olds (FDA) NSAIDS safe in COVID-19 (Lancet Rheum) Post-COVID black fungus (Laryngol Otol) HCQ and increased mortality (Nat Comm) Letters read on TWiV 755 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Thu, May 13, 2021
Tuesday two: SARS-CoV-2 and TLR2
TWiV discusses the finding that the envelope (E) protein of SARS-CoV-2 is sensed by toll-like receptor 2 on cells, leading to the production of inflammatory cytokines that cause damage to cells and tissues in COVID-19. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV vaccine town halls Michelson Prizes FDA authorizes Pfizer/BioNTech mRNA vaccine for adolescents (FDA) TLR2 senses SARS-CoV-2 E protein (Nat Imm) Review on CoV E protein (Virology J) Timestamps by Jolene . Thanks! Weekly Picks Brianne – Lab.Hacks Lab Assistant App Rich – Weird viral DNA spills secrets to biologists ; COVAX Kathy – Planet Earth Now Vincent – Variants at ViralZone Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, May 09, 2021
The ferret nose where the virus goes
TWiV revisits Brazil’s rejection of Sputnik vaccine, examines influenza transmission via the air from the nasal epithelium of ferrets, and a history of accidental releases of polioviruses and their relevance for eradication of poliomyelitis. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV vaccine town halls Sputnik Light Ferret airborne transmission of influenza virus (Nat Comm) Facility releases of poliovirus (Emerg Inf Dis) Polio eradication progress (Polio Erad Init) Letters read on TWiV 753 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Exotic mantis Brianne – Types of Scientific Paper Alan – Rusty Lake Games / Cube Escape Collection Rich – The Departed Could Soon Become Compost in Colorado ; Recompose ( wiki ) Vincent – Public Health Image Library Listener Pick Ivan – Apo
Sat, May 08, 2021
COVID-19 clinical update #61 with Dr. Daniel Griffin
In COVID-19 clinical update #61, Daniel Griffin reviews a modeling of future hospitalizations and deaths by vaccination rates and non pharmaceutical intervention scenarios, performance evaluation of rapid antigen tests, children making up a growing share of new cases, antibody response to mRNA vaccine in solid organ transplant recipients, and outcomes in hospitalized patients treated with tocilizumab. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Modeling future COVID-19 cases (MMWR) Performance of rapid antigen tests (Ann Int Med) Children are growing share of infections (AAP News) Tocilizumab in hospitalized patients (Lancet) Letters read on TWiV 752 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Thu, May 06, 2021
Sputnik spat and furin in ferrets
TWiV examines the claim by Brazil’s ANVISA that the Sputnik vaccine contains replication-competent adenovirus, and a role for the furin cleavage site in SARS-CoV-2 spike for efficient reproduction in the respiratory tract, evasion of antiviral IFITM proteins, and transmission in ferrets. Hosts: Vincent Racaniello , Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV vaccine town halls Brazil rejects Gamaleya vaccine (Sci Transl Med) Russian vaccine behavior (Sci Transl Med) Is Gamaleya vaccine safe ? (Science) Furin cleavage site in replication and transmission (Nat Micro) Furin site loss attenuates pathogenesis (Nature) Timestamps by Jolene . Thanks! Weekly Picks Rich – The diversity and function of sourdough starter microbiomes ; Dunn Lab Wild Sourdough Project Kathy – ISS, Crew Dragon, and the sun Doubly warped world of binary black holes Vincent – Mr. Labman Listener Picks Joy – Abandoned America: Matthew Christopher’s Autopsy of the American Dream Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, May 02, 2021
To err is viral
The TWiVmeisters discuss how copy-back defective viral genomes might modulate the clinical outcome of respiratory syncytial virus infection, and detection of antibodies to henipa- and filo-like viruses in Trinidad bats. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Vaccine education town halls (ASV) RSV cpDVG may influence clinical outcome (Nat Micro) Henipa- and filo-like viruses in Trinidad bats (J Inf Dis) Nice image of cpDVG generation Letters read on TWiV 750 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Olympus Image of the Year Award Alan – We need to improve the welfare of life science trainees Rich – Sheldrick Wildlife Trust ; The Reteti Elephant Sanctuary Kathy – Aria Code Nessun dorma podcast Vincent – Covariants Listener Picks Justin – How Pfizer Makes Its Covid-19 Vaccine Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, May 01, 2021
COVID-19 clinical update #60 with Dr. Daniel Griffin
In COVID-19 clinical update #60, Daniel Griffin summarizes CDC guidance for summer camps, how to protect yourself when fully vaccinated, updated recommendation for J&J vaccine, declining global case fatality rate, and characterization of post-acute sequelae. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Summer camp guidance (CDC) Protect yourself when fully vaccinated (CDC) Updated recommendation on J&J vaccine (MMWR) NY variant B1.526 ( one , two ) Declining global CFR (AJTMH) Protease inhibitor in phase I (Pfizer) Molnupiravir advances (Merck) Post acute sequelae (Nature) Letters read on TWiV 749 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Sun, April 25, 2021
SARS-CoV-2 gets a sense of humoral
A TWiV trio explains a method for sequencing single genomes of SARS-CoV-2 and its use to explore in-host evolution drive by antibody responses, and incidence of cerebral venous thrombosis in COVID-19 patients and vaccine recipients. Hosts: Vincent Racaniello , Alan Dove , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode In-host SARS-CoV-2 evolution drive by antibody (PLoS Path) COVID-19 and CVT (OSF) CoronaVac underperforms (Economist) Precision Vaccines Program postdoc position Letters read on TWiV 748 Timestamps by Jolene . Thanks! Weekly Picks Brianne – Show Your Immune System Some Love Alan – Cyborg sea turtle Vincent – Thomas Brock dies Listener Picks April – The High Line Michel – Why you can’t compare Covid-19 vaccines Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, April 24, 2021
COVID-19 clinical update #59 with Dr. Daniel Griffin
Daniel Griffin discusses a front-line health care worker survey, pre-exposure seropositivity and subsequent infection in healthy young adults, fitted filtration efficiency of double masking, BinaxNow rapid in-home antigen test, postvaccination infections in a nursing facility, safety of mRNA vaccine in pregnant women, case control study of Bamlanivimab, no evidence for brain infection in patients with neurolgical symptoms, and mortality among US patients hospitalized with COVID-19. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Healthcare worker survey (KFF) Seropositivity and infection risk in young adults (Lancet) Efficiency of double masking (JAMA) BinaxNow antigen test (Abbott) mRNA vaccine safety in pregnant persons (NEJM) Bamlanivimab case control study (CID) COVID-19 neuropathology (Brain) Mortality among hospitalized COVID-19 patients (JAMA) Letters read on TWiV 747 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Thu, April 22, 2021
Encephalitis viruses dine on caveolae
Team TWiV explains how alphaviruses like Western equine encephalitis virus cross into the brain from capillaries by caveolin-mediated transcytosis, and reveal scientists’ incentives and attitudes towards public communication. Hosts: Vincent Racaniello , Dickson Despommier , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Viral brain entry by transcytosis across endothelial cells (mBio) Scientists attitudes towards public communication (PNAS) Letters read on TWiV 746 Timestamps by Jolene . Thanks! Weekly Picks Dickson – NASA ingenuity helicopter ride Brianne – Vaccine Efficacy Animation Kathy – Airglow over the Azores Vincent – Gisaid Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, April 18, 2021
Gorilla COVID with Nadine Lamberski
Nadine Lamberski joins TWiV to discuss an outbreak of COVID-19 among gorillas at the San Diego Zoo, and the use of a spike protein-based vaccine to immunize the animals. Hosts: Vincent Racaniello , Alan Dove , Kathy Spindler , and Brianne Barker Guest: Nadine Lamberski Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Gorillas receive COVID-19 vaccine (Nat Geo) COVID-19 vaccine for great apes and mink (Zoetis) Letters read on TWiV 745 Timestamps by Jolene . Thanks! Weekly Picks Brianne – The Dream Vaccine Alan – Taking vaccines to Smith Island Kathy – Daily Overviews Subscribe Tulips Vincent – Nextstrain Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, April 17, 2021
COVID-19 clinical update #58 with Dr. Daniel Griffin
In COVID-19 clinical update #58, Daniel Griffin provides the latest update on the J&J vaccine pause, healthcare worker deaths, children and COVID, physical inactivity associated with higher risk, using monoclonal antibodies for prophylaxis, and shows us how to properly wear a face mask. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Healthcare worker deaths (Guardian) Children and adolescent disease severity (JAMA) Physical inactivity and increased disease risk (BMJ) Expansion of Pfizer/BioNTech EUA ( pdf ) Thrombosis after ChAdOX1 vaccine (NEJM) Your guide to masks (CDC) Phase 3 mAb prevention trial (Regeneron) Letters read on TWiV 744 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Thu, April 15, 2021
Shape-shifting viruses
The TWiVsters explain how the shape of pleomorphic virus particles – spherical or filamentous – determines the probability of virus attachment and fusion, and resistance to selective pressure such as antibodies that block cell entry. Hosts: Vincent Racaniello, Dickson Despommier , Rich Condit , and Amy Rosenfeld Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Pleomorphic virus particles and cell entry (Nat Micro) Letters read on TWiV 743 Timestamps by Jolene . Thanks! Weekly Picks Dickson – A tiny particle’s wobble could upend the laws of physics Rich – COVID-19/SARS-CoV-2: Viruses, Vaccines & Variants Made Easy Amy – Vaccine Anthems Vincent – DarkNet Diaries Ep. 86 Listener Picks Steve – Cover Your Freakin’ Face Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, April 11, 2021
De-fusing COVID-19
TWiV reviews a drug screen for inhibitors of syncytium formation, the fusing of cells caused by SARS-CoV-2, which reveals that the process is regulated by a calcium-activated ion channel and scramblase that is inhibited by the anti-parasite drug Niclosamide. Hosts: Vincent Racaniello, Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode TMEM16 inhibitors block SARS-CoV-2 driven syncytium formation (Nature) Letters read on TWiV 742 Timestamps by Jolene . Thanks! Weekly Picks Brianne – COVID-19: a disaster five years in the making Alan – The Tyranny of Merit Rich – Racism Makes Me Question Everything. I Got the Vaccine Anyway Kathy – The Transcontinental Burrito Tunnel Vincent – Trudy Rey’s YouTube Channel Listener Picks Jeff – Rebecca Lee Smith on Left Right and Center Ryan – Perfect Strangers ( clip ) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, April 10, 2021
COVID-19 clinical update #57 with Dr. Daniel Griffin
In COVID-19 clinical update #57, Daniel Griffin covers children and MIS-C, school opening plans, transmission event with masks, fomite transmission, diagnostic test performance, AZ vaccine and blood clots, and long COVID and the effect of vaccines. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Children with MIS-C (JAMA) Transmission with masks (Op For Inf Dis) Accuracy of diagnostic tests (J Clin Micro) Long COVID in hospitalized patients (BMJ) Neurological and psychiatric outcomes of COVID-19 (medRxiv) Letters read on TWiV 741 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Thu, April 08, 2021
Complementation will get you everywhere
The Guardians of the TWiV-o-verse discuss the process of codon deoptimization for the production of experimental infectious attenuated viral vaccines, and how a respiratory syncytial virus with 619 base changes was rescued by genomes with very large internal deletions. Hosts: Vincent Racaniello, Dickson Despommier , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode NIDO 2021 Symposium ASV hosts free COVID-19 Vaccine Education Town Halls (register here ) Research position in Spindler laboratory Attenuation of poliovirus by codon deoptimization (Science) Rescue of codon-deoptimized RSV by large deletions (PNAS) Letters read on TWiV 740 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Let us now praise tiny ants Brianne – Small-school science Rich – Smallpox ‘virus squads’ and the mandatory vaccinations upheld by the Supreme Court Kathy – The Transcontinental Burrito Tunnel Vincent – Glass music by Robert Tiso Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, April 04, 2021
COVID-19 convalescent plasma with Arturo Casadevall
Arturo Casadevall joins TWiV to discuss the use of convalescent plasma to treat COVID-19, including a history of the process, how plasma is prepared and tested, why it is difficult to conduct randomized clinical trials, how this treatment has fared and his hopes for the future. Hosts: Vincent Racaniello, Alan Dove , Rich Condit , and Brianne Barker Guest: Arturo Casadevall Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Victory for Scientific Pragmatism (New Atlantis) Convalescent plasma levels and risk of COVID-19 death (NEJM) COVID-19 convalescent plasma safety indicators (JCI) COVID-19 convalescent plasma reduces mortality (medRxiv) Pfizer mRNA vaccine in 12-15 year olds (Pfizer) NIDO 2021 Symposium ASV hosts free COVID-19 Vaccine Education Town Halls (register here ) Letters read on TWiV 739 Timestamps by Jolene . Thanks! Weekly Picks Brianne – <a href= "https://www.nytimes.com/2021/03/30/science/blackwater-photo
Sat, April 03, 2021
COVID-19 clinical update #56 with Dr. Daniel Griffin
In COVID-19 clinical update #56, Daniel Griffin note increasing hospitalization in children and young adults, Pfizer vaccine efficacy results in 12-15 year olds, rapid self administered nucleic acid and antigen tests, mRNA vaccine efficacy in real world conditions, and improvement of long COVID after vaccination. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Pfizer mRNA vaccine is 100% effective in 12-15 year olds (Pfizer) Cue at-home PCR test receives FDA EUA (Cue) DxTerity COVID-19 saliva nucleic acid at-home test (Amazon) T-Detect T cell test (T-Detect) GSK submits EUA for VIR-7831 (GSK) Letters read on TWiV 738 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Thu, April 01, 2021
SARS-CoV-2 in NYC wastewater
John, Monica, and Davida join TWiV to discuss development of a method to detect SARS-CoV-2 in raw sewage from all 14 of New York City’s treatment plants, and its use to determine the presence of the genome throughout the pandemic and detection of genome mutations from variants of concern. Hosts: Vincent Racaniello, Dickson Despommier , Rich Condit , and Kathy Spindler Guest: John Dennehy , Davida Smyth , and Monica Trujillo Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Protocol for detecting SARS-CoV-2 RNA in wastewater (medRxiv) Mutations from VOC in NYC wastewater (medRxiv) WHO report on COVID-19 origins ( pdf ) Effectiveness of mRNA vaccines at preventing SARS-CoV-2 infection (MMWR) Prothrombic thrombocytopenic disorder after AZ vaccine (Res Square) NIDO 2021 Symposium 1:12:02 Postdoctoral position at Towson University 1:15:08 ASV hosts free COVID-19 Vaccine Education Town Halls (register here ) Timestamps by Jolene . Thanks! Weekly Picks Dickson – 250,000 Dominoes Brianne – Using RT-PCR in COVID-19 Testing Rich – <a href= "https://www.iflscience.com/plants-and-animals/beaded-lacewings-can-take-down-six-termites-with-a-single-f
Sun, March 28, 2021
Rhapsody in T with Alessandro Sette
Alessandro Sette joins TWiV to discuss the role of T cells in COVID-19, the finding that amino acid changes in SARS-CoV-2 variants of concern have a negligible impact on T cell reactivity in convalescent patients and vaccinees, and whether a next generation vaccine should include more viral proteins than spike. Hosts: Vincent Racaniello, Alan Dove , Rich Condit , and Kathy Spindler Guest: Alessandro Sette Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Little impact of SARS-CoV-2 variants on T cell reactivity (bioRxiv) NIDO 2021 Symposium Postdoctoral position at Towson University ASV hosts free COVID-19 Vaccine Education Town Halls (register here ) Letters read on TWiV 736 Timestamps by Jolene . Thanks! Weekly Picks Alan – The Disinformation Dozen report Rich – No needle, but the damage was done Kathy – Zinn art David Zinn Vincent – Clueless Wall Street Journal Op-Ed Endorses PACE as “Prevailing View” Among Docs Listener Picks Justin – Finnish astrophotographer spends 12 years creating a Milky Way mosaic Intro music is by Ronald Jenkees <
Fri, March 26, 2021
COVID-19 clinical update #55 with Dr. Daniel Griffin
In COVID-19 clinical update #55, Daniel Griffin reviews recommendations for keeping transmission low in school settings, optimal testing strategies for schools and businesses, impact of vaccines on asymptomatic infections, vaccine safety in PASC patients, and early use of aspirin associated with decreased mortality. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode COVID-19 in primary and secondary schools (MMWR) Low transmission in elementary schools (MMWR) COVID-19 testing guidance (CDC) COVID-19 vaccines and asymptomatic infections (Clin Inf Dis) Vaccine safety in long COVID (medRxiv) Phase 3 results of antibody cocktail (Regeneron) Aspirin associated with decreased mortality (Anesth Analg) Post-acute long COVID-19 syndrome (Nat Med) Timing, duration, health impact of PASC (medRxiv) Persistent neurologic and cognitive dysfunction in PASC (Ann Clin Trans Neurol) Letters read on TWiV 735 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Sun, March 21, 2021
Weiss hath no furin like a virus scorned
Susan Weiss returns to TWiV to discuss coronavirus entry into cells and the role of spike protein cleavage by proteases, why lab escaped hypotheses for SARS-CoV-2 are unlikely, and modulation of innate immune responses during infection. Hosts: Vincent Racaniello, Rich Condit , Alan Dove , Brianne Barker , and Amy Rosenfeld Guest: Susan Weiss Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode CoV pathogenesis in CNS (J Neuro Pharm) SARS-CoV-2 induces dsRNA-mediated innate responses (bioRxiv) Screen of FDA-approved drugs (J Viral) Letters read on TWiV 735 Timestamps by Jolene . Thanks! Weekly Picks Brianne – Tiktok of How mRNA Vaccines Work Alan – Dark Rich – Unmixing Color Machine (Ultra Laminar Reversible Flow) – Smarter Every Day 217 Amy – MOMA Calder exhibit , reviewed in NYTimes Vincent – Ripple Training ( free YouTube channel ) Listener Picks Ruth – 100 million year old seafloor bacteria resuscitated Iradis – Linda Zall, CIA spy for science Intro music is by <a hr
Sat, March 20, 2021
COVID-19 clinical update #54 with Dr. Daniel Griffin
In COVID-19 clinical update #54, Daniel Griffin covers effectiveness of 3 vs 6 ft physical distancing, effectiveness of masks, physical distancing, and eye shields, second vaccine dose completion, alleviation of COVID-19 symptoms after vaccination, vaccine trials in children, and IDSA approval of a mAb cocktail. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Effectiveness of 3 ft vs 6 ft (CID) Effect of physical distancing, masks, eye protection (Lancet) Vaccine second dose completion (MMWR) IDSA mAb recommendations (IDSA) Letters read on TWiV 733 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Thu, March 18, 2021
Citizen science with Forest Rohwer and Maria-Isabel Rojas
Forest and Maria-Isabel join TWiV to discuss their their project to engage thousands of citizens to swab inanimate surfaces in the San Diego area, then send the samples to the Rohwer Lab for nucleic acid analysis. Hosts: Vincent Racaniello, Dickson Despommier , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Forest on TWiV 391 Swabbing surfaces in San Diego (10News) Nido21 meeting Molnupiravir in phase 2a (Fierce Biotech) Letters read on TWiV 732 Timestamps by Jolene . Thanks! Weekly Picks Dickson – 10 amazing science tricks with liquids Brianne – How Do Blind Worms See the Color Blue? Rich – Statewide Study Shows Evidence Of Significant COVID-19 Antibodies In Children Kathy – Dark side of the moon as it crosses Earth Vincent – Wasdkeyboards and Novelkeys Listener Pick Bronwen – COVID Pe
Sun, March 14, 2021
The kids aren't alright
On a TWiV tetramer, we review the ongoing outbreaks of Ebolavirus disease in DRC and Guinea, evidence that SARS-CoV-2 infections in children are far more prevalent than are being detected, and recent long COVID estimates from the UK. Hosts: Vincent Racaniello, Rich Condit , Alan Dove , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Ebolavirus disease outbreak continues in Africa (ProMedMail) List of Ebolavirus outbreaks (Wikipedia) Ebolavirus genome sequences from Guinea (virological) Bias in reporting on childhood SARS-CoV-2 infections (Clinical Inf Dis) Estimated SARS-CoV-2 prevalence (MMWR) Estimated burden of SARS-CoV-2 by age group (CDC) UK long COVID estimates ( pdf ) Space Shuttle fly-by Vincent’s office (YouTube) Letters read on TWiV 731 Timestamps by Jolene . Thanks! Weekly Picks Brianne – Who Would Kidnap a Space Telescope? Alan – Radio Garden Rich – Countries with more obesity have had more covid deaths on average Vincent – C
Sat, March 13, 2021
COVID-19 clinical update #53 with Dr. Daniel Griffin
In COVID-19 clinical update #53, Daniel Griffin reviews underreporting of infections and long term disease in children, a blood test for T cells, results of phase 3 trials for monoclonal antibodies, preliminary findings on an oral antiviral, clinical trial of ivermectin, and recommendations for upcoming gatherings. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode SARS-CoV-2 seroprevalence in EUA for T cell test (FDA) Lilly mAb phase 3 results (Lilly) VIR-7831 mAb phase 3 results (Globenewswire) Molnupiravir phase 2a results (Merck) Ivermectin not supported for mild COVID-19 (JAMA) Recommendations for fully vaccinated people (CDC) Letters read on TWiV 730 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Thu, March 11, 2021
A floret of spikes with Matt Frieman
Matt Frieman returns to TWiV to discuss the COVID-19 pandemic from the point of view of a coronavirologist, including his work with Novavax on their spike protein-based vaccine. Hosts: Vincent Racaniello, Dickson Despommier , Rich Condit , Kathy Spindler , and Brianne Barker Guest: Matt Frieman Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Phase 1-2 trial of Novavax protein vaccine (NEJM) MERS-CoV spike nanoparticle vaccine in mice (Vaccine) Novavax phase 3 press release When you’ve been fully vaccinated (CDC) Letters read on TWiV 729 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Covid-19 deaths per million ranked by average income Brianne – KFF COVID-19 Vaccine Monitor for Feb 2021 and KFF COVID-19 Vaccine Monitor Dashboard Rich – The Woman Who Stood Between America and a Generation of ‘Thalidomide Babies’ ( wiki ) Kathy – Quadrantid meteor (<a href= "https://en.wikiped
Sun, March 07, 2021
Cover your nose and mouse
TWiV notes the passing of Mavis Agbandje-McKenna, and reviews data on maximizing fit for cloth and medical procedure masks, SARS-CoV-2 total and subgenomic viral load in hospitalized patients, and effect of changes in spike protein on efficacy in a mouse model of infection. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Mavis Agbandje-McKenna dies (UF) Mavis on TWiV 448 Maximizing mask fit (MMWR) Genomic and subgenomic RNA in COVID-19 patients (medRxiv) Effect of spike changes on protection of mice (mBio) Letters read on TWiV 728 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Wild animal photos Brianne – Greater than COVID Alan – WHO report on infodemic response Rich – Reference Guide to the International Space Station Vincent – 3D Molecular Designs Listener Picks Lisbeth – Have the new jab <br /
Sat, March 06, 2021
COVID-19 clinical update #52 with Dr. Daniel Griffin
In COVID-19 clinical update #52, Daniel Griffin reviews differences in attack rates between children and adults, J&J vaccine phase III data, G6PD deficiency and vaccines, NIH halts convalescent plasma trial, dexamethasone in hospitalized patients, data on tocilizumab, and long COVID in children. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode SARS-CoV-2 attack rates in children and adults (Clin Inf Dis) Documents for J&J COVID-19 vaccine review (FDA) Convalescent plasma and clinical outcomes (JAMA) NIH halts convalescent plasma trial (NIH) Dexamethasone in hospitalized COVID-19 patients (NEJM) Tocilizumab in hospitalized COVID-19 patients (NEJM) Update on long COVID prevalence (UK ONS) Letters read on TWiV 727 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Thu, March 04, 2021
Molecular animator Janet Iwasa
Janet Iwasa joins TWiV to recount how she became a molecular animator, including a pivot during her Ph.D. thesis research, the value of animations in science, and their latest animation of SARS-CoV-2 entry into cells. Hosts: Vincent Racaniello, Rich Condit , Brianne Barker and Kathy Spindler Guest: Janet Iwasa Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode The Animation Lab SARS-CoV-2 animation Documents for J&J COVID-19 vaccine review (FDA) Phase III data ( pdf ) Slide presentation of data ( pdf ) Addendum ( pdf ) Summary of v-Safe data ( pdf ) Timestamps by Jolene . Thanks! Weekly Picks Brianne – How T cells see SARS-CoV2 Rich – Ice bubbles in Lago Bianco, Switzerland Kathy – Music in COVID-19 control tents Vincent – Perseverance runs on processors used in 1990s iMacs Intro music is by Ronald Jenkees Send your virology questi
Sun, February 28, 2021
Eva Harris and Janet Smith clip flavivirus wings
Eva Harris and Janet Smith join TWiV to discuss how an antibody against dengue virus NS1 protein blocks endothelial dysfunction and the potential of treating infections by multiple flaviviruses. Hosts: Vincent Racaniello, Alan Dove , Rich Condit , and Kathy Spindler Guest: Eva Harris and Janet Smith Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Eva Harris on TWiV 228 Zika virus in Nicaragua (virology blog) How an antibody block NS1-mediated endothelial dysfunction (Science) Broadly protective antibody against NS1 (Science) Letters read on TWiV 725 Timestamps by Jolene . Thanks! Weekly Picks Alan – Science Photographer of the Year Awards Rich – Bar Keeper’s Friend Kathy – Perseverance secret message and other Easter eggs , 11 million Earthlings’ names , “ Name the Rover ” essay contest. Sign up to send your name on a future Mars mission. Vincent – COVID-19 dataset Listener Picks
Sat, February 27, 2021
COVID-19 clinical update #51 with Dr. Daniel Griffin
In COVID-19 clinical update #51, Daniel Griffin reviews use of two masks, effectiveness of testing in nursing homes, updates on vaccines, use of nonsteroidal anti-inflammatory drugs, little effect of vitamin D and remdesivir in clinical studies, and a long COVID research initiative from NIH. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Updated NYC mask guidance (NYC Health) Two masks recommended (CDC) Effectiveness of testing in nursing homes (Clin Inf Dis) Vaccine reactogenicity and antibody response after COVID-19 (medRxiv) Bamlanivimab alone or with Etesevimab (JAMA) Non-steroidal anti-inflammatory drugs and death (BMJ) Budesonide and COVID-19 (medRxiv) No effect of vitamin D high dose (JAMA) Remdesivir little effect on hospitalized patients (NEJM) Sequelae 6 months after infection (JAMA) Long COVID initiative (NIH) Letters read on TWiV 724 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Thu, February 25, 2021
COVID-19 palliative care with Ginger Campbell, MD
Ginger Campbell joins TWiV to discuss palliative care for COVID-19 patients, and how to approach the disease from a goals of care perspective. Hosts: Vincent Racaniello, Dickson Despommier , Rich Condit , and Brianne Barker Guest: Ginger Campbell, MD Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Brain Science Podcast Dr. Campbell’s video on palliative care (YouTube) Resources on palliative care (WHO) Interviews with Paul Offit ( one , two ) Being Mortal by Atul Gawande Letters read on TWiV 723 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Soapbox Gallery Brianne – Cell Picture Show Rich – Perseverance Rover’s Descent and Touchdown on Mars (Official NASA Video) Vincent – Our World in Data (see COVID-19 vaccinations ) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, February 21, 2021
More coronaviruses in the pipeline
The entire TWiV team assembles to discuss resurgence of COVID-19 in Manaus, Brazil, discovery of SARS-CoV-2 related viruses in bats in Southeast Asia, and increased Ct values after administration of mRNA vaccine. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Resurgence of COVID-19 in Manaus (Lancet) SARS-CoV-2 related viruses in Southeast Asian bats (Nat Comm) Increased Ct following COVID-19 vaccination (medRxiv) Letters read on TWiV 722 Timestamps by Jolene . Thanks! Weekly Picks Dickson – What is the polar vortex? Brianne – Cloning of the black-footed ferret Alan – Explaining mRNA vaccines with Star Wars Rich – Brighton Collaboration ( BRAVATO ); Ad26 vector template Kathy – Target public health ads to zipcodes Vincent – And Then the Gorillas Started Coughing Listener Pick Kim – Virus getting the shot (<a href= "ht
Sat, February 20, 2021
COVID-19 clinical update #50 with Dr. Daniel Griffin
In COVID-19 clinical update #50, Daniel Griffin discusses CDC guidance on school opening, decreased viral load after vaccination, randomized clinical trial of vitamin D treatment, a study of zinc plus vitamin C, anticoagulation therapy effect on mortality, and multi system inflammatory phase in children. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Guidance on school openings (CDC) Calcifediol Treatment and COVID-19 (Lancet preprints) Zinc and vitamin C for COVID-19 (JAMA) Early anticoagulant therapy (BMJ) Multisystem inflammatory phase in children (CDC) Letters read on TWiV 721 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Sun, February 14, 2021
With vaccines, Offit is on it
Paul Offit joins TWiV to discuss all things vaccine, including how COVID-19 vaccine development was accelerated, whether the vaccines are safe and efficacious, the difference between an EUA and a licensed vaccine, sterilizing immunity, herd immunity, and much more. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guest: Paul Offit Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Vaccine education center Letters read on TWiV 720 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Life in a Day 2020 Brianne – Microcosms in Glass Alan – NEJM article on promoting vaccination, interview with lead author Rich – The Microbescope Vincent – Autism’s False Prophets by Paul Offit Listener Pick Earl – Science is Real Pins Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, February 13, 2021
COVID-19 clinical update #49 with Dr. Daniel Griffin
In COVID-19 clinical update #49, Daniel Griffin discusses CDC guidelines on mask use, drop in test frequency in the US, resurgence of COVID-19 in Brazil, possible impact of Pfizer vaccine on viral load, EUA for bamlanivimab and etesevimab administered together, and preliminary results of Tocilizumab in hospitalized patients. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Resurgence of COVID-19 in Brazil (Lancet) Pfizer vaccine reduces viral load (medRxiv) EUA for bamlanivimab plus etesevimab ( pdf ) Tocilizumab in hospitalized patients (medRxiv) Bacterial superinfections in COVID-19 (Open For Inf Dis) Letters read on TWiV 719 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Thu, February 11, 2021
Recombining vaccine schedules
TWiV explores single dose administration and timing of second dose of AZD1222 COVID-19 vaccine, safety and efficacy of Sputnik V, and control of coronavirus recombination by a viral proofreading exonuclease. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode AZD1222 single dose efficacy and booster timing (Lancet preprint) Safety and efficacy of Sputnik V vaccine (Lancet) Proofreading exonuclease regulates CoV recombination (PLoS Path) Letters read on TWiV 718 Timestamps by Jolene . Thanks! Weekly Picks Brianne – Do scientists read enough fiction? Rich – Insects in flight ; Insect flight|Capturing takeoff Kathy – Badger seal Vincent – MicrobeTV merchandise Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, February 07, 2021
Paul and Theodora, pandemic explorers
Theodora and Paul return to TWiV to explain how they quickly pivoted their retrovirus laboratories towards SARS-CoV-2, their work on the antibody response to infection and its durability, and the emergence of variants with increased resistance to neutralization. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , and Rich Condit Guests: Paul Bieniasz and Theodora Hatziioannou Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Evolution of antibody immunity to SARS-CoV-2 (bioRxiv) mRNA vaccine elicited antibody to variants (bioRxiv) Escape from neutralizing antibodies by SARS-CoV-2 variants (eLife) Musings of an anonymous, pissed off virologist (virology blog) Timestamps by Jolene . Thanks! Weekly Picks Dickson – Mars Perseverance Rover Alan – The Outlaw Ocean Rich – Anand Varma Photography Vincent – Virology Lectures 2021 Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, February 06, 2021
COVID-19 clinical update #48 with Dr. Daniel Griffin
In COVID-19 clinical update #48, Daniel Griffin reviews effect of spike amino acid changes on neutralization with monoclonal antibodies, Sputnik V safety and efficacy results, increased reactogenicity after a single vaccine dose in seropositive individuals, single dose vaccination in seropositive health care workers, and results of three clinical trials on the use of anticoagulants. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Resistance of variants to mAb neutralization (bioRxiv) Safety and efficacy of Sputnik V (Lancet) Increased vaccine reactogenicity in seropositives (medRxiv) Single dose vaccination in seropositive health care workers (medRxiv) Update on vaccine intervals (CDC) Single dose AZD1222 results (Lancet preprints) Three RCT on anticoagulants (NIH) Letters read on TWiV 716 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Thu, February 04, 2021
Fauci ouchy
TWiV explains why hydroxychloroquine failed in humans despite showing antiviral effects in cells, and reviews the published data on the Pfizer/BioNTech mRNA vaccine. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode TMPRSS2 is why hydroxychloroquine failed (PLoS Path) Safety and efficacy of BNT162b2 mRNA vaccine (NEJM) Letters read on TWiV 715 Timestamps by Jolene . Thanks! Weekly Picks Brianne – How the Body Reacts to Viruses Rich – How do wombats poop cubes? Kathy – The Verse by the Side of the Road Vincent – Janet Iwasa’s SARS-CoV-2 entry animation Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, January 31, 2021
The shape of spike with Jason McLellan
Jason McLellan joins TWiV to reveal all we know about the SARS-CoV-2 spike protein, followed by Novavax and J&S phase 3 results and a discussion of variants of concern: neutralization by vaccine-induced antibodies, transmission, and virulence. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Amy Rosenfeld Guest: Jason McLellan Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Prefusion spike structure (Science) Neutralization of VOC by vaccine induced antibodies: Moderna and Pfizer Novavax COVID-19 vaccine phase 3 results (Novavax) J&J COVID-19 vaccine phase 3 results (J&J) B.1.1.7 has been in the US since November 2019 (virological.org) NERVTAG report on B.1.1.7 virulence (pdf) Timestamps by Jolene . Thanks! Weekly Picks Dickson – Pandemic Pivot and Tuba Skinny Alan – Technological challenges in vaccine rollout Rich – I was lucky to find this vaccine anywhere <
Sat, January 30, 2021
COVID-19 clinical update #47 with Dr. Daniel Griffin
In COVID-19 clinical update #47, Daniel Griffin reviews phase 3 results for Novavax and J&J vaccines, transmission in K-12 settings in Wisconsin, data on Lilly and Regeneron monoclonal antibody therapy, and a study of colchicine for treatment of disease. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Novavax vaccine phase 3 results (Novavax) J&J vaccine phase 3 results (J&J) COVID-19 and transmission in K-12 schools (MMWR) Lilly mAb therapy (NEJM) Regeneron mAb prophylaxis (Regeneron) Colchicine for COVID-19 (Cardiol Today) Letters read on TWiV 713 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Thu, January 28, 2021
Deutscher Virus Wahnsinn
Gisa, Steffi, and César join TWiV to discuss their careers, their research, and the COVID-19 pandemic in Germany. Hosts: Vincent Racaniello, Rich Condit , and Kathy Spindler Guests: Gisa Gerold , Stefanie Becker , and César Muñoz-Fontela Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode German Society for Virology Ticks in Germany and TBEV (Sci Rep) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, January 24, 2021
The New Heal
The TWiVers review Biden’s national strategy for the COVID-19 responses and pandemic preparedness, and an evaluation of the BinaxNOW rapid antigen test for SARS-CoV-2 infection. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Biden’s COVID-19 strategy ( pdf ) CDC evaluation of BinaxNOW antigen test (MMWR) FDA instructions for BinaxNOW test ( pdf ) Adam Neely on Sea Shanties (YouTube) Letters read on TWiV 711 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Spelling Bee Brianne – He Made a Viral Bernie Meme Site. Now He Has to Keep it Going Alan – America’s Cup AC75 capsize and aftermath in qualifying race Rich – Game Theory’s UNCENSORED Interview With Dr. Fauci | The Truth About COVID-19 Vaccines Vincent – Top Science Podcasts Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, January 23, 2021
COVID-19 clinical update #46 with Dr. Daniel Griffin
In COVID-19 clinical update #46, Daniel Griffin discusses the BinaxNow rapid antigen test, efficacy of Bamlanivimab in nursing homes, associations of serum vitamin D concentrations with in-hospital mortality and need for invasive mechanical ventilation, trials of IL-6 receptor antagonists, effects of anticoagulants on in-hospital mortality, and symptom persistence in outpatients. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Evaluation of Abbott BinaxNOW (MMWR) Lilly mAb in nursing homes (WSJ) Vitamin D and COVID-19 severity (Mayo Clin Proc) Anticoagulation, aspirin , in-hospital mortality in COVID-19 (medRxiv) Long COVID symptoms in outpatients (Ann Int Med) Letters read on TWiV 710 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Thu, January 21, 2021
COVID cherry picking
In this episode, President Biden elevates his science advisor to his Cabinet, a review of the current flu season, the scientific goals of the WHO-convened Global Study of the Origins of SARS-CoV-2, and answers to listener questions. Hosts: Vincent Racaniello, Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode President’s science advisor to Cabinet (NY Times) Letter from Biden to Lander ( pdf ) Weekly flu (CDC) Weekly NY flu (NYDOH) WHO study on SARS-CoV-2 origins (WHO) Letters read on TWiV 709 Timestamps by Jolene . Thanks! Weekly Picks Kathy – 15 YouTubers play Telestrations Vincent – Vince Beiser Listener Picks Bob, David, Janet – Sea Shanty by A Cappella Science ( YouTube , TikTok , Bandcamp ) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, January 17, 2021
Alpaca llama full of nanobodies
The TWiVy team deconstructs CoronaVac, the inactivated SARS-CoV-2 vaccine produced by Sinovac Biotech, and production of multivalent camelid nanobodies that block infection with the virus and suppress selection of neturalization-resistant variants. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode David Kessler to head Operation Warp Speed (NY Times) Phase 1/2 results of Sinovac inactivated vaccine (Lancet) beta-propiolactone (Wikipedia) Multivalent anti-SARS-CoV-2 nanobodies (Science) Letters read on TWiV 708 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Photos of mob attacking Capitol Brianne – Video of Neutrophil Phagocytosis Alan – Fishing Through the Apocalypse Rich – A Word on Statistics by Wislawa Szymborska Vincent – Letters from an American Listener Pick Mike – Have the new jab Intro music is by Ronald Jenkees
Sat, January 16, 2021
COVID-19 clinical update #45 with Dr. Daniel Griffin
In COVID-19 clinical update #45, Daniel Griffin discusses J&J Ad26 vaccine results, reactogenicity after the second dose of mRNA vaccines, expansion of vaccine eligibility, and the finding that encephalitis after SARS-CoV-2 infection is a cytokine release syndrome. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode J&J Ad26 vaccine phase 1/2 results (NEJM) SARS-CoV-2 encephalitis is a cytokine release syndrome (CID) Letters read on TWiV 707 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Thu, January 14, 2021
Do as Dr. Fauci says
TWiV answers listener questions about pandemic response, excess deaths in 25-44 year olds, vaccines, vaccines, and vaccines. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Poems are at Twiverse 2020 US traffic deaths (Car & Driver) National Vaccine Injury Compensation Program (HRSA) Jet injector (Wikipedia) Letters read on TWiV 706 Timestamps by Jolene . Thanks! Weekly Picks Brianne – We Know Almost Nothing About Giant Viruses Rich – The Coccolithophores Project Kathy – v-safe and Vaccine Handbook Vincent – Gorillas at San Diego Zoo infected with SARS-CoV-2 ( pdf ) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, January 10, 2021
Rocky Mountain COVID with Emily Travanty
Emily Travanty from the Colorado Department of Public Health and Environment joins TWiV to discuss how her laboratory was the first in the US to detect the SARS-CoV-2 variant VOC 202012/01. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guest: Emily Travanty Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode VOC detected in Colorado (WaPo) US has sequenced only 50,000 SARS-CoV-2 genomes (CDC) Human CoV evolves to escape immunity (bioRxiv) Timestamps by Jolene . Thanks! Weekly Picks Dickson – Randal Despommier on saxophone Brianne – Giant Microbes SARS-CoV2 Alan – West of Loathing Rich – Draft landscape of COVID-19 candidate vaccines Vincent – SARS-CoV-2 spillover events Listener Pick Daniel – His Vaccine Story Inspired His Father To Write A Disn ey Classic Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, January 09, 2021
COVID-19 clinical update #44 with Dr. Daniel Griffin
In this COVID-19 clinical update, Daniel Griffin summarizes current status of vaccination in the US, discusses a study on convalescent sera from Argentina, use of remdesivir in patients with kidney disease, and provides further considerations on the use of Ct values in patient management. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Argentine study on plasma therapy (NEJM) Ct values and clinical outcome (Open Forum Inf Dis) Bamlanivimab fact sheet ( FDA pdf ) Cognitive defects in recovered COVID-19 patients (medRxiv) Letters read on TWiV 704 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Thu, January 07, 2021
Does dose matter?
On this episode, a discussion of why modifying the dose schedule of the mRNA vaccines in the US is not a good idea, evidence that lower Ct values on hospital admission is associated with higher mortality, and dose-dependent response to SARS-CoV-2 infection of ferrets. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode BSL-3 Assistant Manager position Follow authorized vaccine dosing schedule (FDA) Mina suggests one vaccine dose (NY Times) UK decision document on vaccine dose ( pdf ) Ct linked to COVID-19 mortality (Open Forum Inf Dis) Dose-dependent infection of ferrets (Nat Comm) Letters read on TWiV 703 Timestamps by Jolene . Thanks! Weekly Picks Brianne – Linsey Marr on masks Kathy – Striped Martian Sand Dunes and Rich – How Microwaving Grapes Makes Plasma Vincent – Musings of an anonymous, pissed off virologist Listener Pick Laura – Auld Lang Syne follow-up Intro music is by <a href= "http://www.ronaldjenkees
Sun, January 03, 2021
Year of the Pandemic
For this first episode of 2021, the complete TWiV team reviews compelling virology stories of 2020, and thanks the multitude of guests who have helped us to navigate the pandemic, and our many listeners who turn to us for scientific facts. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Poems are at Twiverse This little virus went to market ( TWiV 581 ) Host genetics initiative TWiV 628 Inborn errors of immunity & serious COVID TWiV 671 Lisa Gralinski TWiV 674 Tragic gene flow from Neanderthals TWiV 676 Ivermectin and COVID-19 ( TWiV 599 ) DC and Galveston road trips: TWiV 625 , 643 , 646 , 589 , 580 , 583 , 587 ) Fauci and Hotez interviews (TWiV 641 , 687 ) Long-haul COVID, pro-thrombotic autoantibodies (TWiV 680 , 683 ) Minority health and disparities ( TWiV 655 ) Diversity in science ( TWiV 672 , 670 ) SeXX matters ( TWiV
Sat, January 02, 2021
COVID-19 clinical update #43 with Dr. Daniel Griffin
In Daniel Griffin’s final clinical report for 2020, he summarizes what we have learned about the clinical management of COVID-19 patients in the past year. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Attributes and predictors of long COVID-19 (medRxiv) Letters read on TWiV 701 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Thu, December 31, 2020
'Twas COVID and the aerosols
TWiV reviews additional data on the UK variant of SARS-CoV-2, the distinct variant spreading in South Africa, association of afucosylated antiviral IgG with severe COVID-19, approval of AstraZeneca vaccine in the UK, and winners of the pandemic poem contest. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode BSL-3 Assistant Manager position PHE update #2 ( pdf ) South African variant (medRxiv) CDC cautious in conclusions on variant Afucosylated IgG and severe COVID-19 (Science) AstraZeneca vaccine EUA in UK (BBC) Letters read on TWiV 700 Timestamps by Jolene . Thanks! Weekly Picks Brianne – Ready Player Two Kathy – Bert Hubert’s Reverse Engineering of the Pfizer/BioNTech vaccine Rich – Boston Dynamics running robots Vincent – Fever by John Fuller Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, December 27, 2020
Arboviruses at ASTMH
From the 2020 online meeting of the American Society for Tropical Medicine and Hygiene, Vincent speaks with Jonathan Auguste, Carol Blair, Desiree LaBeaud, Louis Lambrechts, and Mauricio Nogueira about their careers and their research on arthropod-borne viruses. Host: Vincent Racaniello Guests: Jonathan Auguste , Carol Blair , Desiree LaBeaud , Louis Lambrechts , and Mauricio Nogueira Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode RNAi in arbovirus-vector interactions (Viruses) Arbovirus emergence via bridge vectors (Sci Rep) Rift Valley fever (Trop Med Inf Dis) Flavivirus infection and cerebrovascular events (Viruses) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, December 26, 2020
COVID-19 clinical update #42 with Dr. Daniel Griffin
Daniel Griffin provides his weekly clinical report on COVID-19, including his own experience with vaccination, guidelines for vaccine distribution, reasons for under-utilization of monoclonal antibody therapy, and much more. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Phased allocation of COVID-19 vaccines ( ACIP slides ) How CDC is making COVID-19 vaccine recommendations (CDC) Letters read on TWiV 698 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Thu, December 24, 2020
The sky is NOT falling
TWiV reviews the latest data on the UK variant of SARS-CoV-2, including some properties of the variant and why it is being closely studied, development of liver cancer in a participant in a adenovirus-associated virus gene therapy trial, and answers to listener questions. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode BSL-3 Assistant Manager position 3:39 NERVTAG meeting minutes ( pdf ) NERVTAG Preliminary genomic characterization of UK variant (virological.org) PHE investigation of UK variant ( pdf ) N501Y does not affect antibody neutralization ( Science , eLife ) WHO notice on UK variant (WHO) Liver tumor during AAV gene therapy (Science) Letters read on TWiV 697 Timestamps by Jolene . Thanks! Weekly Picks Brianne – <a href= "https://www.youtube.com/watch?v=ncdZQRFXXiw&fbclid=IwAR1MIssjXRnH_htPvLlrDlV-rB5I8D8GTGu1SqUyO5F8QPw5Vxm2TEV
Sun, December 20, 2020
Tear down that SARS-CoV-2 manuscript
TWiV explains that COVID-19 is not harmless for young adults, FAA approval for Pfizer mRNA vaccine, lack of justification for the claim of reverse transcription of SARS-CoV-2 RNA and integration into the human genome, and lack of evidence for increased transmission by new variants in the UK. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode BSL-3 laboratory assistant manager position FDA authorizes EUA for Moderna mRNA vaccine (FDA) COVID-19 is not harmless for young adults (NY Times) Excess mortality 25-44 years (JAMA) Pfizer mRNA vaccine approved by FAA (AOPA) SARS-CoV-2 RNA reverse transcription (bioRxiv) Information on UK variant ( GISAID , BMJ ) US agency computers compromised (WaPo) DoD study on <a href= "https://www.washingtonpost.com/local/trafficandcommuting/defense-department-study-finds-low-risk-of-coronavirus-infection-through-air-on-a-packed-airline-flight/2020/10/15/e84aa092-0e30
Fri, December 18, 2020
COVID-19 clinical update #41 with Dr. Daniel Griffin
Daniel Griffin provides his weekly clinical report on COVID-19, including thoughts on the first immunizations with Pfizer mRNA vaccine, the anticipated EUA for the Moderna vaccine, whether the vaccine prevents infection, not just disease, monoclonal antibody therapy, and much more. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode FDA EUA for Pfizer mRNA vaccine (FDA) Ellume at-home SARS-CoV-2 antigen test (Ellume) Pre-K through grade 12 COVID-19 mitigation costs (MMWR) Letters read on TWiV 695 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Thu, December 17, 2020
Mitigating COVID-19
On this episode, TWiV makes Bloomberg Business News 2020 Jealousy List, crushing of CDC revealed by insiders, seasonal influenza during the COVID-19 pandemic, FDA briefing documents from Moderna, and three-quarters attack rate of SARS-CoV-2 during an unmitigated epidemic in Brazil. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode BSL-3 Assistant Manager position TWiV makes Bloomberg Business News 2020 Jealousy List (BBN) Crushing of the CDC (NY Times) Seasonal influenza during COVID-19 pandemic ( jpg ) Moderna briefing documents (FDA) Three-quarters attack rate in Brazil (Science) Outdoor transmission of SARS-CoV-2 (J Inf Dis) Rich Condit reminisces (YouTube) Timestamps by Jolene . Thanks! Weekly Picks Brianne – Fears of a ‘Twindemic’ Recede as Flu Lies Low Kathy – Faculty Equity & COVID-19 UM ADVANCE Rich – ‘Sistine Chapel of the ancients’ rock art
Sun, December 13, 2020
Vax to the future
On this episode, FDA EUA for Pfizer mRNA vaccine, efficacy of AstraZeneca ChAdOx1 COVID-19 vaccine, and an orally administered drug that blocks SARS-CoV-2 transmission in ferrets. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode BSL-3 laboratory assistant manager position FDA advisory committee votes in favor of EUA for Pfizer vaccine (NY Times) Sanofi/Glaxo subunit vaccine steps back (Stat) Efficacy of ChAdOx1 COVID-19 vaccine (Lancet) Oral antiviral blocks SARS-CoV-2 transmission in ferrets (Nat Micro) Letters read on TWiV 693 Timestamps by Jolene . Thanks! Weekly Science Picks Dickson – 2020 In Photos: A Year Like No Other Brianne – Cooking for Geeks Alan – On Food and Cooking Rich – NASA Artemis ( Wiki ) Vincent – The virus, the bats, and us Intro music is by Ronald Jenkees <b
Fri, December 11, 2020
COVID-19 clinical update #40 with Dr. Daniel Griffin
Daniel Griffin provides his weekly clinical report on COVID-19, including the anticipated EUA for the Pfizer mRNA vaccine, mitigation strategies in early care and education settings, expressive aphasia, and much more. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Mitigation strategies in early care and education settings (MMWR) WHO solidarity trial results (NEJM) Letters read on TWiV 692 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Thu, December 10, 2020
SciArt with Laura Splan
SciArtist Laura Splan joins TWiV to reveal her transdisciplinary work that intersects science, technology, design and culture, then we discuss an inverse correlation between mumps virus antibodies induced by MMR vaccine and COVID-19 severity, and whether ivermectin is indicated for treatment of COVID-19. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Guest: Laura Splan Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Laura Splan website BSL-3 Assistant Manager position MMR titers in recovered COVID-19 patients (mBio) Ivermectin and SARS-CoV-2 ( TWiV 599 ) Treatment of COVID-19 with ivermectin (Int J Inf Dis) Ivermectin approved dosing (Mayo Clinic) Briefing document for Pfizer vaccine (FDA) Vaccinated? Wear a mask (NY Times) Efficacy of ChAdOx1 vaccine (Lancet) Mix & Match Pfizer & Oxford jabs (Times Long) SARS-CoV-2 seroprevalence in Seattle (medRxiv) Timestamps by Jolene . Thanks! Weekly Picks Brianne – Patterns for Virus snowflakes Kathy – 2020 Nobel Prize lectures (<a href= "http
Sun, December 06, 2020
This is your brain on SARS-CoV-2
TWiV reviews the difficulties in predicting species susceptibility to SARS-CoV-2 infection by only examining the ACE2 protein, and the olfactory mucosa as a portal of entry into the central nervous system in COVID-19 patients. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , and Rich Condit Guest: Amy Rosenfeld Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode NYC will create pandemic response institute (NY Bus J) Comparison of ACE2 in vertebrates (PNAS) Olfactory transmucosal invasion of CNS by SARS-CoV-2 (Nat Neurosci) Letters read on TWiV 690 Timestamps by Jolene . Thanks! Weekly Science Picks Dickson – National Geographic best animal photos of 2020 Amy – A merican Contagions : Epidemics and the law from Smallpox to COVID-19 by John Fabian Witt Alan – HamSCI citizen science organization Rich – DeepMind’s AI makes gigantic leap in solving protein structures Vincent – Army Ants: Nature’s Ultimate Social Hunters by Daniel Kronauer Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sat, December 05, 2020
COVID-19 clinical update #39 with Dr. Daniel Griffin
Daniel Griffin provides his weekly clinical report on COVID-19, including analysis of vitamin D levels in patients, information on Moderna and Pfizer vaccines, distribution plans suggested by ACIP, and more. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Vitamin D levels in COVID-19 patients (Nature) ACIP recommendations for distribution of COVID-19 vaccine (MMWR) Updated CDC guidance on when to quarantine (CDC) Letters read on TWiV 689 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Thu, December 03, 2020
We put COVID-19 papers through a sieve
TWiV 688: We put COVID-19 papers through a sieve December 2, 2020 On this episode, UK grants EUA for Pfizer vaccine, advice for CDC on who to immunize first, news from Das Coronavirus, SARS-CoV-2 protease regulates innate responses, and viral mRNAs are not an indication of viral replication. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode UK grants EUA for Pfizer vaccine (NY Times) ACIP advice on who to vaccinate first (NY Times) Das coronavirus update SARS-CoV-2 protease regulates innate response (Nature) Viral mRNAs do not indicate viral replication (Nat Comm) Addendum to SARS-CoV-2 discovery paper (Nature) 16:15 SARS-CoV-2 mRNA vaccine and GC formation (Immunity) 29:35 What scientists say about masks (NY Times) 1:29:03 Letters read on TWiV 688 Timestamps by Jolene . Thanks! Weekly Picks Brianne – Pedromics Kathy – Global map at Mars opposition Rich – Janeway’s Immunobiology
Sun, November 29, 2020
Peter Hotez sticks to the vax
Peter Hotez joins TWiV to discuss the COVID-19 pandemic, including why it went out of control in the US, the hijacking of public health practices by anti-science extremist groups, prospects for control, and whether we will be prepared for the next one. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guest: Peter Hote z Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Peter Hotez on TWiP 29 and TWiV Special Wednesday, January 20, 2021 (Microbes Inf) SARS-CoV-2 RBD protein vaccine candidate (bioRxiv) Anti-science extremism in America (Microbes Inf) Low cost accessible COVID-19 vaccine (PLoS NTD) Letters read on TWiV 687 Timestamps by Jolene . Thanks! Weekly Science Picks Dickson – The World’s First Energy-Positive Hotel to Open in Norway Brianne – The Food Lab: Better Hom e Cooking Through Science Alan – ACIP’s ethical principles for COVID-19 vaccine allocation Rich – <a href= "https://en.wikipedia.o
Sat, November 28, 2020
COVID-19 clinical update #38 with Dr. Daniel Griffin
Daniel Griffin provides his weekly clinical report on COVID-19, including new post-exposure guidelines from CDC, clinical trials of Remdesivir and convalescent plasma, FDA EUA for baricitinib and Regeneron’s monoclonal antibody and more. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode WHO Solidarity trial for Remdesivir and other drugs (medRxiv) EUA for Baricitinib (FDA) EUA for Casirivimab and Imdevimab (FDA) RCT: No benefit of convalescent plasma (NEJM) Letters read on TWiV 686 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Thu, November 26, 2020
Pandemicky
The TWiVers analyze efficacy of the AstraZeneca/Oxford adenovirus vectored vaccine, SARS-CoV-2 did not infect miners who became ill 8 years ago after cleaning bat guano from a cave in Yunnan Province, and induction of antigen-specific germinal center responses and production of neutralizing antibody by SARS-CoV-2 mRNA vaccine but not purified protein. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode AZD1222 vaccine efficacy (AstraZeneca) Addendum to SARS-CoV-2 discovery paper (Nature) SARS-CoV-2 mRNA vaccine and GC formation (Immunity) What scientists say about masks (NY Times) Letters read on TWiV 685 Timestamps by Jolene . Thanks! Weekly Picks Brianne – Types of Scientists Coloring Book Kathy – South Pole video Rich – Steve Jobs by Walter Isaacson Vincent – Screenology (I interviewed Deb Sklut here ) Listener Pick Mona – Ad5 vector and podcast with ImmunityBio founder Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@mi
Sun, November 22, 2020
Persistence of SARS-CoV-2 immune memory
Daniel Griffin provides a clinical report on COVID-19, and Shane Crotty explains a study of antibodies, B cells and T cells in patients which suggests that immunological memory to SARS-CoV-2 might be long-lived. Hosts: Vincent Racaniello, Dickson Despommier , Rich Condit , and Brianne Barker Guests: Daniel Griffin and Shane Crotty Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode FDA authorizes Lucira mini home testing kit ( FDA ) 60 day outcomes of COVID-19 patients (Annals Int Med) Immunological memory to SARS-CoV-2 infection at 6 months (bioRxiv) Letters read on TWiV 684 Timestamps by Jolene . Thanks! Weekly Science Picks Dickson – Benoit Mandlebrot’s 96 birthday Brianne – #BlackinImmunoWeek Rich – GoISSWatch ISS Tracking ; Spot The Station (NASA) Vincent – Microbes Rule Listener Pick Agda – Sandwalk Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Thu, November 19, 2020
Two COVID-19 mRNA vaccines
On this episode of TWiV, mRNA vaccines from Moderna and Pfizer show over 90% efficacy, prothrombotic auto-antibodies in serum of COVID-19 patients, and the whereabouts of SARS-CoV-2 in the human body. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Efficacy of Moderna and Pfizer mRNA vaccines Longer shelf life of Moderna vaccine (Moderna) Prothrombotic antibodies in COVID-19 serum (Sci Trans Med) Where is SARS-CoV-2 in the human body ? (PLoS Path) Letters read on TWiV 683 Timestamps by Jolene . Thanks! Weekly Picks Brianne – Picture a Scientist Kathy – Colors of the Moon and Word that hasn’t changed Rich – NASA YouTube channel Vincent – Laura Splan science art Listener Pick Mona – Ad5 vector and podcast with ImmunityBio founder Intro music is by Ronald Jenkees S
Tue, November 17, 2020
Kate Rubins from the International Space Station
From Expedition 64 of International Space Station, Flight Engineer Kate Rubins joins TWiV to discuss experiments that she is working on, including cell cultures, genome sequencing, and plant growth. Hosts: Vincent Racaniello and Rich Condit Guest: Kate Rubins Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, November 15, 2020
Crowley, coats, and cross-reactive antibodies
Daniel Griffin provides a clinical report on COVID-19, Kathleen Crowley explains the role of Environmental Health & Safety departments, update on SARS-CoV-2 transmission in farmed mink, and the presence of pre-existing antibodies to SARS-CoV-2 in unexposed individuals. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guests: Daniel Griffin and Kathleen A. Crowley Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Pfizer vaccine efficacy (Pfizer) Pfizer vaccine (Stat) Distribution of Pfizer vaccine (NY Times) LSTMH vaccine tracker SARS-CoV-2 humans to mink and back in Netherlands (Science) SARS-CoV-2 mink isolates in Denmark (pdf) Preexisting antibodies to SARS-CoV-2 in humans (Science) Letters read on TWiV 681 Timestamps by Jolene . Thanks! Weekly Science Picks Dickson – OSIRIS-REx | NASA Brianne – Virtual Science Museum Tours Alan – <a href= "https://ri
Thu, November 12, 2020
Long-term COVID and ME/CFS
Mady, Fiona, and David join TWiV to discuss patients with long-term COVID and similarities and differences with ME/CFS. Hosts: Vincent Racaniello, Rich Condit , and Brianne Barker Guests: Mady Hornig , Fiona Lowenstein , and David Tuller Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Body Politic Survivor Corps Long-haulers redefining COVID-19 (Ed Yong) I’m 26. Coronavirus sent me to the hospital (Fiona Lowenstein) We need to talk about what coronavirus recoveries look like (Fiona Lowenstein) COVID-19 long term disability (Mady Hornig, David Tuller) At 12, she’s a COVID long-hauler (Davie Tuller) NICE rejects GET, Lightning Process, CBT as cure (virology blog) I want to scream (Occupy M.E.) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, November 08, 2020
Mink, mutation, and myocytes
Daniel Griffin provides a clinical report on COVID-19, Slovlakia’s plan to test all adults for SARS-CoV-2 infection, viral variants arising in Danish mink and their potential threat to humans, why it is unethical to carry out challenge trials, Nipah virus dynamics in bats and spillovers into humans, and direct cardiac damage by spike-mediated cardiomyocyte fusion. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guests: Daniel Griffin and Amy Rosenfeld Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Denmark will cull mink (Reuters) State Serum Institute statement in Danish Unethical to use SARS-CoV-2 human challenge studies (PNAS) Nipah virus dynamics in bats (PNAS) Spike-mediated cardiomyocyte fusion (ResearchSquare) SARS-CoV-2 infects engineered heart tissues (bioRxiv) You cannot lock up all risks groups (Das Coronavirus) Letters read on TWiV 679 Timestamps by Jolene . Thanks! Weekly Science Picks Dickson – CNN News Amy – I voted and <a href= "https://amzn.to/36faWlH"
Thu, November 05, 2020
Fishing for viruses with Nels Elde
Nels joins TWiV to reveal the discovery of a picornavirus of zebrafish by measuring immune responses in the host, genome sequence analysis of the White House COVID-19 outbreak, and a six-fold higher SARS-CoV-2 exposure rate than reported cases in German children. Hosts: Vincent Racaniello, Rich Condit , and Kathy Spindler Guest: Nels Elde Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Zebrafish virus discovery by visualization (Curr Biol) Viral genome sequencing of White House COVID-19 outbreak (medRxiv) Genetic signature of virus that may have infected Trump (NY Times) Sixfold higher SARS-CoV-2 infection than reported in children (Med) Letters read on TWiV 678 Timestamps by Jolene . Thanks! Weekly Science Picks Kathy – Why art is important and Tagging an asteroid Rich – Vendee Globe Vincent – PrePubMed Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, November 01, 2020
Does antibody really know what time it is?
Daniel Griffin provides a clinical report on COVID-19, then we discuss rapid deployment of SARS-CoV-2 testing by research laboratories in San Francisco, longitudinal observation of antibodies to SARS-CoV-2 in patients, and listener questions on vaccines, loss of smell, face masks, and more. Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Daniel’s COVID-19 graph (Twitter) Cornell U containment victory (Bloomberg) Regeneron mAb trial paused (WSJ) CLIAHUB (PLoS Path) Serum antibodies to SARS-CoV-2 over time (paper one , two , three ) Letters read on TWiV 677 Timestamps by Jolene . Thanks! Weekly Science Picks Dickson – Comedy Wildlife Photography Brianne – Ed Yong – Science reporting during a pandemic Alan – Tree Story by Valerie Trouet Rich – Boundless Body Radio Bethany and Casey Ruff Vincent – Wearing is Caring Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Thu, October 29, 2020
Tragic gene flow from Neanderthals
In this episode we explain how regions of the human genome associated with severe COVID-19 are identified, the finding that one of these regions was inherited from Neanderthals, and prolonged SARS-CoV-2 reproduction in an immunocompromised patient. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Genome wide association study of severe COVID-19 (NEJM) Major genetic risk factor for severe COVID-19 inherited from Neanderthals (Nature) COVID-19 host genetics initiative (Eur J Hum Gen) Prolonged SARS-CoV-2 shedding in immunocompromised host (J Inf Dis) Krugman on Barrington Declaration (NY Times) Letters read on TWiV 676 Timestamps by Jolene . Thanks! Weekly Science Picks Brianne – Kids Meet a Virologist Kathy – Harvard glass marine invertebrates 3D online Rich – Chernobyl fungi Vincent – <a
Sun, October 25, 2020
Forget what you've herd about immunity
Daniel Griffin provides a clinical report on COVID-19, then we discuss Bill Foege’s letter to CDC director Robert Redfield, the false promise of herd immunity for COVID-19, secret blueprints for SARS-CoV-2 vaccine trials released, and neuropilin-1 as a possible entry protein for the virus. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Excess COVID-19 Deaths by Age and Race and Ethnicity (MMWR) Excess COVID-19 deaths (JAMA) SARS-CoV-2 transmission (CDC) UK challenge trial (Nature) Inflammatory cytokine signature for severe COVID-19 (Nature) Death in AstraZeneca vaccine trial (Reuters) Herpetic Legion – Reactivation (YouTube) Tech position with Dr. Rosenfeld Biological safety officer position at CUMC Support MicrobeTV at Parasites Without Borders Foege letter to Redfield ( text , NPR article ) False promise of herd immunity (Nature) Secret <a href= "https://www
Thu, October 22, 2020
In the company of coronaviruses with Lisa Gralinski
Lisa joins TWiV to discuss her research on the pathogenesis of SARS-CoV, MERS-CoV, and SARS-CoV-2, including work on vaccines and an antiviral, then we review the SARS-CoV-2 spike protein as a potential analgesic, and listener questions. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler and Brianne Barker Guest: Lisa Gralinski Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode SARS-like bat CoV with potential for human emergence (Nat Med) SARS-CoV susceptibility loci in CC mice (PLoS Genetics) Combination attenuation for SARS-CoV vaccine (J Virol) Orally administered SARS-CoV-2 antiviral (Res Sq) Spike protein induces analgesia (Pain) Letters read on TWiV 674 Timestamps by Jolene . Thanks! Weekly Science Picks Brianne – The Lonely Pipette Podcast: Mentoring with Harmit Malik Kathy – Dr. Boyd the Chemist one and two GREAT short videos one and two , How to read an old school thermometer , New Marvel storyline Wear a Mask parody of Be My Guest Rich – <a href= "https://podcasts.apple.com/us/
Sun, October 18, 2020
Wake up and smell the pandemic
Daniel Griffin provides a clinical report on COVID-19, we debunk the Great Barrington Declaration, and discuss smell and taste changes as early indicators of the pandemic, vascular disease and thrombosis in SARS-CoV-2 infected humans and rhesus macaques, and the ability of the swine pathogen SADS-CoV to infect human respiratory tract cells. Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Daniel’s COVID-19 testing strategy calculator (and medRxiv preprint ) US COVID-19 mortality rates (JAMA) Final remdesivir report (NEJM) Hydroxychloroquine for COVID-19 (NEJM) Tech position with Dr. Rosenfeld Biological safety officer position at CUMC Support MicrobeTV at Parasites Without Borders Smell and taste changes as early pandemic indicators (Nat Comm) Vascular disease and thrombosis in SARS-CoV-2 infected macaques (Cell) SADS-CoV can infect human airway cells (PNAS) Letters read on TWiV 673 Timestamps by Jolene . Thanks! Weekly Science Picks Dickson – The Age of Nature Brianne – Virologist , Immunologist , Science Communicator pins and <a
Thu, October 15, 2020
Black in Microbiology with Ari Kozik and Kishana Taylor
Ari and Kishana, two of the founders of Black in Microbiology, join TWiV to discuss the goals of the organization, then we review pauses of J&J and Lilly COVID-19 vaccine trials, preclinical studies of Regeneron's SARS-CoV-2 monoclonal antibody cocktail, reinfection of a patient in Nevada, and listener questions. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler and Brianne Barker Guest: Ari Kozik and Kishana Taylor Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Black microbiologists push for visibility (NY Times) Black in Microbiology keynotes (YouTube) Black in Microbiology Black in Neuro AstroKate rides again (and on TWiV 444 ) COVID-19 testing strategy calculator (and medRxiv preprint ) Pause of J&J vaccine trial (STAT) Pause of Lilly mAb trial (NY Times) REGN-CoV-2 mAbs in animals (Science) Regeneron investor slides on mAb phase 3 SARS-CoV-2 reinfection in US (Lancet Inf Dis) <a href="https://www.mic
Sun, October 11, 2020
Prizes, polio, and a pandemic puzzle
Daniel Griffin provides a clinical report on COVID-19, then Amy joins us to discuss the 2020 Chemistry Nobel Prize for gene editing using CRISPR/Cas9, continuing circulation of poliovirus in Afghanistan, inborn errors of interferon in patients with severe COVID-19, and listener questions. Hosts: Vincent Racaniello, Alan Dove , and Rich Condit Guests: Daniel Griffin and Amy Rosenfeld Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASH guidelines on anticoagulants in COVID-19 patients (ASH) Followup of adults with noncritical COVID-19 (Clin Micr Inf) Tocilizumab in COVID-19 ICU patients (Lancet Rheum) Tech position with Dr. Rosenfeld Biological safety officer position at CUMC Support MicrobeTV at Parasites Without Borders 2020 Nobel Prize Chemistry ( pdf ) Progress towards polio eradication Afghanistan (MMWR) Inborn errors of IFN and serious COVID-19 (Science) Letters read on TWiV 671 Timestamps by Jolene . Thanks! Weekly Science Picks <st
Thu, October 08, 2020
Coronavirus vaccine preparedness with Kizzmekia Corbett
Kizzmekia Corbett joins TWiV to review her career and her work on respiratory syncytial virus, influenza virus, and coronaviruses and coronavirus vaccines, including her role in development and testing of a spike-encoding mRNA vaccine, and then we review the Nobel Prize for discovery of hepatitis C virus. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler and Brianne Barker Guest: Kizzmekia Corbett Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Pre-fusion structure of CoV spike (Nature) Pre-fusion structure of SARS-CoV-2 spike (Science) Evaluation of mRNA-1273 in nonhuman primates (NEJM) SARS-CoV-2 vaccine from pandemic preparedness (Nature) Nanoparticulate universal influenza vaccine from stem antigens (mBio) Biological safety officer position at Columbia U Medicine Nobel Prize for Hepatitis C virus (pdf) Alter's work on non-A non-B hepatitis ( paper one , paper two ) Houghton: single clone of HCV genome (Science) Rice: Transmission of hepatitis C to chimpanzee (Science) Charlie Rice on TWiV 392 Chemistry Nobel Prize to Doudna and Charpentier (Nobel.org) FDA releases stricter guidelines for COVID-19 vaccines (<a href="https://www.nytimes.com/live/2020/10/06/world/covid-coronavirus?action=click&module=Spotlight&pgtype=Homepage
Mon, October 05, 2020
Presidential COVID-19 with Dr. Daniel Griffin
Daniel Griffin discusses President Trump's case of COVID-19, including the clinical course, the medications he received and why, and expectations for the next few weeks. Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Regeneron CoV-2 mAb cocktail results (Regeneron) Rethinking COVID-19 test sensitivity (NEJM) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, October 04, 2020
All the wrong COVID-19 moves
Daniel Griffin provides a clinical report on COVID-19, including a discussion of the role of vitamin D in COVID-19, Michael and Christopher explain why we have made all the wrong moves during the pandemic, evidence that the D614G amino acid change improves transmission in hamsters, and listener questions. Hosts: Vincent Racaniello, Dickson Despommier , Rich Condit , and Brianne Barker Guests: Daniel Griffin , Michael B. Yaffe , and Christopher D. Barrett Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Regeneron CoV-2 mAb cocktail results (Regeneron) Vitamin D and COVID-19 (Lancet Diabet Endocrin) J&S Ad26 SARS-CoV-2 vaccine phase 1/2a results (medRxiv) All the wrong moves (Science Signaling) Trump main drive of CoV misinformation (NYTimes) Surgisphere scandal (The Scientist) SARS-CoV-2 D614G earlier transmission in vivo (bioRxiv) Das Coronavirus bullet points Letters read on TWiV Timestamps by Jolene . Thanks! Weekly Science Picks Dickson</str
Thu, October 01, 2020
Mice, bats, and coronaviruses with Tony Schountz
Tony Schountz joins TWiV to explain the work of his laboratory showing that deer mice can be infected with and transmit SARS-CoV-2, and how his colony of Jamaican fruit bats is being used to understand their response to virus infections. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler and Brianne Barker Guest: Tony Schountz Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode SARS-CoV-2 infection of deer mice (bioRxiv) Infection of Jamaican fruit bats with MERS-CoV (Sci Rep) Immunological control of virus infections in bats (Front Immunol) Transmission of bat influenza viruses in bats (Nat Micro) Letters read on TWiV 668 Timestamps by Jolene . Thanks! Weekly Science Picks Brianne - Virus Masks Kathy – UV in the vineyards ( video ) Rich - Great White Shark Attack Vincent - Smart WiFi garage door opener Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv <
Sun, September 27, 2020
Building a better virus trap
Daniel Griffin provides a clinical report on COVID-19, review of the phase I and II trials of the Russian prime-boost vaccine, a mouse model that recapitulates age-dependent severe disease, and listener questions. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , and Rich Condit Guest: Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Safety and immunogenicity of Russian COVID-19 vaccine (Lancet) 'Questionable' data in Russian vaccine results (Nature) Mouse model for SARS-CoV-2 ALI and mortality (Cell) Letters read on TWiV 667 Letters to Humans Timestamps by Jolene . Thanks! Weekly Science Picks Dickson - Rewilding Europe Alan - How to Do Nothin g by Jenny Odell Rich - Gene drive engineered mosquitoes Vincent - TWiEVO 60 with 12 guests! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Thu, September 24, 2020
A far-UVC light bulb went off for David Brenner
David Brenner joins TWiV to explain how far-UVC lights could provide protection from SARS-CoV-2 and other airborne viruses in public places, solutions to face mask fogging, transmission during airplane flights, and listener questions. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler and Brianne Barker Guest: David Brenner Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Far-UVC light inactivates viruses (paper one and two ) Tips to avoid mask fogging ( YouTube , article one and two ) Funding for virus hunting Jonna Mazet interview (YouTube) Pandemic fake news (NY Times) Airplane SARS-CoV-2 infections ( summary , article one , two , three ) COVID-19: Wrong moves in wrong places (Science) Das coronavirus bullet points SARS-CoV-2 was not made in a lab (YouTube) Letters read on TWiV 666 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and c
Sun, September 20, 2020
This half-week in coronavirology
Daniel Griffin provides a clinical report on COVID-19, superspreading potential of SARS-CoV-2 in Hong Kong, structure of virion glycoprotein of a commmon cold coronavirus reveals changes driven by prolonged circulation in humans, and listener email. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Increased risk for COVID-19 during pregnancy (MMWR) COVID-19 and community and close contact exposures (MMWR) COVID-19 clusters in Japan (Emerg Inf Dis) Eyeglass use associated with less COVID-19 (JAMA Ophthal) Superspreading of SARS-CoV-2 in Hong Kong (Nat Med) HKU1 HE structure and evolution (Nat Comm) Das Coronavirus summaries TWiVerse Letters read on TWiV 665 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Thu, September 17, 2020
TWiV is for the dogs
On this mid-week edition, does it matter that SARS-CoV-2 is mutating, seasonal coronavirus immunity is short-lived, another bogus claim that the virus was produced in a laboratory (it came from Nature), and answers to listener questions. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Coronavirus is mutating (Nature) Seasonal CoV immunity is short (Nat Med) Sorry, no link to the fake science document! Letters read on TWiV 664 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, September 13, 2020
The joy of vax
Daniel Griffin provides a clinical report on COVID-19, including vaccines, Alan summarizes a vaccine webinar on the most advanced US trials, a nidovirus from snapping turtles, longevity of memory B cells in recovered patients, and listener email. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove , Rich Condit , and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Young adults with COVID-19 (JAMA) Letter from Stanford professors on Atlas (pdf) National Adult and Influenza Immunization Summit Bugger, even the snapping turtles! (PLoS One) Memory B cell longevity in COVID-19 (medRxiv) Letters read on TWiV 663 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Fri, September 11, 2020
Principals of Principles, Fifth Edition
The authors of the textbook Principles of Virology gather to reveal new additions to the fifth edition, including a new author, study questions, and a chapter on therapeutic viruses. Host: Vincent Racaniello Guests: Jane Flint , Anna Marie Skalka , Glenn F. Rall , and Theodora Hatziioannou Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Purchase PoV 5e Volumes 1 + 2 ( link ) Purchase PoV 5e Volume 1 ( link ) Purchase PoV 5e Volume 2 ( link ) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Thu, September 10, 2020
SWAG with Ralph Baric
Ralph Baric returns to TWiV to provide an update on the COVID-19 resurgence in the US, monoclonal antibodies, antiviral drugs, vaccines, immunity and reinfection, reopening schools, and what will happen this fall. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler and Brianne Barker Guest: Ralph Baric Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Broadly neutralizing sarbecovirus mAbs (bioRxiv) Evaluation of mRNA-1273 in nonhuman primates (NEJM) Bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 (bioRxiv) Mouse-adapted SARS-CoV-2 (bioRxiv) READDI Das Coronavirus summaries in English ChAdOx1 vaccine trial halted (NY Times) Impact of high frequency screening (medRxiv) Letters read on TWiV 661 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, September 06, 2020
In case of emergency finish the trial
Daniel Griffin provides a clinical report on COVID-19, then we discuss decline of virus-specific bone marrow B cells within a year after influenza vaccination, the push to release SARS-CoV-2 vaccines before completion of phase 3 trials, and absence of evidence for infectious virus in aerosols. Hosts: Vincent Racaniello, Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Convalescent plasma RCT (medRxiv) Multicenter RCTs on corticosteroids for COVID-19 (JAMA) Decline of influenza B cells a year after vaccine (Science) Be ready to distribute vaccines 1 Nov (WPRI and NYTimes ) EUA during COVID-19: lessons (JAMA) Not evidence for aerosol transmission ( one and two ) Letters read on TWiV 660 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Thu, September 03, 2020
Sloppy coronavirus immunity with Christian Drosten
Christian Drosten returns to TWiV to provide an update on the COVID-19 situation in Germany, and general thoughts on testing, immunity, vaccines, therapeutics, epidemiology, reopening schools, and what will happen this fall. Hosts: Vincent Racaniello, Rich Condit , and Brianne Barker Guest: Christian Drosten Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Christian previously on TWiV 601 Plague percolation phenomenon (Nature) TMPRSS2 inhibitor for SARS-CoV-2 (Cell) Repeated infections with endemic CoV (J Inf Dis) Koch Institute SARS-CoV-2 reports Letters read on TWiV 659 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, August 30, 2020
Everyone needs a H.E.A.R.T.
Daniel Griffin provides a clinical report on COVID-19, then we discuss CDC softening testing guidelines, Moderna vaccine phase I results in older people, Abbott's $5 rapid antigen test, and reinfection with a distinct SARS-CoV-2 isolate, followed by listener email. Hosts: Vincent Racaniello, Alan Dove , Dickson Despommier , and Rich Condit Guest: Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode CDC told to soften SARS-CoV-2 testing guidelines (NYTimes) Moderna investor presentation on mRNA-1273 vaccine ( link ) SARS-CoV-2 reinfection (Clin Inf Dis) Dr. Fauci talks with just about anyone (NYTimes) Letters read on TWiV 658 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Thu, August 27, 2020
Shane Crotty on SARS-CoV-2 immunity
Immunologist Shane Crotty joins TWiV to discuss the antibody and T cell responses to infection with SARS-CoV-2, followed by answers to listener questions. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Guest: Shane Crotty Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Ahead of the Curve by Shane Crotty SARS-CoV-2 T cell epitopes (Cell) Cross-reactive CoV T cell epitopes (Science) Knowns and unknowns about SARS-CoV-2 immunity (Nat Rev Imm) Letters read on TWiV 657 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, August 23, 2020
TWiV 656: See, it can be done!
Daniel Griffin provides a clinical report on COVID-19, surgeons Lisa Smith and David Bruce detail how they have helped their Chattanooga community during the pandemic, then we discuss racial and ethnic disparities among COVID-19 cases, no more premarket review of laboratory developed tests by FDA; and emergency use authorization of convalescent plasma is on hold. Hosts: Vincent Racaniello, Dickson Despommier , Rich Condit , and Brianne Barker Guests: Daniel Griffin , Lisa A. Smith , and W. David Bruce Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode Racial and ethnic disparities in workplace COVID-19 (CDC) Rescission of guidances on laboratory tests (FDA) EUA on convalescent plasma on hold (NY Times) Letters read on TWiV 656 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Thu, August 20, 2020
Minority health with Robert Fullilove
Sociomedical scientist Robert Fullilove joins TWiV to discuss disparities in minority health; FDA announces an EUA on Yale's SalivaDirect, protection of the upper and respiratory tract of mice after intranasal inoculation with an adenovirus-vectored SARS-CoV-2 spike gene, and listener questions. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Guest: Robert Fullilove Click arrow to play Download TWiV 652 (69 MB .mp3, 114 min)<>Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Health of racial and ethnic minority groups (CDC) COVID-19 death/hospitalization by race/ethnicity (CDC) Racial and ethnic disparities in workplace COVID-19 (CDC) SalivaDirect EUA (FDA) Adenovirus vectored SARS-CoV-2 experimental vaccine protects mice (Nat Comm) Letters read on TWiV 655 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, August 16, 2020
TWiVering with excitement
Daniel Griffin provides a clinical report on COVID-19 and the convalescent plasma trial, then we answer listener questions about the Russian vaccine, choir practice, face masks (wear them!), Mina testing, transmission, and much more. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guests: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Daniel's recommendations for COVID-19 testing ( pdf ) Effects of convalescent plasma on COVID-19 (medRxiv) ESCV virtual meeting on COVID-19 The Russian Vaccine (In The Pipeline) Russia's vaccine approval (Science) Letters read on TWiV 654 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Fri, August 14, 2020
Back to school with COVID-19
Alfonso, Ken, Mary and Janet join TWiV to explain their modeling of school reopening strategies during the SARS-CoV-2 pandemic. Hosts: Vincent Racaniello and Rich Condit Guests: Alfonso Landeros , Ken Lange , Mary E. Sehl , and Janet Sinsheimer Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode School reopening strategies (medRxiv) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Thu, August 13, 2020
The rules of contagion with Adam Kucharski
Epidemiologist Adam Kucharski joins TWiV to discuss SARS-CoV-2, including R0, incubation period, herd immunity, asymptomatic infection, superspreaders, children as drivers of pandemics, and how this one will end. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Guest: Adam Kucharski Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode The Rules of Contagion (Amazon affiliate link) Overdispersion in SARS-CoV-2 transmission (Wellcome Open Res) Sorrento Therapeutics test In vitro diagnostics EUAs (FDA) Letters read on TWiV 652 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, August 09, 2020
FDA rules with Denise Esposito
Daniel Griffin provides a clinical report on COVID-19, then former FDA Chief of Staff to the Commissioner Denise Esposito joins us to explain the challenges in approving vaccines, antiviral drugs, and diagnostic tests during a pandemic, followed by answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guests: Daniel Griffin and Denise Esposito Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Template for at-home, OTC diagnostic tests (FDA) Postdoctoral position in Prasad laboratory ( pdf ) Rapidtests.org Masks are cool, Miasma t-shirts (CafePress) Letters read on TWiV 651 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Thu, August 06, 2020
Virology is infinite
In this mid-week episode of Earth's Virology Podcast, we analyze SARS-CoV-2 transmission among youths at a summer camp, adaptation to mice by passage, the importance of T cells for recovery from COVID-19, and listener questions. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Travis County indicators dashboard SARS-CoV-2 transmission at an overnight camp (MMWR) Adaptation of SARS-CoV-2 in mice (Science) Acute SARS-CoV-2 infection impairs DC and T cell responses (Imm) Boulder , Columbia , Illinois rapid saliva tests Letter drafts for $1 testing Letters read on TWiV 650 Timestamps by Jolene . Thanks! Weekly Science Picks Kathy BBC Witness History, Maurice Hilleman 9 minute audio (quotes by Paul Offit) “The fastest vaccine ever developed”And APOD Picture Rocks Sun Dagger Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Tue, August 04, 2020
Ohio State viral
Vincent visits Ohio State University (March 2020) and speaks with Shan-Lu, David, Amanda, Mark, Matt, Chris, and Qiuhong about their careers and their work on retroviruses, hepatitis C virus, coronaviruses, paramyxoviruses, and environmental viruses. Host: Vincent Racaniello Guests: Shan-Lu Liu , David Bisaro , Amanda Panfill , Mark Peeples , Matt Sullivan , Chris Walker , Qiuhong Wang Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode New virus requires international control (Nature) TIM-family proteins inhibit HIV-1 release (PNAS) Designing a HCV vaccine (Curr Op Virol) Attenuated vaccines for RSV in children (J Inf Dis) Plant histone reader suppresses geminivirus infection (J Virol) HTLV-associated malignancy (Curr Op Virol) Coronaviruses in pigs (Curr Op Virol) Marine DNA viral diversity pole to pole (Cell) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, August 02, 2020
Life is for learning
Daniel Griffin provides a clinical report on COVID-19, followed by a review of the findings that children shed as much SARS-CoV-2 viral RNA from the respiratory tract as older patients, the lineage giving rise to SARS-CoV-2 has been circulating in bats in China for decades, and answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guest: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Roche trial of Actemra for COVID-19 fails (Reuters) Postdoctoral position at RML Shedding of SARS-CoV-2 at different ages (JAMA Ped) Evolutionary origins of SARS-CoV-2 (Nat Microbio) Letters read on TWiV 648 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Thu, July 30, 2020
Testing is our way out of this crisis
In this mid-week TWiV, children under 10 do transmit SARS-CoV-2, why hydroxychloroquine does not work for treating COVID-19, scale-up of diagnostic testing, explanation of LAMP testing, and listener questions. Hosts: Vincent Racaniello, Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Children do transmit infection (Emerg Inf Dis) NIH RADx initiative (NEJM) Rockefeller Foundation testing plan HCQ observational study (Int J Inf Dis) Can't kill HCQ (Science Based Medicine) HCQ does not inhibit SARS-CoV-2 in human lung cells (Nature) HCQ does not inhibit SARS-CoV-2 in nonhuman primates (Nature) Shut-down to stop SARS-CoV-2 (WaPo) Racine firefighters doing LAMP (Wired) LAMP ( video , webinar , paper 1 , paper 2 ) Letter drafts for $1 testing Letters read on TWiV 647 Timestamps by Jolene . Thanks! Weekly Science Pi
Tue, July 28, 2020
Virocentricity II with Eugene Koonin
From the NIH campus (recorded February 2020) Vincent and Rich meet with Eugene Koonin to discuss his theories on the evolutionary origins of viruses. Hosts: Vincent Racaniello and Rich Condit Guest: Eugene Koonin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Virocentricity with Eugene Koonin ( TWiV 275 ) Origin of viruses (Nat Rev) Multiple origins of capsid proteins from cells (PNAS) Origins and evolution of global RNA virome (mBio) Evolution of NCLDV of eukaryotes (Adv Virus Res) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, July 26, 2020
Lions and tigers and zookeepers (oh my)
Daniel Griffin provides a clinical report on COVID-19, followed by a review of the State Department document on the Wuhan BSL-4 laboratory, the report on infection of tigers and lions in the Bronx Zoo, and, answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode State Dept. memo on Wuhan BSL-4 lab ( pdf ) Biosafety levels (Wikipedia) Inside a BSL-4 (TWiV) From people to panthers (bioRxiv) Letters read on TWiV 645 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Thu, July 23, 2020
Don't let perfect be the enemy of good
In this mid-week edition, identifying flawed research before it becomes dangerous, Michigan governor tells America to mask-up, Pfizer mRNA vaccine gets $1.95 billion from Warp Speed, preliminary phase I/II results of the ChAdOx1 SARS-CoV-2 vaccine, answers to listener questions. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Click arrow to play Download TWiV 644 (69 MB .mp3, 115 min) Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode US COVID-19 cases (NY Times) Identify flawed research before it is dangerous (NY Times) Mask up , America! (NY Times) $1.95 billion to Pfizer (NY Times) Phase I trial of Pfizer mRNA vaccine (medRxiv) Phase I/II trial of ChAdOx1 vaccine (Lancet) Rockefeller Foundation testing plan TWiV 640 on MedCram Letter drafts for $1 testing Letters read on TWiV 644 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Tue, July 21, 2020
Bernie Moss, the real Poxdoc
From the NIH campus (recorded February 2019) Vincent and Rich meet with Bernie Moss to hear about his training and his remarkable 50-year-plus career working on poxviruses. Hosts: Vincent Racaniello and Rich Condit Guest: Bernie Moss Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Link for this episode Reflections on Bernie Moss' career (JBC) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, July 19, 2020
Bringin' in 50 keys of spike mRNA
Daniel Griffin provides a clinical update on COVID-19, then we discuss phase I preliminary results of the SARS-CoV-2 mRNA vaccine, factors associated with death in 17 million patients, and answer listener questions. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guests: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Travis County virtual Town Hall SARS-CoV-2 mRNA vaccine, preliminary results (NEJM) Factors associated with COVID-19 death (Nature) Letters read on TWiV 642 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Fri, July 17, 2020
COVID-19 with Dr. Anthony Fauci
Dr. Anthony Fauci joins TWiV to discuss SARS-CoV-2 transmission, testing, immunity, pathogenesis, vaccines, and preparedness. Hosts: Vincent Racaniello and Rich Condit Guest: Dr. Anthony Fauci Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Dr. Fauci was previously on TWiV 219 Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Thu, July 16, 2020
Test often, fast turnaround, with Michael Mina
Michael Mina joins TWiV to reveal why frequent and rapid SARS-CoV-2 testing is more important than accuracy, how a daily $1 rapid test could control the pandemic, and why group testing works. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Guests: Michael Mina Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Michael Mina on Immune 26 White House bypasses CDC (NY Times) Test sensitivity is secondary to frequency and turnaround time (medRxiv) Group testing for SARS-CoV-2 (medRxiv) Consider the cycle threshold value (Clin Inf Dis) MERS-CoV spike nanoparticles protect mice from infection (Vaccine) CoV spike protein nanoparticles induce neutralizing antibodies in mice (Vaccine) Letters read on TWiV 640 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Tue, July 14, 2020
Virology Nobel Prizes with Erling Norrby part 2
Vincent and Erling resume their discussion of virology Nobel Prizes, focusing on awards for research on tumor viruses, bacteriophages, virus structure, reverse transcriptase, hepatitis B virus, HIV-1, human papillomaviruses and much more. Host: Vincent Racaniello Guest: Erling Norrby Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Nobel Prizes and Life Sciences by Erling Norrby Nobel Prizes and Nature’s Surprises by Erling Norrby Nobel Prizes and Notable Discoveries by Erling Norrby Nobel Prizes: Cancer, Vision and the Genetic Code by Erling Norrby Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, July 12, 2020
Do, there is no try
Daniel Griffin provides a clinical update on COVID-19, then Viviana Simon joins to review serological assays developed at Mt. Sinai for SARS-CoV-2 infection, tracking the outbreak in NYC, and listener questions. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , and Rich Condit Guests: Viviana Simon , Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Serological assay for SARS-CoV-2 infection (Nat Med) Early spread of SARS-CoV-2 in NYC (Science) Seroconversion of a city (medRxiv) Immune response and PCR positivity of NYC cohort (medRxiv) Letters read on TWiV 638 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Thu, July 09, 2020
Clearing the fog of ignorance
In this episode, approval of an Ad5 vectored SARS-CoV-2 vaccine for the military in China, description and clinical trials of a Novavax vaccine joining Operation Warp Speed, prevalence of SARS-CoV-2 in Spain, shedding and transmissibility of the virus, and listener email. Hosts: Vincent Racaniello , Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode China approves COVID-19 vaccine for military (CNN) Ad5-vectored COVID-19 vaccine phase I results (Lancet) US pays $1.6 billion for Novavax vaccine (NY Times) CEPI awards $388 million to Novavax (Novavax) HHS on Novavax vaccine (HHS) Novavax phase I/II trials (GlobeNewswire) Prevalence of SARS-CoV-2 in Spain (Lancet) Shedding and transmissibility of SARS-CoV-2 (Nature) Letters read on TWiV 637 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and com
Tue, July 07, 2020
Georgia State viral
From Georgia State University, Vincent speaks with Chris, Andrew, Priya, and Richard about their careers and their work on Ebolaviruses, rotavirus, and antiviral drug development. Host: Vincent Racaniello Guests: Chris Basler , Andrew Gewirtz , Priya Luthra , and Richard Plemper Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Mutant Ebolavirus lacks virulence (Cell Rep) Blocking Ebolavirus replication by depleting nucleoside pools (Antiviral Res) Herd immunity against bad actor molecules (PloS Path) Bacteria prevent and cure rotavirus infection (Cell) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, July 05, 2020
Mask hysteria
Daniel Griffin provides a clinical update on COVID-19, then we review SARS-CoV-2 shedding in children, how to resume school safely, the need for widespread testing and wearing face masks, and much more, including listener email. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guests: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Infectious SARS-CoV-2 in nasopharynx of youth (Emerg Inf Dis) SARS-CoV-2 viral load by patient age (Hosp Charité) Viral load in children with COVID-19 (Emerg Inf Dis) Role of children in SARS-CoV-2 transmission (virology blog) Letters read on TWiV 635 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Thu, July 02, 2020
1000 hours of the sunlight of TWiV
TWiV reviews a new H1N1 swine influenza virus from China with pandemic potential, Ad5 vectored SARS-CoV-2 oral vaccine candidate, Operation Warp Speed vaccine candidates, FDA guidance on vaccine approval, and answer listener email. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode New swine flu with pandemic potential ( BBC , PNAS ) Oral SARS-CoV-2 vaccine candidate (ClinicalOmics) Operation Warp Speed (HHS) ACTIV (NIH) Development and licensure of COVID-19 vaccines (FDA) Letters read on TWiV 634 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Tue, June 30, 2020
Singapore viral
From DukeNUS Medical School, Vincent speaks with Ashley, Sheemei, Eng Eong and Dahai about their careers and their research on flaviviruses and sensing of viral RNA. Host: Vincent Racaniello Guests: Sheemei Lok , Dahai Luo , Eng Eong Ooi , and Ashley St. John Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Dengue virus and endothelial permeability (J Clin Invest) Dengue virus morphological switch (PLoS Path) Symptomatic yellow fever vaccine infections (Nat Med) RNA recognition by RIG-I and MDA5 (Nucl Acids Res) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, June 28, 2020
Countering a miasma of anti-think
Daniel Griffin provides a clinical update on COVID-19, then we review SARS-CoV-2 infections in non-humans, vesicular stomatitis in Kansas horses, and answer listener questions. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Kathy Spindler and Brianne Barker Guests: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Dexamethasone for COVID-19 (medRxiv) Proning trial for COVID-19 (Lancet) Tocilizumab for COVID-19 cytokine storm (Chest) Global causes of death Vesicular stomatitis in horses (ProMedMail) Daily tests needed (Atlantic) SARS-CoV-2 infection risks Letters read on TWiV 632 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Thu, June 25, 2020
Lots of eggs in the spike basket
Vincent, Rich, and Brianne discuss a study estimating the fraction of symptoms and severe disease after SARS- CoV-2 infection, cellular immune responses without seroconversion during interfamilial infections, and answer listener email. Hosts: Vincent Racaniello, Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Probability of symptoms and severe COVID-19 (aRxiv) Cellular immune response without seroconversion (medRxiv) Image credit Letters read on TWiV 631 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Wed, June 24, 2020
Singapore Environmental Health Institute
From the Environmental Health Institute in Singapore, Vincent speaks with Director Lee Ching Ng about their work to control viral infectious diseases, including the controlled release of mosquitoes containing Wolbachia endosymbionts to inhibit viral transmission. Host: Vincent Racaniello Guest: Lee Ching Ng Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV!
Sun, June 21, 2020
Coronavirus update, pandemic sitrep
Daniel Griffin provides a clinical update on COVID-19, including analysis of the dexamethasone trial, and then we discuss two Ebolavirus outbreaks in DRC, clinical and virological aspects of asymptomatic SARS-CoV-2 infections, age-dependent effects on transmission, and answer listener email. Hosts: Vincent Racaniello, Dickson Despommier , and Alan Dove Guests: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Dexamethasone reduces COVID-19 deaths (U Oxford) Assessment of asymptomatic COVID-19 (Nature Med) Age-dependent effects on SARS-CoV-2 transmission (Nature Med) Image credit Letters read on TWiV 629 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Thu, June 18, 2020
Physical distance for COVID-19
Vincent and Rich discuss the SARS-CoV-2 D614G amino acid change in the spike glyprotein, duration of infectious virus shedding from patients, virus transmission among hamsters infected in the laboratory, and tackle listener email. Hosts: Vincent Racaniello and Rich Condit Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Austin TX key indicators for staging D614 amino acid change (Scripps) Virus shedding in hospitalized patients (medRxiv) Hamster SARS-CoV-2 model (Nature) COVID-19 host genetic initiative Image credit Letters read on TWiV 628 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Wed, June 17, 2020
Singapore National Centre for Infectious Diseases
Vincent visits the National Centre for Infectious Diseases and speaks with Executive Director Leo Yee-Sin and Consultant Nancy Tee about the main hub for both clinical treatment of infectious diseases and outbreak management in Singapore. Host: Vincent Racaniello Guests: Leo Yee-Sin and Nancy Tee Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode National Centre for Infectious Diseases National Public Health Laboratory Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, June 14, 2020
Ralph Baric and fancy ferrets
Daniel Griffin provides a clinical update on COVID-19, then Ralph Baric joins TWiV to discuss SARS-CoV-2 transmission, vaccines, diagnostic tests, and a new animal model from his laboratory that does not use transgenic mice. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guests: Daniel Griffin , Chuck Knirsch, and Ralph Baric Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode Mouse-adapted SARS-CoV-2 model (bioRxiv) SARS-CoV-2 mRNA vaccine (bioRxiv) ASM resources for #shutdownstem President Obama on sustaining momentum for change (Facebook) America After the Civil War (PBS) Image credit Letters read on TWiV 626 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Thu, June 11, 2020
Fred Murphy, virologist for all seasons
Vincent and Rich visit Fred Murphy to hear about his wide-ranging career in virology, spanning many institutions, involving dangerous viruses like rabies virus, Ebolavirus (he took that famous iconic image), Marburg virus, Lassa virus, coronaviruses, and later writing a history of the field. Hosts: Vincent Racaniello and Rich Condit Guest: Frederick A. Murphy Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Link for this episode (UTMB) Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, June 07, 2020
SeXX matters with Sabra Klein
Daniel Griffin provides a clinical update on COVID-19, then Sabra Klein joins us to discuss the effect of sex, gender, and age on viral infectious disease, including COVID-19. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler and Brianne Barker Guests: Daniel Griffin , Chuck Knirsch, and Sabra Klein Click arrow to play Download TWiV 624 (91 MB .mp3, 152 min) Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode SeXX matters in infectious disease pathogenesis (PLoS Path) Sex and gender impact immune responses to vaccines (Physiol) Testosterone and disease severity in mice (Cell Immunol) Age-associated effects on impact of sex steroids on vaccine responses (NPJ Vaccines) Evolution of greater humoral immunity in females (Curr Opin Physiol) Impact of sex and gender on COVID-19 (Biol Sex Diff) COVID-19 trials should include <a href= "https://pubmed.ncb
Thu, June 04, 2020
Bats and coronaviruses with Peter Daszak
Peter Daszak joins TWiV to explain the work of EcoHealth Alliance in surveillance of bats in China for SARS-related coronaviruses to provide the information needed to prevent future pandemics, and why NIH recently withdrew financial support for their work. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Guest: Peter Daszak Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Bats are reservoirs of SARSr-CoV (Science) Bat SARSr-CoV that binds ACE2 (Nature) Rich gene pool of bat SARSr-CoV (PLoS Path) Bat SARSr-CoV infect humans (Virol Sin) Transmission of bat SARSr-CoV in China (bioRxiv) Global Virome Project (Science) ASV Virtual Workshops 2020 Image credit Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees <br data-rich-text-l
Tue, June 02, 2020
Nonhuman primate model for COVID-19 with Emmie de Wit
Emmie de Wit joins TWiV to explain her work on the pathogenesis of infection with SARS-CoV-2 in rhesus macaques, including studies on remdesivir and vaccine candidate. Hosts: Vincent Racaniello , Rich Condit , and Brianne Barker Guest: Emmie de Wit Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Respiratory disease in macaques inoculated with SARS-CoV-2 (Nature) Clinical benefit of remdesivir in SARS-CoV-2 infected macaques (bioRxiv) Remdesivir for MERS-CoV infection in macaques (PNAS) ChAdOX1 vaccination for SARS-CoV-2 in macaques (bioRxiv) Image credit Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, May 31, 2020
An era of COVID-19 poppycock
Daniel Griffin provides a clinical update on COVID-19, then we review an Ad5 vectored SARS-CoV-2 vaccine, reports on remdesivir and hydroxychloroquine, a drug repurposing study, why some patients infect many others, reducing viral transmission, and much more, including listener email. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler and Brianne Barker Guests: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Safety of Ad5 vectored COVID-19 vaccine (Lancet) Analysis of hydroxychloroquine use (Lancet) Remdesivir study (NEJM) Ancient COVID-19 history (MMWR) Drug repurposing for COVID-19 (bioRxiv) Why do few COVID-19 patients infect others ? (Science) Overdispersion in COVID-19 transmission (Wellcome Open Res) Reducing airborne transmission (Science) Letters read on TWiV 621 Timestamps by <a href="http://www.twitter.com/jrrmicro" target= "_blank" rel="nore
Fri, May 29, 2020
Antibodies and T cells in COVID-19 patients
Jon Yewdell returns to explain studies on detection of antibodies and T cell epitopes in patients who have recovered from COVID-19. Hosts: Vincent Racaniello , Rich Condit , and Brianne Barker Guest: Jon Yewdell Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode T cell targets in COVID-19 patients (Cell) SARS-CoV-2 seroconversion in humans (Nat Med) Convergent antibody responses to SARS-CoV-2 infection (bioRxiv) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Wed, May 27, 2020
Recombination led to emergence of SARS-CoV-2
Raul Rabadan joins TWiV to explain the use of computational biology to demonstrate how recombination and mutation led to emergence of SARS-CoV-2. Hosts: Vincent Racaniello , Rich Condit , and Brianne Barker Guest: Raul Rabadan Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Rabadan Laboratory Understanding Coronavirus (Amazon) Topological Data Analysis for Genomics and Evolution (Amazon) Recombination and mutation shaped SARS-CoV-2 (bioRxiv) Bat CoV with cleavage site insertion (Curr Biol) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Tue, May 26, 2020
Nipah virus at 20
From the Nipah Virus International Conference in Singapore, Vincent speaks with meeting participants about the history of the first Nipah virus outbreak, lessons learned from Hendra virus, surveillance of bats for viruses, and the development of a vaccine. Hosts: Vincent Racaniello Guests: John Mackenzie , Jon Epstein , Eun-Chung Park , and Linfa Wang Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, May 24, 2020
Coronavirus Times
Daniel Griffin provides a clinical update on COVID-19, then we review TETRIS by Paterson NJ, modeling the effects of intervention in the US on cases and deaths, mixing PCR and serology data, and much more, including listener email. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Playing tennis safely (USTA) Scientists denounce end to CoV grant (NY Times) ASMBMB denounces end to CoV grant ( pdf ) For TETRIS, turn to Paterson NJ (NY Times) NJ Dept of Health (image credit) Differential effects of intervention timing ( medRxiv and NY Times ) Texas to stop combining test results (Statesman) How could CDC make that mistake ? (Atlantic) <li
Thu, May 21, 2020
Singing about coronavirus
Vincent, Kathy and Rich discuss COVID-19 research paper overload, Moderna's mRNA vaccine Phase I results, increase of ACE2 RNA by cigarette smoke, and answer listener questions. Hosts: Vincent Racaniello , Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Drowning in COVID-19 papers (Science) CORD-19 2019 NCRC AI powered literature review SciSight Graphical guide to CoV vaccines (Nature) Moderna Phase I results Liposomes and lipid nanoparticles (Exelead) Cigarette smoke increases ACE2 (Dev Cell) Letters read on TWiV 616 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Tue, May 19, 2020
Peter Daszak of EcoHealth Alliance
Vincent speaks with Peter Daszak, President of EcoHealth Alliance, a global nonprofit organization dedicated to protecting wildlife and public health from the emergence of disease. Hosts: Vincent Racaniello Guests: Peter Daszak Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Intro music is by Ronald Jenkees . 20% off The Invisible ABCs for TWiV listeners! Use promo code: ABC20 at checkout. Send your virology questions and comments to twiv@microbe.tv
Sun, May 17, 2020
COVID Tetris - Test, trace, isolate
Daniel Griffin provides a clinical update on COVID-19, then we review results showing requirement for the furin site in the SARS-CoV-2 spike for replication, US state vaccine exemptions, concerns with a rapid diagnostic test, and answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Triple therapy for COVID-19 (Lancet) Virology podcast goes viral (Thalia Gigerenzer) Paul Stays Home ( pdf ) Multibasic cleavage site essential for SARS-CoV-2 infection (Mol Cell) Mumbai engulfed by CoV (NY Times) All must be <a href= "https://u4984893.ct.sendgrid.net/ls/click?upn=SpLp-2FYq0UU0xrqvVF45tlSqPePVbnq1g1kXY63Z3L-2BnvDEr-2BkRRDCvcwcFgEqCBsh2qPpDBmWEJER-2FfVR54EHapXRamjJVgzkulE6FLJ1x5gaG6loe5ldlvza63HA2TGo3OswyVexl15dAO0X3qOHLKpDftWloAonTdeG-2BSr5WON4btCARo3ZW-2F4tZCYr89okHtPWXarmFw2HN1jyfEDvs-2BjJA5Z-2FiFqetRv8lyzem0-3Di89R_4W0QawhXcjyqrEqmfhAI6GGzUoLdF7CY8i-2B6uyUplVgSvk3HwFg1cdI9KeOOi7DFApi740bFxuUbjCEwIlG1QzIwfa5K3wMoOabI4FcR5ISrP8mHjGgiYWEtDV2R7e398MGxSBTEeU0enx7GfZu-2B2b-2BO-2FtXEPtgij9BKoLh8x2I-2BiXvLL38KzwG8NOCr2SDDjfQfUJQ-2BHUPljCSyzRnnSPgXKgqWvu5L8pmBzNQIoX7VM3tig-2FYBZ5OFlsp-2BmoQ0oYhAk66pzT8pHbO0cNLfdZKYpfoqA6pLs2MrJs67O0st1AsvWLrkuqy8KLAdl1c5aA3CFQXhTuNx4Cz0Ghe6NVF5CA7Ng4EpogK4pgxgHfQnFE8LIKEkescod52DaGayaFQ4BuwbPJo83fEv0MwFfM0WpdFrnhqidGv3GLnBvEQFgOhOj-2B4AZizwOHdm-2F0ufH87otZTIJb9HukTkadBr7X9IDt8BD9-2B7weA5dHvRUX3z22qziv9nubLy1L1yB29F9Z6-2FlT7kgfpdMBey
Thu, May 14, 2020
Jenner, vaccines, and COVID-19
Vincent, Kathy and Rich explain the Jenner Institute's SARS-CoV-2 vaccine, the NIH decision to stop the Remdesivir study, and answer listener questions. Hosts: Vincent Racaniello, Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode COVID-19 brings out dark side of science ( Mother Jones , Wired ) Jenner Institute COVID-19 vaccine (BioSpace) Recombineering (Nucleic Acids Res) Vaccines lecture (YouTube) ChAdOx1 MERS vaccines protects NHP (Lancet Inf Dis) Chimpanzee adenovirus vector (PLoS One) Ad-MERS vaccine protects monkeys (NIH) Rapid COVID-19 vaccine development (Science) Strategic approach to COVID-19 vaccines (Science) NIH decision to stop remdesivir study (Stat) 80,000 flu deaths this winter (Stat) Science and singing (YouTube) COVID-19 at choir practice (Emerg Inf Dis)
Tue, May 12, 2020
CEPI, preventing the next pandemic
From the Nipah Virus International Conference in Singapore, Vincent speaks with Richard Hatchett, CEO of CEPI, about its mission to stimulate and accelerate the development of vaccines against emerging infectious diseases. Hosts: Vincent Racaniello Guests: Richard Hatchett and Linfa Wang Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, May 10, 2020
Corona and crowns
Daniel Griffin provides a weekly clinical update on COVID-19, then Michael Schmidt discusses how dentistry can be safely practiced during a pandemic, followed by answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guests: Daniel Griffin and Michael Schmidt Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode OSHA guidance for dentistry COVID0-19 challenges for dentistry (J Dent Res) COVID-19 and dentistry (Int J Env Res Pub Health) Mouthrinses for dentistry (J Clin Med) Disingenuous plandemic documentary (Big Think) Letters read on TWiV 611 Image credit Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Thu, May 07, 2020
Coronavirus FAQ
The TWiV team summarizes serology-based tests for SARS-CoV-2, lack of effect of ACE inhibitors or ARBs on COVID-19 severity, and answers listener questions. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode FDA revises statement on antibody tests (FDA) Serology-based tests for SARS-CoV-2 (Center for Health Security) ACE inhibitors, ARBs not linked to COVID-19 severity ( Mehra study , Mancia study , Reynolds study ) Global COVID-19 CFR (CEBM) Debunking transmission mutation: TWiEVO 55 Letters read on TWiV 610 Image credit Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, May 03, 2020
TWiV 609: A coronavirus chronology with Susan Weiss
Susan Weiss recalls some of her 40 years of research on coronaviruses, including mouse hepatitis virus, MERS-CoV, and now SARS-CoV-2. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Guest: Susan Weiss Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Coronaviruses by Susan Weiss (YouTube) Forty years with coronaviruses (JEM) No credible evidence that SARS-CoV-2 came from a lab (Emerg Micr Infect) CoV and antagonism of RNAse L (mBio) Exoribonuclease needed for MHV innate antagonism (J Virol) RNAse L and ADAR (eLife) Emerging viruses respiratory award (Amer Lung Assoc) Image credit Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Fri, May 01, 2020
Daniel Griffin's COVID-19 clinical report
Daniel Griffin updates the clinical situation with COVID-19 patients, followed by analysis of the remedesivir clinical trial results, and answers listener questions. Hosts: Vincent Racaniello and Rich Condit Guest: Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Pulmonary embolism in COVID-19 (Emerg Inf Dis) Patch Study Remdesivir in adults with severe COVID-19 (Lancet) ACTT remdesivir trial (NIAID) Commentary on remdesivir trials (Lancet) FDA expected to issue remdesivir EUA (Contaigon Live) Recovered COVID-19 patients wrong (Korea Herald) Letters read on TWiV 608 Image credit Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Wed, April 29, 2020
Coronavirus epidemiology with Jeff Shaman
Jeff Shaman returns to TWiV to explain why more SARS-CoV-2 testing and contact tracing is needed to stop the pandemic, and provide insights on immunity and reinfection from seasonal CoVs, the problems with antibody tests, and what to expect in the coming months. Hosts: Vincent Racaniello and Rich Condit Guest: Jeff Shaman Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode COVID-19 findings and simulations (Shaman Lab) Reconciling diverse estimates of infection rates (pdf) Undocumented SARS-CoV-2 infections (Science) Simulations of SARS-CoV-2 spread (pdf) Repeated infections with diverse CoV (pdf) Letters read on TWiV 606 Image credit Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, April 26, 2020
Evidence-based science and medicine for COVID-19
Daniel Griffin provides his weekly update on the COVID-19 clinical situation, followed by our discussion of tests of an inactivated vaccine, results of serological surveys, an inhibitor of the cell protease needed for virus entry, and answers to listener questions. Hosts: Vincent Racaniello, Alan Dove , Rich Condit , and Kathy Spindler Guest: Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Inactivated SARS-CoV-2 vaccine protects monkeys (bioRxiv) Saliva is more sensitve than nasopharyngeal swab (medRxiv) NY serological survey results (NY Times) FDA caveats on serological tests (FDA) Federal guidelines on when to open When to open: Roadmap , blog , video explainer Blocking TMPRSS2 blocks SARS-CoV-2 infection (Cell) Lawmakers want human challenge studies (Science) Letters read on TWiV 606 Image credit Timestamps by Jolene . Thanks!<
Thu, April 23, 2020
READDI for the next pandemic
Ralph Baric, Mark Heise and Nat Moorman discuss their non-profit initiative READDI, Rapidly Emerging Antiviral Drug Discovery Initiative, to start making drugs now for the next pandemic virus. Hosts: Vincent Racaniello, Rich Condit , and Kathy Spindler Guests: Ralph Baric , Mark Heise , and Nat Moorman Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode READDI.org CEPI DNDi Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Tue, April 21, 2020
Oral poliovaccine to prevent SARS-CoV-2 infection
Kostya Chumakov discusses the hypothesis that oral poliovirus vaccine can provide non-specific protection against many other viruses, and might prevent infection with SARS-CoV-2. Host: Vincent Racaniello Guest: Kostya Chumakov Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Nonpathogenic enteroviruses to prevent human disease ( pdf ) OPV for COVID-19 ( pdf ) Enteroviruses to prevent human infections ( pdf ) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, April 19, 2020
Cloudy with a chance of coronavirus
Daniel Griffin provides his weekly update on the COVID-19 clinical situation, followed by results of seroprevalence studies, analysis of CpG dinucleotide frequencies in the SARS-CoV-2 genome, and answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode CpG frequency in SARS-CoV-2 genome (Mol Biol Evol) SARS-CoV-2 screening before delivery (NEJM) SARS-CoV-2 seroprevalence in Santa Clara (medRxiv) SARS-CoV-2 seroprevalence in homeless shelter (NEPR) Letters read on TWiV 603 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Thu, April 16, 2020
Coronavirus immunology with Stanley Perlman
Stanley Perlman joins TWiV to discuss immune responses to coronaviruses, including seasonal CoV, MERS, SARS, and SARS-CoV-2, including prospects for a vaccine. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Guest: Stanley Perlman Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Perlman Laboratory An Iowa Caucus of Viruses ( TWiV 538 ) Anti-SARS-CoV spike IgG and acute lung injury (JCI Insight) T cell responses to respiratory CoV (Immunol Res) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Tue, April 14, 2020
Das coronavirus with Christian Drosten
Coronavirus expert Christian Drosten joins Vincent to provide a view from Germany on COVID-19 and SARS-CoV-2. Host: Vincent Racaniello Guest: Christian Drosten Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Das Coronavirus podcast Identification of SARS-CoV in Germany (NEJM) 29 nt deletion in genome of SARS-CoV (Sci Rep) 382 nt deletion in genome of SARS-CoV-2 (bioRxiv) Virological assessment of COVID-19 patients (Nature) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, April 12, 2020
SARS-CoV-2 - enter the Coronials
Daniel Griffin joins TWiV to update on the clinical situation, then we discuss a 382 nucleotide deletion in the SARS-CoV-2 genome, a scenario for emergence of the virus from a bat, followed by answers to listener email. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode 382 nt deletion in genome of SARS-CoV-2 (bioRxiv) Recombination and mutation leading to SARS-CoV-2 (bioRxiv) Letters read on TWiV 600 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Wed, April 08, 2020
Coronavirus update - we need a plan
Doris Cully joins TWiV to discuss inhibition of SARS-CoV-2 in cell culture by ivermectin, followed by continuing analysis of the coronavirus pandemic caused by SARS-CoV-2 including COVID-19 in Nadia the tiger, and prediction of respiratory failure by levels of IL-6. Hosts: Vincent Racaniello, Alan Dove , Rich Condit , and Brianne Barker Guest: Doris Cully Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Ivermectin inhibits SARS-CoV-2 in cell culture (Antiviral Res) Tiger at NY zoo positive for SARS-CoV-2 (NY Times) IL-6 level predicts respiratory failure in COVID-19 patients (medRxiv) Infection fatality rate for managing pandemic (virology blog) Image credit Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, April 05, 2020
Who was that masked man? Coronavirus update with Daniel Griffin
Daniel Griffin MD returns to TWiV from a hospital parking lot to provide updates on COVID-19 diagnostics, clinical picture, and therapeutics, followed by our coverage of the coronavirus pandemic caused by SARS-CoV-2. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit , and Kathy Spindler Guest: Daniel Griffin, MD Download TWiV 598 (70 MB .mp3, 115 min) Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Restricted dispensing of Plaquenil in NY state Virology of COVID-19 patients (Nature) Susceptibility of domestic animals to SARS-CoV-2 (bioRxiv_ Cloth face masks for all of US (NY Times) Masks and respiratory virus shedding (Nat Med) 50 million face masks to Japanese households (Kyodo News) More than you want to know about face masks (Slate Star Codex) Why is COVID-19 less severe in children? (virology blog) Tracking SARS-CoV-2 in sewage (UM) 1918 <a href= "https://www.nationalgeographic.com/history/2020/03/how-cities-flattened-curve-1918-spanish-flu-pande
Fri, April 03, 2020
A lot of immunology and some COVID-19 with Jon Yewdell
Immunologist Jon Yewdell joins Vincent and Rich to discuss immune responses in the context of infection with SARS-CoV-2. Hosts: Vincent Racaniello and Rich Condit Guest: Jon Yewdell Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Thu, April 02, 2020
COVID-19 - an ounce of prevention
TWiV covers trials of hydroxychloroquine and convalescent plasma therapy for COVID-19, and answers listener questions on blood tests for antibodies, cross-protection among coronaviruses, acquiring infection from food or the gas pump, face masks containing copper, and much more. Hosts: Vincent Racaniello, Alan Dove , and Rich Condit Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Emergency use of hydroxychloroquine (FDA) Trial of hydroxycholorquine in COVID-19 patients ( China , France ) COVID-19 in critically ill patients , Seattle (NEJM) Feasibility of convalescent plasma therapy for COVID-19 (medRxiv) Letters read on TWiV 596 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, March 29, 2020
Coronavirus update - Daniel Griffin MD in the parking lot
Daniel Griffin MD joins TWiV from a hospital parking lot to provide updates on COVID-19 diagnostics, clinical picture, and therapeutics, and then the TWiV team continues coverage of the coronavirus pandemic caused by SARS-CoV-2. Hosts: Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove , Rich Condit , and Kathy Spindler Guest: Daniel Griffin, MD Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Tocilizumab (Wiki) Nares swab for SARS-CoV-2 (Star Trib) US SARS-CoV-2 epidemic curve (CDC) Cleaning and disinfecting (CDC) Cleaning fruits and vegetables (FDA) Coronavirus food safety (FDA) Vaccine development for SARS-CoV-2 (pdf) Image by Michele Banks Letters read on TWiV 595 Timestamps by Jolene .
Sat, March 28, 2020
Conversation with a COVID-19 patient, Ian Lipkin
Ian Lipkin joins Vincent to talk about his experience as a COVID-19 patient, and issues surrounding the disease and SARS-CoV-2 including limiting transmission, antivirals, vaccines, and much more. Hosts: Vincent Racaniello Guest: W. Ian Lipkin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Center for Infection and Immunity Control the Contagion videos Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Thu, March 26, 2020
Coronavirus update with Mark Denison, MD
Pediatric infectious disease physician and coronavirologist Mark Denison joins Vincent for a discussion of COVID-19 and SARS-CoV-2 with an emphasis on antiviral therapeutics. Hosts: Vincent Racaniello Guest: Mark Denison Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Wed, March 25, 2020
Coronavirus update - Shelter in place
A TWiV foursome provides an update on the SARS-CoV-2 pandemic, including antibody testing kits, FDA emergency approval of convalescent sera, and answer listener questions about the dangers of mail delivery and take out foods, decontamination of PPE, diagnostic testing, and much more. Hosts: Vincent Racaniello, Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Coronavirus test kit Rapid SARS-CoV-2 serological assay (medRxiv) Is Dr. Fauci in trouble ? (NY Times) FDA approves emergency use of convalescent serum (FDA) Image by Michele Banks Letters read on TWiV 594 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, March 22, 2020
Coronavirus update - flatten the curve
Daniel Griffin joins Ori and the TWiV team an update on the SARS-CoV-2 pandemic, including gastrointestinal illness associated with infection, use of hydroxychloroquine and other antivirals, his experiences treating many patients in the New York area, and much more. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Guests: Daniel Griffin , Ori Lieberman , and Valeria Cagno Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Pregnancy and COVID-19 papers ( 1 , 2 , 3 , 4 , 5 ) Second dog infected with SARS-CoV-2 (ProMedMail) Italian site with infographic in English Image by Michele Banks Letters read on TWiV 593 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Thu, March 19, 2020
Coronavirus update - dangerous curve ahead
Ori joins TWiV for an update on the SARS-CoV-2 pandemic, including scary modeling, clinical trials for antivirals and vaccines, asymptomatic transmission, and much more inspired by listener email. Hosts: Vincent Racaniello, Alan Dove , and Rich Condit Guest: Ori Lieberman Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Scary modeling (Imperial College London) Avigan vs SARS-CoV-2 (NHK) SARS-CoV-2 mRNA vaccine (Clinical Trials) SARS-CoV-2 stability (NEJM) Pediatric COVID-19 ( one , two ) SARS-CoV-2 asymptomatic infection ( one , two ) CDC data on SARS-CoV-2 CFR (MMWR) Hydroxycholorquine trial for COVID-19 (Mediterranee-infection) Macaque SARS-CoV-2 immunity (bioRxiv) Image by Michele Banks Letters read on TWiV 591 Timestamps by Jolene . Thanks! Intro music is by <a href="http://ww
Wed, March 18, 2020
SARS-CoV-2 epidemiology with Stephen Morse
Epidemiologist Stephen Morse joins Vincent to discuss epidemiology of SARS-CoV-2 and preparedness for the COVID-19 pandemic. Hosts: Vincent Racaniello Guest: Stephen Morse Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Tue, March 17, 2020
A medical student perspective on COVID-19
Ori Lieberman joins Vincent to discuss COVID-19, the disease caused by SARS-CoV-2, gleaned from his experience during clinical rotations in medical school. Hosts: Vincent Racaniello Guest: Ori Lieberman Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, March 15, 2020
Coronavirus update with Ralph Baric
Ralph Baric joins TWiV to dissect the coronavirus pandemic caused by SARS-CoV-2, including discussion on community spread, asymptomatic infections, origin of the virus, transmission, vaccine development, and much more. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guest: Ralph Baric Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Aerosol and surface stability of SARS-CoV-2 (medRxiv) Clinical course and risk factors for COVID-19 (Lancet, pdf) Face mask use during SARS-CoV outbreak (EID) COVID-19 and Italy (Lancet) Letters read on TWiV 591 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, March 08, 2020
COVID-19 and coronavirus - we have mail
The TWiV trio continues in-depth coverage of COVID-19 and SARS-CoV-2, including discussion on genome mutation and circulating lineages, handwashing, facemasks, cruise ship outbreaks, the South Korean situation, and much more. Hosts: Vincent Racaniello, Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Stanley Perlman answers CoV questions (Boston Globe) Fist bump (Am J Infect Control) Joint WHO-China report (pdf) Second coronavirus (LA Times) Response to second coronavirus (virological.org) COVID-19 animal models (STAT) Clinical predictors of COVID-19 mortality (Inten Care Med) CoV by the numbers (NY Times) Contamination of bar soaps (Microbios) SARS-CoV-2 vaccine timeline (NPR) How new vaccines are <a href= "https://www.gsk.com/en-gb/research-a
Thu, March 05, 2020
Coronavirus SARS-CoV-2 and COVID-19 update
Infectious disease physician Daniel Griffin and virologist Valeria Cagno join Vincent to provide updates on the situation with SARS-CoV-2 and COVID-19 in New York and Italy. Host: Vincent Racaniello Guests: Daniel Griffin and Valeria Cagno Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, March 01, 2020
Coronavirus update - it could be bad
Vincent and Rich update the current situation with COVID-19 and SARS-CoV-2, including fatality ratios, virus spreading outside of China, immunity to infection, vaccines, antivirals and much more. Hosts: Vincent Racaniello and Rich Condit Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode WHO CoV sitreps How to Prepare for the Coronavirus (NY Times) Multiple shedding routes of SARS-CoV-2 (Emerg Microbes Inf) Cruise ship a/c could promote virus spread (Purdue news) Image credit Letters read on TWiV 589 Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, February 23, 2020
Coronavirus update - Save the pangolin!
The TWiV team returns this week to SARS-CoV-2019 coverage to review the latest epi curves, the fatality rate, furin cleavage site and receptor binding domain in the spike glycoprotein, related CoV recovered from pangolins, evidence that the virus did not escape from a laboratory, and many more questions sent in by listeners. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode WHO CoV sitreps Epidemiology of COVID-19 (China CDC) COVID-19 incubation period (J Med Virol) China clinical trials for COVID-19 (Nature) Furin cleavage site in SARS-CoV-2 spike (virology blog) Proximal origin of SARS-CoV-2 (Virological) Pangolin photos (Nat Geo) Letters read on TWiV 588 Timestamps by Jolene . Thanks! Weekly Science Picks Kathy - The deep sea Rich - World's oldest message in a bottle Dickson - Coronavirus: A visual guide Vincent - Recent NSABB meeting Video
Sun, February 16, 2020
One bite is all it takes
Vincent and Rich return to the University of Texas Medical Branch at Galveston to speak with Dennis Bente, Shannan Rossi, Nikos Vasilakis, and Scott Weaver about their work on viruses transmitted by mosquitoes and ticks. Hosts: Vincent Racaniello and Rich Condit Guests: Dennis Bente , Shannan Rossi , Nikos Vasilakis , and Scott Weaver Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Measles virus vectored chikungunya vaccine (J Inf Dis) World Reference Center for Emerging Viruses and Arboviruses Insect-specific alphavirus vaccine vector (Nat Med) Legacy of arbovirus hunters (Viruses) Electron microscopy for novel arboviruses (Viruses) Sylvatic dengue (Am J Trop Med Hyg) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, February 09, 2020
Coronavirus update: wash your hands
In this week's coverage of the coronavirus epidemic, the TWiV team discusses the fatality rate, China's initial reaction to the outbreak, conspiracy theories, how long the virus remains infectious on surfaces, and evidence for virus in the intestinal tract. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Brianne Download TWiV 586 (72 MB .mp3, 119 min) Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode China reacted too slowly to epidemic (NY Times) Wuhan rounds up infected (NY Times) 2019-nCoV asymptomatic transmission report flawed (Science) Mucus reduces effectiveness of alcohol gels (mSphere) SARS-CoV in feces ( NEJM , Gastroenterology ) Inadequate plumbing and spread of SARS-CoV (WHO) Persistence of virus on surfaces ( one , two , three , four ) Letters read on TWiV 586 Timestamps by Jolene . Thanks! Weekly Science Picks Brianne - <a href= "https://ccdd.hsph.harvard.edu/mutation-adapt
Sun, February 02, 2020
The coronavirus epidemic
The TWiVerers continue their coverage of the new coronavirus outbreak in China, as the number of cases increase dramatically and the virus begins person-to-person transmission in other countries. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV 2020 Real time tracking of 2019-nCoV (JHU) Estimation of 2019-nCoV R0 (Int J Inf Dis) WHO Sitreps on 2019-nCoV Coronavirus overtakes SARS (SCMP) HHS press conference Discovery of 2019-nCoV (bioRxiv) Rich CoV genes in bats (PLoS Path) Early 2019-nCoV transmission dynamics (NEJM) Clinical features of early 2019-nCoV patients (Lancet) Remdesvir for MERS-CoV (Nat Commun) Transmissibility of 2019-nCoV (Imperial Coll, pdf) Comparison of <a href= "https://www.theguardian.com/news/datablog/ng-interactive/2014/oct/15/visualised-how-
Sun, January 26, 2020
Year of the coronavirus
Coronavirus expert Ralph Baric joins TWiV to explain the virology and epidemiology of the recent zoonotic outbreak spreading across China and overseas. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler Guest: Ralph Baric Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV 2020 WHO coronavirus sitreps CIDRAP article on coronavirus vaccines Phylogenetic analysis of 2019-nCoV ACE2 is 2019-nCoV receptor (bioRxiv) Visual explainer of Huanan market (SCMP) Clinical features of 2019-nCoV patients (Lancet) Familial cluster of pneumonia caused by 2019-nCoV (Lancet) SARS-CoV 29 nt deletion reduces replication (Sci Rep) NSABB 2019 TWiV World Tour t-shirt Letters read on TWiV 584 Timestamps by Jolene . Thanks! </
Sun, January 19, 2020
Galveston virus hunters
Vincent and Rich travel to Galveston National Laboratory to speak with Jim LeDuc, Tom Ksiazek, and Bob Tesch about their long careers as virus hunters. Hosts: Vincent Racaniello and Rich Condit Guests: Jim LeDuc , Tom Ksiazek , and Bob Tesh Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, January 12, 2020
This little virus went to market
TWiV provides updates on the new coronavirus causing respiratory disease in China, the current influenza season, and the epidemic of African swine fever, including determination of the three-dimensional structure of the virus particle. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , Kathy Spindler , and Brianne Barker Download TWiV 582 (71 MB .mp3, 118 min) Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV 2020 NJ ready to remove religious vaccine exemptions (Patch) New virus causing pneumonia in China ( NY Times ) New China virus is coronavirus ( NY Times , ProMedMail ) Weekly influenza cases (CDC) Future of influenza vaccines (Vaccines) Household influenza vaccine study (Int J Epidemiol) African swine fever (USDA) African swine fever infographics ( one , two ) Race for African swine fever <a href= "https://www.the-scientist.com/news-opinion/scientists-race-to-build-vaccine-for-afric
Sun, January 05, 2020
Alimentary particles
For the first TWiV of 2020 we reveal that microbiome depletion with antibiotics alters the immune response to influenza vaccine, and how successive blood meals facilitate virus dissemination in mosquitoes and transmission potential. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV 2020 Vaccines are safe and effective (Science) Microbiome perturbation alters response to flu vaccine (Cell) Successive blood meals aid virus dissemination in mosquitoes (Nat Micro) Letters read on TWiV 581 Timestamps by Jolene . Thanks! Weekly Science Picks Brianne - Retrovirus cookie cutter! (and Phage , Adenovirus , Rabies virus , and Antibody Alan - “ Yah! Yah! Yah! ” by Jack London, and the true story it’s based on Dickson - Why whales are big but not bigger
Sun, December 29, 2019
Noncoding RNA with Chris Sullivan
From the University of Texas at Austin, Vincent and Rich speak with Chris Sullivan about his work on miRNAs encoded in the genomes of polyomaviruses and papillomaviruses, and how an RNA triphosphatase restricts hepatitis C virus replication. Hosts: Vincent Racaniello and Rich Condit Guest: Chris Sullivan Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Sullivan lab Virus-encoded miRNAs in papillomaviruses (PLoS Path) Murine polyomavirus miRNA promotes viruria (J Virol) DUSP11 helps XRN restrict hepatitis C virus (PNAS) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, December 22, 2019
Reno viral
Vincent speaks with virologists at the University of Nevada at Reno about their careers and their work on herpesviruses, arboviruses, and the development of diagnostics for infectious diseases. Host: Vincent Racaniello Guests: Dave AuCoin , Cyprian Rossetto , Claudia Rückert , and Subhash Verma Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode PAN's labyrinth (Viruses) KSHV SOX protein DNAse activity (J Virol) Vertical flow immunoassay for pathogen detection (Talanta) Small RNA responses of mosquitoes (Insect Biochem Mol Biol) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, December 15, 2019
Prometheus project
Vincent speaks with members of Prometheus, a team of academic and industrial scientists assembled to develop antibody-based therapeutics against infections caused by tick-borne Crimean-Congo hemorrhagic fever virus and rodent-borne hantaviruses, for which no approved vaccines or specific drugs are available. Host: Vincent Racaniello Guests: Kartik Chandran , Zachary Bornholdt , Steven Bradfute , John Dye , Matthias Forsell , Jason McLellan , Laura Walker , and Cecelia Vial . Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode NIH U19 grant mechanism $22 million Prometheus grant Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, December 08, 2019
Virologie structurale with Félix Rey
Vincent speaks with Félix Rey about his career and his work on solving structures of a variety of viruses and the insights learned about viral membrane fusion and antibody-mediated neutralization. Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Unité de Virologie Structurale Tick-borne encephalitis glycoprotein structure (Nature) HCV RNA polymerase structure (PNAS) Flavivirus structural heterogeneity (Curr Op Viral) Antibody responses to flaviviruses (EMBO Rep) Covalently linked dengue envelope dimers (Nat Comm) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, December 01, 2019
Big data in virology and public health
From the 22nd meeting of the European Society for Clinical Virology in Copenhagen, Vincent speaks with Thea, Heli, Kim, Caroline and Irma about big data and its increasing use in virology diagnostics, epidemiology, and public health. Host: Vincent Racaniello Guests: Thea Kølsen Fischer , Kim Benschop , Caroline Brown , Heli Harvala , and Irma Salimovic-Besic Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode 22nd ESCV meeting Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, November 24, 2019
Endless giant virus forms most beautiful
From the Fourth Symposium on Giant Virus Biology in Germany, Vincent, Rich, and Nels speak with Assaf, Stephen, and Alexandra about their careers and their work on giant viruses that infect ocean hosts: Emiliana huxleyi , Aureococcus anophagefferans , and a choanoflagellate. Hosts: Vincent Racaniello , Rich Condit , and Nels Elde Guests: Assaf Vardi , Stephen Wilhelm , and Alexandra Worden Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode 4th Ringberg Symposium on Giant Virus Biology In-plaque mass spectrometry imaging (Nature Micro) Infection by brown tide virus , AaV (Front Micro) Choano virus with a rhodopsin photosystem (PNAS) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, November 17, 2019
How economics shapes science
From Georgia State, Vincent speaks with economics professor Paula Stephan about the ways science is supported in the US, how universities offload risks, the absence of risk-taking, and much more. Hosts: Vincent Racaniello Guest: Paula Stephan Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode How Economics Shapes Science Coalition for Next Generation Life Science Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, November 10, 2019
Inventing viruses
William Summers joins the TWiV team to discuss some virology history, including the ever-changing concept of 'virus' and the contribution of phage research to the study of animal viruses. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Rich Condit Guest: William Summers Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Bill’s ASV 2019 talk ( PPT download ) Inventing viruses (Ann Rev Virol) Timestamps by Jolene . Thanks! Weekly Science Picks Alan - Restoration of Western Flyer Rich - Purification of phage T7 RNA polymerase Dickson - The Galaxy is Not Flat Bill - Efficacy of tetravalent dengue vaccine Vincent - Blowout by Rachel Maddow Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, November 03, 2019
Your EV-D68th nervous breakdown
Amy joins the TWiV team to review evidence that enterovirus D68 is an etiologic agent of childhood paralysis, and her finding that the ability of the virus to infect cells of the nervous system is not a recently acquired property. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Kathy Spindler Guest: Amy Rosenfeld Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode EV-D68 antibodies in humans before 2014 outbreak (Emerg Inf Dis) Enterovirus antibodies in CSF of AFM patients (mBio) Serology implicates enteroviruses in AFM (Nat Med) EV-D68 neurotropism is not new (mBio) Letters read on TWiV 572 Timestamps by Jolene . Thanks! Weekly Science Picks Amy - Enterovirus biology and pathogenesis and Acute Flaccid Myelitis Association Rich - Tesla Dickson - Nikon Small World 2019 Photo Competition Kathy - Term limits in academic leadership #1 and #2 Vincent - Coywolf: New hybrid carnivore Listener Picks Anonymous - <a href= "https://
Sun, October 27, 2019
Piwi koalas
The League of Extraordinary Virologists celebrate the eradication of wild poliovirus type 3, and consider the effectiveness of an influenza vaccine produced in insect cells, and how small RNAs are protecting the Koala germline from retroviral invasion. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Flublok (CDC) Adjuvant study of flu vaccines (NIH) Immunogenicity of quadrivalent Flublok (J Inf Dis) Monoclonal antibody response to Flublok (J Virol) Current flu vaccine recommendations (CDC) Double dose flu vaccine immunogenicity (Hum Vac Immunother) piRNA response on retroviral invasion of Koala genome (Cell) piRNAs rise to rescue Koalas (Cell) Image credit Letters read on TWiV 571 Timestamps by Jolene . Thanks! Weekly Science Picks Brianne - The Machinery of Life by David Goodsell Alan - <a href= "https://usdawatercolors.nal.usda.gov/pom/hom
Sun, October 20, 2019
Aarhus viral
At Aarhus University in Denmark, Vincent speaks with Trine Mogensen, Søren Paludan, Ole Søgaard, and Madalina Carter-Timofte about their careers and their work on sensing herpesviral DNA, immunodeficiencies that predispose to severe viral infections, and the path to a cure for HIV/AIDS. Hosts: Vincent Racaniello Guests: Trine Mogensen , Søren Paludan , Ole Søgaard , and Madalina Carter-Timofte Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Aarhus University Findaphd.com Sensing incoming HSV-1 (J Int Cyto Res) Be careful of canons ( TWiV 456 ) Polio and host genetics (Front Micro) TLR9 treatment of AIDS (AIDS) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, October 13, 2019
Smolt'in iron
The TWiV pro-vaxxers reveal viruses that infect endangered wild salmon, and how iron in host serum modulates dengue virus acquisition by mosquitoes. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode New viruses that infect endangered wild salmon (eLife) Host serum iron modulates dengue virus acquisition by mosquitoes (Nat Micro) Image credit Letters read on TWiV 569 Timestamps by Jolene . Thanks! Weekly Science Picks Brianne - Retraction of new CCR5/lifespan study Alan - Nomad Press illustrated science books, and illustrator Lex Cornell Dickson - RARE: Creatures of the Photo Ark Vincent - The Odyssey of Eradication by Thomas Abraham Listener Picks Justin - Mass spec pen Mark - What really brought down the Boeing 737 Max? Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, October 06, 2019
Karolinska viral
In the second episode from the Karolinska Institute in Stockholm, Vincent speaks with Jan Albert, Petter Brodin, and Anna Smed-Sörensen about their work on enterovirus D68, systems immunology, and human pulmonary viral infection and inflammation. Hosts: Vincent Racaniello Guests: Jan Albert , Petter Brodin , and Anna Smed-Sörensen Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Karolinska Huddinge Evolution of enterovirus D68 (Virus Evol) Maternal anti-viral antibodies in newborns (Nat Med) Respiratory phagocytes in human influenza (Front Immunol) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, September 29, 2019
Outbreaks and a breakout
The TWiV team covers outbreaks of eastern equine encephalitis virus in the US and poliovirus in the Philippines, and explain how a chemokine induced by HIV-1 infection helps release more virus particles from cells. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Poliomyelitis returns to the Philippines ( Mashable , virology blog ) EEE in the USA (Am J Trop Med Hyg) Chemokine helps HIV-1 release (eLIFE) Image credit Letters read on TWiV 567 Timestamps by Jolene . Thanks! Weekly Science Picks Brianne - History of infectious disease before/after vaccines Alan - NIH Ham Radio Club Rich - Renewable jet fuel from air Dickson - Newly Discovered Comet Is Likely Interstellar Visitor Kathy - <a href= "https://dynamicecology.wordpress.com/2019/08/13/how-i-think-the-start-of-the-semester-wi
Sun, September 22, 2019
Chicken gumbo and a corona
The TWiV team reveals the protein corona that surrounds virus particles and influences infectivity and amyloid aggregation, and a proofreading-impaired herpesvirus that produces quasispecies-like populations. Hosts: Vincent Racaniello , Alan Dove , and Rich Condit Guest: Kiki Warren Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Human fetal tissue research restrictions (The Scientist) Viral protein corona (Nat Commun) Proofreading-impaired herpesvirus (Nat Micro) Phage quasispecies (Cell) Letters read on TWiV 566 Timestamps by Jolene . Thanks! Weekly Science Picks Alan - Astronomy photographer of the year Rich - Urban living leads to high cholesterol... in crows Kiki - Reversal of epigenetic aging Vincent - General Virology by SE Luria Listener Picks Sindhu - Sweden Solar System Anthony - Surprising role of viruses in evolution with Eugene Koonin Paul - The Obscure Virus Club Intro music is by <a href="http://www.ronaldjenkees.com/" target="_b
Sun, September 15, 2019
Karolinska virology
From the Karolinska Institute in Stockholm, Vincent speaks with Niklas Björkström, Ali Mirazimi, and Matti Sällberg about their work on the impact of chronic hepatitis C virus infection on NK cells, Crimean-Congo hemorrhagic fever virus vaccines, and immunotherapy to block entry of hepatitis B and D viruses. Hosts: Vincent Racaniello Guests: Niklas Björkström , Ali Mirazimi , and Matti Sällberg Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Karolinska Huddinge CCHV experimental vaccines (J Virol) Increased NK function after antiviral cessation (J Inf Dis) Impact of HCV infection on NK cell repertoire (Nat Comm) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, September 08, 2019
Virology Nobel Prizes with Erling Norrby
From the 16th Smögen Summer Symposium on Virology, Vincent speaks with Erling Norrby about how he has used archival material to provide insight into early Nobel Prizes for research on viruses. Hosts: Vincent Racaniello Guest: Erling Norrby Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Swedish Society for Virology Nobel Prizes and Life Sciences by Erling Norrby Nobel Prizes and Nature's Surprises by Erling Norrby Nobel Prizes and Notable Discoveries by Erling Norrby Nobel Prizes: Cancer, Vision and the Genetic Code by Erling Norrby Polio and Nobel Prizes (Ann Neurol) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Tue, September 03, 2019
Call me David Tuller
David Tuller returns to talk about his efforts of the past year to expose the methodological and ethical problems with the PACE and Lightning trials for therapy of ME/CFS. Host: Vincent Racaniello Guest: David Tuller Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, September 01, 2019
BLT on mice
The TWiVologists consider whether to receive an influenza vaccine in August (in the northern hemisphere), and mice implanted with human lung fragments for studying microbial pathogens. Hosts: Vincent Racaniello , Alan Dove , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Waning of influenza vaccine protection (Clin Inf Dis) Precision mouse models for microbial pathogenesis (Nat Biotech) Letters read on TWiV 563 Timestamps by Jolene . Thanks! Weekly Science Picks Brianne - Why we need to increase diversity in the immunology research community Alan - Stock photos of vaccination that don’t suck Kathy - Sample size calculator Vincent - How Economics Shapes Science by Paula Stephan Listener Picks Melinda - Zome Tools Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, August 25, 2019
Take a breath
TWiV travels to Rutgers University to speak with Brad, Kay, Siobain, and Kim about their careers and their work on viruses of plants, fungi, bacteria, diatoms, and coccolithophores. Hosts: Vincent Racaniello , Dickson Despommier , and Brianne Barker Guests: Brad Hillman , Kay Bidle , Siobain Duffy , and Kim Thamatrakoln Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Viruses of plant-interacting fungi (Adv Virus Res) W hy are RNA virus mutation rates so damn high? (PLoS Biol) CRESS viruses (Adv Virus Res) Coccolithovirus facilitation of carbon export in North Atlantic (Nat Micro) Silicon limitation facilitates virus infection of marine diatoms (Nat Micro) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, August 18, 2019
Hot or not
The Autonomous CollecTWiVe reveal two effective treatments for Ebolavirus infection, how a virus in a fungus confers heat tolerance to a plant, and dampened inflammation as a mechanism for bat tolerance to viral infection. Hosts: Vincent Racaniello , Alan Dove , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Two new and effective Ebolavirus treatments ( NIH , Nature ) A virus in a fungus in a plant (Science) Dampened NLRP3-mediated inflammation in bats (Nat Micro) Bat tolerance to virus infection (Nat Micro) Image credit Letters read on TWiV 561 Timestamps by Jolene . Thanks! Weekly Science Picks Brianne - Deaf student makes sign language terms to communicate science Alan - Show Your Stripes Vincent - Sixty Years of Discovery Listener Picks Eric - This drug could end HIV - why hasn't it? Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, August 11, 2019
CEIRS, influenza and company
From the meeting of the Centers of Excellence for Influenza Research and Surveillance, Vincent speaks with Alan, Florian and Jennifer about their careers, the purpose of CEIRS, universal influenza vaccines, and cellular responses to infection in pediatric populations. Host: Vincent Racaniello Guests: Alan Embry , Florian Krammer , and Jennifer Nayak Become a patron of TWiV! Links for this episode NIAID CEIRS 12th CEIRS meeting summary ( pdf ) Antibody response to influenza virus (Nat Rev Micro) Influenza virus CD4 T cells in children and young adults (Sci Rep) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, August 04, 2019
Nectin connection what's your infection?
The complete TWiV team give a report on the Ebola virus outbreak in DRC, and reveal that cell surface nectin proteins cause the transfer of cytoplasmic cargo, including measles virus, between cells. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Fire Alarm at ASV Ebola outbreak sitrep (WHO) Ebola outbreak dashboard (WHO) Ebola outbreak DRC (MSF) Ebola articles at CIDRAP Ebola virus vaccine could run out (STAT news) Nectin mediated cytoplasmic transfer (J Cell Sci) Letters read on TWiV 559 Timestamps by Jolene . Thanks! Weekly Science Picks Brianne - DukeMed Distinguished Award: Bill Joklik Alan - Audubon photography awards for 2019 Rich - Joklik paper on vaccinia virus mRNA ; Joklik MEM</
Sun, July 28, 2019
Joklik's legacy
From ASV 2019 at the University of Minnesota, TWiV explores the origins of the American Society for Virology with Sid Grossberg and Pat Spear. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Guests: Sid Grossberg and Pat Spear Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode American Society for Virology Bill Joklik, 92 How ASV was founded (Virology) Signatures at the Chicago meeting ( page one , page two ) Timeline history of ASV ( jpg ) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, July 21, 2019
Congress in Rotterdam
From the European Congress of Virology in Rotterdam, Vincent and local co-host Ben Berkhout speak with Ron Fouchier, Rosina Girones, and Marie-Paule Kieny about their careers and their work on influenza virus, environmental virology, and developing an Ebola virus vaccine during an epidemic. Hosts: Vincent Racaniello and Ben Berkhout Guests: Ron Fouchier , Rosina Girones , and Marie-Paule Kieny Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ECV2019 Drift of human H2N2 viruses (J Viral) Viruses in urban sewage (Sci Tot Environ) Ebola virus vaccine efficacy (Lancet) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, July 14, 2019
Glycolyl's not for the birds
TWiV minus one reveals delayed neurological deficits in children without microcephaly born to Zika virus infected mothers, and N-glycolyl-neuraminic acid as a receptor for influenza A viruses. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Deficits in children born to Zika virus infected mothers (Nat Med) Zika virus is still a threat (NY Times) N-glycolyl-neuraminic acid as influenza virus receptor (Cell Rep) Letters read on TWiV 556 Timestamps by Jolene . Thanks! Weekly Science Picks Brianne - Foldable viral capsid models and Foldable models demonstrate T numbers Alan - Laws Guide to Nature Drawing and Journaling Dickson - NASA 50th Events Kathy - Alta Obscura’s 17,069 strange and wonderful places Vincent - TWiEVO 44: The enemy of my enemy is my phage Listener Picks Anthony - Global Water Pathogen Project Intro music is by Ronald Jenkees . Send yo
Sun, July 07, 2019
Fidelity and the single cell
From ASM Microbe 2019, Vincent, Brianne and Calvin meet up with Craig Cameron to discuss his career and his work exploring RNA-dependent RNA synthesis and single cell virology. Hosts: Vincent Racaniello , Brianne Barker , and Calvin Yeager Guest: Craig Cameron Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Cameron laboratory Curioscity podcast Ribavirin is an RNA virus mutagen (Nat Med) RNA virus error catastrophe: test using ribavirin (PNAS) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, June 30, 2019
Full fathom five thy viromes lie
A trio TWiVers reports on influenza in Australia, how a host protein impacts bird to human movement of influenza virus, and marine DNA viral diversity in the oceans from pole to pole. Hosts: Vincent Racaniello , Kathy Spindler , and Alan Dove Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Australian Influenza Surveillance Real-time tracking of influenza H3N2 ANP32B , or not to be (eLife) ANP32B on TWiV 377 Species specific differences in ANP32B for influenza virus replication (eLife) Marine viral DNA diversity pole to pole (Cell) Letters read on TWiV 554 Timestamps by Jolene . Thanks! Weekly Science Picks Alan - Stephanie Langel’s Discovery Talk Kathy - Map of languages in the USA Vincent - Grad student mental health with Susanna Harris video and on TWiM 199 Listener Picks Fernando - Pushing back on hyped-up science Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, June 23, 2019
Polio with David Oshinsky
Vincent speaks with David Oshinsky, the Pulitzer Prize-winning author of Polio: An American Story , about the history of poliovirus vaccines. Host: Vincent Racaniello Guest: David Oshinsky Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, June 16, 2019
Delta and the amazing technicolor dreamcoat
Team TWiV reveals DNA polymerases that do not require a primer, and packaging of hepatitis delta virus by the envelope glycoproteins of diverse viruses. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guest: Kiki Warren Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Bacteriophage DNA polymerase is primer-independent (PNAS) Primer-independent DNA polymerase from mobile elements (Cell Rep) Non-HBV helper viruses for HDV (Nat Comm) Waning of measles vaccine immunity ( one , two , three ) Letters read on TWiV 552 Timestamps by Jolene . Thanks! Weekly Science Picks Alan - Seek Rich - Want to See My Genes? Get a Warrant and NIH director will no longer speak on all-male science panels Brianne - Unique scientists Dickson - Vaccines - Calling the Shots Vincent - <a
Sun, June 09, 2019
Golden hands
At Retroviruses 2019 in Cold Spring Harbor, Vincent speaks with virologist Bryan Cullen about his work and his career, together with former associates Ann Skalka, Paul Bieniasz, and Michael Malim. Host: Vincent Racaniello Guests: Bryan Cullen , Paul Bieniasz , Michael Malim , and Ann Skalka Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, June 02, 2019
Covering up the shiny parts
TWiV explains the use of a neuronal cell line to study herpes simplex virus latency and reactivation, and a strategy for creating vaccines that induce antibodies against specific epitopes. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Neuronal cell line supports herpes simplex virus latency (J Virol) Protect, modify, deprotect (PNAS) Timestamps by Jolene . Thanks! Weekly Science Picks Alan - Quabbin Reservoir Rich - Katherine Swan Ginsburg Humanism in Medicine Program ; The Arnold P. Gold Foundation Brianne - UPitt Measles Simulator Dickson - James Webb Space Telescope Vincent - Nobel Prizes and Life Sciences by Erling Norrby Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, May 26, 2019
The church of protocadherin
Kartik and Rohit join the TWiV team to present their identification of protocadherin-1 as a cell receptor for New World hantaviruses. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Guests: Kartik Chandran and Rohit Jangra Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Einstein goes viral ( TWiV 314 ) Michael Rossmann , 88 (virology blog) Protocadherin-1 essential for New World hantavirus entry (Nature) Image credit Timestamps by Jolene . Thanks! This episode is sponsored by the 2019 Chem/Bio Defense Science and Technology Conference. Are you working on innovative research that can shape the future of chemical or biological defense? Submit your abstract and present your work to more than 1,500 leaders from government, academia and industry. Visit www.cbdstconference.com for more details. Weekly Science Picks Alan - Temi and Trint Rich - Using Jupiter's moons to determine where on Earth you are Kathy - Best architecture in every state Vincent - Cyberwire Podcast: The Ghost and the Mole Kartik - Slack <br /
Sun, May 19, 2019
Mice, shrews, and caterpillars
Vincent travels to the European Congress of Virology in Rotterdam and with local co-host Marion Koopmans speak with Martin Beer, Stephan Gunther, and Vera Ross about their careers and their work on Lassa virus, Borna virus, and insect viruses. Hosts: Vincent Racaniello and Marion Koopmans Guests: Martin Beer , Stephan Gunther , and Vera Ros Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ECV2019 Partnerships not parachutes ( TWiV 413 ) Fatal Borna disease virus infection in transplant recipients (NEJM) Sequencing of 2018 Lassa virus outbreak (Science) Zombie caterpillar behavior (Parasitol) Timestamps by Jolene . Thanks! This episode is sponsored by the 2019 Chem/Bio Defense Science and Technology Conference. Are you working on innovative research that can shape the future of chemical or biological defense? Submit your abstract and present your work to more than 1,500 leaders from government, academia and industry. Visit www.cbdstconference.com for more details. Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, May 12, 2019
Upstate virology
Vincent travels to the University at Albany to speak with Cara, Rachel, and Alex about their careers and their work on stress granules, epitranscriptomics, and arboviruses. Host: Vincent Racaniello Guests: Cara Pager , Rachel Netzband , and Alex Ciota Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Five postdocs in North America ( TWiV 194 ) Zika virus subverts stress granules (J Virol) DDX68 modulates miR-122 interaction with HCV RNA (Virol) (+) RNA virus epitranscriptome (Nucl Acids Res) Adaptation of Rabensburg virus to vertebrate hosts (Virol) Effects of Zika virus strain and Aedes species on vector competence (Emerg Inf Dis) Inter- and intra-host genetic variation of West Nile virus and fine-scale evolutionary pressures (Infect Genet Evol) Timestamps by Jolene . Thanks! This episode is sponsored by the 2019 Chem/Bio Defense Science and Technology Conference. Are you working on innovative research that can shape the future of chemical or biological defense? Submit your abstract and present your work to more than 1,500 leaders from government, academia and industry. Visit www.cbdstconference.com for more details. Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, May 05, 2019
Delta blues and chitlins
The un-encapsidated TWiV Humans discuss finding hepatitis D virus-related sequences in birds and snakes, and fatal swine acute diarrhoea syndrome caused by a coronavirus of bat origin. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode European Virus Archive ASV early bird registration ends 15 May FDA approves Dengvaxia Divergent hepatitis D-like agent in birds (Viruses) Novel deltavirus in snakes (mBio) SADS-coronavirus in piglets (Nature) Hosts and sources of endemic human coronaviruses (Adv Virus Res) Image credit Letters read on TWiV 546 Timestamps by Jolene . Thanks! This episode is sponsored by the 2019 Chem/Bio Defense Science and Technology Conference. Are you working on innovative research that can shape the future of chemical or biological defense? Submit your abstract and present your work to more than 1,500 leaders from government, academia and industry. Visit www.cbdstconference.com for more details. Weekly Science Picks Alan - Plots of Data visualization tool Rich - How to control the brain; <a href= "
Sun, April 28, 2019
Biocrimes and misdemeanors
Jens Kuhn returns to TWiV to explain Select Agents, Priority Pathogens, Australia List Pathogens, Risk Group Agents, biosafety, biosecurity, and biosurety. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Brianne Barker Guest: Jens Kuhn Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Bioweapon (TWiV 508) Bioterrorism and Biocrimes by W. Seth Carus Select Agents (selectagents.gov) BMBL Manual 5th Edition (pdf) Threading the NEIDL video (YouTube) Timestamps by Jolene . Thanks! Weekly Science Picks Jens - Forvo pronunciation guide Brianne - How long do vaccines last? Alan - How much hotter is your home town than when you were born? Dickson - 50 Stunning Photos of Earth Vincent - Madness and Memory by Stanley Prusiner Intro music is by Ronald Jenkees . Send your virology questions and
Sun, April 21, 2019
Immunogaga
The TWiV team reveals the repertoire of anti-viral antibodies in newborn humans, and a complement protein that binds the adenovirus capsid and prevents release of the viral DNA. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Maternal anti-viral antibodies in newborns (Nat Med) Complement protein blocks adenovirus uncoating (Cell Host Micr) Antibodies neutralize virus inside cells (virology blog) Image credit Letters read on TWiV 544 Timestamps by Jolene . Thanks! Weekly Science Picks Brianne - Doctors use HIV in gene therapy to fix 'bubble boy' disease Rich - I Want What My Male Colleague Has Kathy - Preventing airborne disease ( video and primary article ) Vincent - The Mueller Report Listener Pick Steve - <a href= "http:
Sun, April 14, 2019
Stoned and senile
The TWiV team discusses Medusavirus, isolated from a hot spring in Japan, and induction of neurodegeneration by recurrent herpes simplex virus 1 infection of mice. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Medusavirus (J Virol) Recurrent herpes simplex virus-1 and Alzheimer's (PLoS Path) Image credit Letters read on TWiV 543 Timestamps by Jolene . Thanks! Weekly Science Picks Brianne - How to Take a Picture of a Black Hole Alan - Jupiter Marble image Rich - NASA Commercial Crew Program ; How SpaceX and Boeing will get Astronauts to the ISS ; Everyday Astronaut Dickson - Sky-High Stunners Kathy - Arts at Michigan photo winners and UM Microscopy Core image contest winners Vincent - <a href= "https://a
Sun, April 07, 2019
Inside Microbiotix
Vincent travels to Microbiotix, Inc, a biopharmaceutical company in Worcester, MA to speak with four members of the company about their discovery and development of small molecule drugs that target serious infectious diseases. Host: Vincent Racaniello Guests: Terry Bowlin, Zach Aron, Grace Lui, and Islam Hussein Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Microbiotix, Inc. MBX-400 Microbiotix pipeline Microbiotix publications Timestamps by Jolene . Thanks! Listener Pick Islam - How to successfully collaborate with industry Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, March 31, 2019
Cloaking devices
The TWiVers present mitoviruses, which infect mitochondria, and how quasi-enveloped hepatitis A virus gets naked again. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Evidence for plant mitoviruses (Virology) Uncoating of quasi-enveloped HAV (eLife) Image credit Letters read on TWiV 541 Timestamps by Jolene . Thanks! Weekly Science Picks Alan - Where and when to see cherry blossoms Dickson - Nebraska floods Kathy - Peeps fungal infection experiment Vincent - Emergency declared in NY over measles, unvaccinated barred from public spaces Listener Pick Sam - STLR conversations Josh - Tree of Life Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, March 24, 2019
Wascally wiruses
The TWiVstars reveal the diversity of herpes simplex virus type 2 in a neonatal population, and parallel adaptation of rabbits in three countries to myxoma virus. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , Alan Dove , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Diversity of HSV2 in neonates (mSphere) Adaptation of rabbits to myxoma virus (Science) Principal component analysis (YouTube) Image credit Letters read on TWiV 540 Timestamps by Jolene . Thanks! Weekly Science Picks Alan - The Quarters Rich - Brian May - New Horizons (Ultima Thule Mix) [Official Music Video] Dickson - How rats became an inescapable part of city living Kathy - Principal Component Analysis (short longer ) and Educational Material about Influenza Viruses Vincent - Why “chickenpox parties” are a terrible idea—in case it’s not obvious Intro music is by <a href="http://www.ronaldjenkee
Sun, March 17, 2019
TWiV 539: Multitudes contain me
The TWiV hosts present two potentially seminal papers, on long-distance chemoattraction of a host by a chlorovirus, and replication of a nanovirus across multiple cells in a plant. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Paul Has Measles now in German (virology blog) Chloroviruses lure hosts (J Virol) Multicellular replication in plants (eLife) Image credit Letters read on TWiV 539 Timestamps by Jolene . Thanks! Weekly Science Picks Brianne - Why Do So Many Scientists Want to be Filmmakers Alan - Better boarding method airlines won’t use Dickson - Mass timber building Kathy - What organisms to study flow chart Vincent - World Pulls Andon Cord on 737 MAX Listener Pick Richard - The Real Cost of Knowledge Islam - 200 icosahedral v
Sun, March 10, 2019
An Iowa caucus of viruses
TWiV travels to the University of Iowa to speak with Wendy Maury and Stanley Perlman about their research on Ebolavirus entry and coronavirus pathogenesis. Hosts: Vincent Racaniello , Rich Condit , and Kathy Spindler Guests: Wendy Maury and Stanley Perlman Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode TIM-1 is receptor for Ebolaviruses (Proc Natl Acad Sci) TIM-1 is receptor for Lassa virus (J Virol) SARS coronavirus causes neuronal death (J Virol) T cells and IL-10 in viral demyelination (J Neuroimmunol) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, March 03, 2019
Boundary issues
The Scholars of the Podcast reveal ribosomal proteins encoded in viral genomes, and a protein cell receptor for bat influenza viruses. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed Roald Dahl endorses measles vaccine Viruses encode ribosomal proteins (Nat Commun) Bat influenza virus receptor (Nature) Going to bat for flu research ( TWiV 173 ) Letters read on TWiV 537 Timestamps by Jolene . Thanks! Weekly Science Picks Brianne - Yes, I'm a Scientist on Twitter. Stop Judging Me. Alan - Impact of vaccines, graphed in heat maps Dickson - Treehoppers Kathy - World watershed maps Rich - Gene Machine by Venk
Sun, February 24, 2019
A flock of seagulls, a herd of seals
Vincent and Alan travel to Tufts Veterinary School where they meet up with members of the Runstadler lab to talk about their work on influenza virus circulation in water birds and seals. Hosts: Vincent Racaniello and Alan Dove Guests: Jonathan Runstadler , Nichola Hill, Wendy Puryear, and Kate Sawatzki Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Cummings School of Veterinary Medicine Influenza virus in North Atlantic grey seals (Emerg Microbes infect) Influenza viruses in Alaskan wild birds (Emerg Inf Dis) Wild bird influenza virus replication in human cells (Infect Genet Evol) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, February 17, 2019
Miles to go before I leak
The TWiV team discuss the use of quantum dots to study uncoating of influenza virus in real time, and induction of endothelial dysfunction by flavivirus NS1 proteins in a tissue-specific manner. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed Quantum dots to visualize influenza entry (PNAS) Quantum dots (Wikipedia) Flavivirus NS1 triggers endothelial dysfunction (Cell Rep) Image credit Letters read on TWiV 535 Timestamps by Jolene . Thanks! Weekly Science Picks Brianne - Hotel Influenza Alan - Your town’s climate in 60 years Dickson - BMC Research in Progress Photo Competition Rich - NASA's Opportunity Rover Mission on Mars Ends (landing animation) Vincent - <a href= "https://kottke.org/19/02/watch-a-single-cell-become-a-complex-o
Sun, February 10, 2019
Portal to the METTL
The TWiV crew reveal a unique portal on the calcivirus capsid formed upon receptor engagement, and the regulation of interferon responses in virus-infected cells by methylation of mRNA. Hosts: Vincent Racaniello , Dickson Despommier , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed Calicivirus portal visualized (Nature) Calicivirus portal - long version (biorXiv) m6A modification and innate response (Nat Immunol) Brianne Barker's immunology course m6A modification and innate response (Genes Dev) Letters read on TWiV 534 Timestamps by Jolene . Thanks! Weekly Science Picks Brianne - The Red Queen's Race Card Game Alan - Pentax Papilio II Dickson - Felice Frankel on improving visual side of science <
Sun, February 03, 2019
Recurring threads
The TWiVosophers review the Chinese plasma virome revealed by non-invasive prenatal testing, and a new filovirus genome from bats in China. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV 2019 European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed Jerard Hurwitz age 90 RIP Paul has Measles now in French (virology blog) Chinese plasma virome (Cell) Blood virome of 8000 humans ( TWiV 435 ) Měnglà filovirus from bats in China (Nat Microbiol) How to write a virus name (ICTV) Ortervirales (J Virol) Virologists oppose new definition of virus species (Arch Virol) Ebola sitrep (WHO) Letters read on TWiV 533 Timestamps by Jolene . Thanks! Weekly Science Picks Brianne - Trying Polar Vortex
Sun, January 27, 2019
Morbillivirus had a little lamb
The TWiVers discuss the spread of African swine fever virus and its threat to pig farming, and the zoonotic potential of peste des petits ruminants virus. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Please take the TWiV listener survey ASV 2019 European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed ASV in Poland does not let go (Ag Buiten ) Alarming ASF outbreak (Science) African swine fever (Euro Comm) African swine fever review (Vet J) ASF in wild boar (EFSA J) ASF in Belgian wild boar (Dept Env Food Rural Aff) Handbook on ASF in wild boar (Stand Grp Experts) Feral hogs (VA DGIF) Nonhuman morbillivirus with zoonotic potential (J Virol) <a href="http://www.microbe.tv/twiv/twiv-532-lett
Sun, January 20, 2019
Circ du RNA
Patrick Moore returns to TWiV to discuss the discovery from the Chang-Moore laboratory of circular RNAs in cells infected with herpesviruses. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Guest: Patrick Moore Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Please take the TWiV listener survey ASV 2019 European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed Cancer virology at Pitt Alice Huang’s DI particles (PubMed) Circular DNA tumor viruses make circular RNAs (PNAS) Backsplice Image credit Timestamps by Jolene . Thanks! Weekly Science Picks Brianne – The herd to the rescue Alan – Magic Wings Butterfly Conservatory Dickson – 100,000 Genomes Project Kathy – Your Age on Other Worlds Vincent – Vitamin D and Prevention of Cancer and Cardiovascular Disease Pat
Sun, January 13, 2019
Quiet please!
Steve Goff returns to TWiV to discuss the work of his laboratory on how retroviral genomes are silenced in infected cells. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Guest: Steve Goff Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! 🎼 They’ll histone you when you start to transcribe, And they’ll histone you just for tryin’ to get by, So be careful when you uncoat your genome, ‘Cause everybody must histone. Links for this episode Please take the TWiV listener survey ASV 2019 European Congress of Virology 2019 Histones loaded onto incoming retroviral DNA (Cell Host Micr) NP220 and silencing of incoming retroviral DNA (Nature) HIV-1 and HUSH ( TWiV 516 ) TWiV World Tour 2018 t-shirt Timestamps by Jolene . Thanks! Weekly Science Picks Alan - The Tangled Tree by David Quammen Dickson - Ammonia could power the globe Kathy - Portmanteaux and A.Word.A.Day Vincent - Curioscity Steve - Alice and Bob Meet the Wall of Fire Listener Pick Chaim - Tony Fauci on getting your flu vac
Tue, January 08, 2019
Rueckert Road
At the University of Wisconsin-Madison, Vincent meets up with one of his virology heroes, Roland R. Rueckert, to talk about his research and his second career as a forest manager. Host: Vincent Racaniello Guest: Roland R. Rueckert Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Video of this episode (YouTube) Roland's first paper (Anesthesiol) Purification of phiX174 (Virology) Studies on viral structure (Virology) Automated gel fractionator (Anal Bioch) Picornaviral gene order (J Virol) Picornavirus protease discovery (J Virol) Poliovirus processing map (J Virol) Nomenclature of picornavirus proteins (J Virol) Black beetle virus (J Virol) Rhinovirus crystallization (PNAS) Mapping mAb binding sites (J Virol) Replication of animal virus in yeast (PNAS) Roland's last paper (J Virol) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, January 06, 2019
Our annual recapsidation
In the first episode for 2019, the TWiV team reviews the amazing virology stories of the past year. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Please take the TWiV listener survey ASV 2019 Satellite Symposia Crowdfunding for EV-D68 research TWiV World Tour 2018 t-shirt (Amazon) Cool virology from 2018 Viruses behind AD? TWiV 505 , TWiV 519 , clinical trial one and two Wolbachia -mosquito release halts dengue ( TWiV 506 ); World Mosquito Program Evolutionary history of RNA viruses: TWiV 491 and TWiV 526 Horsepox as ancestral smallpox vaccine, including synthesis: TWiV 478 Ebola continues: TWiV 494 , TWiV 495 , TWiV 505 , TWiV 507 , TWiV 515 , TWiV 482 Clues to many mysteries: TW
Sun, December 30, 2018
City mouse, country mouse
The TWiV team summarizes the discovery of Sin Nombre virus, and presents evidence that neurotropic flaviviruses can cause intestinal dysmotility syndromes after systemic infection of mice. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Please take the TWiV listener survey ASV 2019 Satellite Symposia Crowdfunding for EV-D68 research Outbreak ( exhibit , TWiV 501 ) Four Corners hantavirus outbreak (Wikipedia) Death at the Corner (Atlantic) Hantavirus infection by US state (CDC) Hantavirus US cases and mortality (CDC) Hantavirus international cases (CDC) Belmont hantavirus death (NYTimes) Intestinal dysmotility following flavivirus infection of mice (Cell) Image credit Letters read on TWiV 527 Timestamps by Jolene . Thanks! Weekly Science Picks Alan - <a href= "https://www.youtube.com
Sun, December 23, 2018
In the beginning there was pol
The TWiV hosts discuss the distribution of prions in the eyes of patients with sporadic Creutzfeldt-Jacob disease, and the origins and evolution of RNA viruses. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Please take the TWiV listener survey ASV 2019 Satellite Symposia Crowdfunding for EV-D68 research Aaron Klug , 1926-2018 (Nature) Prions in sCJD eyes (mBio) Evolution of RNA viruses (mBio) Walter Gilbert's The RNA World (Nature) Image credit Letters read on TWiV 526 Timestamps by Jolene . Thanks! Weekly Science Picks Alan - Population mountains to visualize cities Rich - A Neanderthal Perspective on Human Origins with Svante Pääbo Kathy - NASA Space Mission posters Vincent - Package Thief vs Glitter Bomb Trap Listener Pick Neal - Was a Scientist Jailed? Intro music is by Ronald Jenkees . Send your virology questions and c
Bonus · Wed, December 19, 2018
Vaccines Did Not Cause Rachel's Autism
Vaccine scientist, pediatrician, and autism dad Peter Hotez talks about his new book, Vaccines Did Not Cause Rachel's Autism . Host: Vincent Racaniello Guest: Peter Hotez Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Peter Hotez at Baylor College of Medicine Peter Hotez on Twitter Vaccines Did Not Cause Rachel's Autism (Amazon) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, December 16, 2018
The A Bee Cs of bee viruses
Michelle Flenniken joins TWiV to talk about honeybees and the work of her laboratory on honeybee viruses. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Guest: Michelle Flenniken Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MSU Pollinator Health Center Honeybee antiviral defenses (Sci Rep) The buzz about honeybee viruses (PLoS Path) Recently identified bee viruses (Curr Op Insect Sci) Videos on honey bee research at MSU, honey bee pathogens , honey bee pathogen detection (YouTube) Timestamps by Jolene . Thanks! Weekly Science Picks Michelle - First 21 days of a bee's life ; NPR's Hidden Brain ; Varroa destructor triggers deformed wing virus in bees Brianne - Flu Near You Alan - Skype a Scientist program Rich - NASA's Voyager 2 Probe Enters Interst
Wed, December 12, 2018
Slicing and dicing with Raul
Raul Andino joins Vincent and Amy to talk about the finding that a cricket paralysis virus protein restricts RNA-based immunity in insects by regulating the activity and stability of the Argonaute protein. Hosts: Vincent Racaniello and Amy Rosenfeld Guest: Raul Andino Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode TWiV 138: RISCy business with Raul Andino TWiV 33: Live in Philly Viral protein restricts insect immunity (Cell Host Micr) Timestamps by Jolene . Thanks! Weekly Science Picks Amy - Insectropolis Vincent - Genome-edited baby Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, December 09, 2018
Virology in Zürich
At the University of Zürich, Vincent speaks with virologists Cornel Fraefel, Urs Greber, and Silke Stertz about their careers and their work on AAV2, adenovirus entry, and influenza virus. Hosts: Vincent Racaniello Guests: Cornel Fraefel , Urs Greber , and Silke Stertz Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode AAV2 and HSV1 co-infections (J Virol) Movies of HeLa Fucci cells (J Virol) Cathepsin W and influenza virus entry (mBio) Plaque 2.0 (PLoS One) Video of this episode (YouTube) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, December 02, 2018
Readers of the lost ORF
The TWiVsters review isolation of a naturally occurring DNA virus from fruit flies, and the cell-type specific function of a small transmembrane protein encoded in an open reading frame upstream of the enterovirus polyprotein. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Genome-edited babies (Nature) Second CRISPR pregnancy ? (MIT Tech Rev) Naturally occurring DNA virus of Drosophila (PLoS Path) Upstream protein coding region in enterovirus genome We missed it in 1988! (J Virol) Letters read on TWiV 522 Timestamps by Jolene . Thanks! Weekly Science Picks Alan - $40 internationally standard cup of tea Rich - Mars InSight Mission Dickson - New York Botanical Garden Train Show Kathy - Comedy wildlife photo awards finalists Vincent - Senator Gillibrand calls for funding AFM research and our Crowdsourcing of EV-D68 research Listener Pick Fer
Sun, November 25, 2018
Spitting in the Allee
Team TWiV cover the discovery of another giant virus from 30,000 year old Siberian permafrost, and how viral aggregation accelerates the production of new infectious viruses and increases fitness, demonstrating an Allee effect. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode PhD and postdoctoral programs at Dept of Microbiology, Icahn School of Medicine at Mount Sinai 30,000 year old Mollivirus sibericum (PNAS) Aggregating viruses promotes early replication (Curr Biol) Letters read on TWiV 521 Timestamps by Jolene . Thanks! Weekly Science Picks Brianne - Why don't we have vaccines against everything? Rich - Golden Globe Race Dickson - The Anatomy of Figure Drawing by Robert Demarest and Warder Clyde Allee Kathy - Orientation of the moon’s appearance, Southern Hemisphere Vincent - Paul has Measles in English and Spanish Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, November 18, 2018
This old mouse
The TWiVidae review universal influenza vaccines that are in clinical trials, and discovery of an atypical parvovirus that causes chronic kidney disease in middle aged, immunocompromised laboratory mice. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode PhD and postdoctoral programs at Dept of Microbiology, Icahn School of Medicine at Mount Sinai MSc program Molecular Biology and Pathology of Viruses, Univ College London Virology Comics on sale (Amazon) Outbreak at the Smithsonian NIAID strategic plan for universal influenza vaccine Fauci article on universal influenza vaccine (J Inf Dis) Severe 2017-18 flu season (CDC) Progress on universal influenza vaccine (The Scientist) Influenza vaccine is safe for those with egg allergies Atypical parvovirus drives mouse kidney di
Sun, November 11, 2018
Fishing for viruses in senile
The TWiVomers review a potential role for herpes simplex virus type 1 as a cause of Alzheimer's Disease, including the finding that amyloid-beta acts as an antiviral by enveloping virus particles. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Virology Comics on sale (Amazon) Clinical Trial: antiviral for AD HHV6 and HHV7 transcripts in AD brain ( TWiV 505 ) HSV1 in AD (Front Ag Neuro) Taiwan cohort study on antivirals and AD (Neurother) HSV1 antibodies in CSF (J Med Virol) HSV1 induces amyloid-beta fibrillization (Neuron) Image credit Letters read on TWiV 519 Timestamps by Jolene . Thanks! Weekly Science Picks Brianne - Pandemic (board game) Alan - The Shortwave Radio Audio Archive ( site and blog ) Rich - <a href= "http://southseas.nla.gov.au/i
Sun, November 04, 2018
Hershey's viruses
Vincent travels to Penn State College of Medicine in Hershey, PA to speak with Nick and Leslie about their careers and their work on human cytomegalovirus and retroviruses. Host: Vincent Racaniello Guests: Nicholas Buchkovich and Leslie Parent Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode HIV-1 gag membrane binding domain (J Virol) Nuclear experience for gag (PNAS) Gag in nucleolus (J Virol) YB-1 for retrovirus assembly (J Virol) HCMV controls BiP levels (J Virol) HCMV regulates La (J Virol) Inhibition of HCMV by modulating syntaxin 5 (J Virol) Non-envelopment role for ESCRT-III during HCMV infection (J Virol) Late retroviral budding function (J Virol) Grit by Angela Duckworth The Scientists by John Gribbin Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, October 28, 2018
Just in time for Halloween
Brianne and Vincent tackle two studies that utilize infectious viruses to examine zoonotic potential of Bombali virus, a new ebolavirus from an insectivorous species in Sierra Leone, and a human mumps-like virus from an African flying fox in DRC. Hosts: Vincent Racaniello and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Pan American Society for Clinical Virology San Diego and Houston Regional Meetings It's not SARS 2.0 ( TWiV 364 ) Bats out of hell ( TWiV 183 ) Bombali virus , a new Ebolavirus (Nat Micro) Asymptomatic Ebolavirus infections (virology blog) Bat-borne mumps virus (Cell Rep) Image credit Letters read on TWiV 517 Timestamps by Jolene . Thanks! Weekly Science Picks Brianne - Ed Yong on AFM Vincent - Goggles Optional podcast (especially #243 ) Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, October 21, 2018
HUSH little virus, don't you transcribe
Lonya and Jeremy take the TWiV team beTWIXt primate immunodeficiency virus proteins Vpx and Vpr and how they counteract transcriptional repression of proviruses by the HUSH complex. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , Kathy Spindler , and Brianne Barker Guests: Leonid Yorkovetskiy and Jeremy Luban Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Pan American Society for Clinical Virology San Diego and Houston Regional Meetings Vpr and Vpx counter HUSH (Nat Micro) Vpr and Vpx counter HUSH (bioRxiv version) Schematic of HUSH complex (Lehner lab) Olive colobus monkey sound credit Image credit: William (Ted) Diehl Letters read on TWiV 516 Timestamps by Jolene . Thanks! Weekly Science Picks Brianne - The Chimp and the River by David Quammen Rich - James Cook’s First Voyage Journal ( 20 sec Google Earth summary ) Kathy - High resolution Antarctica map
Sun, October 14, 2018
When virus is in retrograde
The TWiV team notes the passing of Tom Steitz, an outbreak of acute flaccid myelitis in the US, a continuing Ebola virus outbreak in DRC, respiratory vaccinia due to inhalation of ground up rabbit skin, and how a human papillomavirus capsid protein directs virus-containing endosomes towards the nucleus. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Sea Phages program and application materials Tom Steitz , 78 (NY Times) AFM outbreak , US (CIDRAP) AFM surveillance (CDC) Acute Flaccid Paralysis and Enteroviral Infections (Curr Inf Dis Rep) EV-D68 neurotropism (bioRxiv) Ebola virus outbreak continues in DRC (CIDRAP) Vaccinia virus respiratory infection (Int J Inf Dis) HPV L2 penetrates endosome, brings virus retro (Cell) Letters read on TWiV 515 Timestamps by <a href="http://www.twitter.com/jrrmicro" target= "_blank" rel="noo
Sun, October 07, 2018
Staying below the ADAR
The TWiVumvirate reviews this years crop of Nobel Prizes, and how cells prevent leakage of mitochondrial double-stranded RNA into the cytoplasm, which would otherwise lead to the production of interferon. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Sea Phages program and application materials Plant biologists penalized by CNRS (The Scientist) 2018 Nobel Prize in Medicine ( pdf ) 2018 Nobel Prize in Chemistry ( pdf ) 2018 Nobel Prize in Physics ( pdf ) 2018 Nobel Peace Prize (Nobel) Mitochondrial dsRNA triggers IFN (Nature) Letters read on TWiV 514 Timestamps by Jolene . Thanks! Weekly Science Picks 1:28:33 Alan - Compound Interest chemistry graphics Kathy - Writing letters of recommendation Guidelines Trix & Psenka</a
Sun, September 30, 2018
Double-stranded in Belgium
From the 13th International Symposium on dsRNA viruses in Belgium, Vincent speaks with Harry Greenberg about his career and his work on rotaviruses, noroviruses, hepatitis B virus, and influenza virus. Host: Vincent Racaniello Guest: Harry Greenberg Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode 13th dsRNA Virus Symposium Hepatitis in blood donors (Lancet) Interferon treatment of hepatitis B (NEJM) Mycoplasma mutants in volunteers (PNAS) Norwalk virus infection of chimpanzees (J Med Virol) Rotavirus rescue by reassortment (PNAS) Cold-adapted influenza vaccine (Virol) Rotavirus correlates of protection (Curr Opin Virol) Rotavirus vaccine and intussusception (NEJM) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, September 23, 2018
Flexuous SUMO wrestlers
Anne Simon joins the TWiV team to talk about plant viruses, including plum pox virus that devastates nut and stone fruit trees, and a geminivirus protein that regulates viral DNA synthesis. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , Brianne Barker , and Anne Simon Click arrow to play Download TWiV 512 (62 MB .mp3, 103 min) Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Support Viruses Gordon Conference 3:38 Potyvirus (ViralZone) Plum pox (Wikipedia) History, biology, management of plum pox (Mich St Ext) Papaya ring spot virus (Bus Man) Geminivirus (ViralZone) Geminivirus rep impairs PCNA SUMOylation (J Virol) Image credit Letters read on TWiV 512 Timestamps by Jolene . Thanks! Weekly Science Picks Brianne - Why are so many genes unstudied? ( Zimmer and <a href= "https://www.theatlantic.com/s
Sun, September 16, 2018
Accessory found guilty in DC
Ned Landau joins the TWiV team to discuss restriction of HIV replication by SAMHD1, and a viral antagonist that can be used to produce a dendritic cell vaccine. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guest: Ned Landau Become a patron of TWiV! Links for this episode Support Viruses Gordon Conference TWiV #1 24 September 2008 SAMHD1 restricts HIV-1 replication (Nature) SAMHD1 restricts diverse retroviruses (Retrovirology) Vpx degradation of SAMHD1 independent of uncoating (J Virol) Transduction of myeloid cells with Vpx vector (Gene Ther) Letters read on TWiV 511 Timestamps by Jolene . Thanks! Weekly Science Picks Brianne - Online Immunology Course Alan - Bacteria Builder Rich - 2018 Ig Nobel Prizes Dickson - Between Fear and Hope Ned - HUSH silencing of transposons Vincent - Paywall publishing ban ( Schlitz statement ); Curry on DORA Listener Pick Steve - Paywall: Business of Scholarship and Biohazard Islam - <a href= "https://twitter.com
Sun, September 09, 2018
Retroviruses at Cold Spring Harbor
Vincent and Dickson travel to the 44th Retrovirus meeting at Cold Spring Harbor Laboratories, where they speak with John Coffin, Stephen Hughes, Ya-Chi Ho, and Matt Takata about the meeting and their work on HIV-1. Hosts: Vincent Racaniello and Dickson Despommier Guests: John Coffin , Stephen Hughes , Ya-Chi Ho , and Matt Takata Become a patron of TWiV! Links for this episode Cold Spring Harbor Retrovirus Meeting 2018 Retroviruses and cranberries ( TWiV 320 ) Identical proviruses in HIV-1 reservoir (PLoS Path) Measuring HIV-1 latency (PNAS) CG dinucleotide suppression is host defense (Nature) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, September 02, 2018
41,103 bases under the sea
The TWiV team considers whether those who can do, can't teach, and newly discovered viruses of planarians and Aplysia with the largest RNA genomes. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Kathy Spindler and Brianne Barker Become a patron of TWiV! Links for this episode Support Viruses Gordon Conference KNAW Beijerinck Prize Bioterrorism and Biocrimes by Seth Carus (free pdf) History of Biological Warfare by Seth Carus (free) Those Who Can Do, Can't Teach (NYTimes) Planarian nidovirus (bioRxiv) Aplysia nidovirus (bioRxiv) Image credit Letters read on TWiV 509 Weekly Science Picks Brianne - Climate change visualization Alan - Anova sous vide cooker Dickson - Fire season in western US Kathy - Sunscreen in UV and The Projector Illusion Vincent - The Usefulness of Useless Knowledge Listener Pick River - The Conscience of the Pr
Sun, August 26, 2018
Bioweapon
Jens returns to present a brief history of bioweapons, with a focus on the program in the Soviet Union, the largest ever undertaken, and his experience working in the decommissioned Soviet bioweapons laboratory known as Vector. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Kathy Spindler Guest: Jens Kuhn Become a patron of TWiV! Links for this episode Russia's Bioweapons Labs (Nature) Medical Aspects of Biological Warfare The Soviet Biological Weapons Program by Leitenberg, Zilinskas, Kuhn Biological Threats in the 21st Century by Lentzos Bioterrorism and Biocrimes by W. Seth Carus Russia's Secret Weapons (Nature) Image credit Weekly Science Picks Jens - Nudibranchs , Beastly Garden , large nidovirus ( one , two ) Rich - <a href= "https://www.dallasnews.com/news/science-medicine/2018/05/25/l
Sun, August 19, 2018
The fusion of form and function
The TWiV team discuss the biology of Ebola viruses, and how localization of the membrane proteins of vaccinia virus drive function: the fusion machinery sits at the tips of virions, and binding proteins are at the sides. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Become a patron of TWiV! Links for this episode Support Viruses & Cells Gordon Conference Outbreak at the Smithsonian Outbreak (TWiV 501) Latest Ebola virus outbreak , DRC (WHO) Summary of Ebola virus outbreaks (CDC) Ebola virus nomenclature (ICTV) Ebola virus distribution map (CDC) Polarization of vaccinia virus membrane proteins (bioRxiv) Image credit Letters read on TWiV 507 Weekly Science Picks Alan - Puzzled Escape Games Rich - An Extremely Detailed Map of the 2016 Election Dickson - <a href= "https://www.nasa.gov/content/goddard/parker-solar-probe" target= "_blank" rel="noopene
Fri, August 17, 2018
David Tuller is PACEman
David Tuller returns to provide an update of his investigative work to expose the methodological and ethical problems with the PACE trial for ME/CFS. Host: Vincent Racaniello Guest: David Tuller Become a patron of TWiV! Links for this episode Article by Lubet and Tuller (STAT) David's Australian trip (virology blog) Sir Simon scores own goal (virology blog) Lightning process (virology blog) Letter to Parliament (virology blog) Crowdfunding is not conflict of interest (virology blog) Open letter to Lancet 3.0 (virology blog) Mayo still champions GET (virology blog) Image Credit Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, August 12, 2018
A Cafeteria full of jelly rolls
The TWiVniks explain how the three-dimensional structure of the giant Cafeteria roenbergensis virus suggests a new mode of assembly, and the apparent elimination of dengue fever in an Australian city by release of mosquitoes harboring Wolbachia . Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Brianne Barker Become a patron of TWiV! Links for this episode Support Viruses & Cells Gordon Conference New DRC Ebola strains distinct (Outbreak News) Immunizations for new DRC Ebola outbreak (The Scientist) Structure of Cafeteria roenbergensis virus (Sci Rep) Chuan (River) Xiao laboratory CroV movies Scaled deployment of Wolbachia (Gates Open Res) In the wake of Wakefield (BBC) Letters read on TWiV 506 Weekly Science Picks Alan - Ebola research begins at the NEIDL Dickson - Science Photo Library Brianne - First liquid water (underground lake) found on Mars Vincent - <a href= "https://nyti.ms/2mWMDT
Sun, August 05, 2018
Rosebola
The TWiV hosts review persistence of Ebola virus after the end of the Liberian outbreak, and the potential role of two herpesviruses in the pathogenesis of Alzheimer's disease. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler and Brianne Barker Become a patron of TWiV! Links for this episode Support Viruses & Cells Gordon Conference Trump picks science advisor (Scientist) Hendra vaccine: no effect on horses racing (Aust Vet J) Persistence of Ebola virus (Lancet Inf Dis) New Ebolavirus outbreak (Telegraph) Alzheimer's disease and herpesviruses (Neuron) Herpesviruses, beta-amyloid and Alzheimer's disease (Neuron) Letters read on TWiV 505 Weekly Science Picks Alan - Impossible Burger Rich - SpaceX Just Sent Algae to the ISS, Here's How It'll Power Deep Space Missions Dickson - <a href= "http://newsroom.ucla.edu/stories/unexpected-intersection-art-science-U
Sun, July 29, 2018
Flying foxes and barking pigs
The TWiVerinos discuss Nipah virus and the recent outbreak in India, and the first cast of polio in Papua New Guinea in 18 years. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Become a patron of TWiV! Links for this episode Support Viruses & Cells Gordon Conference TWiV 501: Outbreak Nipah virus infection (JCM) Anatomy of an outbreak (The Hindu) Do we need to worry about Nipah virus? (Tufts Now) Nipah virus infection of bats (EID) Papua New Guinea no longer polio-free (virology blog) WHO polio endgame (polioeradication) Letters read on TWiV 504 Weekly Science Picks Alan - Glaciers of the Rockies aerial photos Rich - SpaceX CRS-15 mission to the space station ( wiki ) Dickson - Test of Einstein's theory of relativity Brianne - biorender Vincent
Sun, July 22, 2018
The greening of TWiV
Vincent, Rich and Kathy travel to ASV 2018 at the University of Maryland to speak with Svetlana Folimonova and Anne Simon about their work on viruses that infect plants. Hosts: Vincent Racaniello , Rich Condit , and Kathy Spindler Guests: Svetlana Folimonova and Anne Simon Become a patron of TWiV! Links for this episode Simon laboratory Folimonova laboratory CTV superinfection exclusion (Virol) 3'-CITEs in viral genome (J Virol) Video of this episode (YouTube) Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Fri, July 13, 2018
Texas road phage
The TWiV team travels to Texas A&M University, home of the Center for Phage Technology, where they speak with Ry Young and Jason Gill about their work on viruses that infect bacteria. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Guests: Jason Gill and Ry Young Become a patron of TWiV! Links for this episode Center for Phage Technology at TAMU Personalized phage therapy (PNAS) Phage for biolipid extraction (Sci Rep) Viral protein antibiotic (Nat Micro) Acinetobacter phage depolymerase (J Virol) Structure of phage Qβ (PNAS) Video of this episode (YouTube) Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, July 08, 2018
Outbreak
Vincent visits the Smithsonian Institution and speaks with Sabrina Sholts, Jon Epstein, and Ed Niles about the exhibit Outbreak: Epidemics in a Connected World. Host: Vincent Racaniello Guests: Sabrina Sholts , Jon Epstein , and Ed Niles Become a patron of TWiV! Links for this episode Sabrina Sholts Jonathan Epstein EcoHealth Alliance Outbreak at the Smithsonian ASM partners with Smithsonian (bLog Phase) Vincent as museum object (AMNH) Video of this episode (YouTube) Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, July 01, 2018
Keep virology weird
The entire TWiV team visits The University of Texas in Austin to record episode #500 with guests Jinny Suh, Jason McClellan, and Jon Huibregtse. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guests: Jinny Suh , Jason McClellan , and Jon Huibregtse Become a patron of TWiV! Links for this episode A big list of science podcasts Immunize Texas McClellan Lab Huibregtse Lab John Ring LaMontagne Center for Infectious Disease Video of this episode (YouTube) Weekly Science Picks Alan - The Airplane Cabin Microbiome Rich - Coalition for Epidemic Preparedness Innovations (CEPI) ( wiki ) Dickson - The Big Five Mass Extinctions Kathy - Virus scarves at Red Bubble phage-specific variety Vincent - Science podcasts Listener Pick
Sun, June 24, 2018
Good virologists go to Halifax
Vincent and Alan travel to the Canadian Society for Virology meeting in Halifax, Nova Scotia to speak with Nathalie and Craig about their vision for the society, and with Kate and Ryan about their careers and their research. Hosts: Vincent Racaniello and Alan Dove Guests: Nathalie Grandvaux , Craig McCormick , Kate O'Brien , and Ryan Noyce Become a patron of TWiV! Links for this episode TWiV 2018 World Tour CSV 2018 To wheeze or not to wheeze (Lancet Respir Med) Synthetic infectious horsepox (PLoS One) Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, June 17, 2018
Salivating at ASM Microbe
Vincent, Kathy and Rich travel to ASM Microbe 2018 in Atlanta where they speak with Stacy Horner and Ken Stapleford about their careers and their research. Hosts: Vincent Racaniello , Rich Condit , and Kathy Spindler Guests: Stacy Horner and Ken Stapleford Become a patron of TWiV! Links for this episode TWiV 2018 World Tour RNA modifications go viral (Plos Path) N6-methyladenosine in flavivirus genomes (Cell Host Micr) Chikungunya virus evolution (Cell Host Micr) Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, June 10, 2018
Europic 2018
At Europic 2018, a meeting on picornaviruses in the Netherlands, Vincent speaks with Sasha Gorbalenya, Jim Hogle, Ann Palmenberg and Frank van Kuppeveld about their careers and their research. Hosts: Vincent Racaniello and Rich Condit Guests: Sasha Gorbalenya , Jim Hogle , Ann Palmenberg , and Frank van Kuppeveld Become a patron of TWiV! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, June 03, 2018
Vaccines work, whether or not you believe in them
Vincent and Rich recorded this episode at Vaccines in the 21st Century, a meeting held at the University of California, Irvine, where they spoke with Stacy Schultz-Cherry, Douglas Diekema, and Andrew Noymer about vaccine facts and fiction. Hosts: Vincent Racaniello and Rich Condit Guests: Stacey Schultz-Cherry , Douglas Diekema , and Andrew Noymer Become a patron of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine International dsRNA Virus Symposium Dummheit (Healthc Policy) Universal influenza vaccine (mBio) Vaccine personal belief exemptions (Ann Rev Pub Health) Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, May 27, 2018
Influenza virus keeps its ion channel 20
The TWiVerati follow up on the Ebola virus outbreak, virulence of Ebola-Makona, and reveal how a parasitoid is revealed to hyperparasitoids, and binding of influenza virus to a calcium ion channel to mediate influenza virus entry. Hosts: Vincent Racaniello , Alan Dove , and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine International dsRNA Virus Symposium Tracing Ebola virus contacts (CIDRAP) WHO FAQ Ebola virus vaccine (WHO) Nipah virus outbreak (CIDRAP) Revealing parasitoid to hyperparasitoid (PNAS) Hyperparasitoid video (YouTube) Calcium channel and influenza virus entry (Cell Host Microbe) Letters read on TWiV 495 Weekly Science Picks Alan - National Cryptologic Museum Rich - Science is mostly about staring Dickson - <a href= "https://co
Sun, May 20, 2018
Ebola Makona is the opposite of hakuna matata
Vincent, Kathy, and Alan review the ongoing outbreak of Ebola virus in the Democratic Republic of the Congo, and the finding that mutations identified in the 2015 West African epidemic do not alter pathogenesis in animals. Hosts: Vincent Racaniello , Alan Dove , and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine International dsRNA Virus Symposium New Ebola virus outbreak in DRC (WHO) Ebola virus case in urban area of DRC (WHO) Ebola virus outbreak not PHEIC (WHO) Ebola virus vaccine arrives in DRC (CIDRAP) Recent Ebola-Makona mutations do not alter pathogenesis (Cell Rep) Letters read on TWiV 494 Weekly Science Picks Alan - Happy 35th birthday , PCR Kathy - Everything can be a speaker Vincent - Ocean rise due to rocks (<a href= "https://twitter.com/chockenberry/status/
Sun, May 13, 2018
Condit is on drugs and norovirus is lit
The TWiVerati discuss the FDA Advisory Committee deliberation on the anti-poxvirus drug tecovirimat, and immune cells in gut-associated lymphoid tissue as the major target during acute murine norovirus infection. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine FDA meeting materials for tecovirimat (FDA) SIGA Briefing Information (pdf) Errata to the SIGA Briefing Information (pdf) Gut immune cells major targets of norovirus infection (Nat Micro) RNAscope (J Mol Diag) Image credit Letters read on TWiV 493 Weekly Science Picks Alan - Personal Finance for PhDs by Emily Roberts Kathy - Optical illusions fool artificial intelligence Rich - 2017-2018 snowfall graphic Dickson
Sun, May 06, 2018
CRISPR diagnostics
The Masters of the TWiXome review the development of sensitive, portable, and field-based viral diagnostics using the CRISPR-Cas system. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine Norovirus outbreaks from nori (Emerging Inf Dis) SHERLOCK (Science) HUDSON (Science) DETECTR (Science) Letters read on TWiV 492 Weekly Science Picks Alan - Decline of local newspapers leaves epidemiologists blind Kathy - Journal oversight, mental health research Rich - The Big Sort: An Insider's Tour of a Recycling Plant Dickson - When Science Meets Art Vincent - A Crack in Creation by Doudna and Sternberg Listener Pick Tom - <a href= "https://www.nytimes.com/2018/04/13/scien
Sun, April 29, 2018
The Ileum and the Odyssey
The TWiVome deconstructs the evolutionary history of RNA viruses, and immune promortion of murine norovirus pathogenesis by replication in intestinal tuft cells. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine Evolutionary history of RNA viruses (Nature) The amphioxus song Norovirus tropism for tuft cells (Science) Letters read on TWiV 491 Weekly Science Picks Alan - Oligodendroglioma in song Kathy - Everything-repellent coating to grime proof phone screens & more Rich - Gaia star map Dickson - Clouds are complicated Vincent - Eradicating polio with a vaccine we must stop using Listener Pick Stephen - Forget the Avengers, it took real heroes to mak
Sun, April 22, 2018
Shave ice and giant viruses
From the TWiV team, human cowpox infection possibly acquired from a pet cat, and a new giant mimivirus of green algae with genes encoding enzymes of fermentation. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 ASV Job Site revamped Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine Dick Courtney obit Human cowpox infection (NEJM) Mimivirus encodes fermentation genes (Virology) Letters read on TWiV 490 Weekly Science Picks Kathy - Landscapes that look like another world (but they are from Spain) Rich - Brighton Collaboration ; Viral Vector Vaccines Safety Working Group (V3SWG) ( Chen & DeStefano: Vaccine adverse events: causal or coincidental? ) Dickson - Clouds of Jupiter and EBNA2 and autoimmunity Vincent - More than one-third of graduate students report being depressed (<a href= "https://www.nature.com/articles/nbt
Sun, April 15, 2018
CD4 Hunter
Vincent visits Sandra Urdaneta-Hartmann at Drexel University College of Medicine in Philadelphia to talk about the development of the mobile video game 'CD4 Hunter'. Host: Vincent Racaniello Guest: Sandra Urdaneta-Hartmann Become a patron of TWiV! Links for this episode CD4 Hunter iOS Android Sandra on Twitter Carla Brown on Twitter Inactivation of HIV in breast milk (Retrovirology) Nipple shield to inactivate HIV (Int J Pharm) Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, April 08, 2018
Who nose if it will work in humans
The TWiV team reveals that recent mumps virus outbreaks in the US are due to waning vaccine efficacy, and an intranasally delivered small interfering RNA that controls West Nile infection in the brain. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 ASV 2018 Microbiology Student Symposium at UC Berkeley Support Viruses & Cells Gordon Conference Waning mumps vaccine in US (Sci Trans Med) siRNA control of West Nile virus brain infection (Cell Host Microbe) Image credit Letters read on TWiV 488 Weekly Science Picks Kathy - Peak bloom and photographing cherry blossoms Dickson - Origins of vertebrate RNA viruses Alan - Rare footage of anglerfish in the deep ocean Vincent - NIH must reduce disparities in funding Listener Picks Mariann - Eden Project and Bellyvision Apparatus and the Like Amir - <a href= "https://www.icr.ac.uk/news-features/latest-features/winners-of-th
Sun, April 01, 2018
Milwaukee viral
At the Medical College of Wisconsin, Vincent talks with current and former members of the Department of Microbiology and Immunology about their work and their careers. Host: Vincent Racaniello Guests: Dominique Carter , Sid Grossberg , John Kirby , Scott Terhune , and Vera Terakanova Become a patron of TWiV! Intro music by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, March 25, 2018
Sean Whelan on being haploid
Sean Whelan returns to TWiV to speak with Vincent about using haploid cell lines to identify genes encoding cell receptors for viruses, including Ebolavirus, Lassa virus, and more. Host: Vincent Racaniello Guest: Sean Whelan Become a patron of TWiV! Links for this episode Ebola virus entry requires the cholesterol transporter Niemann-Pick C1 (Nature) Lassa virus entry requires a trigger-induced receptor switch (Science) Infectious Entry Pathway Mediated by the Human ERV K Envelope Protein (J Virol) Novel Broad-Spectrum Virus Entry Inhibitor (J Virol) Mechanism of membrane fusion induced by VSV G protein (PNAS) NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry (Cell Host Micr) Image credit Intro music by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, March 18, 2018
Fishing with defective flies
The TWiV posse considers viral insulin-like peptides encoded in fish genomes, and insect antiviral immunity by production of viral DNA from defective genomes of RNA viruses. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Kathy Spindler , and Brianne Barker Become a patron of TWiV! Links for this episode ASM Microbe 2018 Insulin-like peptides in Iridovirus genomes (PNAS) Dicer-2 dependent generation of cvDNA from defective genomes (Cell Host Micr) Carla Saleh on insect antiviral immunity ( TWiV 301 ) RNAseIII ancient antiviral RNA platform ( TWiV 450 ) cvDNA precursor to EVEs ( TWiV 482 ) Image credit: Paul Young Letters read on TWiV 485 Weekly Science Picks Kathy - Vegas casinos lost money on physicists Brianne - Astronaut twin's DNA is not 7% different! Dickson - Parasitic Diseases lecture videos Alan - In Season blog by Donna Long Vincent - Buckyball viruses Listener Picks Paul - Wine labels ( front , back ) Intr
Sun, March 11, 2018
Float like a mimivirus STING like a bat
The TWiVumvirate discuss the giant Tupanvirus, with the longest tail in the known virosphere, and dampened STING dependent interferon activation in bats. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Kathy Spindler , and Brianne Barker Become a patron of TWiV! Links for this episode ASM Microbe 2018 Tailed giant Tupanvirus (Nat Commun) Soda Lakes (Wikipedia) Dampened STING in bats (Cell Host Microbe) Image credit Letters read on TWiV 484 Weekly Science Picks Kathy - How to read a phylogenetic tree Brianne - No immune overload for vaccines Dickson - Flowchart of viral families Alan - Letters to a Pre-Scientist Vincent - True believers, entrepreneurs, and scammers in alternative medicine and Simply Put: Vaccines Save Lives Listener Picks
Sun, March 04, 2018
Every infection is unhappy in its own way
Vincent and the Virals review undermining of antiviral effectiveness by genital inflammation, and heterogeneity of influenza virus infection in single cells. Hosts: Vincent Racaniello , Alan Dove , and Kathy Spindler Become a patron of TWiV! Links for this episode USA Science and Engineering Festival Genital inflammation and antiviral effectiveness (Nat Med) Single cell infection heterogeneity (eLife) Single-cell poliovirus infection (Virology) Image credit Letters read on TWiV 483 Weekly Science Picks Kathy - Dance Dance Rich - Snopes Alan - Next Generation Science Standards Vincent - TWiEVO 28: Genetics of skin pigmentation in Africa Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, February 25, 2018
Don't EVEome without antibody expressed
The TWiV Masters discuss serologic evidence of Ebolavirus infection in a population with no outbreaks, and the set of endogenous viral elements in the mosquito genome. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Kathy Spindler , and Brianne Barker Become a patron of TWiV! Links for this episode USA Science and Engineering Festival Ebolavirus infection without an outbreak (J Inf Dis) A. aegypti EVEome (Curr Biol) One Loop to Rule Them All (Trends Biochem Sci) Image credit Letters read on TWiV 482 Weekly Science Picks Kathy - Origami sound barrier Brianne - iBiology Dickson - Switched-on bats Alan - Hawaii’s communication breakdown Vincent - Inside the Federal Bureau of way too many guns and What I Saw Treating Parkland Victims Listener Pick</h3
Sun, February 18, 2018
And biles to go before I delete
The TWiVodrome considers the intestinal tract as an alternative infection route for MERS coronavirus, and how reduced accumulation of defective viral RNAs might lead to severe influenza. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode HaHa influenza virus (mBio) MERS coronavirus intestinal transmission (Sci Adv) Simulated gastric and intestinal fluids Stomacher Defective genomes and severe influenza (PLoS Path) Image credit Letters read on TWiV 481 Weekly Science Picks Kathy - CD45.1 and CD45.2 mice may not be functionally equivalent Rich - Relative humidity versus dewpoint (video) Dickson - Underwater photography winners Alan - Photo of a single atom Vincent - <a href= "https://www.the-scientist.com/?articles.view/articleNo/51780/title/Proposed-Federal-Budget-Slashes-Funds-to-EPA--CDC/&utm_campaign=TS_DAILY%20NEWSLETTER_2018&utm_source=hs_email&utm_medium=email&utm_content=60643678&_hsenc=p2ANqtz-_4I01kfdA9WkrDjg2rFagBORv6kV08tS2AygD1NUnt2TrrFJzT1X4-1kq2sWA58ToVivEB
Sun, February 11, 2018
The PFU in your achoo
Scott Hensley joins the TWiVites to review the current influenza season and presence of the virus in exhaled breath of symptomatic cases. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guest: Scott Hensley Become a patron of TWiV! Links for this episode Weekly influenza surveillance (CDC) Influenza vaccination status (CDC) H3N2 glycosylation site and eggs (PNAS) Influenza virus in exhaled breath (PNAS) Geometric Defects and Icosahedral Viruses (Viruses) Image credit Letters read on TWiV 480 Weekly Science Picks Kathy - Flow Virometry Rich - Falcon Heavy Launch links: Flight diagram ; Launch including booster landing ; Tesla in space ; Tesla orbit ; Reusable booster failures ; Booster size Dickson</stro
Sun, February 04, 2018
Trypsin the flight fantastic
The TWiVome explores induction of antiviral responses by repeating patterns of capsids, and a fungus in the mosquito gut that aids dengue virus replication. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode Innate immune detection of capsid patterns (mBio) Mosquito gut fungus aids dengue virus replication (eLife) Nominate MicrobeTV for a Keck award Image credit Letters read on TWiV 479 Weekly Science Picks Kathy - Great Lakes, false color Rich - Times 360 Lego factory tour Dickson - 3D printed houses Alan - The new terms for trust in journalism Vincent - A Tale of Two Cultures and Why Science Blogging Still Matters Listener Picks Jolene - Immune Quest Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, January 28, 2018
A pox on your horse
The TWiV team explains how infectious horsepox virus - likely the ancestor of smallpox vaccines - was recovered from chemically synthesized DNA fragments. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode ASV 2018: asv.org , asv2018.umd.edu Potential Zika virus related birth defects , USA (MMWR) Bordering on an outbreak (Tex Obs) Horsepox virus from synthesized DNA (PLoS One) Horsepox based smallpox vaccine (NEJM) Has horsepox become extinct? (Vet Rec) Evolutionary path of smallpox vaccines (Lancet Inf Dis) Equination (Vaccine) Image credit Letters read on TWiV 478 Weekly Science Picks Kathy - UM EEB photo contest Rich - Dino-Lite digital microscope and <a href= "https://www.microscope.com/microscope-camer
Sat, January 20, 2018
Raiders of the lost Arc
The TWiVodrome explains how a gag-like protein from a retrotransposon forms virus-like particles that carry mRNA within vesicles across the synapse. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode ASV 2018: asv.org , asv2018.umd.edu Arc virus-like particles transport RNA across the synapse ( mammalian , Drosophila ) Chemical synapse (Wikipedia) 2 minute video on the neuron Image credit Letters read on TWiV 477 Weekly Science Picks Kathy - Ice cliffs form over the weekend Rich - The Courage To Invent: A NASA Roboticist Tells Her Story ( Ayanna Howard ) Dickson - 2017 Was One of the Hottest Years on Record Alan - Experimenter gender and replicability Vincent - <a href
Sun, January 14, 2018
In ACOD1 we trust
Nels joins the TWiV team to talk about his work on genomic accordions in vaccinia virus, hepatitis B virus in a 439 year old mummy, and viral induction of energy synthesis by a long noncoding RNA. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guest: Nels Elde Click arrow to play Download TWiV 476 (63 MB .mp3, 105 min) Subscribe (free): iTunes , RSS , email Become a patron of TWiV! Links for this episode ASV 2018: asv.org , asv2018.umd.edu TWiV is a must-listen (WaPo) More on poxvirus accordions (bioRxiv) HBV from a 439 year old mummy (PLoS Path) lncRNA promotes viral replication by inducing metabolism (Science) Making Data Visual Letters read on TWiV 476 Weekly Science Picks Nels - Everyday Evolution Kath
Sun, January 07, 2018
Everything is viral
In the first episode for 2018, the TWiV team reviews the amazing virology stories of 2017. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Become a patron of TWiV! Links for this episode ASV 2018: asv.org , asv2018.umd.edu Virology stories of 2017 - in no particular order A virologist in space - TWiV 444 Cool things viruses do: Astrovirus capsids are enterotoxins TWiV 423; giant Klosneuviruses encode lots of stuff for translation TWiV 437 ; Giant Noumeaviruses quickly make the nucleus temporarily leaky TWiV 440 TWiV 438 Drs. TWiV go to Washington and the March for Science Unexpected stuff: TWiV 451 Expectorate the unexpected; TWiV 470 Just a passing phage; TWiV 456 Be careful of canons; TWiV 455 Pork and genes; TWiV 432 gamete fusion protein from viruses TWiV 443 On a leaf no one can hear you scream. The puppet master. TWiV 448 Mavis the structure maven Viruses are us: TWiV 472 Riddle of the skinks; TWiV 439 The purloined envelope; TWiV 434 Live long and pupate Antiviral RNA: TWiV 433 Poops viruses and worms; TWiV 449 The sound of non-silencing; TWiV 450 Ben tenOever and RNA out Viruses as tools: TWiV 461 Gotta trace them all Flaviviruses: TWiV 473 , <a href= "http://www.microbe.tv/twi
Sun, December 31, 2017
Call me fish meal
The TWiVanguardians take on Bodo saltans virus, a leviathan which infects an abundant flagellated eukaryote in Earth's waters. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Become a patron of TWiV! Links for this episode ASV 2018: asv.org , asv2018.umd.edu Support Microbe.tv Anti-dengue antibody and disease (J Inf Dis) Bodo saltans virus (biorXiv) Kinetoplast DNA (Euk Cell) Crossword puzzle for book contest (pdf) Letters read on TWiV 474 Weekly Science Picks Kathy - Every second Dickson - Top 10 Science Images 2017 Alan - Shortwave Radiogram Vincent - Science March on Instagram Listener Picks Islam - Class Crossword ( Armored Penguin ) Peter - The Last of the Iron Lungs Intro music is by Ronald Jenkees . Send your virology questions and
Sun, December 24, 2017
Assessing a risk and infecting you twice
The Fellowship of the Virus discuss enhancement of dengue disease in humans: the contribution of antibody concentration and increased binding to Fc receptors. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode ASV 2018: asv.org , asv2018.umd.edu Support Microbe.tv NEIDL is approved NIH lifts GOF moratorium (Science) Blackburn steps down as head of Salk Institute (SD Union Trib) ADE of dengue disease in humans (Science) Commentary on ADE of dengue disease (Science) ADE of dengue disease and antibody binding to Fc (Science) Letters read on TWiV 473 Weekly Science Picks Kathy - Today in Science History Dickson - 10 Breakthrough Technologies 2017 Rich - SpaceX to orbit a Tesla <
Bonus · Wed, December 20, 2017
Ray Ortega in the podcaster's studio
Vincent speaks with professional podcast producer Ray Ortega about his career and the power of the podcast. Host: Vincent Racaniello Guest: Ray Ortega Become a patron of TWiV! Links for this episode Ray on Twitter The Podcasters' Studio Produce Picker Podcast Ray's YouTube channel Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, December 17, 2017
The riddle of the skinks
The TWiV team reveal the origin of the poxvirus membrane, and how a retrovirus drove the development of the placenta of a lizard. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode ASV 2018: asv.org , asv2018.umd.edu Support Microbe.tv Origin of poxvirus membrane (PNAS) Poxvirus movies: Movie S1 , Movie S2 , Movie S3 , Movie S4 , Movie S5 Lizard placenta from a retrovirus (PNAS) Letters read on TWiV 472 Weekly Science Picks Kathy - Google doodles Discoverer of photosynthesis Robert Koch Dickson - Nature Photography Winners Rich - The Raging Idiots Planet Song Alan - <a href= "http://www.zoobo
Sun, December 10, 2017
Songs of innocence and experience
The TWiVerinos discuss restriction of dengue virus vaccine by Sanofi, and data which suggest that Dengvaxia causes enhanced disease in previously uninfected recipients. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode ASV 2018: asv.org , asv2018.umd.edu Sanofi update on D engvaxia Trouble for dengue vaccine (Reuters) Sanofi restricts dengue vaccine (CIDRAP) Dengvaxia enhances disease (Vaccine) Interview with Jeff Almond Dengue vaccine on TWiV 319 , TWiV 370 , TWIV 384 Image credit Letters read on TWiV 471 Weekly Science Picks Kathy - NASA is reinventing the wheel Dickson - Stunning neuroscience images Rich - Moneyball by Michael Lewis (<a href= "http://www.imdb.com/title/tt1210166/?ref_=nv_
Sun, December 03, 2017
Just a passing phage
The TWiV ninjas reveal that bacteriophage particles rapidly move across monolayers of eukaryotic cells from different tissues. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode Transcytosis of bacteriophage across cell layers (mBio) Image credit Letters read on TWiV 470 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. Get $30 off your first delivery and FREE SHIPPING by going to b lueapron.com/twiv . Weekly Science Picks Kathy - Photo of 3200 year-old tree in one image Dickson - Microsculpture Rich - A Short History Of Humans And Germs Alan - Planets app Vincent - Laptops Are Great. But Not During a Lecture or a Meeting Listener Picks Basel - Joint Pathology Center John - OpenStax Intro music is by Ronald Jenkees . Send your virol
Sun, November 26, 2017
Mycovirus stuffed potatoes
The TWiV hosts discuss a plant virus that infects a fungus, and whether you need to work insane hours to succeed in science. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode Phytopathogenic fungus hosts a plant virus (PNAS) Franklin column (PNAS) Potato famine mystery solved (History) Protein Data Bank You do not need to work 80 hours per week (THE) How I Learned To Stop Worrying (Sci Am) Image credit: Truth Wins by Jon Yewdell Letters read on TWiV 469 This episode is brought to you by the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. For more information about the Department, visit http://bit.ly/micromssm This episode is brought to you by the Virology and Gene Therapy PhD program at the Mayo Clinic Graduate School of Biomedical Sciences in Rochester, Minnesota. The renowned Mayo Clinic Virology and Gene Therapy program is currently accepting appl
Sun, November 19, 2017
Zika by the slice
Amy joins the TWiV team to talk about her career and her work on Zika virus neurotropism using embryonic mouse organotypic brain slice cultures. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guest: Amy Rosenfeld Become a patron of TWiV! Links for this episode Grad students face tax hike (Nature) House voted to bankrupt grad students (NYTimes) Neurotropism of early and late Zika virus isolates (PNAS) Zika virus blocks the neuron road (virology blog) Letters read on TWiV 468 This episode is brought to you by the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. For more information about the Department, visit http://bit.ly/micromssm This episode is brought to you by the Virology and Gene Therapy PhD program at the Mayo Clinic Graduate School of Biomedical Sciences in Rochester, Minnesota. The renowned Mayo Clinic Virology and Gene Therapy program is currently accepting applications until December first. If you want to be trained in the exciting fields of oncolytic virotherapy, gene therapy, vaccine creation, or basic virology, visit mayoclinic.org</
Sun, November 12, 2017
Jon and Ted's Excellent Adventure
Jon and Teddy Yewdell join the TWiV team to talk about their careers, their research, and the problems with biomedical research. Hosts: Vincent Racaniello , Alan Dove ,and Rich Condit Guest: Jon Yewdell and Teddy Yewdell Become a patron of TWiV! Links for this episode Jon Yewdell laboratory Chaudhuri laboratory Truth Wins by Jon Yewdell ( epub or mobi download) Noncoding RNAs and class switch recombination (Int Imm) Translating DRiPs (J Leuk Biol) Lamprey VLRP response to influenza virus (eLife) The Biomedical Research Crisis ( TWiV 208 ) This episode is brought to you by the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. For more information about the Department, visit http://bit.ly/micromssm Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, November 05, 2017
The Capsid Club
From Indiana University, Vincent and Kathy speak with Tuli Mukhopadhyay, John Patton, and Adam Zlotnick about their careers and their work on alphaviruses, hepatitis B virus, and rotaviruses. Host: Vincent Racaniello and Kathy Spindler Guests: Tuli Mukhopadhyay , John Patton , and Adam Zlotnick Become a patron of TWiV! Links for this episode Mukhopadhyay lab Patton lab Zlotnick lab Tuli on Twitter Palmitoylation of Sindbis virus TF protein (J Virol) Hepatitis B virus structure (Ann Rev Virol) Rotavirus RNA polymerase (Curr Opin Virol) Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, October 29, 2017
Theodora the explorer
Theodora Hatziioannou joins the TWiV team to discuss a macaque model for AIDS, and how a cell protein that blocks HIV-1 infection interacts with double-stranded RNA. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guest: Theodora Hatziioannou Become a patron of TWiV! Links for this episode ASU-UofA Joint Virology Symposium Laboratory of Retrovirology , Rockefeller University HIV-1-induced AIDS in monkeys (Science) APOBEC3H bound to duplex RNA (Nat Comm) Center for HIV RNA studies Image: Two molecules of APOBEC3H bound to dsRNA This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. Get $30 off your first delivery and FREE SHIPPING by going to blueapron.com/twiv . This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com Weekly Science Picks Theodora - To Kill A Mockingbird </
Sun, October 22, 2017
Boston baked viruses
At Tufts University Dental School in Boston, Vincent speaks with Katya Heldwein and Sean Whelan about their careers and their work on herpesvirus structure and replication of vesicular stomatitis virus. Host: Vincent Racaniello Guests: Katya Heldwein and Sean Whelan Become a patron of TWiV! Links for this episode Crystal structure of HSV gB (Science) Crystal structure of HSV fusion regulator gH-gL (Nat Struct Mol Biol) Nuclear Exodus: Herpesviruses Lead the Way (Ann Rev Virol) VSV Pseudotypes Bearing gB, gD, gH, and gL (J Virol) Recovery of infectious VSV from cDNA clones (PNAS) Structure of the L Protein of VSV (Cell) Unique strategy for mRNA cap methylation by VSV (PNAS) Molecular architecture of VSV RNA polymerase (PNAS) This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, October 15, 2017
We haven't meth but these names ring Nobel
The TWiViridae review the 2017 Nobel Prizes for cryoEM and circadian rhythms, and discuss modulation of plant virus replication by RNA methylation. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode Truth Wins by Jonathan Yewdell ( epub or mobi ) Gabriel Victora awarded MacArthur Prize Forty Years of mRNA Splicing (CSH) 2017 Chemistry Nobel: Jacques Dubochet , Joachim Frank , Richard Henderson 2017 Physiology or Medicine Nobel: Jeffrey C. Hall , Michael Rosbash , Michael W. Young 2017 Nobel Prize in Chemistry (pdf) 2017 Nobel Prize in Physiology of Medicine (pdf) Jonathan Weiner on TWiEVO 19 RNA methylation modulates plant virus infectivity (PNAS) Letters read on TWiV 463</l
Bonus · Sat, October 14, 2017
Tear it up with David Tuller
David Tuller returns to discuss his efforts to expose the methodological and ethical problems with the PACE trial for ME/CFS. Hosts: Vincent Racaniello Guest: David Tuller Become a patron of TWiV! Links for this episode All of David's ME/CFS articles at virology blog David Tuller on Twitter Through the Shadowlands by Julie Rehmeyer Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sat, October 07, 2017
TWiV 462: Splicing RNA with Phillip A. Sharp
Vincent speaks with 1993 Nobel Laureate Phillip A. Sharp about his career and his seminal discovery of RNA splicing in mammalian cells, which changed our understanding of gene structure. Hosts: Vincent Racaniello Guest: Phillip A. Sharp Become a patron of TWiV! Links for this episode Meet the Microbiologist Sharp Laboratory Spliced segments of adenovirus late mRNA (PNAS) Video of this interview (YouTube) This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sat, September 30, 2017
Gotta trace them all!
The TWiVers discuss the declining readability of scientific texts, and review the use of self-inactivating rabies virus for tracing neural circuits. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Kathy Spindler Guest: Brianne Barker Become a patron of TWiV! Links for this episode Meet the Microbiologist TWiV 1 : West Nile Virus Decreasing readability of scientific texts (eLife) Measure text readability Tracing neural circuits with self-inactivating rabies virus (Cell) Cre driver network (NIH) Monosynaptic tracing with rabies virus (Neuron) Letters read on TWiV 461 This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com Weekly Science Picks Kathy - Best eclipse video (to date) and s olargraph Dickson - Photos by Will Eades Brianne -
Sun, September 24, 2017
Penn, a great sandbox for science
Vincent travels to the University of Pennsylvania and speaks with virologists Gary Cohen, Scott Hensley, Carolina Lopez, and Susan Weiss about their careers and their research. Host: Vincent Racaniello Guests: Gary Cohen , Scott Hensley , Carolina Lopez , and Susan Weiss Become a patron of TWiV! Links for this episode Cohen Laboratory Hensley Laboratory Lopez Laboratory Weiss Laboratory This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, September 17, 2017
Polio turns over a new leaf
The TWiV team reviews the first FDA approved gene therapy, accidental exposure to poliovirus type 2 in a manufacturing plant, and production of a candidate poliovirus vaccine in plants. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Conference on Viral Manipulation of Nuclear Processes ASM Public Outreach Fellowship Kymriah approved (PennMed) CAR T cells (NCBI) Cost of Kymriah (NYTimes) Accidental exposure to poliovirus type 2 (Eurosurveill) GAPIII (WHO) Poliovaccine candidate in plants (Nat Commun) Vertical vaccine farm ( TWiV 47 ) All picornaviruses, all the time ( TWiV 425 ) Image credit Letters read on TWiV 459 This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments fo
Sat, September 09, 2017
Saliva of the fittest
The TWiVians present an imported case of yellow fever in New York City, and explain how a dengue virus subgenomic RNA disrupts immunity in mosquito salivary glands to increase virus replication. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Conference on Viral Manipulation of Nuclear Processes Roger W. Hendrix, 74 (Pittsburgh Post-Gazette) Roger Hendrix video on TWiV #135 Yellow fever in traveler returning from Peru (MMWR) Dengue subgenomic RNA in mosquito salivary gland (PLoS Path) Image credit Letters read on TWiV 458 This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com Weekly Science Picks Kathy - Antibody validation <a href= "http://www.biotechniques.com/
Sun, September 03, 2017
The Red Queen meets the White Rabbit
Brianne returns to the TWiV Gang to discuss the distribution of proteins on the influenza viral genome, and the evolution of myxoma virus that was released in Australia to control the rabbit population. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Rich Condit Guest: Brianne Barker Become a patron of TWiV! Links for this episode First genetically engineered salmon sold in Canada Nucleoprotein on influenza virus RNA (Nucl Acids Res) Evolution of released myxoma virus in Australia (PNAS) Image credit Letters read on TWiV 457 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase - WITH FREE SHIPPING - by going to blueapron.com/twiv . This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com Weekly Science Picks Brianne - 3D printed viruses Dickson - Secrets of Schooling Alan - Making sails in the Nevada desert
Sat, August 26, 2017
Be careful of canons
Brianne joins the TWiVMasters to explain how mutations in genes encoding RNA polymerase III predispose children to severe varicella, and detection of an RNA virus by a DNA sensor. Hosts: Vincent Racaniello and Rich Condit Guest: Brianne Barker Become a patron of TWiV! Links for this episode RNA pol III mutations underlie severe varicella (J Clin Inves) Dengue virus activates cGAS by release of mitochondrial DNA (Sci Rep) Dengue virus NS2B protein targets cGAS for degradation (Nat Micr) Image credit Letters read on TWiV 456 This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com Weekly Science Picks Brianne - Up-Goer Five Challenge (related to Thing Explainer ) Rich - The Farthest: Voyager in Space and Vipassana Momma: Science Vincent - Episode of Revisionist History: The Basement Tapes Listener Pick Jennie - What Pie
Sun, August 20, 2017
Pork and Beans
Erin joins the TWiVirions to discuss a computer exploit encoded in DNA, creation of pigs free of endogenous retroviruses, and mutations in the gene encoding an innate sensor of RNA in children with severe viral respiratory disease. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Guest: Erin Garcia Become a patron of TWiV! Links for this episode DNA-based computer exploit (pdf) Inactivation of porcine endogenous retrovirus in pigs (Science) Severe viral respiratory infections in children with IFIH1 mutations (PNAS) IRF7 deficiency and severe respiratory infection ( TWiV 336 ) Image credit Letters read on TWiV 455 This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com Weekly Science Picks Erin - What If? by Randall Monroe Rich - Art.Science.Gallery ( J. Haley Gillespie ) Kathy - Astronomy photographer of the year shortlist Alan - Upcoming Eclipses Vincent - <a href= "https://youtu.be/eWMsfAPHXi0" target="_blank"
Sun, August 13, 2017
FGCU, Zika
Sharon and Scott return to TWiV for a Zika virus update, including their work on viral evolution and spread, and whether pre-existing immunity to dengue virus enhances pathogenesis. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Guests: Sharon Isern and Scott Michael Become a patron of TWiV! Links for this episode Hurricane Zika ( TWiV 410 ) 454 Corporation (Wikipedia) Regional Zika update, Americas (PAHO, WHO) Zika virus serum bank (pdf) Zika virus evolution and spread in the Americas (Nature) Multiple introductions of Zika virus in US (Nature) Inhibition of Zika Virus Replication by Wolbachia (J Virol) Zika virus pathogenesis in rhesus macaques unaffected by immunity to dengue virus (Nat Commun) Impact of flavivirus immunity on Zika virus infection in rhesus macaques (PLoS Path) Enhancement of Zika virus pathogenesis by antiflavivirus immunity (Science) No ADE by dengue antibodies in Zika virus patients (Clin Inf Dis) Oropharyngeal mucosal transmission of Zika virus in rhesus macaques (Nat Commun) <a href="http://mic
Sun, August 06, 2017
Neurovirology with Diane Griffin
From the Vector-Borne Viruses Symposium in Hamilton, Montana, Dickson and Vincent speak with Diane Griffin about her career and her work on understanding viral infections of the central nervous system. Hosts: Vincent Racaniello and Dickson Despommier Guest: Diane Griffin Become a patron of TWiV! Links for this episode Vector-Borne Viruses Symposium Diane Griffin Adoptive immunization of immunosuppressed mice infected with Sindbis virus Role of the immune response in age-dependent resistance of mice to encephalitis due to Sindbis virus Antibody-mediated clearance of alphavirus infection from neurons Persistence of viral RNA in mouse brains after recovery from acute alphavirus encephalitis Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene Bc1-2 protects mice against fatal alphavirus encephalitis This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv . Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sat, July 29, 2017
TWiV 452: Kiss that frog
Lynda Coughlan joins the weekly virtual bus companions for a discussion of a host defense peptide from frogs that destroys influenza virus, and mouse models for acute and chronic hepacivirus infection. Hosts: Vincent Racaniello , Alan Dove , and Kathy Spindler Guest: Lynda Coughlan Become a patron of TWiV! Links for this episode Linda on Virus Watch and BSGCT Anti-influenza peptide from frogs (Immunity) Magainins (Wikipedia) Urumi Kathy's defensin paper (PLoS Path) World Hepatitis Day Mouse model for hepacivirus infection (Science) Letters read on TWiV 452 Weekly Science Picks Kathy - US rivers as subway map Lynda - No Time to Lose: A Life in Pursuit of Deadly Viruses by Peter Piot Alan - Apollo-era computers found in dead engineer’s basement Vincent - 110 NFL Brains, research article in JAMA and The best science is often accidental Listener Pick Stig - Security Now! and <a href= "http://amzn.to/2vg4LNQ" ta
Sun, July 23, 2017
TWiV 451: Expectorate the unexpected
The TWiV scientists reveal that mosquitoes transmit different West Nile virus populations with each blood meal, only to have the diversity purged in a bird host. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode Driving past a milestone ( TWiP 100 ) Debug Fresno (Verily blog) What could possibly go wrong? ( TWiV 388 ) Chestnut blight (ProMedMail) Hypovirus molecular biology (Adv Virus Res) Mosquitoes transmit unique WNV populations (Cell Rep) Teaching science using pseudoscience Image credit Letters read on TWiV 451 Weekly Science Picks Kathy - Approaching Jupiter and Michigan parents about vaccination Rich - Math Limericks from Futility Closet Alan - NASA flyover of Pluto Vincent - Talk show host nominated as USDA chief scientist <h
Sun, July 16, 2017
TWiV 450: Ben tenOever and RNA out
Ben tenOever joins the TWiVoli to discuss the evolution of RNA interference and his lab's finding that RNAse III nucleases, needed for the maturation of cellular RNAs, are an ancient antiviral RNA recognition platform in all domains of life. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guest: Ben tenOever Become a patron of TWiV! Links for this episode RNAseIII is an ancient antiviral effector (Nature) Influenza suppression of RNAi (PNAS) Questioning mammalian antiviral RNAi (Nat Micro) Antiviral protection via RdRp (PLoS Path) Evolution of antiviral defense (Cell Host Micr) Letters read on TWiV 450 Weekly Science Picks Ben - Invisible Invaders by Peter Radetsky Kathy - ASV 2017 Virolympics Crossword solved (pdf) and National Museum of the Air Force Rich - Columbia river gorge and Undaunted Courage by Stephen Ambrose Dickson - All the World's Earthquakes Alan - Map of Roman roads Vincent - <a href= "http://www.hhmi.org/news
Sun, July 09, 2017
TWiV 449: The sound of non-silencing
The TWiV Council explores the finding that facial appearance affects science communication, and evidence that RNA interference confers antiviral immunity in mammalian cells. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Become a patron of TWiV! Links for this episode JMBE SciComm Issue Facial appearance affects science communication (PNAS) Your face matters to science (virology blog) RNA based antiviral immunity in mammals (Immunity) How mice say nodavirus ( TWiV 245 ) Press release on science meeting gender disparity The Traditional Lecture is Not Dead. I Would Know – I’m A Professor (virology blog) Sound of Silence by Disturbed (YouTube) Letters read on TWiV 449 Weekly Science Picks Kathy - ASV 2017 Virolympics Crossword (pdf) Dickson - The Visible Mouse Alan - Is profitable publishing bad for science? Vincent - Locally Sourced Science Listener Pick Neva - <a href= "https://www.youtube.com/watch?v=7zgQN3N_TuU" ta
Sun, July 02, 2017
TWiV 448: Mavis the Structure Maven
From ASV 2017 in Madison, Wisconsin, the complete TWiV team speaks with Mavis Agbandje-McKenna about her career and her work solving virus structures by x-ray crystallography and cryo-electron microscopy. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guest: Mavis Agbandje-McKenna Become a patron of TWiV! This episode of TWiV is sponsored by Promega Corporation. Promega is a leader in providing innovative solutions and technical support to the life science industry. The company’s 3,500 products support scientists’ worldwide to advance their knowledge in genomics, proteomics, cellular analysis, drug discovery and human identification. Founded in 1978, the company is headquartered in Madison, WI with branches in 16 countries and over 50 global distributors. Promega products are used by life scientists who are asking fundamental questions about biological processes applying their knowledge to diagnose and treat diseases or discover new therapeutics. For more information about Promega, visit www.promega.com/ASV Weekly Science Picks Kathy - Doktor Kaboom! Dickson - Mars as you've never seen it before Alan - Eclipse 2017 Rich - Sirens of Titan by Kurt Vonnegut Vincent - Research!America Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sat, June 24, 2017
TWiV 447: Un-impacting an elephant
The glorious TWiVerati un-impact their email backlog, anwering questions about viruses, viruses, viruses, viruses, viruses, and more. You should listen - our fans ask great questions! Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode JMBE SciComm Issue Female role models in engineering (PNAS) Gender equity at ASM meeting (mBio) Invisible Frontiers Time, Love, Memory The Eighth Day of Creation Predatory journals recruit fake editor Photo by Anthony Olszewski Letters read on TWiV 447 Weekly Science Picks Kathy - Oskar Fischinger Google Doodle Dickson - Ten Tiny But Terrifying Micro Monsters Alan - Hunting mammoth ivory in Siberia Rich - Occam’s razor Vincent - Blame vax for illness without proof, says EU Listener Pick Ed - <a href= "http://www.bbc.co.uk/programmes/b00bw5
Sat, June 17, 2017
TWiV 446: Old sins die hard
The TWiV hosts review an analysis of gender parity trends at virology conferences, and the origin and unusual pathogenesis of the 1918 pandemic H1N1 influenza virus. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode ASM grant writing online course Gender parity trends at virology meetings (J Virol) Professor gender perpetuates gender gap (NBER) Next generation researchers initiative (NIH) NIH abandons grant cap (Science) Genesis and pathogenesis of 1918 H1N1 influenza virus (PNAS) Image credit Letters read on TWiV 446 Weekly Science Picks Kathy - BioKids Critter Catalog Dickson - Shanghai Vertical Farm Alan - Colossal Cave Adventure open source Rich - Life on Mars (<a h
Sun, June 11, 2017
TWiV 445: A nido virology meeting
From Nido2017 in Kansas City, Vincent meets up with three virologists to talk about their careers and their work on nidoviruses. Host: Vincent Racaniello Guests: Margo Brinton , Luis Enjuanes , and Linda Saif Become a patron of TWiV! Links for this episode Murine flavivirus resistance gene (PNAS) TIA-1/TIAR binding sites in West Nile virus RNA (J Virol) Infectious coronavirus DNA in BAC (PNAS) Norovirus binding to lettuce (Appl Env Micro) This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Sun, June 04, 2017
TWiV 444: Astro Kate, The Right Stuff
From ASM Microbe 2017 at New Orleans, Vincent and Rich meet up with astronaut Kate Rubins to talk about becoming an astronaut, space travel, and doing science in space. Hosts: Vincent Racaniello and Rich Condit Guest: Kate Rubins Become a patron of TWiV! Links for this episode Live from the Space Station, NASA Astronaut Kate Rubins Kate Rubins ( NASA , Wikipedia ) Expedition 48-49 launches to the ISS Expedition 48-49 Crew Docks to the Space Station Expedition 48-49 Crew Welcomed to the Space Station Expedition 48 Crew Hands Over the Space Station to Expedition 49 Photo by Chris Condayan Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Wed, May 31, 2017
TWiV Special: Trial by Error, Continued
David Tuller returns to discuss the continuing saga of the UK's PACE trial for chronic fatigue syndrome, including the accusation that he is engaging in libelous blogging. Host: Vincent Racaniello Guest: David Tuller Become a patron of TWiV! Links for this episode TWiV 397: Trial by Error All articles by David Tuller at virology blog Getting it wrong on chronic fatigue syndrome (NY Times) Esther Crawley slide (Twitter) David's fundraising page Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, May 28, 2017
TWiV 443: On a leaf, no one can hear you scream
The TWiVsters reveal the puppet master: an RNA virus injected with wasp eggs that paralyzes the ladybug so that she protects the cocoon until the adult emerges. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode ASM grant writing online course Who is the puppet master ? (Proc Roy Soc B) Why ladybird ? Ladybird ladybird Dinocampus coccinellae Image credit Letters read on TWiV 443 Weekly Science Picks Kathy - Science Showcase Video Contest Alan - Biochemical pathways on one chart Rich - 35th America’s Cup Vincent - Viruses ( pdf ) and A whole new Jupiter Listener Pick Peter - Fake typhoid epidemic saves Polish city and Life gets complicated when disease overruns your town Ralph - Dilbert on climate change Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv</
Sun, May 21, 2017
TWiV 442: The New York Tim
Freelance science journalist Tim Requarth joins the TWiVers to explain why scientists should stop thinking that explaining science will fix information illiteracy. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Guest: Tim Requarth Become a patron of TWiV! Links for this episode Neuwrite JMBE science communication issue Smallpox vaccination day The problem with facts (Fin Times) Countering antivaccination attitudes (PNAS) Effective messages in vaccine promotion (Pediatrics) Science curiosity and political information processing (Political Psychol) Teaching science using pseudoscience (D. Duncan) Letters read on TWiV 442 Weekly Science Picks Kathy - Life Saver Lightning Alan - Model rocket engine burning in slow-mo Rich - scistarter Vincent - The quest to wipe out a virus and FCC Votes to Begin Dismantling Net Neutrality Listener Pick Robert - <a href= "https://www.dropbox.com/s/mtrmgsjnx
Sun, May 14, 2017
TWiV 441: Don't ChrY for me influenza
The Beacons of Viral Education (aka the TWiVoners) reveal a cost of being a male mouse - the Y chromosome regulates their susceptibility to influenza virus infection. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Grant Writing Online Course Giant viruses not from fourth domain of life (Virology) Nuclear envelope disruption during parvovirus infection (J Virol) Nuclear deformation during SV40 infection (Nucleus) Y chromosome regulates mouse susceptibility to influenza virus (PNAS) Consomic strains (Mamm Genome) Giants among viruses ( TWiV 261 ) Image credit Letters read on TWiV 441 Weekly Science Picks Kathy - Social science research on “luck” in motherhood Alan - Foiling dinghy built by engineering students ( video ) Rich - Human Exploration Research Analog (HERA) Vincent - Make measles great again in Michigan and
Sun, May 07, 2017
TWiV 440: I hardly noumeavirus
No problem being nice to Dickson in this episode, because he's absent for a discussion of a new giant virus that replicates in the cytoplasm yet transiently accesses the nucleus to bootstrap infection. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe Noumeavirus cytoplasmic replication depends on transient nuclear access (Nat Commun) Giants among viruses ( TWiV 261 ) Image credit Letters read on TWiV 440 Weekly Science Picks Kathy - U-M Rubik’s Cube story #1 video #2 video #3 video Alan - You're not going to believe this Rich - High School student builds robot to solve Rubrik's cube Vincent - NIH limits grant money and The abomination of a bill Listener Pick Ken - The Fab Lab with Crazy Aunt Lindsey L
Sun, April 30, 2017
TWiV 439: The purloined envelope
Paul Bieniasz joins the TWiV team to talk about the co-option, millions of years ago, of an endogenous retrovirus envelope protein by hominid ancestors for host defense against viral infection. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guest: Paul Bieniasz Become a patron of TWiV! Links for this episode ASM Grant Writing Online Course Bieniasz Laboratory Julius S. Youngner, 96 Distinguished virology career of Julius S. Youngner ( TWiV 373 ) Reconstitution of a human ERV (PNAS) Co-option of ERV envelope for host defense (eLife) Letters read on TWiV 439 Weekly Science Picks Kathy - UM Science Communication TeachOut Alan - LLNL nuclear test videos Rich - The Great A.I. Awakening ( Artificial neural network ; DeepDream ; Dee
Sun, April 23, 2017
TWiV 438: Drs. TWiV go to Washington
On the eve of the March for Science, the TWiV team gathers at ASM Headquarters in Washington, DC with guests Stefano and Susie to talk about the state of science communication. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Rich Condit Guests: Stefano Bertuzzi and Susan Sharp Become a patron of TWiV! Links for this episode Journal of Microbiology & Biology Education sci comm issue ASM Cultures Stefano Bertuzzi and the scientists' big picture (Washington Post) March for Science The March for Science (NY Times) I have always marched for science (virology blog) A scientist who studies marches on the March (Atlantic) What exactly are people marching for (Atlantic) Explaining science won't fix information illiteracy Letters read on TWiV 438 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv Week
Sun, April 16, 2017
TWiV 437: Kathy's new spindle virus
The TWiVsters reveal new giant viruses that argue against a fourth domain of life, and discovery of viruses in the oceanic basement. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode Journal of Microbiology & Biology Education sci comm issue Mark Wainberg dies Giant viruses with many translation system components (Science) Viruses in the oceanic basement (mBio) 2-back test Photo by Judy Letters read on TWiV 437 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv Weekly Science Picks Kathy - Cloud appreciation society Rich - High Rise Urban Farming Dickson - Planets orbiting a distant star Vincent - TWiEVO 18: Raiders of the lost orco Listener Pick Kevin - Cherry blossoms at Brooklyn Botanical Garden Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, April 09, 2017
TWiV 436: Virology above Cayuga's waters
Host: Vincent Racaniello Guests: Susan Daniel , Colin Parrish , and Gary Whittaker At Cornell University in Ithaca, New York, Vincent speaks with Susan, Colin, and Gary about the work of their laboratories on parvoviruses, influenza viruses, and coronaviruses that infect dogs, cats, horses and other mammals. Become a patron of TWiV! Links for this episode Daniel Laboratory Parrish Laboratory Whittaker Laboratory This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sun, April 02, 2017
TWiV 435: Two virus particles walk into a cell
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVome discuss the blood virome of 8,420 humans, and thoroughly geek out on a paper about the number of parental viruses in a plaque. Become a patron of TWiV! Links for this episode ASM Grant Writing Course Screwworm letters Blood DNA virome of 8,240 humans (PLoS Path) Plaque co-infection frequencies (mBio) Ode to a plaque ( TWiV 68 ) Counting viruses (Virus Watch) First animal virus plaque assay (J Exp Med) Letters read on TWiV 435 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv Weekly Science Picks Alan - Couple donates insect collection Kathy - Why is science important to you? Rich - Hook Dickson - Ten Incredible Astronomy Pictures Vincent - Why Trum
Sun, March 26, 2017
TWiV 434: Live long and pupate
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler The esteemed TWiVumvirate reveal the discovery of a new negative stranded RNA virus of wasps that regulates longevity and sex ratio of its parasitoid host. Become a patron of TWiV! Links for this episode ASM Microbe 2017 Parasitoid wasp virus regulates sex ratio (PLoS Path) What is a contig ? Image credit Letters read on TWiV 434 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv Weekly Science Picks Alan - The Wrath of Khan from Bug Chicks Kathy - Boaty McBoatface submarine launching Dickson - Fierce animal portraits Vincent - Westworld Listener Picks Hannah - Plague, Inc Stig - John Oliver: Trump vs the truth Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv
Sat, March 18, 2017
TWiV 433: Poops viruses and worms
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler The lovely TWiV team explore evolution of our fecal virome, and the antiviral RNA interference response in the nematode C. elegans . Become a patron of TWiV! Links for this episode ASM Clinical Virology Symposium Evolution of the human fecal virome (PNAS) Antiviral RNAi response in C. elegans (Curr Biol) Orsay virus ( TWiV 123 ) Broad VSV host range (J Comp Neurol) Image credit Letters read on TWiV 433 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv Weekly Science Picks Alan - Contact information for Senators and Representatives Kathy - How Tumor Virology Transformed Oncology Dickson - Seven new species of Peacock Spider Vincent - Proposed NIH budget cut and <a href= "https://www.nytimes.com/2017/03/16/us/oxford-comma-lawsuit.html?ribbon-ad-idx=4&src=trending&module=Ribbon&
Sun, March 12, 2017
TWiV 432: Conjunction junction, what's your function?
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler The TWiVites discuss Zika virus seroprevalence in wild monkeys, Zika virus mRNA vaccines, and a gamete fusion protein inherited from viruses. Become a patron of TWiV! Links for this episode Nido2017 Meeting ASMCUE Seroprevalence of Zika virus in wild monkeys and baboons (mSphere) Zika virus mRNA vaccines ( paper one , paper two ) Gamete fusion protein is type II viral fusogen ( paper one , paper two ) Image credit Letters read on TWiV 432 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv Weekly Science Picks Alan - Raspberry pi Kathy - The Worst F&#%ing Words Ever Dickson - NASA images of climate change Brianne - How herd immunity works Vincent - Radioactive boars in Fukushima Listener Pick Margaret - <a href= "http://www.ravelry.com
Sun, March 05, 2017
TWiV 431: Niemann-Pick of the weak
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVirions reveal bacteriophage genes that control eukaryotic reproduction, and the biochemical basis for increased Ebolavirus glycoprotein activity during the recent outbreak. Become a patron of TWiV! Links for this episode Nido2017 Meeting ASM Microbe 2017 Mark Buller obituary RS virus pipeline ( pdf ) Prophage WO genes and cytoplasmic incompatibility (Nature) Vanderbilt Virology ( TWiV 332 ) Basis for increased Ebolavirus glycoprotein activity (Cell Host Micr) Letters read on TWiV 431 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv Weekly Science Picks Rich - Germ Theory by Robert P. Gaynes Alan - Student Scientist Partnerships Kathy - Symbiartic Dickson - PaleoBioDB Navigator Vincent - Kusama Infinity Room <
Sun, February 26, 2017
TWiV 430: The persistence of herpesvirus
Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Kathy Spindler The TWiX cabal discuss sexual transmission of Zika virus in mice, and how immune escape enables herpes simplex virus escape from latency. Become a patron of TWiV! Links for this episode Nido2017 Meeting ASM Clinical Virology Symposium Zika virus sexual transmission in mice (Cell Rep) Viral RNA is not infectious virus (virology blog) Methyl-phospho switch (TWiV 369) Immune escape of herpesvirus from latency (Cell Rep) Restarting lytic gene expression (J Virol) Letters read on TWiV 430 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv Weekly Science Picks Rich - Vipassana Momma ( Dravet Syndrome ) Kathy - Landlines Chrome Experiments Dickson - Origami Revolution Vincent - <a href= "https://www.nytimes.com/2017/02/17/science/santiago-ramon-y-cajal-beautiful-brain.html?hp&action=click&pgtype=Homepage&clickSource=story-he
Sun, February 19, 2017
TWiV 429: Zika Experimental Science Team
Host: Vincent Racaniello Guests: Katie Antony, Tom Friedrich , Emma Mohr, and David O'Connor Vincent meets with members of team ZEST at the University of Wisconsin Madison to discuss their macaque model for Zika virus pathogenesis. Become a patron of TWiV! Links for this episode Badgers Go Viral ( TWiV 260 ) Rhesus macaque model of Zika virus infection (Nat Commun) Heterologous Zika virus protection in macaques (PLoS NTD) ZEST Data Portal This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twiv Send your virology questions and comments to twiv@microbe.tv
Sun, February 12, 2017
TWiV 428: Lyse globally, protect locally
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVsters explain how superspreader bacteriophages release intact DNA from infected cells, and the role of astrocytes in protecting the cerebellum from virus infection. Become a patron of TWiV! Links for this episode Nido2017 Meeting Superspreader bacteriophages (mBio) Astrocytes , interferon, and viral infection (JCI) Viral disruption of blood brain barrier (Trends Micro) On Warts by Lewis Thomas ( pdf ) Letters read on TWiV 428 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twiv Weekly Science Picks Alan - Skulls Unlimited Rich - Bernard Moss Reflection Kathy - Why vaccines don't cause autism Dickson - Honomobo Vincent - Trump vs FDA Send your virology questions and comments to twiv@microbe.tv
Wed, February 08, 2017
TWiV Special: Vincent Munster on MERS-coronavirus and Ebolavirus
Host: Vincent Racaniello Guest: Vincent Munster At the Rocky Mountain Laboratory in Hamilton, Montana, Vincent speaks with Vincent Munster about the work of his laboratory on MERS-coronavirus and Ebolaviruses. Become a patron of TWiV! Links for this episode Rocky Mountain Laboratory Munster Laboratory Small town, big science ( TWiM 140 ) Image credit Send your virology questions and comments to twiv@microbe.tv
Sun, February 05, 2017
TWiV 427: It was a DURC and UV light
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler The TWiVoids discuss the March for Science, the GOF moratorium, and a classic virology paper on mapping the gene order for vesicular stomatitis virus. Become a patron of TWiV! Links for this episode ASM 2017 election is now open - VOTE HERE ASM Election questions: Which positions are we voting for? What is the ASM Board of Directors? Organization Chart What is the Council on Microbial Sciences? Organization Chart FAQs Scientists' march is bad idea (NY Times) GOF moratorium lifted (Archived White House) VSV gene order (PNAS) VSV gene order later (PNAS) Letters read on TWiV 427 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twiv Weekly Science Picks Alan - <a href= "http://nerdist.com/neil-gaiman-and-terry-pratchetts-good
Sun, January 29, 2017
TWiV 426: I'm Axl, and I'll be your cervid today
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler The sages of TWiV explain how chronic wasting disease of cervids could be caused by spontaneous misfolding of prion protein, and the role of the membrane protein Axl in Zika virus entry into cells. Become a patron of TWiV! Links for this episode Register for ASV 2017 ASM 2017 election is now open - VOTE HERE ASM Election questions: Which positions are we voting for? What is the ASM Board of Directors? Organization Chart What is the Council on Microbial Sciences? Organization Chart FAQs Scientists March on Washington Spontaneous generation of unique cervid strain (mSphere) Zika virus entry into human glial cells via Axl (Cell Rep) Article collections: PNAS , Cell , Nature , Virology Letters read on TWiV 426 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe deli
Sun, January 22, 2017
TWiV 425: All picornaviruses, all the time
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVaniellos discuss a thermostable poliovirus empty capsid vaccine, and two cell genes that act as a switch between entry and clearance of picornavirus infection. Become a patron of TWiV! Links for this episode Register for ASV 2017 ASM-ASV Conference on Interplay of Viral and Bacterial Pathogens XKCD #242 Thermostable poliovirus empty capsid vaccine (PLoS Path) Switch between viral entry and clearance (Nature) Glass poliovirus by Jason Roberts Letters read on TWiV 425 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twiv . Weekly Science Picks Alan - Medical lab whirligig Dickson - Antarctica's Colorful Underwater World Kathy - Prince Rupert’s drops #1 and #2 Rich - Dylan's 30th - Eric Clapton --Don’t Think Twice, It’s All R
Sun, January 15, 2017
TWiV 424: FLERVergnügen
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guest: Trudy Rey Trudy joins the the TWiVlords to discuss new tests for detecting prions in the blood, and evidence showing that foamy retroviruses originated in the seas with their jawed vertebrate hosts at least 450 million years ago. Become a patron of TWiV! Links for this episode Welcome omega tau to MicrobeTV Register for ASV 2017 Oliver Smithies dies Assays for prions in the blood ( one , two ) Biosafety working on prions (Michigan State) Marine origin of retroviruses in Palaeozoic era (Nature Comm) Cancer Virus by Dorothy Crawford Adenovirus and obesity (Int J Chronic Dis) Image credit Letters read on TWiV 424 Weekly Science Picks Trudy - Artist Jenni Viljaniemi Alan - Radio Garden Dickson - World's First Green Energy Boat Kathy</stron
Sun, January 08, 2017
TWiV 423: Dry, well formed, and light brown
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guest: Jared Rice The TWiV academia discuss induction of diarrhea by the capsid protein of an astrovirus, and association of a fungal RNA virus with white-nose syndrome of North American bats. Become a patron of TWiV! Links for this episode Register for ASV 2017 ASM-ASV Conference on Interplay of Viral and Bacterial Pathogens Astrovirus capsid protein induces diarrhea (mBio) Fungal virus associated with white-nose syndrome (PLoS Path) Image credit Letters read on TWiV 423 Weekly Science Picks Alan - GPS visualizer Dickson - James Webb Space Telescope and The Vertical Farm Kathy - First Snowflake Photos ( One and Two ) Rich - Red Mars by Kim Stanley Robinson Vincent - Carrie Fisher Fought for the Rebel Alliance and Mental Health Awareness Listener Pick Ken</st
Sun, January 01, 2017
TWiV 422: Watching the icosahedron drop
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVestigators wrap up 2016 with a discussion of the year's ten compelling virology stories. Become a patron of TWiV! Should auld infections be forgot And never T-cells primed? Will cross-reacting antigens Protect the host next time? Links for this episode Register for ASV 2017 ASM-ASV Conference on Interplay of Viral and Bacterial Pathogens Ten virology stories from 2016 Zika virus (first covered in 2015, TWiV 368 ) Ebolavirus Eukaryotic genes in Wolbachia phage ( TWiV 412 ) Harold "400" Varmus ( TWiV 400 ) and many other guests Vaccines Mutualism Mosquitoes and viruses Vector victorious ( TWiV 401 ) Animal models of virus infections Virus evolution Current Zika virus infections (ECDC) Early Zika virus infections in Hawaii (PLoS NTD) Zika virus vaccine for whom? (NYTimes) Final results for Ebola virus vaccine (Lancet) Photo from Mohammad Letters read on TWiV 422 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from
Sun, December 25, 2016
TWiV 421: Like flies on shot
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guest: Nathan Letts The TWiVnauts present another example of an infectious but replication incompetent vaccine, an insect specific arborvirus bearing chikungunya virus structural proteins. Become a patron of TWiV! Links for this episode Register for ASV 2017 ASM-ASV Conference on Interplay of Viral and Bacterial Pathogens Chikungunya virus vaccine using insect virus platform (Nat Med) Ebola vaccine results ( NYTimes , paper ) Letters read on TWiV 421 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. Weekly Science Picks Alan - Open Access Button Dickson - National Geographic Photographs Kathy - World's Tiniest Radio Receiver Nathan - Mutter Museum, Philadelphia Vincent<
Sun, December 18, 2016
TWiV 420: Orthogonal vectors
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiV gurus describe how to use an orthogonal translation system to produce infectious but replication-incompetent influenza vaccines. Become a patron of TWiV! Links for this episode Register for ASV 2017 Local Zika virus transmission in Texas Texaszika.org Local dengue virus transmission in Texas (EID) No more Zika virus transmission in Florida (FL DOH) Dengue virus antibodies enhance Zika virus infection (Clin Trans Imm) Infectious, replication incompetent influenza virus vaccine (Science) Pyrrolysl-tRNA synthetase (Biochem Biophys Acta) History of nonsense suppression (Stan Maloy) Suppression of poliovirus amber mutant (Cell) Remembering mumps (PLoS Path) Letters read on TWiV 420 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. Weekly Science Picks Alan - Superbugs game <b
Sun, December 11, 2016
TWiV 419: The selfless gene
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVrific gang reveal how integration of a virophage into the nuclear genome of a marine protozoan enhances host survival after infection with a giant virus. Become a patron of TWiV! Links for this episode Microcephaly associated with Zika virus infection in Colombia (MMWR) Virophage genome integration and activation by superinfection (Nature) Don Nelson interview (pdf) Page view and h index for paper rank (PLoS One) Credit for image of C. roenbergensis Letters read on TWiV 419 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. Weekly Science Picks Alan - Lab Wars Dickson - Star in a Jar Fusion Reactor Rich - You're a Bee. This is What it Feels Like. Kathy - List of Potential Predatory Journals Vincent - <a href= "https://www.statnews.com/2016/12/06/crispr-court-hearing-br
Sun, December 04, 2016
TWiV 418: Of mice and MERS
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVsters describe a new animal model for MERS coronavirus-induced acute respiratory distress syndrome, produced by CRISPR/Cas9 editing of the mouse gene encoding an ortholog of the virus receptor. Become a patron of TWiV! Links for this episode New mouse model for MERS (Nat Micro) RNA-guided genome engineering (Science) Photo by Finny Letters read on TWiV 418 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 27:50 This show is sponsored by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. This Holiday season give someone a Drobo to keep all their files and memories safe forever. TWiV listeners can save 20% or more off of their purchase of a Drobo 5D, Drobo 5Dt, Drobo 5N, or any 8-drive or 12-drive system at www.drobostore.com by December 31, 2016 using discount code MICROBE20. Register for ASV 2017 at Madison, Wisconsin Weekly Science Picks Alan - Human population through time Dickson - Every Orbit Cassini Has Taken Rich - OK GO: Walk Her Walk Kathy - M
Thu, December 01, 2016
TWiV Special: Gary Nabel on World AIDS Day 2016
Host: Vincent Racaniello Guest: Gary Nabel Vincent speaks with Gary Nabel, Chief Scientific Officer at Sanofi and former Director of the Vaccine Research Institute of NIAID, about his career and his work on HIV vaccines. Become a patron of TWiV! Links for this episode World AIDS Day Video of this interview (YouTube) Send your virology questions and comments to twiv@microbe.tv
Sun, November 27, 2016
TWiV 417: O is the loneliest letter
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The Fellowship of the Virus trace the early history of HIV in North America, based on genome sequences obtained from late 1970s archival sera, which also reveal that Gaetan Dugas was not Patient Zero. Become a patron of TWiV! Links for this episode WHO: Zika virus is no longer a PHEIC World AIDS Day Early HIV/AIDS history in North America (Nature) Dugas was not AIDS patient zero (virology blog) Image credit Letters read on TWiV 417 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm Register for the 2017 ASM Grant Writing Online course . Weekly Science Picks Alan - VP8SGI <str
Sun, November 20, 2016
TWiV 416: Scattered seeds dormant
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The multi-dimensional TWiV-brane bring you the entries in the haiku/limerick contest, and explain how a giant virus infects a host within another host (it has to do with predators!). Become a patron of TWiV! Links for this episode Predators allow virus infection of endosymbiont (PNAS) Image credit Letters read on TWiV 416 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 1:34:40 Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm 5:05 Register for the 2017 ASM Grant Writing Online course . Weekly Science Picks Alan - Cubes in Space Dickson - The Architecture of Eden by H. Pearlman and A. Whalley Rich - Studying the building blocks of life in stereo ( <a href= "http://www.heliyon.c
Sun, November 13, 2016
TWiV 415: Ebola pipettors and the philosopher's clone
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Guests: Jeremy Luban , Aaron Lin , and Ted Diehl Jeremy, Aaron, and Ted join the TWiV team to discuss their work on identifying a single amino acid change i n the Ebola virus glycoprotein from the West African outbreak that increases infectivity in human cells. Become a patron of TWiV! Links for this episode Ebola virus glycoprotein with increased infectivity (Cell) Effect in cells of Ebola virus mutations from West African outbreak (Cell) Ebola virus in semen for over 500 days (Clin Inf Dis) Puzzling origin of 2014 Ebola virus outbreak (J Virol) Mutant Ebola virus may have caused explosive outbreak (Goats and Soda) Virus Genomics and Evolution website This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 1:05:40 Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm 1:35 Register for the 2017 ASM Grant Writing Online course . Weekly Science Picks Jeremy – Real time tracking of Ebola vir
Sun, November 06, 2016
TWiV 414: Zika in the guys with Diamond
Host: Vincent Racaniello Guest: Michael Diamond Michael Diamond visits the TWiV studio to talk about chikungunya virus and his laboratory's work on a mouse model of Zika virus, including the recent finding of testicular damage caused by viral replication. Become a patron of TWiV! Links for this episode Chikungunya virus chronic joint disease caused by adaptive response (J Virol) Mouse model of Zika virus pathogenesis (Cell Host Micr) Zika virus infection during mouse pregnancy (Cell) Zika virus infection damages mouse testes (Nature) Uveitis and Zika virus in tears in mice (Cell Rep) This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm Register for the 2017 ASM Scientific Writing and Publishing Online Course . Send your virology questions and comments to twiv@microbe.tv
Sun, October 30, 2016
TWiV 413: Partnerships not parachutes
Hosts: Vincent Racaniello, Alan Dove , and Paul Duprex Guests: Ralph Baric , Felix Drexler , Marion Koopmans , and Stacey Schultz-Cherry From the EIDA2Z conference at Boston University, Vincent, Alan and Paul meet up with Ralph Baric, Felix Drexler, Marion Koopmans, Stacey Schultz-Cherry to talk about discovering, understanding, protecting, and collaborating on emerging infectious diseases. Become a patron of TWiV! Links for this episode EIDA2Z meeting MERS-CoV infection of Alpaca (EID) Origins of HAV in small mammals (PNAS) WHO recommendations on influenza vaccine composition Collaborative Cross mice Video of this episode at YouTube This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100. Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For mo
Sun, October 23, 2016
TWiV 412: WO, open the borders and rig the infection
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Guest: Mark Fuccio The TWiVome reveal the first eukaryotic genes found in a bacteriophage of Wolbachia , and how DNA tumor virus oncogenes antagonize sensing of cytoplasmic DNA by the cell. Become a patron of TWiV! Links for this episode Zika virus in vaginal secretions (EID) Zika virus in semen (EID) Eukaryotic genes in a bacteriophage (Nat Commun) Seth Bordenstein on TWiV 332 DNA tumor virus oncogenes antagonize cGAS-STING (Science) Letters read on TWiV 412 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100. Weekly Science Picks Mark - EFN Enterprise Futures Network and Mission Log Podcast Alan - 2016 Wildlife Comedy Photography Rich - <a href= "http://www.zutalabs.com/wp-content/uploads/2015/11/PocketPrinter-Segment-on-Vimeo.mp4?_=2" target=
Sun, October 16, 2016
TWiV 411: Chicken runs
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler The TWiVeroos examine a reverse spillover of Newcastle disease virus vaccines into wild birds, and identification of a protein cell receptor for murine noroviruses. Become a patron of TWiV! Links for this episode MicrobeTV Store Florida DOH Daily Zika Update Zika virus in new Miami neighborhood ( CNN , NYTimes ) NDV vaccine virus in wild birds (PLoS One) Protein cell receptor for murine norovirus ( Science , PNAS ) Poliovirus receptor analysis (J Virol) Letters read on TWiV 411 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at <a href="http://www.drobostore.com" target="_blank
Sun, October 09, 2016
TWiV 410: Hurricane Zika
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Guests: Sharon Isern and Scott Michael Sharon and Scott join the TWiV team to talk about their work on dengue antibody-dependent enhancement of Zika virus infection, and identifying the virus in mosquitoes from Miami. Become a patron of TWiV! Links for this episode Live at Florida Gulf Coast University ( TWiV #111 ) Florida DOH Daily Zika Update Regional Zika update, Americas (PAHO, WHO) NJ Zika Bill Dengue virus antibodies enhance Zika virus infection (bioRxiv) First detection of Zika virus in Brazilian A. aegyptii (Mem Inst Oswaldo Cruz) 2017 ASM Scientific Writing and Publishing Online Course Letters read on TWiV 410 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect y
Sun, October 02, 2016
TWiV 409: A Nef is enough
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guest: Jeremy Luban Jeremy joins the TWiVeroids to tell the amazing story of how the function of the HIV-1 protein called Nef was discovered and found to promote infection by excluding the host protein SERINC from virus particles. Become a patron of TWiV! Links for this episode No recovery in PACE trial (virology blog) The real PACE data (virology blog) Contagious Thinking Florida DOH daily Zika update Congress does not fail on Zika (NPR) Nef history (Luban lab) Nef excludes SERINC from virions (Nature) SERINC counters Nef (Nature) ASM Grant Writing Online Course Letters read on TWiV 409 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code
Sun, September 25, 2016
TWiV 408: Boston Quammens
Hosts: Vincent Racaniello and Alan Dove Guest: David Quammen Four years after filming 'Threading the NEIDL', Vincent and Alan return to the National Emerging Infectious Diseases Laboratory BSL4 facility at Boston University where they speak with science writer David Quammen. Watch this episode at YouTube Become a patron of TWiV! Links for this episode David Quammen's website Spillover by David Quammen Threading the NEIDL (TWiV 200) The NEIDL at Boston University This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100. Send your virology questions and comments to twiv@microbe.tv
Wed, September 21, 2016
TWiV 407: Tar Heels go viral, part two
Host: Vincent Racaniello Guests: Ralph Baric , Kristina De Paris , Tal Kafri , Helen Lazear , Mark Heise , and David Margolis In the second of two shows recorded at the University of North Carolina in Chapel Hill, Vincent meets up with faculty members to talk about how they got into science, their research on RNA viruses, and what they would be doing if they were not scientists. View video of this episode at YouTube Become a patron of TWiV! This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100. Send your virology questions and comments to twiv@microbe.tv
Sun, September 18, 2016
TWiV 407: Tar Heels go viral, part one
Host: Vincent Racaniello Guests: Dirk Dittmer , Cary Moody , Nat Moorman , Nancy Raab-Traub , Lishan Su , and Jennifer Webster-Cyriaque In the first of two shows recorded at the University of North Carolina in Chapel Hill, Vincent meets up with faculty members to talk about how they got into science, their research on DNA viruses, and what they would be doing if they were not scientists. View video of this episode at YouTube Become a patron of TWiV! This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100. Send your virology questions and comments to twiv@microbe.tv
Sun, September 11, 2016
TWiV 406: Pow, right in the enteroids!
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiV team discussed eye infections caused by Zika virus, failure of Culex mosquitoes to transmit the virus, and replication of norovirus in stem cell derived enteroids. Become a patron of TWiV! Links for this episode Florida DOH daily Zika update Congress fails again on Zika (NY Times) Culex pipiens does not support Zika virus replication (EID) Zika virus in the eye (Cell Rep) Norovirus replication in enteroids (Science) Norovirus replication in B cells ( TWiV 312 ) Baylor press release Norovirus replication in B cells confirmed (Antiviral Res) Letters read on TWiV 406 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit <a href="http://ww
Sun, September 04, 2016
TWiV 405: All the world's a phage
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler The TWiXers discuss a study on vertical transmission of Zika virus by Aedes mosquitoes, and uncovering Earth's virome by mining existing metagenomic sequence data. Become a patron of TWiV! Links for this episode Roger Tsien , 64 (UC San Diego Health) CDC running out of Zika money (NYTimes) Zika virus in Miami mosquitoes (NYTimes) No Zika virus in Rio Olympics (NYTimes) Vertical transmission of Zika virus in Aedes aegypti (AJTMH) Uncovering Earth's virome (Nature) Image credit (Global water volume) Letters read on TWiV 405 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiosityst
Sun, August 28, 2016
TWiV 404: Not found
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Rich Condit From the twiVivants, follow up on FluMist and Zoster vaccines, Zika virus update, and isolation of a multicomponent animal virus from mosquitoes. Become a patron of TWiV! Links for this episode FluMist problem (FDA) DA Henderson obituary (NY Times) DA Henderson, smallpox eradicator (TWiV Special) Efficacy of VZV vaccine (Ther Adv Vaccines) Zika virus burden, Puerto Rico (JAMA) Zika virus in Miami Beach (STAT) Congenital brain anomalies and Zika virus (Radiology) Congenital Zika syndrome with arthrogryposis (BMJ) Multicomponent animal virus from mosquitoes (Cell Host Microbe) Breaking rules of infection (NPR) Image credit Letters read on TWiV 404 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. This episode is also
Tue, August 23, 2016
TWiV Special: DA Henderson, smallpox eradicator
Donald “D.A.” Henderson, a physician, educator, and epidemiologist who led the World Health Organization’s campaign to eradicate smallpox, died at 87 years of age on Aug. 19, 2016. Vincent was fortunate to have the opportunity to speak with DA Henderson in 2014 about his career, the smallpox eradication effort, and what it means for the eradication of polio. Become a patron of TWiV! This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100. Send your virology questions and comments to twiv@microbe.tv
Sun, August 21, 2016
TWiV 403: It's not easy being vaccine
Hosts: Vincent Racaniello , Alan Dove , and Rich Condit The TWiV team takes on an experimental plant-based poliovirus vaccine, contradictory findings on the efficacy of Flumist, waning protection conferred by Zostavax, a new adjuvanted subunit zoster vaccine. Become a patron of TWiV! Links for this episode Tribunal orders release of PACE trial data (Valerie Eliot Smith) Our request for PACE trial data (virology blog) GM mosquito release on ballot (NPR) Florida Keys Mosquito Control District on TWiV #111 Cold chain and virus free plant based polio vaccine (Plant Biotechnol J) Disappointing flu vaccine effectiveness (CBC) ACIP votes down use of LAIV (CDC) LAIV as effective as inactivated flu vaccine (Ann Int Med) Flumist does work (NPR) Declining effectiveness of zoster vaccine (J Inf Dis) Efficacy of adjuvanted subunit zoster vaccine (NEJM) Risk of zoster from vaccine (J Inf Dis) Image credit: ViralZone Letters read on TWiV 403 This episode is brought to you by CuriosityStream, a subscription
Sun, August 14, 2016
TWiV 402: The plight of the bumblebee
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Rich Condit Polio returns to Nigeria, Zika virus spreads in Miami, and virus infection of plants attracts bumblebees for pollination, from the virus gentlepeople at TWiV. Become a patron of TWiV! Links for this episode Marian Horzinek , 80 (ProMedMail) Polio in Nigeria ( Atlantic , Stat , ProMedMail ) Zika virus spreads in Miami (NYTimes) More Zika virus vaccines (Science) Back to work on Zika, Congress ! (Asbury Park Press) Lack of funding will stymie Zika vaccines (Wash Examiner) FDA OK on genetically modified mosquitoes (FDA) CMV attracts aphid vectors ( TWiV #70 ) CMV attracts pollinating bumblebees (PLoS Path) Earth dwarfed by solar flare (jpg) Letters read on TWiV 402 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at <a href="http://curiosi
Sun, August 07, 2016
TWiV 401: Vector victorious
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Zika virus spreads in the USA, a Zika virus DNA vaccine goes into phase I trials, and how mosquito bites enhance virus replication and disease, from the friendly TWiFolk Vincent, Dickson, Alan, and Kathy. Become a patron of TWiV! Links for this episode Beverly Griffin, 86 ( 1 2 3 ) Zika virus in the US (CDC) Zika virus spreading in Miami (CDC) Zika virus in Florida (NY Times) NIH begins phase I trial of Zika virus DNA vaccine (NIAID) Mosquito salive enhances West Nile replication in mice (J Virol) Mosquito bites enhance virus infection (Immunity) Photo of A. aegyptii and mouse ears from Marieke Pingen Letters read on TWiV 401 This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. This episode is also brought to you by Drobo, a family of safe, expandable, y
Sun, July 31, 2016
TWiV 400: Harold '400' Varmus, a scientist for all seasons
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guest: Harold Varmus The TWiV team is together in New York City for a conversation with Nobel Laureate Harold Varmus about his remarkable career in science. Become a patron of TWiV! Links for this episode Varmus Laboratory Varmus and Kandel on Charlie Rose (transcript) Rescuing biomedical research Letters read on TWiV 400 Video of this episode at YouTube This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE. This episode was made possible by PLoS Pathogens - the leading Open Access journal to publish breakthroughs in understanding pathogens and their interactions with host organisms and each other. PLOS Pathogens fosters the open exchange of ideas across fields, publishing original research on viruses, bacteria, fungi, parasites, and prions. For more information, check out www.plospathogens.org Weekly Science Picks Alan - A year on Earth Rich - TWiV #1: West Nile Virus Dickson - Chasing storms, chasing beauty Kathy - Bioartography and FASEB image and video compet
Sun, July 24, 2016
TWiV 399: Zika la femme
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Rich Condit The latest Zika virus news from the ConTWiVstadors, including a case of female to male transmission, risk of infection at the 2016 summer Olympics, a DNA vaccine, antibody-dependent enhancement by dengue antibodies, and sites of replication in the placenta. Links for this episode Zika virus disease in the US (CDC) Female to male Zika virus transmission (CDC) Zika virus in female genital tract (Lancet) Zika virus transmission in Utah ( CDC and NYTimes ) Olympic Zika virus risk (CDC) 15 companies on Zika virus vaccines (WSJ) Zika virus DNA vaccine in mice (Nature) Zika virus disease in Colombia (NEJM) Dengue virus antibody dependent enhancement of Zika virus (PNAS) Zika virus antibodies enhance dengue virus disease (Science) Zika virus in human placenta and developing brain (bioRxiv) Zika virus targets different human placenta cells (Cell Host Microbe) Letters read on TWiV 399 This episode is sponsored by CuriosityStream. Get two months free when you sign up at
Sun, July 17, 2016
TWiV 398: Permission to be intuitive
Host: Vincent Racaniello Guest: Sandy Weller Vincent speaks with Sandy Weller about her career and her work on the mechanisms of synthesis, maturation and cleavage and packaging of viral DNA genomes. Become a patron of TWiV! Links for this episode Cell killing by avian leukosis virus (Sandy's first paper, J Virol) ND10 protein and herpes simplex virus replication (J Virol) Recombination promoted by DNA viruses (Ann Rev Micro) HSV-1 and DNA damage response (Fut Virol) Video of this episode at YouTube This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE. Send your virology questions and comments to twiv@microbe.tv
Sun, July 10, 2016
TWiV 397: Trial by Error
Host: Vincent Racaniello Guest: David Tuller Vincent speaks with David Tuller about flaws in the U.K's $8 million PACE trial for chronic fatigue syndrome, and efforts to have the trial data released. Become a patron of TWiV! Links for this episode Science and journalism ( TWiV 111 ) Chronic fatigue syndrome and the CDC (virology blog) PACE trial (Lancet) Trial by error part one , two , three (virology blog) PACE economics analysis (PLoS One) All articles by David Tuller at virology blog Valerie Eliot Smith's blog Karina Hansen , prisioner of Denmark This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE. Send your virology questions and comments to twiv@microbe.tv
Sun, July 03, 2016
TWiV 396: Influenza viruses with Peter Palese
Host: Vincent Racaniello Guest: Peter Palese Vincent speaks with Peter Palese about his illustrious career in virology, from early work on neuraminidases to universal influenza virus vaccines. Become a patron of TWiV! Links for this episode Palese Laboratory Pig kidney neuraminidase (Hoppe Seylers Z Physiol Chem) DNAse in cytoplasmic DNA virus (Virology) Inhibitor of influenza virus neuraminidase (Virology) Influenza neuraminidase defective mutants (Virology) Swine influenza virus of 1976 RNA pattern (Nature) 1977 influenza H1N1 similar to 1950s strains (Nature) H5N1 influenza : Facts, not fear (PNAS) Influenza HA stalk immunity in ferrets (J Virol) This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE. Send your virology questions and comments to twiv@microbe.tv
Sun, June 26, 2016
TWiV 395: The cancer thief
Hosts: Vincent Racaniello, Rich Condit , and Kathy Spindler Guest: Stephen J. Russell From ASV 2016 at Virginia Tech, Vincent, Rich and Kathy speak with Stephen Russell about his career and his work on oncolytic virotherapy - using viruses to treat cancers. Become a patron of TWiV! Links for this episode Hokies go viral ( TWiV 285 ) MV NIS de Myelo ( TWiV 298 ) Remission of disseminated myeloma after MV treatment (Mayo Clin Proc) miRNA detargeting (J Virol) Video of this episode at YouTube This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE. Weekly Science Picks Kathy - Can you explain your science in 30 seconds? and How Far Can We Go? Rich - Small asteroid Earth's companion Vincent - The Gene by Siddhartha Mukherjee Listener Picks Dylan - Microsculpture by Levon Biss ( website ) Send your virology questions and comments to twiv@microbe.tv
Sun, June 19, 2016
TWiV 394: Cards in a hand
Hosts: Vincent Racaniello and Alan Dove Guest: Erica Ollmann Saphire Vincent and Alan speak with Erica about her career and her work on understanding the functions of proteins of Ebolaviruses, Marburg virus, and other hemorrhagic fever viruses, at ASM Microbe 2016 in Boston, MA. Become a patron of TWiV! Links for this episode Structure of antibodies bound to Ebola virus glycoprotein (PNAS) Structure of cross-reactive filovirus antibody (Cell) Multiple functions of Ebola virus VP40 protein (Cell) View video of this episode on YouTube Letters read on TWiV 394 This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE. Weekly Science Picks Alan - Slime Lapse Vincent - Virus Watch Listener Picks Patricia - NECSS , People Behind the Science , The Life Scientific Peter - Iron Lung on eBay Send your virology questions and comments to twiv@microbe.tv
Sun, June 12, 2016
TWiV 393: Lovers and livers
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler The TWiVerati revisit possible sexual transmission of Zika virus, and reveal how a cell protein that allows hepatitis C virus replication in cell culture enhances vitamin E mediated protection against lipid peroxidation. Become a patron of TWiV! Links for this episode Late sexual transmission of Zika virus (Lancet) Zika virus disease in US (CDC) Zika virus lab accident (ABC News) Mosquito eradication (virology blog) Florida mosquito control (TWiV 111) How tequila mosquito (TWiV 178) SEC14L2 allows HCV replication in cell culture (Nature) Lipid peroxidation (Wikipedia) HCV replicase regulated by lipid peroxidation (Nat Med) Letters read on TWiV 393 This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE. Also brought to you by ASV 2016 Weekly Science Picks Alan - All About That Space Rich - The Expanse by James S.A. Corey (<a href="http:
Sun, June 05, 2016
TWiV 392: Zika virus!
Host: Vincent Racaniello Guests: Michael Diamond , Michaela Gack , Laura Kramer , and Charles Rice Four virologists discuss our current understanding of Zika virus biology, pathogenesis, transmission, and prevention, in this special live episode recorded at the American Society for Microbiology in Washington, DC. [powerpress url="http://traffic.libsyn.com/twiv/TWiV392.mp3"] Click arrow to play Download TWiV 392 (62 MB .mp3, 85 min) Subscribe (free): iTunes , RSS , email , Google Play Music Video of this episode at YouTube This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE. Send your virology questions and comments to twiv@microbe.tv
Sun, May 29, 2016
TWiV 391: Whiter reefs, fresh breath
Hosts: Vincent Racaniello , Alan Dove , and Rich Condit Guests: David Pride and Forest Rohwer If you have always wanted to know what coral reefs and the human oral cavity have in common, listen as guests David Pride and Forest Rohwer talk about their work on the microbiomes and viromes of these two environments, and you'll also understand why mucus is cool. Links for this episode Lytic to temperate switching of viral communities (Nature) Viromes in ancestral holobiont Hydra (PLoS One) Phage in human oral cavity (J Oral Micro) Human oral viruses are personal, consistent, gender specific (ISME) Video of this episode at YouTube This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE. Weekly Science Picks Alan - Vax Pack Hero Rich - Helicopter autorotation Vincent - Live in Our Phage World by Forest Rohwer, Merry Youle, Heather Maughan, Nao Hisakawa Listener Picks Matt - Experiment.com Send your virology questions and comments to twiv@microbe.tv
Sun, May 22, 2016
TWiV 390: Building a better mosquito trap
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guests: Ethan Jackson and Jonathan Carlson Project Premonition, a Microsoft Research project that uses drones to capture mosquitoes and analyze them for pathogens, preprint servers, and three mouse models for Zika virus induced birth defects are the topics of this episode hosted by the TWiumvirate and theirs guests Ethan and Jonathan. Links for this episode Project Premonition Premonition feasibility study in Grenada Zika virus causes microcephaly in mice (Cell Stem Cell) Brazilian Zika virus causes defects in experimental models (Nature) Zika virus causes placental damage and fetal demise in mice (Cell) Letters read on TWiV 390 This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE. Also brought to you by ASV 2016 Weekly Science Picks Dickson - Germany nearly reached 100% renewable power Alan - Vertical City documentary and Lumino City game <
Sun, May 15, 2016
TWiV 389: Alphabet hepatitis with Stan Lemon
Host: Vincent Racaniello Guest: Stan Lemon Vincent speaks with Stan Lemon about his career in virology, from early work on Epstein Barr virus, through making essential discoveries about hepatitis A virus, hepatitis C virus, and rhinoviruses. Links for this episode Live in Edmonton, Eh? ( TWiV 235 ) Replication of EBV in epithelial cells (Nature) Returning to Carolina after 14 years Evolutionary origins of hepatitis A virus (TWiV 265) cre in rhinovirus genome (RNA) Naked viruses that aren't always naked (Ann Rev Virol) miR-122 and hepatitis C virus RNA (Cell Host Micr) This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE. Send your virology questions and comments to twiv@microbe.tv
Sun, May 08, 2016
TWiV 388: What could possibly go wrong?
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Preprint servers, the structure of an antibody bound to Zika virus, blocking Zika virus replication in mosquitoes with Wolbachia , and killing carp in Australia with a herpesvirus are topics of this episode hosted by Vincent, Dickson, Alan, and Kathy. Links for this episode biorXiv preprint server Please review Vaccines and Your Child Structure of antibody bound to Zika virus E protein (Cell Host Microbe) Wolbachia blocks Zika virus in mosquitoes (Cell Host Microbe) Zimmer on Wolbachia and Zika virus (NY Times) Fauci on Zika virus vaccine (Science) Carpageddon (The Conversation) Letters read on TWiV 388 This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE. Also brought to you by ASV 2016 Weekly Science Picks Dickson - EarthEnv Alan - Research funding by lottery Kathy - Eugenia Cheng Math and Baking Vincent - Zika Diaries Listener Pi
Sun, May 01, 2016
TWiV 387: Quaxxed
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Guest: Nina Martin Nina Martin joins the TWiV team to talk about the movie Vaxxed, her bout with dengue fever, and the latest research on Zika virus. Links for this episode Public Health United Fifty Shades of Science (TEDx) Parents convicted in death of toddler (Science Based Medicine) CDC: Zika virus causes microcephaly (NEJM) Dengue virus antibodies enhance Zika virus infection (biorXiv) Zika virus in Brazilian nonhuman primates (biorXiv) Zika virus IgM in CSF of microcephalic babies (Lancet) Brain organoids for modeling Zika virus infection (Cell) Letters read on TWiV 387 This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE. Also brought to you by ASV 2016 Weekly Science Picks Nina - Vaccines and Your Child by Paul Offit and Charlotte Moser Dickson - The animals of Chernobyl Alan - Five rules of lab safety Kathy - 20 best science images of the year? Vincent - <a href=
Sun, April 24, 2016
TWiV 386: The dolphins did it
Hosts: Vincent Racaniello , Rich Condit , and Kathy Spindler Guests: Ted Diehl and Welkin Johnson Ted and Welkin inform the TWiV team how the evolution of ancient retroviruses can be inferred by studying their sequences in the genomes of modern mammals, and join in a discussion of virus dispersal during different methods for drying hands. Links for this episode More fun than a monkey full of viruses ( TWiV 122 ) Tracking ancient retrovirus evolution in mammals (eLife) Virus dispersal during hand drying (J Appl Micro) More than you wanted to know about hand drying ( one , two , three , four , five , six ) This episode is sponsored by ASM Agar Art Contest , ASM Grant Writing Course , and ASV 2016 Weekly Science Picks 1:30:20 Welkin - Lab Girl by Hope Jahren ( essay ) Ted - Accidental brilliance in science Rich - Perpetual motion? Kathy - R0 graphic and explanation <a href="http://www.sciencedirect.com/science/
Sun, April 17, 2016
TWiV 385: Failure
Hosts: Vincent Racaniello and Dickson Despommier Guest: Stuart Firestein Stuart joins Vincent and Dickson to talk about his sequel to Ignorance , a book called Failure , which seeks to make science more appealing by revealing its faults. Links for this episode Stuart Firestein's site Ignorance with Stuart Firestein (TWiV Special) The pursuit of ignorance (TED) Ignorance by Stuart Firestein Failure by Stuart Firestein This episode is sponsored by ASM Agar Art Contest and ASV 2016 Send your virology questions and comments to twiv@microbe.tv
Sun, April 10, 2016
TWiV 384: Agent 003, a view to a fish kill
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove and Rich Condit Guests: Nischay Mishra and Ian Lipkin Nischay and Ian join the TWiVions to discuss mass die-offs of tilapia by a novel orthomyxo-like virus, Ian's editorial on the movie Vaxxed , and new vaccines to prevent dengue virus infections, including a human challenge model. Links for this episode Novel orthomyxo-like virus in Tilapia die-offs (mBio) Fish flu ( TWiV 41 ) Anti-vaccination lunacy won't stop (WSJ) Single-dose dengue vaccine effective (J Inf Dis) Dengue vaccine needs (J Inf Dis) Composition of TV003 (J Inf Dis) Dengue vaccine mutagenesis (Curr Top Micr Imm) Dengue human challenge model (Sci Transl Med) Yellow fever alarm (STAT) Experiment: Zika virus UC Berkeley Microbiology Student Symposium Image credit Letters read on TWiV 384 This episode is sponsored by ASM Agar Art Contest , ASM Grant Writing Course , and ASV 2016 Weekly Science Picks Rich - Dune by Frank Herbert <s
Sun, April 03, 2016
TWiV 383: A zillion Zika papers and a Brazilian
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove and Kathy Spindler Guest: Esper Kallas Esper and the Merry TWiXters analyze the latest data on Zika virus and microcephaly in Brazil, and discuss publications on a mouse model for disease, infection of a fetus, mosquito vector competence, and the cryo-EM structure of the virus particle. Links for this episode Zika virus in the Americas (Science) Co-circulation of dengue, Zika, chik in Brazil (Medicine) Murine model for Zika virus infection (Am J Trop Med Hyg) Zika virus susceptibility of A. aegypti and A. albopictus (PLoS NTD) Infectious Zika virus from saliva (EuroSurveill) Zika virus spread through saliva? (Braz Oral Res) Five Zika virus reviews ( one , two , three , four , five ) Zika virus and microcephaly, Brazil (MMWR) Zika virus in urine (EuroSurveill) Zika virus infection of fetus (NEJM) Real-time sharing of Zika virus data (JAMA) Image credit: Richard Kuhn Letters read on TWiV 383 This episode is sponsored by ASM Agar Art Contest and ASV 2016 Weekly Science Picks Esper - The Chaos by <span style="fo
Sun, March 27, 2016
TWiV 382: Everyone's a little bit viral
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove and Kathy Spindler Guests: Nels Elde and Edward Chuong Nels and Ed join the TWiV team to talk about their observation that regulation of the human interferon response depends on regulatory sequences that were co-opted millions of years ago from endogenous retroviruses. Links for this episode Endogenous retroviruses and regulation of innate immunity (Science) Placenta is viral (Nature) An ERV that maintains pluripotency of human embryonic stem cells (TWiV 279) Letters read on TWiV 382 This episode is sponsored by ASM Agar Art Contest and ASV 2016 Weekly Science Picks Nels - Don't Get Me Started - Matt Giorgianni Alan - Sun's magnetic field ( paper ) Dickson - Most realistic dinosaur terrifies Vincent - Top secret! Kathy - Zika virus risk for US 50 cities ( paper ) Ed - <a href="http://www.sciencemag.org/news/2016/03/w
Sun, March 20, 2016
TWiV 381: Add viruses and Zimmer
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guest: Carl Zimmer Carl Zimmer joins the TWiV team to talk about his career in science writing, the real meaning of copy-paste, science publishing, the value of Twitter, preprint servers, his thoughts on science outreach, and much more. Links for this episode Carlzimmer.com All Carl's articles at NYTimes Carl at Stat The Loom Staying afloat in the rising tide of science (Cell) Parasite Rex Planet of Viruses Handful of biologists went rogue (NYTimes) This episode is sponsored by ASV 2016 and ASM Agar Art Contest Weekly Science Picks Carl - Surprising benefit of viral DNA Alan - Global ship traffic Dickson - Music with 2000 marbles Vincent - The whiteboard revolution Kathy - How to interpret UK and A
Sun, March 13, 2016
TWiV 380: Viruses visible in le microscope photonique
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVeroos deliver the weekly Zika Report, then talk about a cryoEM structure of a plant virus that reveals how the RNA genome is packaged in the capsid, and MIMIVIRE, a CRISPR-like defense system in giant eukaryotic viruses. Links for this episode First worms, then viruses, now dormant cyber pathogens (Zdziarski blog) Guillain-Barré with Zika virus in urine (Eurosurveillance) Zika virus in urine , Brazil (J Clin Virol) Zika in pregnant women in Rio (NEJM) Issues with NEJM pregnant women study (Epi-Ramble) Zika virus and meningoencephalitis (NEJM) Zika virus and acute myelitis (Lancet) Person to person transmission of Zika virus (MMWR) Pyrethroids and mouse microcephaly ( one , two ) Zika virus illustrations (Visual Science) Cowpea mosaic virus at high resolution (Nat Comm) MIMIVIRE confers resistance to virophage (Nature) CRISPR in a phage ( TWiM 56 ) National Academy of Sciences GoFoc meeting
Sun, March 06, 2016
TWiV 379: A mouse divided
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guest: Scott Tibbetts Scott Tibbetts joins the TWiVists to describe his work on the role of a herpesviral nocoding RNA in establishment of peripheral latency, and then we visit two last minute additions to the Zika virus literature. Links for this episode Noncoding RNA required for establishment of latency (mSphere) 17:20 Lessons learned from in vivo studies of a viral noncoding RNA (mSphere) 1:05:05 Zika virus in pregnant women in Rio de Janeiro (NEJM) 1:06:10 Zika virus infects cortical neural progenitors (Cell Stem Cell) 1:12:00 Image credit Letters read on TWiV 379 1:15:10 This episode is sponsored by 32nd Clinical Virology Symposium and Microbe Magazine Podcast 4:15, 1:05:25 Weekly Science Picks 1:42:45 Alan - Okeanos Explorer Dickson - Rome Reborn Vincent - Twitter Missing Manual Scott - Best Science Images of 2015 Kathy - Space Travel Posters Rich - <a href="https://itunes.a
Sun, February 28, 2016
TWiV 378: Herpes plays DUBstep
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Guests: Greg Smith and Mark Fuccio Greg Smith joins the TWiVirate to reveal how his lab discovered a switch that controls herpesvirus neuroinvasion, and then we visit the week's news about Zika virus. Links for this episode Dynamic ubiquitination drives herpesvirus neuroinvasion (PNAS) Releasing Zika virus data in real time (Nature) Zika virus infection and stillbirths (PLoS NTD) Zika virus infection, imported , Italy (Eurosurveillance) Letters read on TWiV 378 This episode is sponsored by 32nd Clinical Virology Symposium and Microbe Magazine Podcast Weekly Science Picks Alan - Science byline counting project Dickson - Bill Nye on climate change Vincent - Zdziarski's blog of things (Apple's motion to vacate ) Greg - Atlas, the next generation Kathy - Sources of Chaco wood Mark - How Dogs Love Us by Gregory Berns Lis
Sun, February 21, 2016
TWiV 377: Chicken with a side of Zika
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVniks review the past week's findings on Zika virus and microcephaly, and reveal a chicken protein that provides insight on the restriction of transmission of avian influenza viruses to humans. Links for this episode Larvicide not involved in microcephaly (CBS News) Obama seeks $1.8b for Zika virus (Guardian) Zika virus in Puerto Rico (MMWR) Zika virus in semen (EID) Zika virus in Indonesia (EID) Phylogeny of Zika virus (EID) Zika virus may cause mental disease (NYTimes) Zika virus from amniotic fluid (Lancet) Host protein underlies avian influenza host restriction (Nature) Wendy Barclay on TWiV 177 Home to roost (Cell) Image credit Letters read on TWiV 377 This episode is sponsored by 32nd Clinical Virology Symposium and Microbe Magazine Podcast Weekly Science Picks Alan - <a href="http://www2.cdc.gov/nip/adultimmsched/
Sun, February 14, 2016
TWiV 376: The flavi of the month is Zika
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guest: Jeremy Luban The TWiV team discusses the latest data on Zika virus, including ocular defects in infants with microcephaly, and isolation of the entire viral genome from fetal brain tissue. Links for this episode Ocular findings in infants with microcephaly ( JAMA and Arq Bras Oft ) Evidence of Zika virus infection in brain and placenta (MMWR) Zika virus associated with microcephaly (NEJM) Hard-core sequencing (Science) Zika virus and microcephaly (virology blog) Zika virus in the Americas (NEJM) JEV and WNV transplacental infections Rubella virus facts (WHO) Share your Zika virus reagents (virology blog) No link between anencephaly and Cache Valley Virus (EID) Image credit Letters read on TWiV 376 This episode is sponsored by 32nd Clinical Virology Symposium and ASM Microbe 2016 Weekly Science Picks Alan - <a href="http://phdcomics.com
Sun, February 07, 2016
TWiV 375: Zika and you will find
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Guests: Carolyn Coyne , Helen Lazear , and Jeremy Luban The TWiVziks present everything you want to know about Zika virus, including association of infection with microcephaly and Guillain-Barré syndrome, transmission, epidemiology, and much more. Links for this episode Zika outbreak in Brazil (EID) 13:40 Zika summary (ProMedMail) 19:30 Zika and microcephaly (MMWR) 27:30 Facts about microcephaly (CDC) Brazil Ministry of Health microcephaly numbers Zika spread in Americas (MMWR) Deu Zica 42:30 Microcephaly in Brazil (Lancet) 46:10 GM mosquitoes did not start Zika outbreak (Discover) 1:31:30 Debunking myths around Zika (Mad Virologist) Sexual transmission vs sexually transmissible (virology blog) 1:22:10 CDC Zika travel guidance 1:15:45 CDC on Zika and sex 1:17:10 Image credit: Esper Kallas, University of Sao Paulo <
Sun, January 31, 2016
TWiV 374: Discordance in B
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVniks consider the role of a cell enzyme that removes a protein linked to the 5'-end of the picornavirus genome, and the connection between malaria, Epstein-Barr virus, and endemic Burkitt's lymphoma. Links for this episode Divergent requirements for removing VPg (mBio) Bond, covalent bond ( TWiV 210 ) Link between malaria and endemic Burkitt's lymphoma (PLoS Path) Multifactorial role of malaria in Burkitt's lymphoma (PLoS Path) Plasmodium infection promotes AID-dependent B cell lymphoma (Cell) Children's cancer dependent on climatic factors (Nature) Denis Burkitt (Wikipedia) Request for PACE trial data (virology blog) Letters read on TWiV 374 This episode is sponsored by 32nd Clinical Virology Symposium and ASM Grant Writing Webinar Weekly Science Picks Alan - Indoor skydiving Vincent - Cancer Virus by Crawford, Johannessen, and Rickinson Rich - Wit Kathy - The Only Woman in the Room by E
Sun, January 24, 2016
TWiV 373: The distinguished virology career of Julius S. Youngner
Host: Vincent Racaniello Guest: Julius S. Youngner Vincent speaks with Julius about his long career in virology, including his crucial work as part of the team at the University of Pittsburgh that developed the Salk inactivated poliovirus vaccine. Links for this episode Trypsin for cell cultures (Proc Soc Exp Biol Med) Interferon induction by nonviral stimuli (J Gen Physiol) Interferons of different molecular weight (Proc Soc Exp Biol Med) Poliovirus thermal mutants (J Bacteriol) Combination of different cells in culture (Science) Equine influenza vaccine (Eq Vet J) Younger role in Salk vaccine (interview, amednews) Cutter Incident (JRSM) Video of this episode - coming as soon as I can get home! Send your virology questions and comments to twiv@microbe.tv
Sun, January 17, 2016
TWiV 372: Latent viral tendencies
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler The TWiV-osphere introduces influenza D virus, virus-like particles encoded in the wasp genome which protect its eggs from caterpillar immunity, and a cytomegalovirus protein counters a host restriction protein that prevents establishment of latency. Links for this episode Ebolavirus update (ProMedMail) Influenza D virus (mBio) Vincent's influenza C virus paper (J Virol) Virus-like particles protect wasp eggs (Sci Adv) CMV protein foils cell defense against latency (Sci Adv) Image credit: Mark Letters read on TWiV 372 This episode is sponsored by ASM Grant Writing Webinar and ASM Biodefense Weekly Science Picks Alan - Go viral Vincent - 3D virus popsicles ( 3ders, dangerous popsicles ) Rich - Galileo thermometer Kathy - Thing Explainer by Randall Munroe Listener Picks Christiane - Using PowerPoint to shine Send your virology questions and comments to twiv@microbe.tv
Sun, January 10, 2016
TWiV 371: Sympathy for the devil
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVologists discuss the finding of a second transmissible cancer in Tasmanian devils, and development of new poliovirus strains for the production of inactivated vaccine in the post-eradication era. Links for this episode Second transmissible cancer in Tasmanian Devils (PNAS) New strains for production of IPV (PLoS Path) Synchronized switch to bivalent OPV (polioeradication.org) Virologists, start your poliovirus destruction (virology blog) Image is a painting by George Kush Letters read on TWiV 371 This episode is sponsored by ASM Grant Writing Webinar and ASM Biodefense Weekly Science Picks Alan - Skyfaring by Mark Vanhoenacker Vincent - Your Cells. Their Research. Your permission? Rich - NASA UV photos of the sun Kathy - Aurora bike lights Dickson - Unfilled vials Listener Picks Kevin - John Oliver on nutritional supplements <
Sun, January 03, 2016
TWiV 370: Ten out of 15
Hosts: Vincent Racaniello , Alan Dove , and Kathy Spindler The TWiVomics review ten captivating virology stories from 2015. Ten virology stories from 2015 Recoding to make vaccines and study viral functions: TWiV 351: The dengue code TWiV 362: Gotta catch ’em all and n ew paper Defining the virome: TWiV 365: Blood, feuds, and a foodborne disease , TWiV 362: Gotta catch ’em all , TWiV 356: Got viruses? , TWiV 355: Baby’s first virome , TWiV 342: Public epitope #1 , TWiV 323: A skid loader full of viromes Ebola outbreak wanes, vaccines tested, persistence noted: TWiV 361: Zombie viruses on the loose , TWiV 349: One ring to vaccinate them all , TWiV 341: Ebolavirus experiences , TWiV 336: Brought to you by the letters H, N, P, and Eye , TWiV 335: Ebola lite Spillovers and scares: TWi
Sun, December 27, 2015
TWiV 369: Camel runny noses and other JNK
Hosts: Vincent Racaniello , Alan Dove , and Kathy Spindler A swarm of virologists discusses testing of a MERS coronavirus vaccine for camels, and how a neuronal stress pathway reactivates herpes simplex virus. Links for this episode MERS coronavirus vaccine for camels (Science) WHO MERS summary Neuronal stress pathway and herpes simplex virus reactivation (Cell Host Micr) Stress flips a chromatin switch (Cell Host Micr) How herpes simplex virus reactivates (UNC press release) Histone antibodies database New antibody portal (UNC press release) Image credit Letters read on TWiV 369 This episode is sponsored by Clinical Virology Symposium Weekly Science Picks Alan - SpaceX Falcon 9 landing Vincent - Scientists: Engage the public! and Lego contest winners Kathy - Google Ngram viewer Listener Picks Dennis - Americapox: The missing plague Mark - WeatherSpark and <a href="http://journa
Sun, December 20, 2015
TWiV 368: Infected, you will be
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler A plaque of virologists explores the biology of Zika virus and recent outbreaks, and the contribution of a filamentous bacteriophage to the development of biofilms. Links for this episode More cowbell (Wikipedia) Microcephaly in Brazil (Outbreak News) Non-vector borne Zika transmission (EID) Zika virus outside Africa (EID) Zika virus possible sexual transmission (EID) Zika virus in saliva (J Clin Virol) Dengue's cousin Zika (Micr Inf) Filamentous phage promote biofilm assembly (Cell Host Micr) Biofilm history (MSU) Pseudomonas phage Pf1 Image credit Letters read on TWiV 368 This episode is sponsored by Clinical Virology Symposium and ASM Microbe Weekly Science Picks Alan - Twelve days of norovirus Vincent - This Week in Evolution Rich - In the Kingdom of Ice by Hampton Sides Kathy - Kajanjian lectu
Sun, December 13, 2015
TWiV 367: Two sides to a Coyne
Hosts: Vincent Racaniello , Dickson Despommier, Alan Dove , Rich Condit, and Kathy Spindler Guests: Carolyn Coyne and Coyne Drummond Two Coynes join the TWiV overlords to explain their t hree-dimensional culture model of polarized intestinal cells for studying enterovirus infection. Links for this episode Carolyn and placentas on TWiV 193 Three-dimensional cell culture model (mSphere) Bioreactor video (JoVE) Neurovirologist Richard T. Johnson, 84 ( Hopkins and virology blog ) Tardigrade HGT disputed (BioRxiv) Exaptation of archaeal virus capsid protein from Cas4 (Biol Dir) Image credit Letters read on TWiV 367 This episode is sponsored by ASM Microbe Weekly Science Picks Kathy - Tardigrade genome sequence ( video ) Alan - Antibiotic action nonprofit group Vincent - Ex Machina and genome editing moratorium Rich - <a href="http://www.launchphotography.com/" target="_b
Sun, December 06, 2015
TWiV 366: Doctorates down under
Host: Vincent Racaniello Guests: Carla Giles, Zoe Dyson, Brianna McLean, and Caitlin O'Brien In Melbourne, Australia, Vincent speaks with four PhD students about their research projects and what it's like to get a doctorate down under. Video of this episode: view at YouTube This episode is sponsored by ASM Microbe and ASM Biodefense . Send your virology questions and comments to twiv@twiv.tv TWiV is a MicrobeTV Production
Sun, November 29, 2015
TWiV 365: Blood, feuds, and a foodborne disease
Hosts: Vincent Racaniello , Alan Dove , and Kathy Spindler For a TWiV Thanksgiving, Vincent, Alan, and Kathy trace the feud over genome editing, a new virus discovered in human blood, and the origins of hepatitis A virus. Links for this episode Battle over genome editing (Wired) 10:05 First description of CRISPR in E. coli (J Bacteriol) 14:00 Cas genes identified (Mol Micro) 14:20 CRISPR-Cas provides immunity to bacterial viruses (Science) 15:35 Cas9-crRNA complex mediates DNA cleavage (PNAS) 16:55 Dual RNA-guided DNA endonuclease in bacterial immunity (Science) 17:50 Genome engineering using CRISPR/Cas (Science) 18:50 Cpf1 endonuclease (Cell) 23:10 Classification of CRISPR/Cas systems (Nat Rev Micro) 23:50 Summit on gene editing 21:25 Novel human virus in transfusion recipients (mBio) 27:00 Origins of hepatitis A virus in small mammals (PNAS) 55:05 Image credit Letters read on TWiV 365 7:00, 1:20:35 This episode is sponsored by ASM Microbe , ASM Biodefense , and the 32nd Clinical Virology Symposium . ( 1:10 , 1:18:30) </
Sun, November 22, 2015
TWiV 364: It's not SARS 2.0
Hosts: Vincent Racaniello , Rich Condit , and Kathy Spindler Guests: Ralph Baric and Vineet Menachery Vincent, Rich, and Kathy speak with Ralph and Vineet about their research on the potential of SARS-like bat coronaviruses to infect human cells and cause disease in mice. Links for this episode Zoonotic potential of SARS-like bat viruses (Nature) SARS-CoV susceptibility loci via collaborative cross (PLoS Genetics) 47:00, 57:25 Ebright and Wain-Hobson quotes (Nature) 1:17:20 Misleading press release (UNC) 1:24:45 Super powerful SARS 2.0 (not!) (Motherboard) SARS-like bat virus can jump without mutating (not!) (Daily Mail) 1:26:30 Photo credit Letters read on TWiV 364 1:47:40 This episode is sponsored by Mt. Sinai Department of Microbiology (2:10) , ASM Education (33:25) , and the 32nd Clinical Virology Symposium (1:51:30) Timestamps by Jennifer . Thanks! Weekly Science Picks 1:53:00 Kathy - California Dept of Public Health Rich - Leafy greens on space station <a href="ht
Sun, November 15, 2015
TWiV 363: Eat flu and dyad
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler The TWiVers reveal influenza virus replication in the ferret mammary gland and spread to a nursing infant, and selection of transmissible influenza viruses in the soft palate. Links for this episode Photos of my visit to OHSU (Facebook) 6:30 Folta departs (Facebook) 9:25 T-VEC approved for melanoma (FDA) 14:45 Talimogene laherparepvec (Wikipedia) 15:10 T-VEC phase III trial (J Clin Oncol) 17:35 How drugs are named (PopSci) 16:35 Influenza transmission in mother-child dyad (PLoS Path) 23:10 Soft palate and influenza transmission (Nature) 41:00 Blausen 0872 UpperRespiratorySystem " by BruceBlaus . When using this image in external sources it can be cited as:Blausen.com staff. " Blausen gallery 2014 ". Wikiversity Journal of Medicine. DOI : 10.15347/wjm/2014.010 . ISSN 20018762 . - Own work . Licensed under CC BY 3.0 via <a href="https://commons
Sun, November 08, 2015
TWiV 362: Gotta catch 'em all
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler With their usual verve, the virus virtuosos illuminate a new method to identify all the viral nucleic acids in a sample, and regulation of viral gene expression by codon usage. Links for this episode Virome capture sequencing (mBio) 15:40 Codon usage regulates viral gene expression (PNAS) 40:00 Harold S. Ginsberg (Wikipedia) 7:15 Letters read on TWiV 362 6:50, 1:03:20 This episode is sponsored by ASM Education : ASM MOOC 5:45 Timestamps by Jennifer . Thanks! Weekly Science Picks 1:39:20 Kathy - Adam Savage, Andy Weir and Chris Hadfield talk about The Martian Alan - Project Apollo photo archive - and video Rich - Watch A Bowling Ball And Feather Falling In A Vacuum Dickson - California drought Vincent - Does AAAS care about Ebola anymore? Listener Picks Anonymous - Lives saved by vaccination Paul - <a href="https://drive.google.com/file/
Sun, November 01, 2015
TWiV 361: Zombie viruses on the loose
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Rich Condit The TWiVsters discuss Frederick Novy's return from retirement to recover a lost rat virus, and evidence for persistence of Ebolavirus in semen. Links for this episode Frederick Novy and the rat virus (Ann Int Med) 18:20 The rat virus (J Inf Dis) 22:55 Recovery of the rat virus (J Inf Dis) 35:20 Ebola sitrep 42:25 Meningitis in Glaswegian Ebolavirus nurse ( ProMedMail , Medscape ) 45:50 Sexual transmission of Ebolavirus (NEJM) 50:25 Ebolavirus RNA persistence in semen (NEJM) 1:04:25 Airplane banner falls into Hudson River (jpg) Image credit Letters read on TWiV 361 7:25, 1:13:25 This episode is sponsored by ASM Education : ASM MOOC 3:50 Weekly Science Picks 1:27:05 Alan - Sticky Rich - Arthur C. Clarke predicts the Internet (so did Vannevar Bush ) Dickson - Nikon Small World Photomicrography winners Vincent - Pat Schloss on <a href="http://blog.
Sun, October 25, 2015
TWiV 360: From Southeastern Michigan
Hosts: Vincent Racaniello and Kathy Spindler Guests: Michael Imperiale , Adam Lauring , and Akira Ohno Vincent visits the University of Michigan where he and Kathy speak with Michael, Adam, and Akira about polyomaviruses, virus evolution, and virus assembly, on the occasion of naming the department of Microbiology & Immunology a Milestones in Microbiology site. Links for this episode World Polio Day 3:20 Mole Day 5:25 The rat virus (J Inf Dis) 20:00 Polyomavirus miRNAs (Curr Op Virol) 39:30 Costs of GOF pause (mBio) 45:00 Lethal mutagenesis of influenza virus (J Virol) 1:03:35 Mutational robustness in RNA virus evolution (Nat Rev Micro) 52:00 Membrane binding of gag (mBio) 1:12:55 Cell proteins in retrovirus particles (J Virol) 1:23:15 Michael's twitter Adam's twitter Video of this episode - view below or at YouTube Weekly Science Picks 1:27:30 Kathy - Ada Lovelace and Charles Babbage Lego #1 and #2 and Ada Lovelace Day Vincent - MiSciWriters Listener Picks Junio - XKCD marks the spot Kari - Spoonflower Send your virology questions and comments to twiv@twiv.tv
Sat, October 17, 2015
TWiV 359: A Blossom by any other name
Host: Vincent Racaniello Guest: Blossom Damania Vincent speaks with Blossom about her laboratory's research on Kaposi's sarcoma-associated herpesvirus, including how it transforms cells, the switch between lytic and latent replication, and its interaction with the innate immune system of the host. Links for this episode Damania Laboratory Modulation of cGAS-STING by KSHV (PNAS) KSHV vIRF1 interacts with ISG15 pathway member (J Virol) KSHV NLR homolog inhibits inflammasome (Science) KSHV inhibition of PI3K and mTOR (Blood) KSHV confers survival advantage to endothelial cells (Cancer Res) UNC Global Oncology Program Blossom on Twitte r Video of this episode - view at YouTube Send your virology questions and comments to twiv@twiv.tv
Sun, October 11, 2015
TWiV 358: Virology and proteomics with Ileana Cristea
Host: Vincent Racaniello Guest: Ileana Cristea Vincent meets up with Ileana at Princeton University to talk about how her laboratory integrates molecular virology, mass spectrometry-based proteomics, and bioinformatics to unravel the interplay between virus and host. Links for this episode Cristea Laboratory Ileana's work previously on TWiV 269 Blowing off steam (Cell Host Micr) Nuclear viral DNA sensors (J Biol Chem) mSystems Video of this episode - view at YouTube (coming soon!) Send your virology questions and comments to twiv@twiv.tv
Sun, October 04, 2015
TWiV 357: Mistletoe on the Tree of Life
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guest: Jens Kuhn Jens joins the TWiVomics to discuss the strengths and weaknesses of viral taxonomy, including its history and evolution, how viruses are ordered, and why T. rex was classified without having a living isolate. Links for this episode Jens' previous TWiV (283) 5:15 International Committee on the Taxonomy of Viruses (ICTV) 27:50 ICTV 9th Report 32:55 Classifying viruses by capsid architecture (Curr Opin Virol) 1:43:00 Image credit Letters read on TWiV 357 10:55, 1:55:40 Timestamps by Jennifer . Thanks! Weekly Science Picks 56:30, 2:07:15 Alan - The Jefferson Grid Rich - Summer of Science Kathy - Bill Nye dances The Click Dickson - The Martian Jens - How I Killed Pluto , Life in Our Phage World , Why the Seahorse Tail is Square Vincent - Do
Sun, September 27, 2015
TWiV 356: Got viruses?
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guest: Stephanie Neal Stephanie joins the super professors to discuss the gut virome of children with serious malnutrition, caterpillar genes acquired from parasitic wasps, and the effect of adding chemokines to a simian immunodeficiency virus DNA vaccine. Links for this episode Invitrogen Science Hero Awards 15:05 Gut DNA viromes of twins with severe malnutrition (PNAS) 34:30 Random forests 48:00 Wasps engineer caterpillars (PLoS Genetics) 50:20 Chemokine-adjuvanted SIV DNA vaccine (Mucos Immunol) 1:02:20 Guide to chemokines (pdf) Role for CCR10 in IgA secreting cell accumulation (J Immunol) CCL28 controls IgA plasma cell accumulation (J Exp Med) In vivo electroporation 1:07:25, 1:09:50 Kathy's groan (jpg) Image credit Letters read on TWiV 356 14:55 Weekly Science Picks 1:18:35, 1:45:30 Alan - Plates from Hooke's Micrographia Rich - <a hre
Sun, September 20, 2015
TWiV 355: Baby's first virome
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiV team considers the effect of a Leishmaniavirus on the efficacy of drug treatment, and the human fecal virome and microbiome in twins during early infancy. Links for this episode Announcing mSphere 5:50 Leishmania virus influences drug outcome ( paper 1 , paper 2 ) 25:15 Human gut virome and microbiome in infants (Nat Med) 46:00 Multiple displacement amplification (Wiki) 46:00 Virome of adult twins (Nature) 49:15 Illumination by Kevin Folta 1:31:00 Folta story at RetractionWatch 1:41:40 Image credit Letters read on TWiV 355 9:40, 1:20:30 This episode is sponsored by ASMGAP 5:00 Timestamps by Jennifer . Thanks! Weekly Science Picks 1:42:20 Alan - Vexed Muddler store Rich - <a href="https://en.wikipedia.org/wiki/Ivanpah
Sun, September 13, 2015
TWiV 354: The cat in the HAART
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The esteemed doctors of TWiV review a new giant virus recovered from the Siberian permafrost, why influenza virus gain of function experiments are valuable, and feline immunodeficiency virus. Links for this episode Non-viral proteins in vaccinia virus particles (Arch Virol) 8:15 Thing a week (Jonathan Coulton, downloads ) 23:20 Immortal Life pornographic? Not! (HuffPost) 25:25 Mollivirus sibericum (PNAS) 27:00 Don't worry about Frankenvirus (WashPost) 27:10 We need flu GOF research ( article , Wisc State J , Science ) 40:35 Isolation of FIV (Science) 50:20 FIV at Cornell Vet 1:06:25 <a href="h
Sun, September 06, 2015
TWiV 353: STING and the antiviral police
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler The TWiVniacs discuss twenty-eight years of poliovirus shedding by an immunodeficient patient, and packaging of the innate cytoplasmic signaling molecule cyclic GMP-AMP in virus particles. Links for this episode 28 years of poliovirus shedding (PLoS Path) 36:50 NOT a rare poliovirus (Wash Post) 44:35 Ukraine polio outbreak (ProMedMail) 41:00 Virus particle transfer of cGAMP (Science one , two ) 47:50 cGAS on TWiV 222 47:05 <a style="color: #1155cc; padding: 0px; margin:
Sun, August 30, 2015
TWiV 352: Science art with Michele Banks
Host: Vincent Racaniello Guest: Michele Banks Vincent meets up with Michele Banks in Washington, DC to discuss her career as a creator of science-themed art. Links for this episode Michele Banks on Twitter Artologica Michele's blog The Finch and the Pea Joseph Cornell Not Exactly Rocket Science (Ed Yong) Tree of Life (Jonathan Eisen) Home Microbiome Study Kitten Microbiome Project Science Online The Vexed Muddler Luke Jerram A Daily Dish (Klari Reis) Neuroscience art (Greg Dunn) Ai Weiwei Video of this episode - coming soon Video of Michele working in her studio - view at YouTube <p style="color: rgb(51, 51, 51); font-family: Georgia, 'Times New Roman', 'Bitstream Charter', Times, serif; font-size: 16px; line-heigh
Sun, August 23, 2015
TWiV 351: The dengue code
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The Masters of the ScienTWIVic Universe discuss a novel poxvirus isolate from an immunosuppressed patient, H1N1 and the gain-of-function debate, and attenuation of dengue virus by recoding the genome. Links for this episode Paula Pitha-Rowe (Balt Sun) Novel poxvirus (CID) H1N1 and gain-of-function debate (mBio) Recoding dengue virus genome (PNAS) Attenuation by dinucleotide frequency change (PNAS) Codon pair and dinucleotide bias not distinguished (PNAS) Codon pair deoptimization artefact of CG/UA change (eLife) Can engineering subdue viral vaccine reversion? (Virus Evol) Attenuation by a thousand cuts (NEJM) Image credit Letters read on TWiV 351 Weekly Science Picks Alan - Genetic roulette Rich - The Huntington Kathy - Simulated vomiting machine ( video ) Dickson - Last Cassini Saturn flyby Vincent - Decaying Still Life (YouTube) Listener Pick of the We
Sun, August 16, 2015
TWiV 350: Viral gene therapy with Katherine High
Host: Vincent Racaniello Guest: Katherine A. High Vincent speaks with Katherine High about her career and her work on using viral gene therapy to treat inherited disorders. This episode is drawn from one of twenty-six video interviews with leading scientists who have made significant contributions to the field of virology, part of the new edition of the textbook Principles of Virology . Links for this episode Katherine A. High, MD AAV gene therapy for congenital blindness (Sci Trans Med) Gene therapy for hemophilia (Hematol) AAV capsid decoys (Sci Trans Med) Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sun, August 09, 2015
TWiV 349: One ring to vaccinate them all
Hosts: Vincent Racaniello , Alan Dove , and Rich Condit Vincent, Alan and Rich explain how to make a functional ribosome with tethered subunits, and review the results of a phase III VSV-vectored Ebolavirus vaccine trial in Guinea. Links for this episode Social media specialist position at ASM WHO dismisses Catholic church on vaccine safety U of T Dean resigns over anti-vaccine course (Tor Star) Vaccine Adverse Event Reporting System (VAERS) Countering anti-vaccination attitudes (PNAS) Designer ribosome (Nature) rVSV-EBOV preliminary report (NEJM) rVSV-EBOV phase III interim report (pdf, Lancet) World on verge of Ebolavirus vaccine (WHO) Ebolavirus vaccine in Africa (virology blog) Letters read on TWiV 349 11:55 <p style="color: rgb(51, 51, 51); font-family: Georgia, 'Times New Roman', 'Bitstream Charter', Times, serif; font-size:
Sun, August 02, 2015
TWiV 348: Chicken shift
Hosts: Vincent Racaniello and Rich Condit Vincent and Rich discuss fruit fly viruses, one year without polio in Nigeria, and a permissive Marek's disease viral vaccine that allows transmission of virulent viruses. Links for this episode Virology tenure-track position at NCI (pdf) ASM Agar Art Contest Nigeria on brink of polio eradication (Nature) Dengue in Africa (Tyler Sharp) Permissive vaccines and virulence (PLoS Biol) Marek's disease vaccines and virulence (Ed Yong) Image credit Letters read on TWiV 348 This episode is sponsored by ASM GAP Weekly Science Picks Rich - Swan-Ganz catheter (<a href="https://en.wikipedia.org/wiki/Pulmonary_
Sun, July 26, 2015
TWiV 347: Rose rosette and squirrel roulette
Hosts: Vincent Racaniello , Alan Dove , and Rich Condit Vincent, Alan, and Rich discuss the virus behind rose rosette disease, and fatal human encephalitis caused by a variegated squirrel bornavirus. Links for this episode Virology tenure-track position at NIH (pdf) 7:00 Voinnet investigation is a Swiss Federal secret (twitter) 12:25 Rose rosette disease in Ft. Worth (Star Telegram) 29:35 Rose rosette virus discovered (J Gen Virol) 34:25 Emeravirus (ViralZone) 33:55 Eriophyid mites (MI Botanical Garden) 32:40 Mite vector of rose rosette disease (U Florida) 34:55 Image credit Squirrel bornavirus associated with human encephalitis (NEJM) 38:40 Poll: How do you consume podcasts? 1:21:40 Letters read on TWiV 347 8:10, 59:40 This episode is sponsored by ASM GAP and <a href="http://www.icaac.org/?utm_source=icaac&utm_medium=redirect&utm_campaign=icaac-icc" target="_blan
Sun, July 19, 2015
TWiV 346: A double helical career
Hosts: Vincent Racaniello , Rich Condit , and Kathy Spindler Guest: Joan Steitz This episode was recorded at the 34th Annual Meeting of the American Society for Virology, where Vincent, Rich, and Kathy spoke with Joan Steitz, a tireless promoter of women in science and one of the greatest scientists of our generation. Links for this episode ASV annual meeting , Western University Steitz Laboratory at Yale University Steitz Laboratory on Twitter Panoramic photo of ASV TWiV by Matt Evans Photos of ASV2015 (Facebook) Video of this episode - view at YouTube Weekly Science Picks Kathy - Charity Hall Rich - Ribosome binding sites of phage R17 mRNA Vincent - Pluto flyby Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sun, July 12, 2015
TWiV 345: How a vaccine got the nod
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler The TWiVonauts review how the weather affects West Nile virus disease in the US, benefit of B cell depletion for ME/CFS patients, and an autoimmune reaction induced by influenza virus vaccine that leads to narcolepsy. Links for this episode Virology faculty position, University of Toledo Weather and West Nile virus disease (AJTMH) B cell depletion benefits ME/CFS patients (PLoS One) Antibodies to influenza nucleoprotein cause narcolepsy (Science Transl Med) Letters read on TWiV 345 This episode is sponsored by ASM GAP - turn your science into a company Weekly Science Picks Dickson - Algal DMS releasing enzyme Alan - Science of beer aging Kathy - The Art of Science winners <a href="http://www.sciencedirect.com/science/journal/00426822/466/supp/C" tar
Sun, July 05, 2015
TWiV 344: Glasgwegians go viral
Host: Vincent Racaniello Guests: Ruth Jarrett , Glen Nemerow , and Esther Schnettler At the Glasgow Science Festival microTALKS, Vincent speaks with Ruth, Glen, and Esther about their research on viruses and Hodgkin lymphoma, adenovirus structure and entry into cells, and interactions between arthropod borne viruses and their hosts. Links for this episode Glasgow Science Festival microTALKS Hodgkin lymphoma (Histopath) HHV-6 and Hodgkin lymphoma (PLoS One) Adenovirus entry (PLoS Path) Adenovirus membrane penetration (Virology) Mosquito pathways that limit CHIK replication (PLoS Negl Trop Dis) Tick antiviral RNAi (Nucl Acids Res) Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sun, June 28, 2015
TWiV 343: The silence of the turnips
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVerinoes discuss the potential for prion spread by plants, global circulation patterns of influenza virus, and the roles of Argonautes and a viral protein in RNA silencing in plants. Links for this episode Prions in plants (Cell Rep) 11:35 Global influenza virus circulation (Nature) 20:40 Rough patch for plant RNA silencing (Lab Times) 29:50 Role of Argonaute proteins in plant viral defense (PLoS Path) 32:15 Rub-inoculation (YouTube) 42:45 Image credit Letters read on TWiV 343 4:00, 1:11:45 Timestamps by Jennifer . Thank you! Weekly Science Picks 1:41:45 Dickson - Global rainfall and snowfall map and A Week in the Life of Rain Alan - <a href="https://yout
Sun, June 21, 2015
TWiV 342: Public epitope #1
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVniks discuss the structure of a virus that reproduces in an extreme environment, long-term consequences of Ebolavirus infection, and VirScan, a method to identify the different virus infections you have had in your lifetime. Links for this episode Virus with A-form DNA (Science) Viruses in the extreme (virology blog) Sequelae of Ebolavirus infection (Lancet Inf Dis) Long term Ebolavirus effects (virology blog) Take the chili ME challenge Serological profiling of human viral infections (Science) Your viral past (virology blog) Letters read on TWiV 342 Timestamps by Jennifer . Thank you! Weekly Science Picks Dickson - Incredible photos Alan
Sun, June 14, 2015
TWiV 341: Ebolavirus experiences
Host: Vincent Racaniello Guests: Adam Kucharski , Gillian Slack , and Emma Thomson Vincent returns to the University of Glasgow MRC-Center for Virus Research and speaks with Emma, Gillian, and Adam about their ebolavirus experiences: caring for an infected patient, working in an Ebola treatment center in Sierra Leone, and making epidemiological predictions about the outbreak in west Africa. Links for this episode Tribute to Richard Elliott Donate to mesothelioma research for Richard Elliott CVR science blog Photos of our visit Ceilidh goes viral! Video of this episode - view below or at YouTube Timestamps by Jennifer . Thank you! Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sun, June 07, 2015
TWiV 340: No shift, measles
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiV teams reviews a MERS-coronavirus serosurvey and an outbreak in South Korea, and constraints on measles virus antigenic variation. Links for this episode Richard Elliott on TWiV 177 MERS-CoV outbreak , South Korea (ProMedMail) MERS-CoV serosurvey (Lancet Inf Dis) Biolabs in your backyard (USA Today) Constraints on measles virus antigenic variation (Cell Rep) Selection bias and bombers (John D. Cook) Virology (journal) Image credit: Cameron Moll Letters read on TWiV 340 Weekly Science Picks Dickson - Singapore Flower Dome and Cloud Forest Alan - Rescuing biomedical research Kathy - The value of basic research Rich - <a href="http://www.scienced
Sun, May 31, 2015
TWiV 339: Herpes and the sashimi plot
Hosts: Vincent Racaniello , Alan Dove , and Kathy Spindler Tre TWiV amici present three snippets and a side of sashimi: how herpesvirus inhibits host cell gene expression by disrupting transcription termination. Links for this episode Searching for Steamer in the oceans Lassa fever death in NJ ( CDC and NYTimes ) Transgenic mouse model for MERS-CoV (J Virol) First West Nile virus disease case in Texas Herpesvirus disrupts host transcription termination (Nat Comm) Sashimi plots Broad benefits of measles virus immunization ( TWiM #104 ) Avian influenza outbreak (NPR) The virome in health and disease (Immunity) Image credit Letters read on TWiV 339 Weekly Science Picks <p style="color: #333333; font-family: Georgia, 'Times New Roman', 'Bitst
Sun, May 24, 2015
TWiV 338: Coyotes have sushi
Hosts: Vincent Racaniello and Kathy Spindler Guest: Laura Newcomb Vincent and Kathy visit Laura Newcomb at California State University San Bernardino, where they talk about Laura's viral tatoos, and a protein that protects the mosquito brain from lethal flavivirus infection. Links for this episode Neuron-specific mosquito antiviral mechanism (PLoS Path) Letters read on TWiV 338 Photos of our visit Video of this episode - view at YouTube Weekly Science Picks Laura - NP siRNA inhibits different influenza viruses (Antiviral Res) Kathy - Time-lapse mining Vincent - Does the public trust science? Listener Pick of the Week Paul - Degree-Off XKCD Peter - Ebola containment , <a
Sun, May 17, 2015
TWiV 337: Steamer
Host: Vincent Racaniello Guests: Michael Metzger and Steve Goff Vincent meets up with Michael and Steve to discuss their finding of a transmissible tumor in soft shell clams associated with a retrovirus-like element in the clam genome. Links for this episode Hemocytic leukemia in soft shell clam (Sci Total Environ) Activation of Steamer in neoplastic hemocytes (PNAS) Transmission of clonal cancer cells in clams (Cell) Steve Goff on TWiV #76 Image credit Timestamps by Jennifer . Thank you! Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sun, May 10, 2015
TWiV 336: Brought to you by the letters H, N, P, and Eye
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVsters explore mutations in the interferon pathway associated with severe influenza in a child, outbreaks of avian influenza in North American poultry farms, Ebolavirus infection of the eye weeks after recovery, and Ebolavirus stability on surfaces and fluids. This episode is sponsored by @ASM Conferences and ASM Microbe Links for this episode Life threatening influenza and IRF7 deficiency (Science) Whole exome sequencing (Wikipedia) Herpes encephalitis in children with Trif deficiency ( TWiV 175 ) Avian influenza in the US ( USDA ,
Sun, May 03, 2015
TWiV 335: Ebola lite
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVumvirate discusses a whole Ebolavirus vaccine that protects primates, the finding that Ebolavirus is not undergoing rapid evolution, and a proposal to increase the pool of life science researchers by cutting money and time from grants. This episode is sponsored by ASM Microbe and ICAAC/ICC Links for this episode Possible sexual transmission of Ebolavirus (MMWR) Ebolavirus whole-virus vaccine protects primates (Science) Biologically contained Ebolaviruses (PNAS) Ebolavirus is evolving but not changing (Virology) Ebolavirus not undergoing rapid evolution (Science) Letters read on TWiV 335 Timestamps by Jennifer . Thank you! Weekly Science Picks Alan - Pinboard <a href="http://www.sitesucker.us/home.html" target="_blank
Sun, April 26, 2015
TWiV 334: In vino virus
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVles talk about endogenous viruses in plants, sex and Ebolavirus transmission, an outbreak of canine influenza in the US, Dr. Oz, and doubling the NIH budget. This episode is sponsored by SciMed Solutions and ASM Education . Links for this episode Pinot noir and viruses (Wine Spectator) 35:00 Endogenous florendoviruses (Nat Commun) 35:30 Sex and Ebolavirus transmission ( WHO , CDC , NYTimes ) 54:10 Ebolavirus waiting (NYTimes) 57:35 Canine influenza outbreak ( ProMed , NorthStarVets ) 1:01:10 Dr. Oz under fire ( NYTimes ) 1:06:20 TV doctors (Brit Med J) 1:09:50 Double the NIH budget (NYTimes) 1:11:45 <l
Sun, April 19, 2015
TWiV 333: Naturally curious chimeras
Host: Vincent Racaniello Guests: Ben Fensterheim, Megan Freeman, Bobak Parang, and Meredith Rogers Vincent returns to Vanderbilt University and meets up with Ben, Megan, Bobak, and Meredith to learn about life in the Medical Scientist Training Program. Links for this episode MTGR1 and intestinal secretory lineage allocation (Faseb J) Coronaviruses induce macropinocytosis (mBio) PD-1 and respiratory virus reinfection (J Immunol) Vanderbilt MSTP on Facebook Video of this episode: view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sun, April 12, 2015
TWiV 332: Vanderbilt virology
Host: Vincent Racaniello Guests: Seth Bordenstein , James Crowe , and Mark Denison Vincent visits Vanderbilt University and meets up with Seth, Jim, and Mark to talk about their work on a virus of Wolbachia, anti-viral antibodies, and coronaviruses. Links for this episode SARS-CoV error correction (PLoS Path) 19:00 Marburg virus neutralization by a human antibody (Cell one and two ) 56:35 Phage WO , Wolbachia and Drosophila (Peer J) 1:02:00 Seth's blog Symbionticism 1:31:30 Seth on Twitter Video of this episode: view at YouTube Timestamps by Jennifer . Thank you! Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sun, April 05, 2015
TWiV 331: Why is this outbreak different from all other outbreaks?
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiV team discusses the possible association of the respiratory pathogen enterovirus D68 with neurological disease. This episode is sponsored by SciMed Solutions and ASM Education . Links for this episode Clusters of AFP associated with enterovirus D68 (Lancet) 31:35 Novel outbreak enterovirus D68 strain (Lancet Inf Dis) 53:00 Enterovirus D68 in Norway (Euro Surveill) 1:12:00 Unknown enemy (Nature) 1:10:40 Enterovirus D68 on TWiV 302 Letters read on TWiV 331 8:00, 1:23:50 Timestamps by Jennifer . Thank you! Weekly Science Picks 1:53:50 Alan - OU0POLIO ham radio special event station ( on air reports )<a href="http://www.sitesucker
Sun, March 29, 2015
TWiV 330: A swinging gate
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVers explain how a protein platform assists the hepatitis C virus RNA polymerase to begin the task of making viral genomes. Links for this episode NYAS Afterschool STEM Mentoring Program Concerns about editing the human germline ( Science , Nature ) Engineering the perfect baby (MIT Tech Rev) RNA recognition by HCV polymerase (Science) Kickstarting an RNA polymerase (Science) A protein platform for priming (virology blog) Apoenzyme and holoenzyme (Wikibooks) Ebolavirus will not become a respiratory pathogen (virology blog) Burkholderia pseudomallei (CDC) Letters read on TWiV 330 Timestamps by Jennifer . Thank you! <h3 style="color: rgb(51, 51, 51); font-family: Ge
Sun, March 22, 2015
TWiV 329: Pox in the balance
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiV team reviews identification of immune biomarkers in CFS/ME patients, and how a cell nuclease controls the innate immune response to vaccinia virus infection. Links for this episode Immune signatures in ME/CFS (Science Adv) 11:15 Systemic exertion intolerance disease (Lancet) 19:50 Cell nuclease controls anti-viral responses (Cell Host Micr) 25:10 Poxvirus decapping enzymes prevent innate responses (Cell Host Micr) 1:15:40 Caps off to poxviruses (Cell Host Micr) Drummer Mohr (YouTube) 1:24:05 Bornavirus in squirrel breeders (ProMedMail) 1:28:45 Principles of Microbial Diversity 5:30 Journal of Microbiology & Biology Education 1:24:25 Cross-stitch by Anne Marie 1:34:40 Letters read on TWiV 329 1:25:00 Timestamps by Jennifer. Thank you! Weekly Science Picks 1:35:10 <p style="color: #333333; font-family: Georgia, 'Times New Roman', 'Bitstream Charter', Times, serif; font-size: 16px; line-heig
Sun, March 15, 2015
TWiV 328: Lariat tricks in 3D
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVocateurs discuss how the RNA polymerase of enteroviruses binds a component of the splicing machinery and inhibits mRNA processing. Links for this episode Viral polymerase binds Prp8 to inhibit mRNA splicing (PLoS Path) Prp8 protein of the spliceosome (RNA) Nuclear entry of poliovirus RdRp (Virol) RNA processing (TWiV 216) Measles in USA (CDC) Principles of Microbial Diversity Journal of Microbiology & Biology Education Letters read on TWiV 328 Weekly Science Picks Alan - Positively Negative (PLoS One) Rich - ISS assembly<
Sun, March 08, 2015
TWiV 327: Does a gorilla shift in the woods?
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The eTWiVicators review evidence that the HIV-1 group O epidemic began with a single cross-species transmission of virus from western lowland gorillas. Links for this episode Traces of ATCV-1 associated with laboratory contamination (PNAS) ATCV-1 findings not explained by contamination (PNAS) Origin of HIV-1 group O epidemic in western lowland gorillas (PNAS) INNO-LIA Principles of Microbial Diversity Image credit: John Letters read on TWiV 327 Weekly Science Picks Alan - California bill to eliminate personal vaccine exemptions Rich - Kepler observatory ( Kepler-186f ) Kathy - USGS disease map Dickson<
Sun, March 01, 2015
TWiV 326: Giving HIV a flat tyr
Hosts: Vincent Racaniello , Alan Dove , and Rich Condit The sternutating TWiVers discuss preventing infection of cells and animals by a soluble CD4-CCR5 molecule that binds to HIV-1 virus particles. Links for this episode Dif-tor heh smusma (NY Times) Immunization preterm premature infants (Thanks, Johnye!) HIV and SHIV protection conferred by eCD4-Ig (Nature) Tyrosine sulfation (Wikipedia) GBV-C and Ebolavirus infection (J Virol) Letters read on TWiV 326 Weekly Science Picks Alan - Toms River by Dan Fagin Rich - Spin by Robert Charles Vincent - FCC votes for net neutrality (ArsTechnica) Listener Pick of the Week <p style="color: #333333; font-family: Georgia, 'Times New Roman', 'B
Sun, February 22, 2015
TWiV 325: Wildcats go viral
Host: Vincent Racaniello Guests: Rollie Clem and Lorena Passarelli Vincent visits the 'Little Apple' and speaks with Rollie and Lorena about their work on mosquito-born viruses and baculoviruses. Links for this episode Apoptosis inhibition in A. aegypti (Apop) Initiator caspase in armyworm (Insect Bioc Mol Biol) Manipulating apoptosis in A. aegypti (J Virol) Viral inhibitors of apoptosis (Sem Cell Dev Biol) Baculoviruses: Sophisticated pathogens (PLoS Path) Baculovirus morphogenesis (Virol) Barriers to baculovirus success (Virol) Baculovirus endonuclease (J Virol) Baculovirus DNA damage response (J Virol) Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sun, February 15, 2015
TWiV 324: Viruses in the miR may appear more numerous
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guest: Lee Feinman Lee joins the TWiV team to discuss the value of post-doctoral training, and how a cellular microRNA assists in the replication of hepatitis C virus. Links for this episode Spin by Robert Charles Wilson Immunization of preterm infants (Dev Period Med) miR-122 alters HCV translation-replication balance (Cell Host Micr) Holding a miR to HCV (TWiV 180) Treating hepatitis C by blocking miR-122 (virology blog) Click chemistry (Wikipedia) Image credit Ebolavirus sitrep (WHO) Letters read on TWiV 324 Weekly Science Picks Lee - Furthering America's Re
Sat, February 07, 2015
TWiV 323: A skid loader full of viromes
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler The family TWiVidae discuss changes in the human fecal virome associated with Crohn's disease and ulcerative colitis. Links for this episode Enteric virome changes in inflammatory bowel disease (Cell) Gov. Christie stumbles on vaccination (NY Times) Anti-vax psychology (NPR) Vaccine skeptic changes her mind (NPR) Ebolavirus sitrep (WHO) Letters read on TWiV 323 Weekly Science Picks Alan - Sitesucker Rich - Snake picked wrong dinner Dickson - Sapporo Snow Festival Vincent - Mapping NYC subway DNA <h3 style="color: #333333; font-family: Georgia, 'Times New Roman', 'Bitstream Charter'
Sun, February 01, 2015
TWiV 322: Postcards from the edge of the membrane
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler The TWiVodes answer listener email about hantaviruses, antivirals, H1N1 vaccine and narcolepsy, credibility of peer review, Bourbon virus, influenza vaccine, careers in virology, and much more. Links for this episode Bourbon virus (NY Times) Thogotovirus (ViralZone) Drug induced apoptosis and HIV infection (PLoS One) Mumps cases and outbreaks (CDC) Opossums as pets? (doc) Cat found Letters read on TWiV 322 Weekly Science Picks Alan - Boom by Tony Horowitz Kathy - Octopus supermom Dickson - Macrophotography Vincent - Virology lectures 2015 ( virology blog and <a href="https://www.youtube.com/pla
Sun, January 25, 2015
TWiV 321: aTRIP and a pause
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Guest: Paul Duprex Paul joins the TWiV team to discuss the current moratorium on viral research to alter transmission, range and resistance, infectivity and immunity, and pathogenesis. Links for this episode Wain-Hobson objects ( one , two , three , four ) Influenza H7N1 transmission experiments (J Virol) Epistemological perspective on aTRIP experiments (mBio) Limited scientific value and risk (mBio) Reply to limited scientific value (mBio) Risks and benefits of aTRIP experiments (mBio) Apocalypse as rhetorical device in aTRIP debate (mBio) Moratorium on aTRIP experiments Moratorium on aTRIP research (mBio) Risks of influenza virus transmis
Sat, January 17, 2015
TWiV 320: Retroviruses and cranberries
Host: Vincent Racaniello Guest: John Coffin Vincent speaks with John Coffin about his career studying retroviruses, including working with Howard Temin, endogenous retroviruses, XMRV, chronic fatigue syndrome and prostate cancer, HIV/AIDS, and his interest in growing cranberries. Links for this episode John Coffin (Wikipedia) Specific HIV integration sites (Science) Novel retrovirus in modern birds (J Virol) Recombinant origin of XMRV (Science) Cranberry harvest (jpg) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sun, January 11, 2015
TWiV 319: Breaking breakbone
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVers review the outcomes of two recent phase 3 clinical trials of a quadrivalent dengue virus vaccine in Asia and Latin America. Links for this episode Efficacy of dengue vaccine (NEJM) Preventing dengue (NEJM) Dengue viruses (Scitable) Intention to treat (Wikipedia) Image credit: Jean-Yves Sgro Letters read on TWiV 319 Weekly Science Picks Alan - The Toaster Project by Thomas Thwaites Rich - SpaceX reusable rocket ( SpaceX ) Kathy - Antarctica: A Year on Ice Dickson - <a href="http:/
Sun, January 04, 2015
TWiV 318: Last year in virology
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler The TWiV gang reviews ten fascinating, compelling, and riveting virology stories from 2014. Ten virology stories of 2014 Ebola virus outbreak (TWiV 314 , 309 , 308 , 307 , 306 , 305 , 304 , 303 , 302 , 298 , 297 , 283 ) Directional uncoating of rhinovirus RNA (TWiV 267 ) Pandemic pathogen controversy (TWiV 287 ) Viral evolution (TWiV 275 ) Borna virus inhibition by endogenous DNA (TWiV 303 ) MERS-CoV in dromedary camels (TWiV special , TWiV 287 )</li
Sun, December 28, 2014
TWiV 317: Brazil goes viral
Host: Vincent Racaniello Guests: Eurico Arruda, Gustavo Acrani, Cintia Bittar, Tatiana Domitrovic, and Suellen Galvino-Costa On his second trip to Brazil, Vincent joins Eurico to speak with three young virologists, Gustavo, Cintia, Tatiana, and Suellen, about their work and their prospects for careers in science. Video of this episode: view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sun, December 21, 2014
TWiV 316: The enemy of my enemy is not my friend
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Vincent, Alan, Rich and Kathy discuss how interleukin 10 modulation of Th17 helper cells contribute to alphavirus pathogenesis. Links for this episode IL10 modulation of Th17 cells during alphavirus pathogenesis (PNAS) Th17 cells involved in influenza mediated gut injury (J Exp Med) Helper T cells 2014-15 flu season (CDC) Key facts about flu & flu vaccine (CDC) Does the flu vaccine work ? (Turbid plaque) Effectiveness of flu vaccine (virology blog) Image credit Letters read on TWiV 316 Weekly Science Picks Alan - It came from the pond Rich - Wanderers Kathy - <a href="http://astore.amazon.com/virologyws-20/detail/0670025852" ta
Sat, December 13, 2014
TWiV 315: Must be something in the water
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Vincent, Alan, Rich and Kathy association of a virus with sea star melting disease, and the finding of a phycodnavirus in the oropharynx of humans with altered cognitive functions. Links for this episode National Influenza Immunization Week (CDC) Densovirus associated with sea star wasting disease (PNAS) A virus that melts sea stars (virology blog) Chlorovirus in human oropharynx (PNAS) Algal virus in humans (virology blog) Image credit Letters read on TWiV 315 Weekly Science Picks Alan - ReelLife Science 2014 Winners Rich - The Martian by Andy Weir Kathy - Dance Your Ph.D. Winner <a href="http://www.sciencedirect.com/science/jour
Sun, December 07, 2014
TWiV 314: Einstein goes viral
Host: Vincent Racaniello Guests: Kartik Chandran , Ganjam Kalpana , and Margaret Kielian Vincent travels to Albert Einstein College of Medicine where he speaks with Kartik, Ganjam, and Margaret about their work on Ebolavirus entry, a tumor suppressor that binds the HIV-1 integrase, and the entry of togaviruses and flaviviruses into cells. Links for this episode Antibodies that protect against Sudan virus (ACS Chem Biol) Ebola virus entry requires NPC1 (EMBO J) A toggle switch for virus entry (Nat Comm) Imaging alphavirus exit (J Virol) Defects in HIV-1 unable to interact with INI1 (Retrovirol) Cell cycle arrest by INI1 (Mol Cell Biol) Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sun, November 30, 2014
TWiV 313: With viruses like these, who needs enemas?
Hosts: Vincent Racaniello , Alan Dove , and Rich Condit Vincent, Alan, and Rich discuss how norovirus, an enteric virus, can replace the functions of the gut microbiome. Links for this episode Ebola virus update (WHO) Norovirus can replace functions of gut microbiome (Nature) Post-vaccinal distemper encephalitis (N Z Vet J) Novel sea otter poxvirus (J Wildl Dis) Poliovirus escapes antibodies (virology blog) CDC whistleblower saga (Sci Based Med) Snopes on CDC whistleblower Image credit Letters read on TWiV 313 Video of this episode - view at YouTube Weekly Science Picks Alan - Retrocomputing Rich - Where is Rosetta? <a href="http://www.sciencedirect.com/science/journal/00426822/466/su
Sun, November 23, 2014
TWiV 312: She sells B cells
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVbolans discuss the finding that human noroviruses, major causes of gastroenteritis, can for the first time be propagated in B cell cultures, with the help of enteric bacteria. This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC . Links for this episode Ebola virus appropriations (White House) ASM Ebola FAQ Quarantine due to Ebola virus in semen (NPR) Enteric bacteria promote norovirus infection of B cells (Science) Norovirus emerges (Zimmer) Stephanie Karst
Sun, November 16, 2014
TWiV 311: Bulldogs go viral
Host: Vincent Racaniello Guests: Zhen Fu and Biao He Vincent visits the University of Georgia where he speaks with Zhen Fu and Biao He about their work on rabies virus and paramyxoviruses. Links for this episode Blood-brain permeability and rabies survival (Antiviral Res) Rabies induces blood-brain permeability (J Virol) Virus neutralizing antibodies in CNS of non-lethal rabies (PLoS Neg Trop Dis) RSV vaccine based on PIV5 (Vaccine) New mumps vaccine (J Virol) PIV5-based influenza virus vaccine (J Virol) Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sun, November 09, 2014
TWiV 310: From bacteriophage to retroviruses with Ann Skalka
Hosts: Vincent Racaniello and Glenn Rall Guest: Ann Skalka Vincent and Glenn meet up with Ann and talk about her long and productive career in virology, from biochemistry to bacteriophage lambda to retroviruses. Links for this episode Skalka laboratory Asilomar Conference on recombinant DNA Unexpected inheritance (PLoS Path) Viral sequences in vertebrate genomes (J Virol) Assembly of integrase multimers (J Biol Chem) Cell cycle and retrovirus integration (J Cell Bioch) Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sun, November 02, 2014
TWiV 309: Ebola email
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVocytes answer questions about Ebola virus, including mode of transmission, quarantine, incubation period, immunity, and much more. This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC . Links for this episode Guidelines for monitoring potentially infected persons (CDC) ASTMH meeting rejects attendees from Ebola countries (ScienceInsider) Defense Threat Reduction Agency call for Ebola virus proposals NSF calls for Ebola virus proposals Review of Ebola virus human-human transmission (CDC) How Firestone controlled Ebola virus (M
Sat, October 25, 2014
TWiV 308: The Running Mad Professor
Host: Vincent Racaniello Guest: Tom Solomon Tom talks with Vincent about viral central nervous system infections of global importance, Ebola virus, and running the fastest marathon dressed as a doctor. Links for this episode World's biggest brain Tom's YouTube channel Sex, drugs, and emerging viruses (TedX) The Running Mad Professor Image credit: ClickLiverpool Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sun, October 19, 2014
TWiV 307: Ebola aetiology
Hosts: Vincent Racaniello , Alan Dove , and Kathy Spindler Guest: Tara C. Smith Tara Smith joins the TWiEBOVsters to discuss the Ebola virus outbreak in west Africa, spread of the disease to and within the US, transmission of the virus, and much more. This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC . Links for this episode Science communications fellow at ASM Nation turns to science (New Yorker) CDC employees in West Africa (CDC) <a href="http://bigstory.ap.org/article/6fd22fbcca0c47318cb178596d57dc7a/un-we-bot
Sun, October 12, 2014
TWiV 306: This Week in Ebolavirus
Hosts: Vincent Racaniello , Alan Dove , and Kathy Spindler The Grand Masters of the TWiV discuss Ebola virus transmission, air travel from West Africa, Ebola virus infectivity on surfaces, the Dallas Ebola virus patient, and Ebola virus in dogs. This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC . Links for this episode Science communications fellow at ASM CDC Ebola virus fact sheet (pdf) CDC Ebola virus infographic (pdf) No Reston virus replication in arthropods (Am J Trop Med Hyg) Inoculation of plants and animals with Ebola virus (Emerg Inf Dis) Arthropod studies during Ebola virus outbreak (J Inf Dis) Medbox: Ebola toolbox Facts about bushmeat and Ebola (pdf, CDC) <
Sun, October 05, 2014
TWiV 305: Rhymes with shinola
Hosts: Vincent Racaniello , Alan Dove , and Kathy Spindler Vincent, Alan, and Kathy continue their coverage of the Ebola virus outbreak in West Africa, with a discussion of case fatality ratio, reproductive index, a conspiracy theory, and spread of the virus to the United States. This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC . Links for this episode Science communications fellow at ASM Can we get AIDS from mosquito bites ? (J La State Med Soc) Why mosquitoes cannot transmit AIDS Isolation of Bundibugyo ebolavirus in Uganda (PLoS Path) Ebola virus disease outbreak, Nigeria (MMWR) Nigeria contains Ebola virus outbreak (NY Times) First Ebola virus case <a href="http:
Sun, September 28, 2014
TWiV 304: Given X, solve for EBOV
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Guest: Jeff Shaman The TWiV team consults an epidemiologist to forecast the future scope of the Ebola virus epidemic in West Africa. This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC . Links for this episode Science communications fellow at ASM Estimating future cases in Ebola virus epidemic (MMWR) Columbia prediction of Ebola outbreak The Ebola emergency (NEJM) Q&As on Ebola virus transmission (CDC) Ebola virus transmission to monkeys (Lancet) <a href="http://www.ncbi.nlm.n
Sun, September 21, 2014
TWiV 303: Borna this way
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler The TWiV team discusses transmission of Ebola virus, and inhibition of Borna disease virus replication by viral DNA in the ground squirrel genome. This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC . Links for this episode 2014 Ebola virus outbreak at Healthmap Ebola virus transmission from bodily fluids and fomites (JID) Value of gain of function experiments (mBio) Rich Condit in the Washington Post on Ebola virus NPR on Ebola virus transmission What we are not afraid to say about Ebola virus (virology blog) Inhibition of <a href="http://www.pnas.org/content/111/36/13175.a
Sun, September 14, 2014
TWiV 302: The sky is falling
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVers discuss the growing Ebola virus outbreak in West Africa, and an epidemic of respiratory disease in the US caused by enterovirus D68. Links for this episode Cancer patient saved by measles virus Ebola virus genome sequences (Science) Robert Garry on Ebola outbreak Aerosol transmission WHO Ebola outbreak summary CDC Ebola outbreak page Ebola outbreak epi curve CED Ebola outbreak info graphic Ebola response roadmap (CDC) Ebola outbreak discussion at ICAAC Human trial of Ebola virus vaccine (CNN) Chimpanzee adenovirus vectored Ebola virus vaccine (Nat Med) How US Ebola patients were <a href="http://www.scientificamerican.com/article/ebola-doctor-reveals-how-infected-americans-were-cured/" target="_blank"
Sat, September 06, 2014
TWiV 301: Marine viruses and insect defense
Host: Vincent Racaniello Guests: Carla Saleh and Curtis Suttle At the International Congress of Virology in Montreal, Vincent speaks with Carla and Curtis about their work on RNA interference and antiviral defense in fruit flies, and viruses in the sea, the greatest biodiversity on Earth. Links for this episode Greatest biodiversity on Earth (Genome) Cafeteria roenbergensis virus (PNAS) Marine viruses (Nat Rev Micro) RNAi and reverse transcription is antiviral in flies (Nat Imm) Friendly persistent infections (Curr Op Micro) RNAi and antiviral defense in Drosophila (Dev Comp Imm) Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sun, August 31, 2014
TWiV 300: So happy together
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Recording together for the first time, the TWiV team celebrates their 300th recording at the American Society for Microbiology headquarters in Washington, DC, where Vincent speaks with Dickson, Alan, Rich, and Kathy about their careers in science. Links for this episode So Happy Together (The Turtles) Viral Hemorrhagic Fever Consortium Support Kenema VHFC program Letters read on TWiV 298 Video of this episode - view at YouTube Weekly Science Picks Alan - The Internet's Original Sin Dickson - Placidcoyote Rich - Scientific Method, Grail Style Kathy - Viruses Throughout Life and Time </
Sun, August 24, 2014
TWiV 299: Rocky Mountain virology
Host: Vincent Racaniello Guests: Marshall Bloom , Sonja Best , and Byron Caughey Vincent visits the Rocky Mountain Laboratories in Hamilton, Montana and speaks with Marshall, Sonja, and Byron about their work on tick-born flaviviruses, innate immunity, and prion diseases. Links for this episode Rocky Mountain Laboratories , NIH Flavivirus persistence (Path Dis) Flaviviruses antagonize IRF1 (J Imm) Prion test using nasal brushings (NEJM) Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sun, August 17, 2014
TWiV 298: MV-NIS de myelo
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler The TWiV gang answer follow-up questions about the Ebola virus outbreak in West Africa, then discuss treatment of disseminated multiple myeloma with oncolytic measles virus. Links for this episode Use of unregistered interventions for Ebola virus disease (WHO) Response to anthrax and H5N1 incidents (CDC) Remission of disseminated cancer after treatment with oncolytic measles virus (Mayo Clin Proc) New viruses for cancer therapy (Nat Rev Micro) Cattaneo on TWiV Image credit Letters read on TWiV 298 Weekly Science Picks Alan - WTF, Evolution?! by Mara Grunbaum Rich - Cold Spring Harbor Oral History Collection Kathy - Inside insides <a href="http://rna.
Sun, August 10, 2014
TWiV 297: Ebola! Don't panic
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler The TWiVites present an all-ebolavirus episode, tackling virology, epidemiology, and approaches to prevention and cure that are in the pipeline. Links for this episode Risks and benefits of gain-of-function experiments (mBio) Scientists for Science US Policy for oversight of DURC (pdf) US framework for guiding H5N1 transmission expts (pdf) Extra oversight for H7N9 experiments (Science) TWiV 283: No Reston for the weary Is it Ebolavirus or Ebola virus? (virology blog) Ebola virus disease update (WHO) Ebola virus disease FAQ (WHO) Ebola hemorrhagic fever (CDC) Ebola virus disease: ecology meets economy (PLoS NTD) 2014 Ebola virus outbreak (J Gen Virol) <a href="http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6325a4.h
Sun, August 03, 2014
TWiV 296: The real Batman, Linfa Wang
Host: Vincent Racaniello Guest: Linfa Wang Vincent visits the Australian Animal Health Laboratory in Geelong, Australia and speaks with Linfa about his work on bats and bat viruses. Links for this episode Hendra virus vaccine (Emer Inf Dis) Comparison of bat genomes (Science) Endogenous retroviruses in bats (Retrovirol) The Bat Pack Bats in Geelong (YouTube) Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sun, July 27, 2014
TWiV 295: A nonslip grippe and Lassa's LAMP
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Rich Condit The TWiVome discusses an miRNA based strategy to mitigate risk of gain of function studies, and identification of a second receptor required for Lassa virus entry. Links for this episode miRNA strategy to minimize risk (Nat BioT) NIH Office of Science Policy NIH recombinant DNA guidelines Second receptor for Lassa virus entry (Science) Lassa fever (Wikipedia) Fever! The discovery of Lassa virus ( TWiV 9 ) Letters read on TWiV 294 Weekly Science Picks Alan - Nicky Bay macrophotography (Flickr) Rich - FASEB Third annual BioArt competition Vincent - Up Close podcast (<a href="http://upclose.unimelb.edu.au/episode/309-viral-diary-global-rise-and-near
Sun, July 20, 2014
TWiV 294: Smallpox and anthrax and flu, oh my!
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Rich Condit The TWiV team reviews the discovery of old vials of smallpox virus at NIH, anthrax and influenza mishaps at CDC, the baby who was not cured of HIV, Cambridge Working Group, and sacking of NSABB members. Links for this episode Newly discovered smallpox (CDC) Infectious smallpox in FDA storage (FDA) Report on potential anthrax exposure (pdf, CDC) CDC Director on unsafe practices (NY Times) HIV returns to baby (NY Times) Original HIV baby cured article (NEJM) Cambridge Working Group NSABB members released (ScienceInsider) Letters read on TWiV 294 Weekly Science Picks Alan - Optivisor Ric
Sun, July 13, 2014
TWiV 293: Virology Down Under
Host: Vincent Racaniello Guests: Melissa Churchill , Alex Khromykh , Gilda Tachedjian , and Paul Young Vincent visits Melbourne, Australia and speaks with Melissa, Alex, Gilda, and Paul about their work on HIV infection of the central nervous system, West Nile virus, microbicides for HIV, and the Koala retrovirus. Links for this episode Where does HIV hide ? (Curr Op HIV AIDS) Subgenomic flavivirus RNA (Viruses) Vaginal lactic acid and HIV (J Antimicro Chem) Koala retroviruses (Retrovirology) Coming soon - Video of this episode at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sun, July 06, 2014
TWiV 292: Medimmune goes viral
Host: Vincent Racaniello Guests: Wade Blair, Matt Dickson, Nicole Kallewaard-Lelay, and Ken Miller Vincent visits Medimmune and speaks with Wade, Matt, Nicole, and Ken about why they work in industry and their daily roles in a biotechnology company. Links for this episode Medimmune, LLC Medimmune on Twitter Medimmune history and products Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sun, June 29, 2014
TWiV 291: Ft. Collins abuzz with virologists
Hosts: Vincent Racaniello , Rich Condit , and Kathy Spindler Guests: Clodagh O'Shea and Ron Fouchier Vincent, Rich, and Kathy and their guests Clodagh and Ron recorded this episode at the 33rd annual meeting of the American Society for Virology at Colorado State University in Ft. Collins, Colorado. Links for this episode Viral polymer that inactivates tumor suppressors (Cell) Mutations driving airborne transmission of influenza H5N1 virus (Cell) Transmission of influenza H7N1 virus in ferrets (J Virol) Ron Fouchier on TWiV #177 Photo credit: Matt Evans Thanks to David Quammen for the title Video of this episode - view at YouTube Weekly Science Picks Rich - No sexual transmission of HCV (Am J Gastro)<stro
Wed, June 18, 2014
TWiV 290: Baylor goes viral
Host: Vincent Racaniello Guests: Janet Butel and Rick Lloyd Vincent meets up with Janet Butel and Rick Lloyd at Baylor College of Medicine to talk about their work on polyomaviruses and virus induced stress. Links for this episode SV40 microRNAs (PLoS Path) SV40 seroprevalence (J Infect) Viruses and stress granules (PLoS Path) Viral inhibition of stress granule formation (Cell Host Micr) Video of this episode - view below or at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sun, June 15, 2014
TWiV 289: Vinny and the capsids
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Vinny and the capsids answer listener questions about the definition of life, state vaccination laws, the basic science funding problem, viral ecology, inactivation of viruses by pressure, and much more. Links for this episode Varun's research poll Letters read on TWiV 289 Weekly Science Picks Alan - The Science of Good Cooking Vincent - The Shooter Report (pdf) Kathy - Daily overview Dickson - Girl rising Listener Pick of the Week Johnye - Ri channel Ricardo - Open spin microscope (<a href="http://www.nikonsmallworld.com/galleries/swim/2013-small-world-in-motion-competition" target="
Sun, June 08, 2014
TWiV 288: ebircsnart esreveR
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The Twivsters discuss how reverse transcriptase encoded in the human genome might produce DNA copies of RNA viruses in infected cells. Links for this episode Should variola virus be destroyed ? (poll at virology blog) DNA complementary to non-retroviral RNA viruses (Sci Rep) Integration of arenavirus DNA into cell genome (virology blog) Infectious respiratory syncytial DNA (PNAS) Tysabri and PML JC and PML (J Imm Res) Igor Koralnik laboratory Jean-Luc Doumont ( Kathy's pick, TWiV 268 ) Bullet points kill (TED) Letters read on TWiV 288 Weekly Science Picks Rich - Luvalamps <a href="http://science
Sun, June 01, 2014
TWiV 287: A potentially pandemic podcast
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Kathy Spindler , and Matt Frieman Matt updates the TWiV team on MERS-coronavirus, and joins in a discussion of whether we should further regulate research on potentially pandemic pathogens. Links for this episode MERS stories at CIDRAP MERS at CDC MERS in the US (CDC) MERS-CoV map MERS-CoV infection after camel exposure (EID) MERS-CoV in dromedaries from Egypt, Sudan, Ethiopia (EID) MERS-CoV antivirals ( one , two , three , four ) Experiments with novel potential pathogens (PLoS Med) Unacceptable risks (Bull Atom Sci) TWiX Bingo (thanks, Mark!) Letters read on TWiV 287 Weekly Science Picks <p style="color: rgb(51, 51, 51); font-family: Georgia, 'Times New Roman', 'Bitstream C
Mon, May 26, 2014
TWiV 286: Boston TWiV party
Hosts: Vincent Racaniello and Alan Dove Guests: Julie Pfeiffer and Paul Duprex Vincent and Alan meet up with Julie and Paul at the General Meeting of the American Society for Microbiology in Boston, to talk about their work on the pathogenesis of poliovirus and measles virus. Links for this episode Threading the NEIDL (YouTube) Transmission of measles virus from macaques (J Gen Virol) Tropism of green measles virus in macaques (J Virol) Intestinal microbiota promote enteric virus replication (Science) Bacterial LPS enhances poliovirus stability (Cell Host Micr) Video of this episode - view below or at YouTube Weekly Science Picks Vincent - ASM Live 2014 Alan - I will not follow the herd Paul - Invisible Threat Julie - The importance of stupidity in biological rese
Sat, May 17, 2014
TWiV 285: Hokies go viral
Host: Vincent Racaniello Guests: XJ Meng and Sarah McDonald Vincent meets up with XJ and Sarah at Virginia Tech to talk about their work on viruses of swine and rotaviruses. Links for this episode Hepatitis E virus (Int J Env Res Pub Health) Porcine and human anelloviruses (J Virol) Origin of porcine epidemic diarrhea virus in US (mBio) Distinguishing rotaviruses (J Virol) Molecular epidemiology of rotaviruses (J Virol) Core domains in rotavirus polymerase encapsidation (J Gen Virol) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sun, May 11, 2014
TWiV 284: By the pricking of my thumbs, something wicked this way comes
Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Kathy Spindler The TWiV team discusses how skin scarification promotes a nonspecific immune response, and whether remaining stocks of smallpox virus should be destroyed. Links for this episode Skin scarification protects against vaccinia virus disease (J Virol) Smallpox research agenda (PLoS Path) WHO report on variola research (pdf) Review of smallpox research program for WHO (pdf) How I record my lectures (virology blog) Letters read on TWiV 284 Weekly Science Picks Rich - EPCOT Vincent - Medical Biotechnology Kathy - Alan Alda interview and Flame Challenge winner <
Sun, May 04, 2014
TWiV 283: No Reston for the weary
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Guest: Jens H. Kuhn Jens speaks with the TWiV team about filoviruses, including the recent Ebola virus outbreak in Guinea. Links for this episode Review of Zanamavir clinical trials (Brit Med J) Ebola virus disease in Guinea (NEJM) Filovirus nomenclature (virology blog) Ebola virus disease, West Africa (ProMedMail) How lethal are ebolaviruses? (virology blog) Letters read on TWiV 283 Weekly Science Picks Alan - AMNH digital special collections Vincent - Viral entry into host cells (Stefan Pöhlmann PhD, Graham Simmons PhD, eds) Kathy - Papilloma song lyrics (pdf) Jens - </s
Sun, April 27, 2014
TWiV 282: Tamiflu and tenure too
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler The TWiV team reviews a meta-analysis of clinical trial reports on using Tamiflu for influenza, and suggestions on how to rescue US biomedical research from its systemic flaws. Links for this episode World Malaria Day Review of oseltamivir clinical trials (Brit Med J) Effectiveness of Tamiflu questioned (NHS choices) Tamiflu campaign (Brit Med J) Rescuing US biomedical research (PNAS) Letters read on TWiV 282 Weekly Science Picks Alan - Northampton Airport Vincent - Particle Fever Kathy - Turn iPhone into microscope Rich - My favorite science gifs Listener Pick of the Week Nathan
Mon, April 21, 2014
TWiV 281: The Salk legacy with Peter L. Salk
Host: Vincent Racaniello Guest: Peter L. Salk Vincent meets up with Peter L. Salk to talk about development of the first poliovaccine, eradication of poliomyelitis, and Jonas Salk's 100th birth anniversary. Links for this episode Jonas Salk Legacy Foundation The Cutter Incident by Paul Offit Splendid Solution by Jeffrey Kluger ( review ) Coming soon: Video of this episode Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sun, April 13, 2014
TWiV 280: Post viral
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiVmeisters answer listener email about the NEIDL, negative results, patenting MERS-coronavirus, human papillomavirus transmission, canine distemper virus, and much, much more. Links for this episode Poxvirus viability in historical relics (EID) TWiM 74 : It came from the Siberian permafrost How to read a scientific paper Image credit: Not only quilts Letters read on TWiV 280 Weekly Science Picks Alan - Heartbleed explanation Vincent - Agriculture science today podcast Kathy - Quizlet flashcards ( online and iTu
Sun, April 06, 2014
TWiV 279: The missing LNC
Hosts: Vincent Racaniello , Alan Dove , and Kathy Spindler Vincent, Alan, and Kathy reveal how a retrovirus in the human genome keeps embryonic stem cells in a pluripotent state, from where they can differentiate into all cells of the body. Links for this episode Retrovirus needed for stem cell identity (Nat Struc Mol Biol) HERV-H is a marker for pluripotency (Retrovirology) Letters read on TWiV 279 Weekly Science Picks Alan - Heathkit Vincent - How to think about autism risk and Autism prevalence Kathy - Distortions Listener Pick of the Week Joseph - <a
Sun, March 30, 2014
TWiV 278: Flushing HIV down the zinc
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Vincent, Dickson, Alan, and Kathy discuss disruption of the ccr5 gene in lymphocytes of patients infected with HIV-1. Links for this episode Gene editing of ccr5 in AIDS patients (NEJM) HIV gets the zinc finger (TWiV 144) Genome engineering with zinc finger nucleases (Genetics) Photo credit: Watty's Wall Stuff Mice lie, monkeys exaggerate t-shirt design (thanks, Christophe) Letters read on TWiV 278 Weekly Science Picks Alan - Digital scale model of solar system Dickson - Font of knowledge Vincent - Measles outbreaks tr
Sun, March 23, 2014
TWiV 277: My podcast Vinny
Hosts: Glenn Rall , Ann Skalka , and Vincent Racaniello Glenn and Ann meet up with Vincent to talk about his career in science and science communication. Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sun, March 16, 2014
TWiV 276: Ramblers go viral
Host: Vincent Racaniello Guests: Susan Baker and Thomas Gallagher Vincent meets up with Susan Baker and Tom Gallagher at Loyola University to talk about their work on coronaviruses. Links for this episode Papain-like viral proteases (Virus Res) MERS-CoV papain-like protease (Virology) Mouse model for MERS-CoV (PNAS) Receptor and MERS-CoV infection (J Virol) Letters read on TWiV 276 Video of this episode - view at YouTube Weekly Science Picks Vincent - First demonstration of Macintosh, 1984 Listener Pick of the Week Lance - <a href="http://astore.amazon.com/vir
Sun, March 09, 2014
TWiV 275: Virocentricity with Eugene Koonin
Hosts: Vincent Racaniello and Rich Condit Guest: Eugene Koonin Vincent and Rich meet up with Eugene Koonin to talk about the central role of viruses in the evolution of all life. Links for this episode Virocentric view of evolution (Curr Op Virol) Proposed order Megavirales (Arch Virol) Pithovirus (PNAS) Selfish virus-like elements (Virol J) Pandoraviruses are derived Phycodnaviruses (Biol Direct) Video of this episode - view below at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sun, March 02, 2014
TWiV 274: Data dump
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiV team discusses recent cases of polio-like paralysis in California, and the virome of 14th century paleofeces. Links for this episode MERS-CoV in dromedary camels (EID) Virologist Al Kapikian dies Polio-like illness in CA (ProMedMail) Acute flaccid paralysis AFP in India (EID) Enterovirus 68 (MMWR) EV 68 CNS infection (Arch Path Lab Med) Polio-free does not mean paralysis-free (The Hindu) Viruses in 14th century coprolite (AEM) Coprolite and paleofeces Ancient poxvirus (EID) Giant coprolite (WordADay) Letters read on TWiV 274 <h3 style="color: #333333; font-family: Georgia, 'Times New Roman', 'Bitstream C
Tue, February 25, 2014
TWiV special: MERS-coronavirus in dromedary camels
Host: Vincent Racaniello Guests: W. Ian Lipkin and Thomas Briese Vincent meets up with Ian and Thomas to discuss their finding that MERS-coronavirus has been circulating in dromedary camels in the Kingdom of Saudi Arabia since at least 1992. Links for this episode MERS-CoV in dromedary camels (mBio) TWiV 251: Don't kiss the camel TWiV 247: Today's weather in virology TWiV 239: Filterable camels Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sun, February 23, 2014
TWiV 273: Lambda is not just a phage
Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Kathy Spindler The TWiVome dissect the finding that interferon lambda alleles predict the outcome of hepatitis C virus infection. Links for this episode Interferon lambda and HCV outcome (Cell Host Micr) Laser capture microdissection (Wikipedia) HCV dependent fluorescent reporter (Nat Biotech) Bats and viruses (PLoS Path) White nose syndrome (PLoS Path) Mouse phenome database Letters read on TWiV 273 Weekly Science Picks Rich - Think like a scientist ( one , two ); Science controversies Dickson - Visualization challenge 2013 Vincent - </st
Sun, February 16, 2014
TWiV 272: Give peas a chance
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiV team describes aphid control by using a viral capsid protein to deliver a spider toxin to plants, and a human endogenous retrovirus that enhances expression of a neuronal gene. Links for this episode Toxin delivery to plants by viral capsid protein (Nat Biotech) Pea enation mosaic virus (ViralZone) Image credit: Aphid membrane feeding chamber (Sci Rep) Aphid feeding chamber (YouTube) Parafilm (Wikipedia) Human endogenous retrovirus enhances neural gene (PNAS) Flu, common cold , alternative medicine (NCCAM) Cold vs flu (CDC) Phage hunters Bed bugs and infectious disease (PLoS Path) Letters read on TWiV 272 Weekly Science Picks Alan - <a href
Sun, February 09, 2014
TWiV 271: To bee, or not to bee, that is the infection
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Ashlee Bennett The TWiV crew discusses two reports on viruses that might have crossed kingdoms, from plants to honeybees and from plants to vertebrates. Links for this episode Tobacco ringspot virus in honeybees (mBio) Plant virus that switched to vertebrates (PNAS) CDC influenza activity and surveillance With Esmeralda at ASM Biodefense (jpg) Image credit: Virginia Tech Learning Resources Center Letters read on TWiV 271 Weekly Science Picks Alan - Nagasaki bombing (YouTube) Rich - GoPro Red Bull Stratos (YouTube) Dickson - Solar orbs Vincent - Socrative <h3 style="color: #333333; font-family: Georgia, 'Times New Roma
Sun, February 02, 2014
TWiV 270: Homeland virology
Hosts: Vincent Racaniello and Rich Condit Guests: Dennis Hruby and Yoshihiro Kawaoka Vincent and Rich discuss avian influenza virus and an antiviral drug against smallpox with Dennis and Yoshi at the ASM Biodefense and Emerging Diseases Research Meeting in Washington, DC. Links for this episode ASM Biodefense Meeting Influenza H5N1 transmission (Virus Res) Aerosol transmission of H5N1 virus in ferrets (Nature) Characterization of H7N9 virus from humans (Nature) ST-246 efficacy in primates (AAC) Antiviral options for biodefense (Curr Op Virol) ST-246 safety in humans (Antimicrob Agents Chemother) Gain-of-function experiments (Science) Letters read on TWiV 270 Video of this episode - view at Vimeo Weekly Science Picks Vincent - Quanta Maga
Sun, January 26, 2014
TWiV 269: Herpesvirus stops a nuclear attack
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The complete TWiV team reviews evidence for sensing of herpesviral DNA in the nucleus by the cell protein IFI16. Links for this episode IFI16 is a nuclear pathogen sensor (Cell Host Micr) Nuclear IFI16 sensing of and antagonism by herpesvirus (PNAS) Acetylation regulates IFI16 location (PNAS) Letters read on TWiV 269 Weekly Science Picks Kathy - Female conveners and speakers Alan - Sandgrains Rich - 2013 Lamborghini Aventador Vincent - Happy Birthday Mac and 128K Mac teardown Dickson - Farmdominion Listener Pick of the Week <p style="margin-bottom: 1.3em; color: #333333; font-fa
Sun, January 19, 2014
TWiV 268: Transmission is inevitable
Hosts: Vincent Racaniello , Alan Dove , Kathy Spindler , and Ashlee Bennett Vincent, Alan, Kathy, and Ashlee discuss fomites in physicians offices, plant virus factories involved in aphid transmission, and clues from the bat genome about flight and immunity. Links for this episode How viruses cause disease (Coursera) How clean is your iPad (Which?) Meeting announcement: From emerging to pandemic viruses CaMV virus factories involved in aphid transmission (J Virol) Caulimovirus (ViralZone) CaMV responds instantly to vector (eLIFE) Aphid acquiring CaMV (J Virol) Bat genomes , flight, and immunity (Science) Letters read on TWiV 268 Weekly Science Picks Kathy - Jean-Luc Doumont ( slides , communicating science, website, <a href="ht
Sun, January 12, 2014
TWiV 267: Snow in the headlights
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Vincent, Alan, Rich and Kathy review a protease essential for influenza pathogenesis in mice, and directionality of rhinovirus RNA exit from the capsid. Links for this episode Protease essential for influenza pathogenesis in mice (PLoS Path) Rhinovirus uncoating is directional (PLoS Path) Fluorescence correlation spectroscopy Capillary electrophoresis (Wiki) Letters read on TWiV 267 Weekly Science Picks Kathy - Amazing maps Alan - Florida to NJ in 156 seconds (YouTube) Rich - Whiteout over Great Lakes from Space Vincent - LORiOLA viral necklaces <a href="http://www.faa.gov/news/pre
Sun, January 05, 2014
TWiV 266: A pathogenic vicious cycle
Hosts: Vincent Racaniello , Alan Dove , and Kathy Spindler Vincent, Alan, and Kathy discuss finding viruses in outer space, varying results obtained from personal genetic testing, and depletion of CD4 cells during HIV infection by pyroptosis. Links for this episode We should hunt for viruses in space (New Scientist) I had my DNA picture taken (NY Times) CD4 cell death by pyroptosis (Nature) Abortive HIV infection in lymphoid tissue (Cell) IFI16 sensor required for HIV mediated cell death (Science) PubMed Commons Preferential CTL targeting of Gag (Cell Rep) Exonic transcription protein binding (Science) Letters read on TWiV 266 Video of this episode - view at YouTube Weekly Science Picks Kathy - 17 mundane things, mind blowing views <a href="http://www.yout
Sun, December 29, 2013
TWiV 265: This year in virology
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler In their final episode of the year, the TWiV team reviews ten compelling virology stories from 2013. Links for this episode Antiviral RNAi (TWiV 255 , 256 , 263 ) MERS-CoV (TWiV 215 , 223 , 224 , 233 , 239 , 247 , 251 , 258 ) Placental trophoblasts confer viral resistance (TWiV 241 ) Origin of REV (TWiV 248 ) Phage T7 gets a cat scan (TWiV 220 ) It's a cGAS! (TWiV 222 ) Dual virus-host arms race (TWiV 242 ) Pandoraviruses (TWiV 246 , 261 ) CMV based SIV vaccine (TWiV <a href="
Sun, December 22, 2013
TWiV 264: We should do an all-email show some day
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler The TWiVites read listener questions and comments about public engagement in science, vaccines, RNAi, reprogramming CD8 cells to treat cancer, rabies, and much more. Links for this episode Viral gifts Controlling plant viruses by vector control (Ann Rev Phyto) Flavivirus RNAi suppressor (J Virol) Entre probetas podcast (iTunes) Hedgehog central Reprogramming T cells for leukemia therapy (NEJM) Petri Dish podcast On Your Mind podcast Letters read on TWiV 264 Weekly Science Picks Kathy - Sorting algorithms visualized Alan - Stratodean Rich - Art in Science by Polyxeni Potter Vincent - Pixel Genes <
Sun, December 15, 2013
TWiV 263: Game of clones
Hosts: Vincent Racaniello , Dickson Despommier, Alan Dove , Rich Condit , Kathy Spindler , and Ben tenOever Ben joins the TWiV team to reveal the winner of his contest in which influenza viruses carrying different interferon-stimulated genes vie against one another in mice. Links for this episode Virusninja Game of clones (Vax Rep) Game of clones bracket Letters read on TWiV 263 Weekly Science Picks Kathy - The Brain Scoop , esp. Where My Ladies At Alan - Say 'hi' to a spaceship (YouTube) Rich - Garmin BlueChart Mobile and Active Captain Vincent - Journal boycott ( one , two ) D ickson - <a href="http://science.discovery.com/tv-shows/futurescape
Mon, December 09, 2013
TWiV 262: Wrong form, right professor
Host: Vincent Racaniello Guest: Ann Palmenberg Vincent returns to the University of Wisconsin - Madison to speak with Ann Palmenberg about her career in virology. Links for this episode Palmenberg lab website - great resources Genome sequences of all rhinoviruses (J All Clin Imm) Cardioviral poly(C) tracts (Arch Virol Supp) EMCV disruption of nuclear transport (PNAS) Picornavirus protease in replicase gene (J Virol) Bacteriophage Qbeta replicase (J Virol) Thanks to Jordan for the episode title! Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sun, December 01, 2013
TWiV 261: Giants among viruses
Hosts: Vincent Racaniello and James Van Etten Guests: Chantal Abergel and Jean-Michel Claverie Vincent meets up with Chantal and Jean-Michel at the first International Symposium on Giant Virus Biology in Tegernsee, Germany, to discuss their work on Mimivirus, Megavirus, and Pandoravirus. Links for this episode Unanswered giant virus questions (Adv Virus Res) Fourth domain of life (Commun Integr Biol) Pandoraviruses (Science) Phaeocystis globosa virus (PNAS) Cafeteria roenbergensis virus (PNAS) Symposium group photo (jpg) Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sun, November 24, 2013
TWiV 260: Badgers go viral
Host: Vincent Racaniello Guests: Tom Friedrich , Tony Goldberg , and David O'Connor Vincent visits the University of Wisconsin, Madison and speaks with Tom, Tony, and David about their work on virus discovery at the AIDS Vaccine Research Laboratory. Links for this episode A tick in Tony's nose (Am J Trop Med Hyg) Two new SIV from colobus monkeys in Uganda (Biomed Cent) Pegivirus diversity in Uganda (J Gen Virol) Simian hemorrhagic fever virus diversity in African primates (J Virol) Video of this episode - coming soon Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sat, November 16, 2013
TWiV 259: Windows into the soul of a cell
Hosts: Vincent Racaniello and Rich Condit Guest: Jaquelin Dudley Vincent and Rich join Jackie at the University of Texas, Austin to talk about her work on mouse mammary tumor virus. Links for this episode Rem signal peptide processing and function (J Virol) MMTV null mice and tumorigenesis (J Virol) Jackie's publications (PubMed) I want my MMTV (TWiV 242) Live at ASV in Madison (TWiV 193) Symbiotic safecrackers (TWiV 154) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Mon, November 11, 2013
TWiV 258: Hedging our bats
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , Kathy Spindler , and Matt Frieman Matt joins the TWiV team to discuss the discovery of a SARS-like coronavirus in bats that can infect human cells, and what is going on with MERS-coronavirus. Links for this episode S ARS-like virus in bats binds ACE2 (Nature) Bat SARS-like virus that infects human cells (virology blog) Coronavirus infections update (WHO) Lack of MERS coronavirus antibodies in humans (EID) Mice not susceptible to MERS-CoV (J Gen Virol) MERS-CoV case imported into Spain MERS-CoV like virus in European hedgehogs (J Virol) DPP4 amino acids positively selected in bats (Virol J) Image credit: Richie Frieman Letters read on TWiV 258 <h3 style="color: #333333; font-family: Georgia, 'Times New Roman', 'Bit
Sun, November 03, 2013
TWiV 257: Caveat mTOR
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The TWiV team consider how the kinase mTOR modulates the antibody response to provide broad protection against influenza virus, and explore the problems with scientific research. Links for this episode T wo lives intertwined (Ann Rev Imm) John Holland, 83 Kinase mTOR modulates antibody response (Nat Imm) Drug widens immunity to flu (TheScientist) Concerto in B (TWiV 161) How science goes wrong (Economist) Trouble at the lab (Economist) Reforming science (TWiV 184) Letters read on TWiV 257 Weekly Science Picks Dickson - Tesla Motors supercharger <a href="http://www.npr.org/blogs/13.7/2013/03/27/17464
Sun, October 27, 2013
TWiV 256: How mice say nodavirus
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Vincent, Dickson, Alan, Rich, and Kathy review two papers that present evidence for RNA interference as an antiviral immunity mechanism in mammals. Links for this episode: World Polio Day Mole Day John Holland's publications RNAi is antiviral in mammals (Science) Antiviral RNA interference in mammals (Science) RNAi, antiviral after all (Science) Is RNA interference antiviral in mammals? (Cell Host Microbe) Nodamura virus (Nature) E bolavirus proteins suppress RNAi (J Virol) Illustrated is an siRNA (orange), dicer (top right), and argonaute (bottom) Letters read on TWiV 256 Weekly Science Picks Dickson - </strong
Mon, October 21, 2013
TWiV 255: Longhorns go viral
Hosts: Vincent Racaniello and Rich Condit Guests: Robert Krug and Christopher Sullivan Vincent and Rich visit the University of Texas at Austin and meet up with Bob and Chris to talk about their work on influenza virus and microRNAs. Links for this episode: Virus-encoded microRNAs (PLoS Path) microRNA targetomes of polyomavirus (J Virol) Innate and RNAi reciprocal inhibition (Cell) ISG15 pathway (Trends Micro) Role of viral NS1 protein (Virology) Cap-snatching (Cell) Weekly Science Picks Rich - Unraveling Bolero Vincent - New botulinum toxin , DURC implications , and inconvenient truths Send your virology questions and comments (email or mp3 file)
Sun, October 13, 2013
TWiV 254: Ninety-nine macaques on the wall
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Vincent, Dickson, Alan, and Kathy review clearance of simian immunodeficiency virus infection from macaques by immunization with SIV proteins encoded in a rhesus cytomegalovirus vector. Links for this episode: Immune clearance of SIV infection (Nature) Rhesus CMV vectors (Nature Medicine) Types of memory T cells (WikiPedia) Goldilocks approach to vaccines (Scilogs) Chimeric HA influenza vaccine (J Virol) Influenza vaccine matched vs mismatched (BMC Medicine) Letters read on TWiV 254 Weekly Science Picks Dickson - The Man Who Planted Trees by Jean Giono Kathy - A boy and his atom and Moving Atoms (YouTube) Alan - It is pitch dark and <a href="http://www.youtube.com/watch?v=L
Sun, October 06, 2013
TWiV 253: I don't know anything about sorghum
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler In this second consecutive all-email episode, the complete TWiV team reads questions and comments from listeners about systemic antiviral responses, wild type poliovirus in Israel, Turkish scientists, viral symbiotes, and much more. Links for this episode: One Nation in support of biomedical research? Bilim Kazani (The Cauldron of Science) Science for Gezi State of Turkish Science Pathogenesis of feline coronavirus (EID) Dinosaurs plagued by infection (PLoS One) Dinosaur renaissance (WikiPedia) Birds are dinosaurs (AMNH) Influenza vaccine enhances disease in pigs (Sci Transl Med) Gut microbes influence B-cell development (Nature) Circovirus in dogs (EID) We the microbiologist Letters read on TWiV 251 <h3 style="color: #333333; font-family: Georgia, 'Times New Roman', 'Bitstream Char
Sun, September 29, 2013
TWiV 252: Who read the last email?
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The complete TWiV team reads email from listeners about anti-vaccine activists, a career in microbiology, placentas, a virology textbook, the HeLa cell genome, norovirus, and much more. Links for this episode: Anthropic principle 1999 vaccine article by Alan Dove (Nature) Image credit: Jason Roberts Letters read on TWiV 251 Weekly Science Picks Dickson - A Sand County Almanac by Aldo Leopold Kathy - Noctilucent clouds and aurora over Scotland Alan - Flu vaccination map Rich - There's a fly in my urinal Vincent - Picornaviridae.com Listener Pick of the Week Peter -
Fri, September 20, 2013
TWiV 251: Don't kiss the camel
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The complete TWiV crew reviews work on MERS-coronavirus, including serological studies in camels, production of an infectious DNA clone, and identification of an interferon antagonist. Links for this episode: Stephan Chron dies (NY Times) Philip Marcus dies (NY Times) Philip Marcus on TWiV #197 Ellen Fanning dies (news@Vanderbilt) Donald Low dies (CBC News) MERS timeline MERS-CoV seroepidemiology (Eurosurveillance) MERS-CoV neutralizing antibodies in camels (Lancet Inf Dis) MERS-CoV vaccine candidate (mBio) MERS-CoV infectious DNA (PNAS) MERS-CoV protein 4a is IFN antagonist (J Virol) Letters read on TWiV 251 <h3
Sun, September 15, 2013
TWiV 250: Wookie viruses
Hosts: Vincent Racaniello and Robert Garcea Vincent and Robert recorded this episode at the 53rd ICAAC in Denver, where they talked about polyomaviruses. Links for this episode: A cornucopia of human polyomaviruses (Nat Rev Micro) Polyoma assembly factories in nucleus (PLoS Path) Overprinting gene in Merkel cell polyomavirus (PNAS) Human JCV as population marker (PLoS One) Letters read on TWiV 250 Video of this episode ( YouTube ) Weekly Science Picks Robert - The Panic Virus by Seth Mnookin Vincent - Aliens chestburster behind the scenes Listener Pick of the Week Adam - Virology Fact of the Day Christophe - <a href="http://www.abc.net.a
Mon, September 09, 2013
TWiV 249: An inordinate fondness for viruses
Hosts: Vincent Racaniello , Dickson Despommier, Alan Dove , and Rich Condit Vincent, Dickson, Alan and Rich discuss an estimate of the number of different mammalian viruses on Earth. Links for this episode: Estimate of unknown viral diversity in mammals (mBio) How many viruses on Earth? (virology blog) Letters read on TWiV 249 Weekly Science Picks Alan - Extreme macrophotography Dickson - Baloney detection kit Rich - Mutant silkworms spin colored silk ( original article ) Vincent - FlightRadar24 Listener Pick of the Week Jenn - Ebola by William Close Jenn - <a href="http://astore.amazon.com/virologyws-
Sun, September 01, 2013
TWiV 248: TWiP infects TWiV
Hosts: Vincent Racaniello , Dickson Despommier, and Rich Condit Vincent, Dickson, and Rich reveal how experiments with a malaria parasite lead to the introduction of a mammalian retrovirus into birds. Links for this episode: Scientists cast doubt on MERS origin (NY Times) Animal reservoirs of SARS coronavirus (Virus Res) Jo Handelsman in the White House Origins of REV (PLoS Biology) Inadvertent transfer (virology blog) Mongoose, pheasant, pox, retrovirus (PLoS Biol) Evolutionary history of REVs Amazing story (Ed Yong) My wife's P. lophurae paper (Mol Bio Parasitol) William Trager's SNV paper (Exp Biol Med) EBV detection tests (Clin Diag Lab Immunol) Letters read on TWiV 248 Weekly Science Picks Dickson - Google Sky Rich - </stro
Mon, August 26, 2013
TWiV 247: Today's weather in virology
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Special guest: Ian Lipkin Ian joins Vincent, Alan, Rich, and Kathy to describe how his laboratory is searching for the origin of MERS-coronavirus. Links for this episode: M ERS-CoV in bats (EID) Mystery virus (NY Times) Part of MERS-CoV found in bat (virology blog() T. perforatus Frag virus (Virol J) Even Nature got it wrong! ( Nature ) Bats: Important reservoirs of emerging viruses (Clin Micro Rev) Letters read on TWiV 247 Weekly Science Picks Kathy - Rainbows explained (Frazz) Alan - Challenge.gov <a href="http://www.npr.org/blogs/13.7/201
Sun, August 18, 2013
TWiV 246: Pandora, pandemics, and privacy
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Vincent, Alan, Rich, and Kathy discuss the huge Pandoravirus, virologists planning H7N9 gain of function experiments, and limited access to the HeLa cell genome sequence. Links for this episode: Pandoraviruses (Science) Unlike anything seen before (virology blog) H7N9 gain of function experiments planned ( Nature , Science ) Virologists plan H7N9 gain of function experiments (virology blog) Creating a deadly virus ? Not!! (USA Today) HeLa cell genome sequence (Nature) NIH Director explains HeLa agreement (Nature) HeLa deal (Nature) Biospecimen policy (Nature) Sequencing HeLa the right way (turbidplaque) Skloot on HeLa deal (The Scientist) HeLa deal (<a href="http://www.nytimes.com/2013/08/08/science/
Sun, August 11, 2013
TWiV 245: Writing Principles of Virology
Host: Vincent Racaniello Guests: S. Jane Flint, Lynn Enquist, Glenn Rall, and Ann Skalka The authors of the popular textbook Principles of Virology discuss how the book was conceived and written. Links for this episode: Principles of Virology Lahiere's General Virology by SE Luria Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Mon, August 05, 2013
TWiV 244: Back in the CVVR
Hosts: Vincent Racaniello and Alan Dove Guests: Dan Barouch and Jeff Teigler This episode of TWiV was recorded before an audience at the Beth Israel Deaconess Medical Center, where Vincent and Alan spoke with Dan and Jeff about AIDS vaccines. Links for this episode: Human study of adenovirus 26 HIV-1 envelope vaccine (J Inf Dis) Seroepidemiology of adenovirus serotypes (Vaccine) SIV infection associated with expansion of gut virome (Cell, TWiV #204 ) Global approach to HIV-1 vaccine development (Immunol Rev) Innate cytokine responses to adenoviruses (J Virol) microRNAs as mediators of viral evasion (Nat Immunol) Letters read on TWiV 244 Weekly Science Picks Jeff - Science in the News ; How to succeed in science ( part one and part two ) <a href="http://www.npr.org/blogs/13.7/2013/03/27/174647716/h
Sun, July 28, 2013
TWiV 243: Live from ASV at Penn State
Hosts: Vincent Racaniello , Rich Condit , and Kathy Spindler Guests: Rebecca Dutch and Christiane Wobus On this episode of TWiV, which was recorded before a large enthusiastic audience at the annual meeting of the American Society for Virology, Vincent, Rich, and Kathy speak with Rebecca and Christiane about their work on metapneumoviruses and noroviruses. Links for this episode: TWiV 143 with Stephanie Karst American Society for Virology Mouse model for human norovirus (mBio) Paramyxovirus fusion (Viruses) Photo credit: Matt Evans Weekly Science Picks Kathy - Shuffling cards Vincent - Dave Bhella - Electron cryomicroscopy Rich</stro
Sat, July 20, 2013
TWiV 242: I want my MMTV
Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler The complete TWiV team talks about how two different viruses shape the evolution of an essential housekeeping protein. Links for this episode: Dual virus-host arms race (PLoS Biology) Dual virus-receptor duel (see comments - virology blog) Ferritin and transferrin (Protein Data Bank) Money for nothing (YouTube) Letters read on TWiV 242 Weekly Science Picks Dickson - Mantid images Kathy - No email? (phd comics) Alan - The turbid plaque Vincent - AAM Faq: West Nile Virus Rich - Science is awesome <a href="http://www.youtube.com/watch?v=sLDSNvQjXe8" target="_bla
Sun, July 14, 2013
TWiV 241: The ferret looks ill
Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Vincent, Alan, Rich and Kathy review how human placental trophoblasts confer viral resistance via exosome-mediated delivery of microRNAs, and isolation of the first human influenza virus in 1933. Links for this episode: H uman placental trophoblasts confer viral resistance (PNAS) Placental circulation (Wikipedia) Ovum in uterine decidua (Wikipedia) A virus obtained from influenza patients (Lancet) 80 years ago today (the guardian) Influenza: Exposing the true killer (J Exp Med) Letters read on TWiV 239 Weekly Science Picks Matt - The Kid Should See This Alan - Cassini to photograph Earth Vincent - Cockroaches! (YouTube) Rich - <a href="http
Wed, July 03, 2013
TWiV 240: Virology in Vermont
Host: Vincent Racaniello Guests: Markus Thali and Jason Botten Vincent travels to the University of Vermont to talk with Markus and Jason about their work on HIV, influenza virus, arenaviruses and hantaviruses. Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sat, June 29, 2013
TWiV 239: Filterable camels
Hosts: Vincent Racaniello , Alan Dove , Rich Condit, and Matt Frieman Matt joins Vincent, Alan, and Rich to summarize what we know and what we do not know about the MERS coronavirus. Links for this episode: MERS-CoV update (WHO) MERS-CoV evolution (epidemic) Sick camel linked to MERS-CoV death (7Days) MERS-CoV hospital outbreak (NEJM) MERS-CoV French hospital cluster (Lancet) MERS-CoV family cluster (NEJM) Matt on MERS-CoV on the Voice of Russia Letters read on TWiV 239 Weekly Science Picks Matt - The Kid Should See This Alan - Cassini to photograph Earth Vincent - Cockroaches! (YouTube) Rich - Sydney Brenner (Web of Stories)<a href="http://www.youtube.com/watch?v
Sun, June 23, 2013
TWiV 238: Lost in translation
Hosts: Vincent Racaniello , Rich Condit , and Kathy Spindler Vincent, Rich and Kathy discuss mechanisms of protein synthesis and regulation in virus-infected cells. Links for this episode: Slides for this episode (pdf) T7 ribosomal binding sites (CSH Symp Quant Biol) Tinkering with translation (CSH Persp) Translation at nexus of infection and immunity (Cell Host Microbe) Viral subversion of protein synthesis machinery (Nat Rev Micr) Weekly Science Picks Kathy - Vaccine-preventable outbreaks Rich - To Catch a Virus by John Booss and Marilyn J. August Vincent - This is Water by David Foster Wallace Listener Pick of the Week Jon - <a href="http://www.youtube.com/watch?v=WwslBPj8GgI" ta
Sun, June 16, 2013
TWiV 237: Paleovirology with Michael Emerman
Hosts: Vincent Racaniello and Rich Condit Guest: Michael Emerman Vincent and Rich recorded this episode at the Fred Hutchinson Cancer Research Center in Seattle, WA, where they met up with Michael to talk about his work on the molecular and evolutionary basis of HIV replication and pathogenesis. Links for this episode: Ancient origins of SIV (PLoS Path) Paleovirology (PLoS Biology) Harmit Malik on TWiV 205 Sara Sawyer on TWiV 193 Listener Pick of the Week Molly - Facts in the case of Dr. Andrew Wakefield Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sun, June 09, 2013
TWIV 236: Flu gets the VIP treatment
Hosts: Vincent Racaniello , Alan Dove , and Kathy Spindler Vincent, Alan and Kathy review novel approaches to preventing influenza virus infection. Links for this episode: Ultraprotective influenza vaccine in mice (PNAS) Vectored immunoprophylaxis of influenza in mice (Nat Biotech) Intranasal antibody gene transfer protects agains influenza (Sci Transl Med) Estimating influenza associated deaths (CDC) Multistate HAV outbreak (CDC) Subscribe to Microbeworld video (YouTube) Save podcasting (EFF) Letters read on TWiV 236 Weekly Science Picks Alan - Psychology of antivaccinationists Vincent - Virology on Coursera Kathy - Meteorites through the ages <h3 style="color: #333333; font-family: Georgia, 'Times New Roman'
Mon, June 03, 2013
TWiV 235: Live in Edmonton, eh?
Hosts: Vincent Racaniello and Rich Condit Guests: Dave Evans , Stan Lemon , and Lorne Tyrrell Vincent and Rich recorded this episode before an audience at the 2nd Li Ka Shing Institute of Virology Symposium at the University of Alberta, where they spoke with Dave, Stan, and Lorne about their work on poxvirus vaccines and recombination, an enveloped picornavirus, antivirals against hepatitis B and C viruses, and supporting virology research in Alberta. Links for this episode: Li Ka Shing Institute of Virology Alberta Heritage Foundation for Medical Research Raised on a farm (YouTube) Vaccinia virus strains in Dryvax vaccine (J Virol) Vaccinia DNA polymerase and recombination (J Virol) Picornavirus hijacks cell membrane (Nature) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sun, May 26, 2013
TWiV 234: Live in Denver
Hosts: Vincent Racaniello and Kathy Spindler Guests: Nels Elde and Tom Shenk Vincent and Kathy recorded this episode before an audience at the 2013 General Meeting of the American Society for Microbiology in Denver, Colorado, where they spoke with Nels and Tom about their work on the evolution of virus-host conflict and how viruses influence the cell metabolome. Links for this episode: A cross-species view on viruses (Curr Op Virol) Pox has got a squeeze box (TWiV 198) Saturated fatty acids needed for CMV (PLoS Path) CMV and HSV metabolomes differ (PLoS Path) Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Sat, May 18, 2013
TWiV 233: We're surrounded
Hosts: Vincent Racaniello , Rich Condit , Alan Dove , and Kathy Spindler Vincent, Rich, Alan and Kathy review aerosol transmission studies of influenza H1N1 x H5N1 reassortants, H7N9 infections in China, and the MERS coronavirus. Links for this episode: Aerosol transmission of H1N1 x H5N1 reassortants (Science) It's good science (virology blog) Viral engineering dangers (Nature) Colorblind web page filter Influenza H7N9 update (ProMedMail) Influenza H7N9 risk assessment (WHO, pdf) Influenza H7N9 confirmed cases (WHO) New coronavirus gets a new name (ScienceInsider) Novel coronavirus infection update (WHO) Coronavirus infections (WHO) Letters read on TWiV 233 Weekly Science Picks </str
Sun, May 12, 2013
TWiV 232: Gophers go viral
Hosts: Vincent Racaniello , Roberto Cattaneo , Reuben Harris , Lou Mansky , and Leslie Schiff Vincent meets up with Roberto, Reuben, Lou, and Leslie at the University of Minnesota to talk about their work on HIV-1, APOBEC proteins, measles virus, and teaching virology to undergraduates. Links for this episode: University of Minnesota virology timeline Revisiting HIV-1 lethal mutagenesis (Trends Micro) Exploiting HIV-1 drug repositioning (J Virol) 5-azaC induces HIV-1 lethal mutagenesis (J Virol) HIV-1 fitness and mutation rate (J Mol Biol) APOBEC3 mutagenesis in breast cancer (Nature) Restriction factors of HIV (J Biol Chem) Nectin-4 is epithelial measles receptor (Nature) Photographs of this episode: Click here Video of this episode - YouTube <span style="t
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